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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXIII | Pages 188 - 188
1 May 2012
Roger G Lane R Phillips M Huckson M Liang S
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Introduction

The concept and method of repeatedly connecting an extracorporeal blood pump to produce elevated pancycle inflow pressures to ischaemic limbs is presented. The aim of this study was to determine if intermittent increased perfusion would improve the clinical picture in peripheral arterial disease.

Methods

Animal studies—to determine the safety and efficacy of the pumping and the access device were performed on 12 sheep. Following successful completion of that study, pilot studies of 18 patients were treated using the Peripheral Access Device (PAD) and Hypertensive Extracorporeal Limb Hyperperfusion (HELP). Treatment was offered to patients who had no other alternative than major amputation. Patients were treated for less than 100 hours of total pumping, broken over three or less treatment periods over approximately one week. Improvement was measured by pain scores, clinical examination and digital thermography.