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Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_12 | Pages 29 - 29
1 Oct 2018
Lawrie CM Schwabe M Pierce A Barrack RL
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Introduction

Cemented total knee arthroplasty (TKA) remains the gold standard with survivorship above 90% at greater than 10 years postoperatively. However, with younger, heavier, more active patients undergoing TKA at an increasing rate, cementless implants have the appeal of potential for improved implant fixation longevity and decreased rates of aseptic loosening. The cementless implants are more expensive than their cemented counterparts such that implant costs may create a barrier to utilization. However, such comparisons fail to consider the unavoidable additional costs of cementing, including the cost of operating room time, cement and cementing accessories. The purpose of this study is to compare the actual cost of cemented and cementless TKA.

Methods

The TKA cost calculation included the cost of operative time, implants, cement and cementing accessories. The difference in operative time between cemented and cementless TKA was determined from a previously published study of 100 TKAs performed using a cemented (55) or press fit (45) implant of the same design performed at a single institution by four fellowship trained arthroplasty surgeons. The decision to use cemented or cementless design in these patients was made based on patient bone quality intraoperatively. Operative time was compared between groups using a Student's two-tailed T-test. The cost of operating room time was based on estimates in the recent literature. The cost of cement and cementing accessories was estimated based on publically available market data. The cost of implants was estimated from institutional data for multiple companies.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_12 | Pages 19 - 19
1 Oct 2018
Kazarian GS Barrack TN Donaldson MJ Lawrie CM Miller GA Haddad FS Barrack RL
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Introduction

Implant malalignment is an important predictor of prosthetic failure following total knee arthroplasty (TKA). The purpose of this study was to determine the incidence of outliers for common alignment targets and the impact of surgeon volume and experience on the accuracy of implant alignment with current generation manual instrumentation.

Methods

This study was a retrospective, multi-center, radiographic analysis of 1675 consecutive primary uncomplicated TKAs from seven surgeons at three academic and state-funded centers in the US and UK. Surgeons were categorized as “high-volume” (≥50 TKAs/year) and “high-experience” (≥5 years post-fellowship). Femorotibial, tibial varus/valgus, and posterior tibial slope angles were digitally measured using postoperative radiographs. Femorotibial (<2° or >8° valgus), tibial (> ±3° deviation from the neutral axis), and tibial slope (<0° or >7° of flexion for cruciate retaining, <0° or >5° of flexion for posterior stabilized) angle outliers were identified. The proportion of outliers among surgeons in each subgroup was compared.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 42 - 42
1 Oct 2018
Schloemann DT Edelstein AI Barrack RL
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Introduction

Malposition of the acetabular component in total hip arthroplasty (THA) is linked to multiple adverse outcomes. Changes in the sagittal plane position of the pelvis, owing both to patient positioning in the operating room and to altered spinopelvic alignment following surgery, potentially contribute to variation in component position. The dynamics of sagittal plane pelvic position before, during, and after THA have not been defined. We measured the differences in pelvic ratio, a measure of sagittal plane pelvic position, between preoperative, intraoperative, and postoperative anteroposterior (AP) radiographs of patients undergoing THA in the lateral decubitus position.

Methods

We retrospectively compared the radiographic pelvic ratio among 90 patients undergoing THA. AP radiographs were obtained in the standing position preoperatively and at 6 weeks after surgery; in the lateral decubitus position after trial reduction intraoperatively; and in the supine position in the post anesthesia care unit (PACU). Pelvic ratio was defined as the ratio between the vertical distance from the inferior sacroiliac (SI) joints to the superior pubic symphysis and the horizontal distance between the inferior SI joints. Radlink software was used to determine the pelvic ratio on each radiograph. Changes in apparent cup position based on changes in pelvic ratio were calculated using data from the literature, and a change of at least 10 degrees in acetabular component position was defined as clinically meaningful. Analyses were performed using paired t-tests, with p<0.05 defined as significant.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 11 - 11
1 Oct 2018
Nam D Salih R Riegler V Nunley RM Clohisy JC Lombardi AV Berend KR Barrack RL
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Introduction

Despite well-fixed implants, persistent pain following total hip arthroplasty (THA) remains a concern. Various surgical approaches have been advocated, yet whether patient-reported pain differs amongst techniques has not been investigated. This study's purposes were to determine differences in patient-reported pain based on surgical approach (direct anterior –DA versus posterolateral-PL) or PL approach incision length. Our hypothesis was that no differences in patient-reported pain would be present.

