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The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 2 | Pages 154 - 158
1 Feb 2008
Calder JD Hine AL Pearse MF Revell PA

Total hip replacement in patients with advanced osteonecrosis of the femoral head is often complicated by early loosening of the femoral component. Recent evidence has suggested that abnormal bone extending into the proximal femur may be responsible for the early failure of the femoral component. We aimed to identify which patients were at high risk of early failure by evaluating gadolinium-enhanced MR images of histologically-confirmed osteonecrotic lesions beyond the femoral head.

Although the MR signal intensity has been shown to correlate well with osteonecrosis in the femoral head, it was found to be relatively insensitive at identifying lesions below the head, with a sensitivity of only 51% and a predictive value of a negative result of only 48%. However, the specificity was 90%, with the predictive value of a positive MRI finding being 86%. Only those patients with osteonecrosis of the femoral head secondary to sickle-cell disease, who are known to be at high risk of early loosening, had changes in the MR signal in the greater trochanter and the femoral shaft. This observation suggests that changes in the MR signal beyond the femoral head may represent osteonecrotic lesions in areas essential for the fixation of the femoral component. Pre-operative identification of such lesions in the neck of the femur may be important when considering hip resurfacing for osteonecrosis of the femoral head, following which early loosening of the femoral component and fracture of the neck are possible complications.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_II | Pages 159 - 159
1 Feb 2003
Nicol SG George MD Pearse MF
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Impaction bone grafting has become an established technique in restoring acetabular and femoral bone stock loss during hip replacement surgery. This study presents our preliminary results using this technique to restore acetabular bone stock loss during cemented total hip replacement, with particular reference to the use of a preformed perforated metallic mesh to contain major acetabular defects.

In 52 patients (55 hips), acetabular reconstruction with impaction bone grafting was undertaken during total hip replacement (7 primary and 48 revision, of which 13 had previously undergone multiple revisions). The mean age at the time of surgery was 68 (range 34 to 88). In 31 cases (30 segmental or combined acetabular deficiencies, and one case of pelvic discontinuity) a pre-formed stainless steel mesh was utilised to contain the impacted morsellised bone graft. There were no perioperative deaths or deep infections and few complications (2 non-recurrent dislocations and 2 deep vein thromboses). At a mean follow-up of 40 months (range 18 to 91 months) there have been no revisions for any reason. Three patients who died before a minimum follow-up of 18 months have been excluded. Of the 49 patients (52 hips) remaining, clinical hip scores (Merle d’Aubigne and Postel) averaged 5.3 for pain, 4.2 for walking ability, and 5.3 for range of movement (with 16 patients in Charnley group A, 14 in group B, and 19 in group C). There was one case of radiographic loosening, with a radiolucent line > 2mm diameter in all 3 zones of DeLee and Charnley, although the cup has not migrated and the patient remains pain-free. All other cases show radiographic changes suggestive of ongoing graft incorporation.

We consider that the use of preformed metallic meshes extends the scope of impaction bone grafting to include cases where major segmental acetabular deficiencies are encountered, allowing restoration of bone stock and an anatomical centre of hip rotation, with encouraging preliminary clinical and radiological results.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 38 - 39
1 Jan 2003
Naique SB Madhav RT Pearse MF
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31 cases of high-energy proximal tibial fractures were retrospectively analysed. The series included 22 cases of Schatzker VI and 9 cases of proximal tibial extraarticular fractures. There were 7 females and 24 males, with average age being 45years(26–94). There were 12 open fractures ( 1 Gustilo grade1, 10 grade 3b and one 3c); while 19 cases had Tcherne’s grade 2–3 injury. 4 patients developed compartment syndromes requiring fasciotomy. All fractures were treated with preliminary ligamentotaxis using a unilateral external fixator. In addition, Open fractures underwent radical debridement with the one case of 3c requiring vascular reconstruction. CT scan was then done to assess the joint incongruity ,anatomy of the fracture, and to aid in decision making. The fractures were then fixed using percutaneous techniques and a circular external fixator. Minimal open reduction was resorted to in cases with significant joint depression. In all, 26 cases were managed using percutaneous techniques alone while 5 required minimal open reduction and screw fixation. Bone grafting was done in 6 cases and 11 required a plastics procedure for soft tissue reconstruction. The results were assessed using the radiological Rasmussen’s criteria and the clinically using he IKSS knee score. At a mean follow-up of 31mths, the mean time to metaphyseal union was 18weeks (6–25weeks);. 28 patients had good to excellent clinical scores, while 3 had a fair result. The radiologic assessment graded 12 cases as excellent and 19 as good. Complications included 2 cases with flap edge necrosis, 2 with severe pin tract sepsis, 1 with proximal DVT and one case with septic arthritis.

We conclude that the above treatment protocol yields promising results, preserving good knee function without prejudicing future need for arthroplasty.


The Journal of Bone & Joint Surgery British Volume
Vol. 83-B, Issue 3 | Pages 419 - 422
1 Apr 2001
Calder JDF Pearse MF Revell PA

Our aim was to assess the local extent of osteocyte death in the proximal femur of 16 patients with osteonecrosis of the femoral head. We performed histological examination of the femoral heads and cancellous bone biopsies from four regions of the proximal femur in patients undergoing total hip arthroplasty. A control group consisted of 19 patients with osteoarthritis. All histological specimens were examined in a blinded fashion.

Extensive osteonecrosis was shown in the proximal femur up to 4 cm below the lesser trochanter in the group with osteonecrosis. There was an overall statistically significant difference in the extent of osteocyte death distal to the femoral head between the two groups (p < 0.001). We discuss the implications of these findings as possible contributing factors in regard to the early failure of total hip arthroplasty reported in patients with osteonecrosis of the femoral head.


The Journal of Bone & Joint Surgery British Volume
Vol. 81-B, Issue 4 | Pages 621 - 624
1 Jul 1999
Calder JDF Hollingdale JP Pearse MF

We studied prospectively 30 patients who had a Mitchell’s osteotomy secured by either a suture followed by immobilisation in a plaster boot for six weeks, or by a cortical screw with early mobilisation.

The mean time for return to social activities after fixation by a screw was 2.9 weeks and to work 4.9 weeks, which was significantly earlier than those who had stabilisation by a suture (5.7 and 8.7 weeks, respectively; p < 0.001). Use of a screw also produced a higher degree of patient satisfaction at six weeks, and an earlier return to wearing normal footwear. The improvement in forefoot scores was significantly greater after fixation by a screw at six weeks (p = 0.036) and three months (p = 0.024). At one year, two screws had been removed because of pain at the site of the screw head.

Internal fixation of Mitchell’s osteotomy by a screw allows the safe early mobilisation of patients and reduces the time required for convalescence.