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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_II | Pages 210 - 211
1 May 2011
Dodd M Briffa N Bourke H Ward D
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Introduction: The Durom hip acetabular component is a large diameter metal on metal (MoM) implant that has recently been the subject of much controversy. Dr. Lawrence Dorr, reported in a letter in April 2008 to the American Association of Hip and Knee Surgeons a worryingly high number of early revisions, as many as 8%, within the first 2 years as a result of a loose acetabular component. Following a Zimmer investigation an early revision rate of 5.7% in the US, but not in Europe, was revealed and this has resulted in the withdrawal of the implant from the market in the US and justifiable concern with regards to its usage resulting in decreased implantation within the UK. Surgical technique in the US has been sited as the main reason for failure as a result of low volume centres not performing crucial steps in the technique which include, but are not limited to, line-to-line reaming, use of trials in every case, proper cup position for this device, appropriate impaction techniques and no repositioning. We present the short term results and our experience of the Durom Acetabular component in our centre in the UK.

Method: We reviewed all patients that had a Durom Acetabular component implanted since its usage began in our unit in 2003. No patients were excluded and the end point being revision surgery of the Durom acetabular component. In addition we analysed the plain radiographs of a random selection of 50 patients to assess component integration.

Results: 260 patients had undergone primary hip surgery with the implantation of the Durom Acetabular component. 108 as part of a hip resurfacing and 152 as a large bearing MoM THR. Their follow up ranged from 1 to 7 years. 1 had undergone revision for thigh pain with aseptic failure of the acetabular component, 1 for ALVAL, 3 had undergone revison for infection and 1 for peri-prosthetic fracture. Analysis of the radiographs revealed a number of acetabulae with a lucent line visible around the implant. None of the implants had migrated from their original position at implantation.

Conclusions: At present their appears to be no evidence in our unit that the Durom Acetabular component has a higher than expected rate of early revision. However, a number of patients do appear to have lucency around the component on radiographs raising the possibility of questionable bony integration and on growth. Reports from the United States have suggested that the cup will “spin out” easily at revision showing no signs of bony integration. This may result in an increased revision rate in the future and we suggest that all patients that have a Durom acetabular component in situ be followed up with yearly clinical assesment and radiographs to assess the longevity of this component.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 4 - 4
1 Jan 2003
Bourke H Sandison A Hughes S Reichert I
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Vascular Endothelial Growth Factor (VEGF) has been shown to stimulate angiogenesis in a number of tissues and, in addition, to possess direct vasoactive properties. Stimulation of blood flow and angiogenesis are important features of the fracture healing process, particular in the early phases of healing. Inadequate vascularity has been associated with delayed union after fracture. The periosteum, and in particular its osteogenic cambial layer, has been shown to be very reactive to fracture and to contribute substantially to fracture healing. Fracture haematoma contains a considerable concentration of VEGF and enhanced plasma levels are observed in patients with multiple trauma. VEGF has been suggested to play a role during new bone formation possibly providing an important link between hypertrophic cartilage, angiogenesis and consequent ossification. However, the expression of VEGF in normal periosteum and in periosteum close to a fracture has not been previously reported. We hypothesise that the expression of VEGF in long bone periosteum will show a distinct response to fracture.

We investigated the expression of VEGF in vivo in human periosteum, using immunocytochemistry to detect the expression of Factor VIII and VEGF protein respectively. Under prior approval from the local Ethics Committee, biopsies of periosteal tissues were collected from two distinct groups (1) control and (2) following long bone fracture. Patient age range was 16 – 45 years for both groups. Group 1 consisted of patients (n = 5) who underwent an elective orthopaedic procedure during which periosteum was disrupted. Group 2 patients (n = 8) had long bone fractures from which periosteal tissue was harvested close to the fracture site during internal fixation at various time points following fracture (24 hours to nine days).

In Group 1 the periosteum showed abundant but delicate blood vessels staining throughout for VEGF but there was no other visible staining of other structures or cells. In Group 2 the vasculature in the periosteum close to the fracture site demonstrated a characteristic, time-dependent course of expression of VEGF. At 24 and 48h following fracture the vasculature showed a heterogenous picture. The vessels in periosteum showed signs of activation: thickened endothelia and dilated lumina, but did not express VEGF. At 60h the vessels began to show signs of the presence of VEGF protein and by 4 days most periosteal vessels expressed VEGF. Also at this time, VEGF staining was visible in some of the stromal cells of the periosteum that was not seen in any of the earlier times. At 9 days VEGF was visible not only in the omnipresent vasculature, but now consistently in spindle shaped cells of fibroblastic appearance and chondrocytes throughout the early callus.

This study, though limited by the number of patients, shows for the first time the expression of VEGF in normal periosteum as well as in periosteum during fracture healing. Interestingly, activated vessels in the early healing phase show little expression of VEGF; however it is known that the fracture haematoma contains VEGF in abundance. It is possible that the vasoactive role of VEGF prevails in these early days. There may be a critical time point at around 48h post fracture following which angiogenesis begins and VEGF is expressed in the endothelium throughout the vessel wall. The study suggests an important role for VEGF in the regulation of fracture healing. VEGF is not only expressed in endothelial cells within the periosteum but also in fibroblast-like stem cells and chondrocytes throughout the early callus suggesting it may play an important role in both osteo- and angiogenesis


The Journal of Bone & Joint Surgery British Volume
Vol. 77-B, Issue 4 | Pages 615 - 619
1 Jul 1995
Fraser R Bourke H Broughton N Menelaus M

We reviewed 16 patients with spina bifida and unilateral dislocation of the hip at an average age of 17 years. Nine had a high neurological level (thoracic to L3) and seven a low lesion (L4 to sacral). We assessed the influence of unilateral dislocation of the hip on leg-length discrepancy, hip pain, hip stiffness and pressure sores of the ischial tuberosity. In non-walking patients with high-level lesions, unilateral dislocation gave little functional disability and did not appear to require reduction. In walking patients with low-level lesions, leg-length discrepancy led to a poor gait and functional problems which could be prevented by reduction of the dislocation. In all patients with low lesions, surgery was successful in maintaining reduction; in two of five patients with high lesions it was unsuccessful.