Methods

A retrospective, IRB-approved investigation from 2 centers was performed. 7 fellowship trained arthroplasty surgeons (3 DA, 3 PL, 1 both) enrolled patients undergoing primary THA for non-inflammatory arthritis. PL approach patients were categorized based on incision length (6–8cm, 8–12cm, 12–15cm). Exclusion criteria were a prior hip surgery, revision procedure, or limited postoperative mobility. All THAs were performed using a cementless titanium, proximally coated, tapered femoral stem and hemispherical acetabular component. All patients had a minimum of 1-year clinical follow-up with radiographically well-fixed components.

A pain-drawing questionnaire was administered in which patients identify the location and intensity of pain on an anatomic diagram. Independent Student's t-tests and Chi-square analyses were performed (p<0.05 = significant). Power analysis indicated 800 patients in each cohort would provide adequate power to detect a 4% difference in patient-reported pain (alpha = 0.05, beta = 0.80).


The Bone & Joint Journal
Vol. 99-B, Issue 1_Supple_A | Pages 31 - 36
1 Jan 2017
Haynes J Nam D Barrack RL

Aims

The purpose of our study is to summarise the current scientific findings regarding the impact of obesity on total hip arthroplasty (THA); specifically the influence of obesity on the timing of THA, incidence of complications, and effect on clinical and functional outcomes.

Materials and Methods

We performed a systematic review that was compliant with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines to identify prospective studies from the PubMed/Medline, Embase, and Cochrane Library databases that evaluated primary THA in obese (body mass index (BMI) ≥ 30 kg/m2) patients.


The Bone & Joint Journal
Vol. 99-B, Issue 1_Supple_A | Pages 8 - 13
1 Jan 2017
Haynes J Barrack RL Nam D

Aims

The purpose of this article was to review the current literature pertaining to the use of mobile compression devices (MCDs) for venous thromboembolism (VTE) following total joint arthroplasty (TJA), and to discuss the results of data from our institution.

Patients and Methods

Previous studies have illustrated higher rates of post-operative wound complications, re-operation and re-admission with the use of more aggressive anticoagulation regimens, such as warfarin and factor Xa inhibitors. This highlights the importance of the safety, as well as efficacy, of the chemoprophylactic regimen.


The Bone & Joint Journal
Vol. 98-B, Issue 6 | Pages 736 - 740
1 Jun 2016
Sassoon AA Barrack RL

The use of large-diameter metal-on-metal (MoM) components in total hip arthroplasty (THA) is associated with an increased risk of early failure due to adverse local tissue reaction to metal debris (ARMD) in response to the release of metal ions from the bearing couple and/or head-neck taper corrosion. The aim of this paper was to present a review of the incidence and natural history of ARMD and the forms of treatment, with a focus on the need for and extent of resection or debulking of the pseudotumour. An illustrative case report is presented of a patient with an intra-pelvic pseudotumour associated with a large diameter MoM THA, which was treated successfully with revision of the bearing surface to a dual mobility couple and retention of the well-fixed acetabular and femoral components. The pseudotumour was left in situ. Resolution of the intra-pelvic mass and normalisation of metal ion levels was observed seven months post-operatively.

Cite this article: Bone Joint J 2016;98-B:736–40.


The Bone & Joint Journal
Vol. 98-B, Issue 2 | Pages 173 - 178
1 Feb 2016
Sassoon A Nam D Jackups R Johnson SR Nunley RM Barrack RL

Aims

This study investigated whether the use of tranexamic acid (TXA) decreased blood loss and transfusion related cost following surface replacement arthroplasty (SRA).

Methods

A retrospective review of patients treated with TXA during a SRA, who did not receive autologous blood (TXA group) was performed. Two comparison groups were established; the first group comprised of patients who donated their own blood pre-operatively (auto group) and the second of patients who did not donate blood pre-operatively (control). Outcomes included transfusions, post-operative haemoglobin (Hgb), complications, and length of post-operative stay.


The Bone & Joint Journal
Vol. 96-B, Issue 12 | Pages 1657 - 1662
1 Dec 2014
Stambough JB Clohisy JC Barrack RL Nunley RM Keeney JA

The aims of this retrospective study were to compare the mid-term outcomes following revision total knee replacement (TKR) in 76 patients (81 knees) < 55 years of age with those of a matched group of primary TKRs based on age, BMI, gender and comorbid conditions. We report the activity levels, functional scores, rates of revision and complications. Compared with patients undergoing primary TKR, those undergoing revision TKR had less improvement in the mean Knee Society function scores (8.14 (–55 to +60) vs 23.3 points (–40 to +80), p < 0.001), a similar improvement in UCLA activity level (p = 0.52), and similar minor complication rates (16% vs 13%, p = 0.83) at a mean follow-up of 4.6 years (2 to 13.4). Further revision surgery was more common among revised TKRs (17% vs 5%, p = 0.02), with deep infection and instability being the most common reasons for failure. As many as one-third of patients aged < 55 years in the revision group had a complication or failure requiring further surgery.

