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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_1 | Pages 68 - 68
1 Feb 2020
Gascoyne T Pejhan S Bohm E Wyss U
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Background

The anatomy of the human knee is very different than the tibiofemoral surface geometry of most modern total knee replacements (TKRs). Many TKRs are designed with simplified articulating surfaces that are mediolaterally symmetrical, resulting in non-natural patterns of motion of the knee joint [1]. Recent orthopaedic trends portray a shift away from basic tibiofemoral geometry towards designs which better replicate natural knee kinematics by adding constraint to the medial condyle and decreasing constraint on the lateral condyle [2]. A recent design concept has paired this theory with the concept of guided kinematic motion throughout the flexion range [3]. The purpose of this study was to validate the kinematic pattern of motion of the surface-guided knee concept through in vitro, mechanical testing.

Methods

Prototypes of the surface-guided knee implant were manufactured using cobalt chromium alloy (femoral component) and ultra-high molecular weight polyethylene (tibial component). The prototypes were installed in a force-controlled knee wear simulator (AMTI, Watertown, MA) to assess kinematic behavior of the tibiofemoral articulation (Figure 1). Axial joint load and knee flexion experienced during lunging and squatting exercises were extracted from literature and used as the primary inputs for the test. Anteroposterior and internal-external rotation of the implant components were left unconstrained so as to be passively driven by the tibiofemoral surface geometry. One hundred cycles of each exercise were performed on the simulator at 0.33 Hz using diluted bovine calf serum as the articular surface lubricant. Component motion and reaction force outputs were collected from the knee simulator and compared against the kinematic targets of the design in order to validate the surface-guided knee concept.


Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 146 - 146
1 Jul 2014
Wyss U Dyrkacz R Ojo O Turgeon T Brandt J
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Summary

Corrosion and fretting damage at the head-neck interface of artificial hip joints is more severe with larger head sizes. This is a concern, as the release of metal particles and ions can cause adverse tissue reactions, similar to those observed high wear metal-on-metal articulations.

Introduction

In the last few years corrosion was increasingly observed at head-neck interfaces of artificial hip joints, especially in joints with larger heads. There has always been evidence of some corrosion at modular junctions of artificial joints, but except for few designs, it was not seen as a real problem. It is important to better understand the factors contributing to corrosion at modular interfaces, so that necessary improvements can be made to minimise or completely avoid corrosion, in order to avoid possible adverse tissue reactions.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_34 | Pages 299 - 299
1 Dec 2013
Dyrkacz R Wyss U Brandt J Turgeon T
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Introduction

This retrieval analysis study consisted of two goals. The first goal was to determine if there was a difference in the corrosion and fretting damage along the taper interface between large femoral heads in comparison to monopolar hemiarthroplasty heads. The second goal was to examine if the diameter of monopolar hemiarthroplasty heads can influence corrosion and fretting damage along the taper interface.

Patients and Methods

This retrieval analysis compared the corrosion and fretting behaviour of 40 mm femoral heads (n = 13) to monopolar hemiarthroplasty heads (n = 17 for a diameter < 50 mm; n = 6 for a diameter ≥ 50 mm) such that all implants had a minimum implantation period of three months, a 12/14 mm taper, and the heads and stems consisted of CoCr alloy. The 40 mm heads articulated with a polyethylene cup whereas the monopolar hemiarthroplasty heads articulated with cartilage. The 40 mm heads were manufactured from one company whereas the monopolar hemiarthroplasty heads were manufactured from four different companies. Corrosion and fretting damage were assessed using a previous technique [1]. Table 1 lists the patient information and reasons for revision whereas Table 2 provides the implant information.

The Mann Whitney U test and the Kruskal-Wallis test were performed for identifying significant differences for corrosion and fretting scores that were not normally distributed (α = 0.05). An unpaired student's t-test was conducted for comparing the head corrosion scores for the two head size groups of monopolar hemiarthroplasty implants since these scores were normally distributed.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 2 - 2
1 Jun 2012
Acker S Kutzner I Bergmann G Deluzio K Wyss U
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Accurate in vivo knee joint contact forces are required for joint simulator protocols and finite element models during the development and testing of total knee replacements (Varadarajan et al., 2008.) More accurate knowledge of knee joint contact forces during high flexion activities may lead to safer high flexion implant designs, better understanding of wear mechanisms, and prevention of complications such as aseptic loosening (Komistek et al., 2005.) High flexion is essential for lifestyle and cultural activities in the developing world, as well as in Western cultures, including ground-level tasks and chores, prayer, leisure, and toileting (Hemmerich et al., 2006.) In vivo tibial loads have been reported while kneeling; but only while the subject was at rest in the kneeling position (Zhao et al., 2007), meaning that the loads were submaximal due to muscle relaxation and thigh-calf contact support. The objective of this study was to report the in vivo loads experienced during high flexion activities and to determine how closely the measured axial joint contact forces can be estimated using a simple, non-invasive model. It provides unique data to better interpret non-invasively determined joint-contact forces, as well as directly measured tiobiofemoral joint contact force data for two subjects.

Two subjects with instrumented tibial implants performed kneeling and deep knee bend activities. Two sets of trials were carried out for each activity. During the first set, an electromagnetic tracking system and two force plates were used to record lower limb kinematics and ground reaction forces under the foot and under the knee when it was on the ground. In the second set, three-dimensional joint contact forces were directly measured in vivo via instrumented tibial implants (Heinlein et al., 2007.) The measured axial joint contact forces were compared to estimates from a non-invasive joint contact force model (Smith et al., 2008.)

