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Bone & Joint Research
Vol. 8, Issue 1 | Pages 3 - 10
1 Jan 2019
Hernandez P Sager B Fa A Liang T Lozano C Khazzam M

Objectives

The purpose of this study was to examine the bactericidal efficacy of hydrogen peroxide (H2O2) on Cutibacterium acnes (C. acnes). We hypothesize that H2O2 reduces the bacterial burden of C. acnes.

Methods

The effect of H2O2 was assessed by testing bactericidal effect, time course analysis, growth inhibition, and minimum bactericidal concentration. To assess the bactericidal effect, bacteria were treated for 30 minutes with 0%, 1%, 3%, 4%, 6%, 8%, or 10% H2O2 in saline or water and compared with 3% topical H2O2 solution. For time course analysis, bacteria were treated with water or saline (controls), 3% H2O2 in water, 3% H2O2 in saline, or 3% topical solution for 5, 10, 15, 20, and 30 minutes. Results were analyzed with a two-way analysis of variance (ANOVA) (p < 0.05).


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 76 - 76
1 Mar 2010
Crist B Khazzam M Wade A Murtha Y Della Rocca G
Full Access

The anterolateral surgical exposure to the distal tibia for pilon fractures has become more popular. One of the potential benefits over the commonly used anteromedial approach is a reduction in wound complications due to the improved soft tissue coverage of the anterolateral tibia. Minimal data exists regarding the rate of complications with the anterolateral approach. The purpose of this study was to evaluate wound complications in the early postoperative period associated with the use of the anterolateral approach for pilon fractures.

Methods: A retrospective review was conducted to identify all operatively treated pilon fractures at our university level 1 trauma center from September 2005 through July 2007. Sixty-eight pilon fractures were identified. All patients were treated with a staged protocol utilizing immediate external fixation followed by delayed open reduction and internal fixation based upon the condition of the soft tissue envelope. Patients who had an anterolateral surgical approach were identified and their medical records were reviewed for the first six weeks postoperatively to determine the rate of wound complications. The endpoint of six weeks was chosen to identify complications related to the surgical exposure alone.

Results: Thirty-six of the sixty-eight patients with pilon fractures had an anterolateral surgical exposure. One additional patient had an anterolateral incision performed for revision of a previously treated pilon fracture. 97% of these fractures were AO/OTA 43-C (three C1, nine C2, and twenty-three C3). The median time delay to definitive fixation was 19 days (10–38 days). Sixteen (44.4%) of the fractures were open, ten of which were Gustilo type III (five IIIA, four IIIB, and one IIIC). Eight of the thirty-seven patients had wound complications related to the anterolateral incision within the first six weeks of definitive fixation. Six patients (16%) had minor complications which were successfully treated with dressing changes and oral antibiotics, and two (5%) had major complications, with evidence of deep wound infection that required formal irrigation and debridement.

Conclusion: In a case series with a high rate of complex open pilon fractures, open reduction and internal fixation utilizing an anterolateral approach provided good exposure of the distal tibia with a low incidence of early wound complications.

Significance: Pilon fractures, especially high energy complex open ones, have a high risk of wound complications. Avoiding complications is the key in managing high energy pilon fractures. This case series provides evidence that the anterolateral approach has a low rate of wound complications in the most complex pilon fractures.