Young patients undergoing revision TKR should be counselled that they can expect somewhat less improvement and a higher risk of complications than occur after primary TKR.

Cite this article: Bone Joint J 2014; 96-B:1657–62


The Bone & Joint Journal
Vol. 96-B, Issue 11_Supple_A | Pages 96 - 100
1 Nov 2014
Nam D Nunley RM Barrack RL

A national, multi-centre study was designed in which a questionnaire quantifying the degree of patient satisfaction and residual symptoms in patients following total knee replacement (TKR) was administered by an independent, blinded third party survey centre. A total of 90% of patients reported satisfaction with the overall functioning of their knee, but 66% felt their knee to be ‘normal’, with the reported incidence of residual symptoms and functional problems ranging from 33% to 54%. Female patients and patients from low-income households had increased odds of reporting dissatisfaction. Neither the use of contemporary implant designs (gender-specific, high-flex, rotating platform) or custom cutting guides (CCG) with a neutral mechanical axis target improved patient-perceived outcomes. However, use of a CCG to perform a so-called kinematically aligned TKR showed a trend towards more patients reporting their knee to feel ‘normal’ when compared with a so called mechanically aligned TKR

This data shows a degree of dissatisfaction and residual symptoms following TKR, and that several recent modifications in implant design and surgical technique have not improved the current situation.

Cite this article: Bone Joint J 2014;96-B(11 Suppl A):96–100.


The Bone & Joint Journal
Vol. 96-B, Issue 5 | Pages 619 - 621
1 May 2014
Adelani MA Johnson SR Keeney JA Nunley RM Barrack RL

Haematomas, drainage, and other non-infectious wound complications following total knee replacement (TKR) have been associated with long-term sequelae, in particular, deep infection. However, the impact of these wound complications on clinical outcome is unknown. This study compares results in 15 patients re-admitted for wound complications within 90 days of TKR to 30 matched patients who underwent uncomplicated total knee replacements. Patients with wound complications had a mean age of 66 years (49 to 83) and mean body mass index (BMI) of 37 (21 to 54), both similar to that of patients without complications (mean age 65 years and mean BMI 35). Those with complications had lower mean Knee Society function scores (46 (0 to 100 vs 66 (20 to 100), p = 0.047) and a higher incidence of mild or greater pain (73% vs 33%, p = 0.01) after two years compared with the non re-admitted group. Expectations in patients with wound complications following TKR should be tempered, even in those who do not develop an infection.

Cite this article: Bone Joint J 2014;96-B:619–21.


The Bone & Joint Journal
Vol. 96-B, Issue 1 | Pages 3 - 4
1 Jan 2014
Barrack RL


The Bone & Joint Journal
Vol. 95-B, Issue 11_Supple_A | Pages 53 - 56
1 Nov 2013
Su EP Barrack RL

Cementless femoral stems are currently preferred for total hip replacement (THR) in the United States. Improvements in stem design, instrumentation and surgical technique have made this technology highly successful, reproducible, and applicable to the vast majority of patients requiring a THR. However, there are ongoing developments in some aspects of stem design that influence clinical results, the incidence of complications and their inherent adaptability in accommodating the needs of individual patients. Here we examine some of these design features.

Cite this article: Bone Joint J 2013;95-B, Supple A:53–6.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11_Supple_A | Pages 95 - 99
1 Nov 2012
Barrack RL Ruh EL Williams BM Ford AD Foreman K Nunley RM

Patient specific cutting guides generated by preoperative Magnetic Resonance Imaging (MRI) of the patient’s extremity have been proposed as a method of improving the consistency of Total Knee Arthroplasty (TKA) alignment and adding efficiency to the operative procedure. The cost of this option was evaluated by quantifying the savings from decreased operative time and instrument processing costs compared to the additional cost of the MRI and the guide. Coronal plane alignment was measured in an unselected consecutive series of 200 TKAs, 100 with standard instrumentation and 100 with custom cutting guides. While the cutting guides had significantly lower total operative time and instrument processing time, the estimated $322 savings was overwhelmed by the $1,500 additional cost of the MRI and the cutting guide. All measures of coronal plane alignment were equivalent between the two groups. The data does not currently support the proposition that patient specific guides add value to TKA.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11_Supple_A | Pages 3 - 7
1 Nov 2012
Barrack RL