The maximum mean axial forces measured during the deep knee bend were 24.2 N/kg at 78.2° flexion (subject A) and 31.1 N/kg at 63.5° flexion (subject B) during the deep knee bend (Figure 1.) During the kneeling activity, the maximum mean axial force measured was 29.8 N/kg at 86.8° flexion (subject B.) While the general shapes of the model-estimated curves were similar to the directly measured curves, the axial joint contact force model underestimated the measured contact forces by 7.0 N/kg on average (Figure 2.) The most likely contributor to this underestimation is the lack of co-contraction in the model.

The study protocol was limited in that data could not be simultaneously collected due to electromagnetic interference between the motion tracking system and the inductively powered instrumented tibial component. Because skin-mounted markers were used, kinematics may be affected by skin motion artefacts. Despite these limitations, this study presents valuable information that will advance the development of high flexion total knee replacements. The study provides in vivo measurements and non-invasive estimates of joint contact forces during high flexion activities that can be used for joint simulator protocols and finite element modeling.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_II | Pages 280 - 280
1 May 2010
Tarabichi S Wyss U Smith S
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Background. Achieving full flexion is critical for total knee arthroplasty patients in the Middle East and Asia, where activities of daily living require a full range of motion. Published kinematic data for these populations is limited. The objective of this study was to compare the normal knee kinematics of Muslim subjects with those of Muslim total knee arthroplasty (TKA) patients with high flexion arthroplasties.

Methods: An electromagnetic tracking system was used to record the motion of the lower limb segments of 14 normal Muslim subjects and 10 Muslim TKA patients. Subjects performed high flexion activities of daily living such as kneeling, Muslim prayer, sitting cross-legged and squatting.

Results. For most activities, the range of motion and maximum angles in three dimensions did not significantly differ between the normal and TKA groups. A statistically significant difference in the mean range of flexion/ extension (but not the mean maximum flexion or mean maximum extension values) was found for the prayer activity only. The majority of normal subjects exhibited an internal rotation pattern with two distinct inflection points and a parabolic abduction pattern over the range of flexion. Fewer TKA patients exhibited these patterns.

Conclusions: Overall, the range of motion and ability to perform activities of daily living did not differ between normal Muslim subjects and Muslim TKA patients with a high flexion mobile bearing total knee arthroplasty. However, patterns of internal rotation and abduction that were exhibited by the majority of normal subjects were evident in fewer TKA patients. Therefore, although the range of motion was not significantly affected by the prosthesis, the patterns of motion for some subjects may have changed.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 434 - 434
1 Apr 2004
Wyss U Rieker C
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A first introduction of a successful metal-on-metal (m-o-m) articulation was made by G.K. McKee in 1956 using a cast CoCrMo alloy for the head and cup. Long-term clinical investigations of m-o-m and polyethylene-on-metal articulation showed similar 20 years follow-up survival rates. This and very good wear results obtained with some of the first generation m-o-m articulation led to a re-introduction of the m-o-m articulation in 1988. A healthy hip joint has a very low friction coefficient and almost no wear due to the optimal lubrication, which, under normal conditions, completely separates the two articulation surfaces. On the other hand all artificial hip prostheses are unable to produce or maintain a permanent lubrication film. Therefore, the surfaces of the prostheses are always subject to wear. Compared to polyethylene liners, wearing at an average linear rate of 0,1 to 0,2mm per year, m-o-m articulations showed generally very little wear. In vitro simulations of the second generation m-o-m articulation on a Stanmore hip simulator showed a steady wear rate of 5.6±7.3μm per million cycles, with a higher wear rate during the running-in phase of about one million cycles. The analysis of over 200 second-generation m-o-m retrieved hip implants showed an average linear wear rate of approximately 5μm per year after the running-in period, with a follow up time of up to ten years. There’s a great concern about the incidence of cancer after a total m-o-m hip replacement. It is very difficult to find a causal relationship between THR and cancer occurrence, as in some studies many cancers were detected within two years after THR, which indicate rather an associative relationship. However, the summarized results do not indicate an increased cancer risk after m-o-m total hip replacements. Over 130,000 m-o-m articulations have been implanted since 1988 and the clinical results have been excellent matching or surpassing current gold standards for hip replacement.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_I | Pages 9 - 9
1 Jan 2004
Burroughs B O’Connor D Sargent M Muratoglu O Rubash H Freiberg A Estok D Jasty M Harris W Deluzio K Krevolin J Wyss U Shen M
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A high proportion of complications following TKR occur at the patellofemoral articulation secondary to delami-nation and adhesive/abrasive wear. Electron beam cross-linking and melting has been shown to substantially reduce delamination and adhesive/abrasive wear in polyethylene tibial inserts. A series of in-vitro patella wear and fatigue tests were developed to explore the benefits of this material at the patellofemoral articulation.

Patellae (NKII, Sulzer Orthopedics, Inc., Austin, TX) were tested on an AMTI (Watertown, MA) knee simulator articulating against the trochlear grove of the femoral component. The simulator controlled flexion/ extension and patellofemoral contact force. Each test included patellae manufactured from conventional and electron beam crosslinked and melted polyethylene. Three different simulations were created: i) normal gait (5 million cycles) with optimal component alignment, ii) stair climbing (2 million cycles) with optimal component alignment, iii) stair climbing (2 million cycles) with 4° of femoral component internal rotation to simulate a component malalignment condition. In the last two simulations all patellae were artificially aged for 35 days in 80°C air to simulate one aspect of the long term oxidative state of each material.

In normal gait, the unaged conventional and highly cross-linked materials demonstrated similar behaviour. In stair climbing with optimal component alignment, the aged conventional patellae developed cracks by 2 million cycles. In stair climbing with component malalign-ment the aged conventional patellae developed cracks and delamination by 1 million cycles. None of the highly cross-linked components showed cracks or delamination. These results demonstrate the potential advantage of highly cross-linked polyethylene for the patella.