Purpose: To assess þbular graft viability and the evolution of the subsequent bone healing into the hosting tunnel. Methods and Materials: Eight patients (10 grafts) with femoral head AVN were examined with 4 consecutive MRI examinations at 2w, 6w, 3m, and 6m postoperatively using a 1T scanner. A dynamic 3D-T1-w TFE sequence (9 sections every 8s) was applied for estimating the perfusion in the graft (SI curve). Multiplanar imaging in the axis of the graft was used for a delayed fat-suppressed T1-w Spin Echo sequence (acquisition matrix 512, slice thickness 3mm). The following parameters were evaluated: a) more or less than 50% increased SI in the graft, b) maximum SI close to the graft, c) maximum width of the medullary enhancement close to the graft, d) width of osteonecrotic area. The þnal MRI examination together with plain x-ray þlms and clinical examination were used to assess outcome. Results: The decrease of% enhancement area in the graft medulla, the gradual decrease of the enhancement in and around the graft, correlated well with the clinical þndings. The dynamic study and the parameter c, showed no correlation with the clinical status. In 2 cases, enhancement close to the upper end of the graft and in the necrotic zone, suggested expanding inversion of the process. Conclusion: High resolution enhanced MRI, may offer an additional means for assessment of the healing process of vascularized peroneal grafts in patients with femoral head necrosis.

Purpose:In this study we investigated the MRI þndings of healing process after arthroscopic meniscal repair. Methods and Materials: 15 patients with buckethandle medial meniscal tears were operated arthroscopically within 3 weeks after injury. All had accurately diagnosed meniscal tear with preoperative MRI. Six patients had an additional anterior cruciate ligament tear, also primarily reconstructed with the meniscal repair. The MR examination was perfrormed with a 1 T scanner, applying the following pulse sequences: T1-w Spin Echo (SE), PD-w Turbo Spin Echo (TSE) with fat suppression, T2-w TSE and T1-w SE in coronal and axial plane after iv administration of paramagnetic contrast agent. The postoperative MRI examinations were performed in 3 weeks intervals starting at the 6th postop and till the 18th , and 6 weeks thereafter. All patients were asymptomatic postoperatively. Results:Grade III and IV signal alterations were present on all MRI scans. Contrast enhanced images showed in addition: a) signal alterations extending through the path of suture out of the meniscus, b) enhancement of the medial collateral ligament simulating injury and c) synovitis in all patients. In one patient examined sequentially, the contrast-enhanced images demonstrated that a and b decreased after 3 months and synovitis was no more evident. Conclusion:Contrast enhanced MRI is the method of choice for demonstrating the normal healing process of the arthroscopic meniscal repair in bucket-handle tears. A gradually disappearing of the abnormal enhancement is related to scar tissue rather than to meniscal retear.

Aims: To assess morbidity and the long term sequellae following multiple compartment syndrome of the tibia. Methods: We prospectively followed 21 referred patients (pts). Syndromeñs etiology, the socioeconomic consequences and the way the condition affects the quality of patientsñ lives were evaluated. Patientsñ morbidity, the number and the severity of the reconstructive operations were assessed. A subjective SF-36 evaluation was also performed. Results: The aetiology of the syndromes was RTA in 13 pts, accident at work in 7 and in 1 patient the result of an osteotomy and external þxation. Late release of the compartments was performed in 9 pts. In the remaining 2 pts release was performed at onset. The consequences were drop-foot in 14 pts, club foot in 2, cavus foot in 8, clawing of toes in 14, ankle stiffness in 7, plantar numbness and anesthesia in 13, plantar callosities in 5 and chronic infection in 8. Effective management involved 1–10 subsequent reconstructive procedures in the following 1 to 5 years with hospitalization ranging from 35 to 360 days. One patient was amputated. Two pts were able to perform an easy job and only those 2 in whom the compartments were released in time returned to previous occupations. The remaining are currently unemployed. Conclusions: Established compartment syndromeñs effects on soft tissue and bone seriously affect limb function, permanently impair quality of the patientñs life and deprive them from working effectively. These þndings emphasize the importance of early diagnosis and prompt release.