Venous thromboembolism (VTE) remains an immediate threat to patients following total hip and knee replacement. While there is a strong consensus that steps should be taken to minimise the risk to patients by utilising some forms of prophylaxis for the vast majority of patients, the methods utilised have been extremely variable. Clinical practice guidelines (CPGs) have been published by various professional organisations for over 25 years to provide recommendations to standardise VTE prophylaxis. Historically, these recommendations have varied widely depending in underlying assumptions, goals, and methodology of the various groups. This effort has previously been exemplified by the American College of Chest Physicians (ACCP) and the American Academy of Orthopaedic Surgeons (AAOS). The former group of medical specialists targeted minimising venographically proven deep vein thrombosis (DVT) (the vast majority of which are asymptomatic) as their primary goal prior to 2012. The latter group of surgeons targeted minimising symptomatic VTE. As a result prior to 2012, the recommendations of the two groups were widely divergent. In the past year, both groups have reassessed the current literature with the principal goals of minimising symptomatic VTE events and bleeding complications. As a result, for the first time the CPGs of these two major subspecialty organisations are in close agreement.


The Journal of Bone & Joint Surgery British Volume
Vol. 94-B, Issue 11_Supple_A | Pages 14 - 18
1 Nov 2012
Lombardi, Jr AV Barrack RL Berend KR Cuckler JM Jacobs JJ Mont MA Schmalzried TP

Since 1996 more than one million metal-on-metal articulations have been implanted worldwide. Adverse reactions to metal debris are escalating. Here we present an algorithmic approach to patient management. The general approach to all arthroplasty patients returning for follow-up begins with a detailed history, querying for pain, discomfort or compromise of function. Symptomatic patients should be evaluated for intra-articular and extra-articular causes of pain. In large head MoM arthroplasty, aseptic loosening may be the source of pain and is frequently difficult to diagnose. Sepsis should be ruled out as a source of pain. Plain radiographs are evaluated to rule out loosening and osteolysis, and assess component position. Laboratory evaluation commences with erythrocyte sedimentation rate and C-reactive protein, which may be elevated. Serum metal ions should be assessed by an approved facility. Aspiration, with manual cell count and culture/sensitivity should be performed, with cloudy to creamy fluid with predominance of monocytes often indicative of failure. Imaging should include ultrasound or metal artifact reduction sequence MRI, specifically evaluating for fluid collections and/or masses about the hip. If adverse reaction to metal debris is suspected then revision to metal or ceramic-on-polyethylene is indicated and can be successful. Delay may be associated with extensive soft-tissue damage and hence poor clinical outcome.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 263 - 263
1 Jul 2011
Barrack RL Burnett RSJ Barnes CL Miller D Clohisy JC Maloney WJ
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Purpose: A study was undertaken to determine the current prevalence of revisions of total knee arthroplasty (TKA) following minimal incision surgery (MIS) and to compare revisions of MIS TKA procedures to revisions of TKA performed following a standard surgical approach.

Method: A consecutive series of revision TKA performed at three centers by five surgeons over a three year time period was reviewed. Revisions performed for infection and re-revisions were excluded. Review of clinical and radiographic data determined incision type, gender, age, time to revision, and primary diagnosis at time of revision.

Results: Two hundred and thirty-seven first time revision TKAs were performed of which 44 (18.6%) had been a MIS primary TKA and 193 (81.4%) had been a standard primary TKA. Patients with MIS were younger (62.1 years versus 66.2 years, p=.02). There was a trend towards a higher percentage of females in the MIS group (75% versus 63%), although this difference was not significant (p=0.12). Most striking was the difference in time to revision which was significantly shorter for the MIS group (14.8 months versus 80 months, p< .001). The MIS group was much more likely to fail at < 12 months (37% versus 5%, p< .001) and at < 24 months (81% versus 22%, p< .001).

Conclusion: MIS TKA accounted for a substantial percentage of revision TKA in recent years at these centers. The high prevalence of MIS failures occurring within 24 months is disturbing and warrants further investigation.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 275 - 275
1 Jul 2011
Burnett RSJ Aggarwal A Givens SA McClure JT Barrack RL
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Purpose: Prophylactic antibiotics are frequently withheld until cultures are obtained in revision TKA. A prospective study was undertaken to determine whether prophylactic pre-operative IV antibiotics would affect the results of cultures obtained intra-operatively.

Method: A consecutive series of 25 TKA’s with a known infecting organism were enrolled over 36 months. Inclusion criteria: clinically infected TKA, a known preoperative infecting organism, and no recent antibiotic therapy. Re-aspiration of the infected TKA was performed following anesthesia and sterile prep. IV antibiotic prophylaxis was then administered and the tourniquet was then inflated. Intra-operative culture swabs and tissue were obtained at arthrotomy. The timing of events was recorded. Pre/post antibiotic culture data were analyzed to determine the effect of IV preoperative prophylactic antibiotics on cultures obtained intra-operatively.

Results: Mean time from end of antibiotic infusion to tourniquet inflation was 15 minutes; to arthrotomy culture was 25 minutes. In all 25 knees the organism(s) cultured at arthrotomy were the same as obtained at pre-operative aspiration. In 24 knees the organism cultured was sensitive to the preoperative prophylactic antibiotics given (Ancef and Vancomycin); one patient grew Candida albicans.

Conclusion: Pre-operative prophylactic antibiotics did not affect the results of intra-operative cultures, and should not be withheld prior to infected TKA surgery when an organism has been identified on aspiration. Based on these results, holding pre-operative antibiotics prior to revision TKA is rarely justified.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 253 - 253
1 Jul 2011
MacDonald SJ Barrack RL Rosenzweig S Guerin JF McCalden RW Bohm E Bourne RB Rorabeck CH
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Purpose: There are two broad-based categories of cementless femoral components performed during total hip arthroplasty: proximally coated versus fully porous coated. While both have enjoyed widespread clinical applications, there remains debate regarding differences in clinical outcome scores, relative incidence of thigh pain and the development of stress shielding. The purpose of this study was to investigate these variables in a multi-center prospective randomized blinded clinical trial.

Method: Between three centers 388 patients were enrolled in this clinical trial. 198 patients received a proximally coated tapered cementless femoral component (Synergy, Smith and Nephew, Memphis) and 190 patients received a fully porous coated cementless femoral component (Prodigy, Depuy, Warsaw). Patients were evaluated pre-operatively, at 3, 6, 12 months and annually thereafter, with multiple validated outcome measures including WOMAC, SF12, HSS, UCLA activity and thigh pain scores. A cohort of 72 patients underwent preoperative and postoperative DEXA scanning.

Results: 367 patients had a minimum of 2 years follow-up (average 6.4 years). There were no differences in age at surgery, BMI, or pre-operative clinical outcome scores (WOMAC, SF12, HSS, UCLA activity, thigh pain) between groups. There were no differences in any post-operative clinical outcome scores at any interval of follow-up. There were no differences in incidence of thigh pain between groups at any time. The only measurable difference between study groups was in bone mineral density evaluation. Bone density change in Gruen zone 7 was 23.7% with the Prodigy stem and 15.3% with the Synergy stem (p=0.011).

Conclusion: Both fully porous coated and proximally porous coated cementless stems performed well, with no clinical differences at a minimum of 2 years follow-up. Only bone mineral density evaluations could detect any differences between these femoral components designs.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 548 - 548
1 Aug 2008
Soler JA Haddad F Barrack RL
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Introduction: Third generation fixation systems allow for the retightening of cables, and are associated with high rates of trochanteric union. This is a prospective study undertaken to evaluate the outcome of the first 40 patients treated with a third generation cable plate and trochanteric hook system.

Methods: 36 patients treated by two revision hip arthroplasty surgeons using a third generation cable plate system were enrolled and followed up. These included 28 females and 12 males with an average age of 64 (range: 48–91). Large hooks were used in 30 with an average of 4.8 cables (range: 4–9). The need to retighten cables intra-operatively was noted. Clinical and radiographic follow-up was undertaken at 2 years.

Results: A third generation fixation system was used for 16 peri-prosthetic fractures, 6 trochanteric non unions, 5 structural femoral allografts, 6 complex revisions and for trochanteric advancement in 3 cases. The first cable tightened was loose by the end of the procedure in the majority of cases and had to be retightened. There were no cases of fretting or cable breakage. Two further trocanteric non unions needed re-fixation and bone grafting in a further procedure

Discussion and Conclusion: Third generation cable system allow for re-tightening, as the cable is not damaged by the crimping mechanism. This facility appears critical as some retightening is invariably required in the process of applying this type of device. There were only 2 re-operations for trochanteric non unions, but the overall outcomes were otherwise excellent, with no fretting or cable breakage. Modern cable systems afford improved, more flexible trochanteric fixation possibilities.