Aim: Evaluation of intermediate clinical and radiographic results of displaced intra-articular fractures of the calcaneus treated with ORIF. Materials- Methods: From 1994 to 2002, 167 displaced intra-articular fractures of the calcaneus were treated with ORIF. There were 145 male and 12 female patients. Mean age 34 years. Standard x-rays, Broden views and CT-scan images in coronal and transverse plane were obtained pre and post operatively. Fractures were classified as type III, IV, V according to Sanders. All fractures were approached through an extended lateral L-type approach. AO calcaneal plate was used. Average follow-up was 5 years. Results: In 143 Sanders type III and IV fractures KITA-OKA score was 91. Reduction failure rate was 5.5%(8 pts). 24 patients had Sanders type V fractures and KITAOKA score was 84 and reduction failure rate was 25% (6 pts). 29/167 patients complained of peroneal tendons tenderness which subsided after hardware removal. 79/167 patients had restriction of subtalar joint movements but no complains (SF_36) There were two superficial wound infections and five patients with delayed wound closure. In a group of 45 patients with similar fracture patterns who were treated conservatively, KITA-OKA score was 71, 41 fractures were malunited, 40 patients had moderate to severe pain and early OA sings. Conclutions: Displaced intra-articular fractures of the calcaneus should be treated as any other displaced intra-articular fracture, with open reduction and stable internal fixation

Introduction: Amputation of the fingertip with loss of the finger pulp, exposed bone and nail bed injury is a common problem, not infrequently neglected. Fingertip reconstruction requires new pulp glabrous skin coverage with sensitivity, buttressed by the nail. The aim of this study is the analysis of our experience from the use of a homodigital, island flap for the reconstruction of amputated fingertips Materials and Methods: The homodigital island flap was applied in 46 patients (57 fingers), at every level of finger amputation with special indication on fingertip coverage. For the index and the middle fingers, use of the ulnar bundle is preferred. For the thumb, ring and little finger use of the radial neurovascular bundle is preferable. The neurovascular bundle is well dissected from the flap to the base of the finger. After suturing of the flap the donor area is covered with split thickness skin graft from the hypothenar. The finger is mobilized one week after the procedure. Results: Postoperatively, ROM was normal in 45 fingers, 6 fingers had 100 loss of extension at the DIP and 6 fingers had loss of motion between 100–200 . TPD was 4mm (3–10mm). Three patients had cold intolerance for 8 months. There was no neuroma or sensitive scar formation and no need for a second operation. According to patients cosmesis was acceptable in all fingers. Conclusions: The use of homodigital island flap provides excellent functional reconstruction of the fingertips after a complex tissue loss in Allen III and IV amputations It is a straightforward operation carried out under wrist block with excellent cosmetic results.

Aim: Fixation implants are usually well tolerated by the patients for prolonged periods of time. However, it is not unusual for some patients to develop persistent pain with acute onset that is often combined with paresthesias. The purpose of this study was to verify if the acute onset of pain that is not combined with clinical or laboratory signs of infection could be attributed to an underlying bacterial colonization of implants. Methods: Sixty-four patients (38 male and 26 female) with mean age of 36 years (range, 10 to 73 years) were included in this study. Patients presented with acute onset of pain and/or paresthesias several years after the implantation of stainless-steel þxation materials (plate-screws: 52 and intramedullary nails: 12), in the upper (13) or lower extremity (51). All patients of the present series had negative clinical and laboratory signs of infection. All patients of the present series had their þxation materials removed in our department. The materials subsequently underwent microbiologic and corrosion evaluation. Results: Patients experienced immediate relief after removal of þxation materials. Cultures were positive in 18% of cases and Staph aureus and epidermidis were most frequently encountered. Pseudomonas and enterococcus were also cultured. Conclusions: The percentage of positive cultures (18%) in the patients of our series indicates that symptoms may be due to the bacterial colonization of implants, despite the absence of sings of infection. Although the administration of antibiotics remains controversial, removal of the implants is indicated in cases with acute delayed onset of pain at the site of the implanted þxation materials.

Aim: The purpose of this study was to evaluate the prevalence of methicillinresistant Staphylococcus aureus (MRSA) isolates in the Orthopaedic Department of a new University Hospital, two years from its opening. Methods: Forty-three consecutive S. aureus isolates, collected from cultures (pus 90%) from consecutive orthopaedic inpatients were included in the study. Resistance to antimicrobial agents was assessed by the disk diffusion method. The mecA-gene was detected by PCR assay, whereas molecular typing of the isolates was performed by PFGE. Results: Only 5 of the 43 strains (11.6%) expressed high level resistance to oxacillin (MIC ≥ 64mg/L). All these isolates possessed mecA-gene and exhibited resistance, except oxacillin, to more than four classes antimicrobial groups. The remaining 38 isolates (34 beta-lactamase positive) were susceptible to oxacillin (MIC ≤ 2mg/L), and expressed a less resistant type than that of MRSA. Molecular typing by PFGE showed apparent heterogeneity among isolates and the absence of predominant clones. Conclusions: The 11.6% prevalence of MRSA is well below the reported average in the literature. Apparently the isolates originated from different sources of contamination. All patients had previous hospitalizations, where they acquired the infections and subsequently transferred the MRSAs to our department. Precautions and measures taken in the wards limited the spread and dissemination of the isolates as demonstrated by the heterogeneity and the absence of predominant clones. These þndings further reiterate the value of the low-cost, standard preventive procedures to control nosocomial infections in a high-risk orthopaedic department.

Aims: The purpose of this study is to to assess the surgical results, complications, and long-term results of vascularized fibula in the treatment of congenital pseudarthrosis of the tibia. Methods: Seven patients who had congenital pseudarthrosis of the tibia were treated consecutively at our clinic between 1992 and 2000 with free vascularized fibular graft. There were four females and three males. The mean age at the time of operation averaged 6.5 years (range 1–12 years). Four left tibias and 3 right tibias were involved. Stability was maintained with internal fixation in four patients, external fixation in two patients and intramedullary pin in one patient. Results: The average follow-up was 2.6 years (range 6 months to 8 years). In five patients, both ends of the graft healed primarily within 2.7 months (range 1.5 to 3 months), and hypertrophy of the fibular graft occurred rapidly with a well-formed medullary canal. In one patient the distal junction did not unite and although required three subsequent operations still not healed. Stress fracture occurred in one patient underwent four additional operations before union achieved. Conclusions: Despiting the continuing problems and the relatively high complication rate, the ultimate results with free vascularized fibula transplant are generally good specially as compared with published series in whom conventional grafting techniques had failed. However, even achieving union of pseudarthrosis is not enough for the resolution of this disease and is only half of the problem; the other half is to maintaining

Objective: The aim of this study was to present a review of intraarticular ganglia of the knee. Materials: Cases of intraarticular ganglia of the knee were isolated from a group of 1405 consecutive patients referred for MR imaging examinations of the knee. Diagnoses were conþrmed by means of a histological study after arthroscopic or surgical excision. Results: 14 pts (10 men and four women) had intraarticular ganglia of the knee. 3 ganglia were found in Hoffañs fat pad, 5 were associated with the anterior cruciate ligament, 5 were associated with the posterior cruciate ligament, and one was associated with the ligament of Humphrey. Pain was the most common complaint. Symptoms grew worse with activity in 9 pts. There was associated limited knee extension in 4 cases and limited knee ßexion in 3 cases. One of the three pts with ganglia in Hoffañs fat pad had a palpable mass on physical examination. The cysts were ßuidþlled, with low T1-w and high T2-w signal intensity. 10 cases demonstrated peripheral thin rim enhancement on fat-suppressed contrast-enhanced T1-w SE images. Grad echo sequences were useful in excluding areas of hemosiderin. Conclusion: Intraarticular ganglia of the knee have been found to occur commonly, with a prevalence of 1.% in the present series. The clinical presentation of intra-articular ganglion cyst is varied according to its intra-articular location. Radiologists should be aware of this entity and its defferential diagnoses. The contrast-enhanced sequences allow intraarticular ganglia to be distinguished from PVNS, synovial hemangioma and synovial sarcoma.

Purpose: To review the MRI findings in transient osteoporosis of the hip (TOH) and to investigate the pattern of perfusion in dynamic studies.

Material and Methods: Twenty-seven patients (29 hips), 23–66 years old, were referred for hip pain without history of trauma. In all patients the diagnosis of TOH based on x-rays (decrease bone density of the femoral head) and MRI (bone marrow edema-BME) was confirmed after complete resolution of symptoms and MRI findings after 6–18 months. MRI studies included T1-w SE, T2-w-SPIR-TSE and contrast enhanced T1-w TFE in dynamic mode and delayed SE. Imaging assessment included joint effusion, location and extent of BME (types A–D), sparing of the femoral head, subchondral linear lesions, and collapse.

Results: Joint effusion was observed in 28 of 29 hips. The extent of BME in the femoral head was type A in 5/29 hips, B in 2/29, C in 16/29, D in 6/29. Associated BME of the acetabulum was depicted in 6/29 hips. In 12/29 hips the bone marrow edema was sparing the subchondral area. Subchondral line was only found in 2/29 hips. On dynamic T1–w images all hips presented with a delayed pattern of perfusion up to 40 sec.

Conclusion: MRI findings are useful in diagnosing TOH and differentiating this entity from early AVN.

Aim: Tissue injury leads to platelets migration and release of growth factors (GF): Platelet-Derived GF (PDGF) and Transforming GF-beta (TGF-b) that are particularly important for the bone repair process. The purpose of our study is to evaluate the new bone formation with the use of AGF-bone graft combination and to estimate the concentrations of PDGF-AB and TGF-b2 during the procedure.

Methods: AGF-bone graft combination was used in 34 patients with long bone defects (24) and spinal fusion (10). TGF-b2 and PDGF-AB concentrations were assessed in samples from blood. Aliquots were taken at each stage of AGF preparation (whole blood, buffy coat, AGF, wound drain) and analyzed for TGF-b2, PDGF-AB concentration and platelet counts. ELISA was performed to quantify concentrations of active PDGF-AB and TGF-b2. Postoperative evaluation was clinical and radiological (radiographs, tomograms, QCT).

Results: Mean follow up time was 9 months. Signs of bone union were apparent in radiographs 3–6 months after the index procedure. Average platelet count increased from 212x106 cells/ml to 680x106 cells/ml (buffy coat) and to 1280x106 cells/ml (AGF concentrate), resulting in a 604% increase. A 480% increase of PDGF-AB levels and a 320% increase of TGF-b2 levels in AGF concentrate comparing to whole blood levels was determined. TGF-b2 and PDGF-AB levels were also detected in samples collected from the wound drains, in increased levels comparing to the AGF concentrates.

Conclusions: In all cases the clinical results were very encouraging with augmented osteogenesis, whereas the laboratory results (increased values of TGF-b2 and PDGF-AB in subsequent stages of the procedure) practically predicted the clinical success.

Purpose: We present the results of subacromial decompression and repair of the rotator cuff through a minimal deltoid-on approach.

Material and Method: Eighty-seven patients with longstanding shoulder pain were evaluated in two years (1999–2000) in our department. In sixty -eight of them symptoms were due to impigment syndrome. Eight patients with follow up time less than six months were excluded from this study, twenty were treated conservatively and the remaining forty (22 female, 18 male, mean age 50.3) underwent surgery. Three x-ray views were obtained in all patients, i.e. standard AP, true AP, and subacromial space projection. MRI was also obtained in all patients. MRI revealed calcific tendinitis in fifteen patients, osteophytes of the acromioclavicular joint in thirteen, a hooked (type III) acromion in ten and partial tear of the supraspinatus tendon in nineteen. In five of them there was also a partial tear of the infraspinatus. Finally, seven patients were suffering of a full thickness tear of the supraspinatus tendon. All patients were operated through a minimal deltoid-on approach. Acromioplasty and coracoacromial ligament dissection was performed in all. In patients with osteoarthritis of the acromioclavicular joint, osteophytes were carefully removed. Calcific deposits were also removed in all patients. In eighteen patients tears of the rotator cuff were detected and repaired using bone anchors.

Results: All patients were examined six months postoperatively. Results were evaluated with CONSTANT SCORE and with a questionnaire for patient’s satisfaction. Thirty-seven patients were very satisfied with the result and three were satisfied. As for Constant score, pain improved at an average of 7.8 points, daily activities by 5.4, and range of movement by 4.2 points. Results were evaluated by the examiner as excellent in thirty-six patients (90%) and very good in four patients.

Conclusion: Deltoid-on approach, in patients with impingement syndrome of the shoulder provides adequate exposure for the surgical repair with minimal trauma and a very low rate of complications.

Purpose: The purpose of this study was to evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) isolates in the Orthopaedic Department of a new University Hospital, two years from its opening.

Material and Methods: Forty-three consecutive S. aureus isolates, collected from cultures (pus 90%) from consecutive orthopaedic inpatients were included in the study. Resistance to antimicrobial agents was assessed by the disk diffusion method. The mecA-gene was detected by PCR assay, whereas molecular typing of the isolates was performed by PFGE.

Results: Only 5 of the 43 strains (11.6%) expressed high level resistance to oxacillin (MIC ≥ 64mg/L). All these isolates possessed mecA-gene and exhibited resistance, except oxacillin, to more than four classes antimicrobial groups. The remaining 38 isolates (34 beta-lactamase positive) were susceptible to oxacillin (MIC ≤ 2mg/D, and expressed a less resistant type than that of MRSA. Molecular typing by PFGE showed apparent heterogeneity among isolates and the absence of predominant clones. Conclusions: The 11.6% prevalence of MRSA is well below the reported average in the literature. Apparently the isolates originated from different sources of contamination. All patients had previous hospitalizations, where they acquired the infections and subsequently transferred the MRSAs to our department.

Precautions and measures taken in the wards limited the spread and dissemination of the isolates as demonstrated by the heterogeneity and the absence of predominant clones. These findings further reiterate the value of the low-cost, standard preventive procedures to control nosocomial infections in a high-risk orthopaedic department.

Purpose: We assessed the consequences of the permanent lesions after multiple compartment syndrome of the tibia. We also assessed the socioeconomic consequences during the period of secondary operations and rehabilitation.

Material and Methods: We followed 20 prospective patients (pts) who were referred to our department after multiple compartment syndrome of the tibia. We present the patiens’ causes, the socioeconomic consequences and the way the condition affects the quality of patiens’ lives. We also assessed the morbidity of the patients and we present the number and the severity of the reconstructive operations which were needed.

The cause was RTA in 13 pts, accident at work in six and in one patient the result of a reconstruction osteotomy and external fixation. The opening of the compartments was done in nine pts but in two of them we caught the condition at an early stage on time. The consequences were a dropped foot in 13 pts, a club foot in two pts, cavus foot in eight pts, clawing of toes in 13 pts, ankle stiffness in six pts, plantar numbness anaesthesia in 12 pts, plantar callosities in five pts and chronic infections in eight pts. The number of reconstructive operations was from one to ten with a hospitalization duration from one month to five years. Only two pts were able to work an easy job and two pts went back to their previous job, those in whom we had opened the compartments in time. In one pts an amputation below the knee was done. The rest of the pts are unemployed or work as assistant.

Conclusion: The permanent lesions after a multiple compartment syndrome of the tibia are very serious for the functioning of the limb, the quality of the pts’s live life and their work. It is very important to prevent this condition by opening all compartments in time (or at a very early stage).

We evaluated the clinical outcome of IM nailing for the treatment of femoral shaft pseudarthrosis in patients who had multiple failed plate osteosyntheses. From January 2000 untill April 2001, 20 (19 male-1 female, mean age 28) patients were treated because of femoral shaft non-union in our institution. All patients had two or more failed plate osteosyntheses. There were no septic non-unions in this group. Eight patients had an established non-union on an average of nine months post-op and the remaining eleven had radiological and clinical evidence of implant failure. There was no segmental bone loss, hi all patients the implants were removed and nailing was performed. Extensive periosteal stripping, bone necrosis and soft-tissue scaring were constant findings in all patients. Twelve patients received interlocking nails. Eight femurs were grafted with iliac crest bone graft. All patients were followed by serial x-rays until union.

There were no postoperative complications. All pseudarthroses were healed within an average of 9.7 months (8–12). Non-unions which received bone graft (eight out of twenty) in day one, were healed faster than those which didn’t. There were no re-operations among these patients. Among the remaining ten patients five were grafted five to six months postoperatively and three had had nail dynamization.

IM nailing for femoral shaft non-unions after multiple failed plate osteosyntheses is a safe and effective method of treatment. Autologous bone graft reduces healing time and re-operation rate.

Purpose: The efficacy of nasal salmon calcitonin (CT) in preventing bone loss after a hip fracture and in reducing the incidence of further contralateral hip fractures was evaluated.

Material and Methods: Fifty women aged 70–80 years who sustained a pertrochanteric fracture were randomly allocated to Group A (200 IU of nasal salmon calcitonin daily for three months) and Group B (placebo). Biochemical bone markers (1st, 7th, 15th, 45th and 90th day post injury) and bone mineral density of the lumbar spine and the intact contralateral hip (4th and 90th postoperative day, and one year after the fracture) were measured.

Results: Patients in the calcitonin group showed statistically significantly higher total (p< 0,005) and bone alkaline phosphatase (p< 0,002) and osteocalcin (p< 0, 05) levels on the 15th day, while statistically significantly lower uCTX values on the 15th (p< 0,045), 45th (p< 0,002) and 90th (p< 0,002) day and uHpr/Cr values on the 15th (p< 0,015) and on the 45th (p< 0.05) day post injury. In the placebo group patients showed a statistically significant reduction (all p values < 0.05) of bone density values at 3 months and one-year post surgery while in the calcitonin group no significant changes from baseline. When the two groups were compared, patients in the calcitonin group showed statistically significantly higher bone mineral density values (all p values < 0.05), in all recorded sites, at 3 months and one-year post operatively. After a four years clinical follow-up, five patients (5/25, 20%) sustained a new fracture of the contralateral hip in the placebo group.

Conclusion: Nasal salmon calcitonin prevented early bone loss in these patients and may have a protective role on the occurrence of a new fracture of the contralateral hip in the same patient.