Background: While generally aware about other infectious diseases, few realize the threats posed by Hepatitis C. We assessed if the Orthopedic surgery residents have adequate knowledge and wheather they take necessary precautions when exposed clinically to Hepatitis C.

Methods: A pre coded structured questionnaire was administered to Orthopedic surgery residents from three provinces and seven cities of Pakistan, who were participating in the Annual Orthopedic Review Course at the Aga Khan University hospital. Unprompted questions, focused on key knowledge issues, while beliefs and practices were assessed through knowledge and attitude towards Hepatitis C infectivity, complications, therapeutic modalities, actual precautions taken by them while handling body secretions of the patients. and their reading habbits about the literature of this disease.

Results: The median number of surgeries participated in, by the forty-three residents was 150 in the last one year. Though 83% knew that there was no vaccine for HCV, majority (66%) was unaware that it is a sexually transmitted disease and 82% did not know about its possibility of being transmitted perinatally. Eighty-eight percent knew about its transmission through a needle prick injury but 71% of the residents were unaware of the fact that in the case of the needle prick, highest risk of acquisition is of HCV when compared to HBV and HIV. In practices, 74% were vaccinated for HBV. When handling a known case of HCV, 87% used an extra pair of gloves while only 50% took extra care with needles. Median number of needle pricks was one in last one year. Only 16% knew the serostatus of the patients they received injury from. Only 28% of the residents knew their own serostatus for HCV compared to 60% for HBV. 60% of these residents were in habit of handling needles with their hands. Knowledge of HCV did not diff

Conclusion: Changing the attitude of the health care workers towards HCV has become increasingly important. We suggest that all new residents should be given a pretest, a lecture, a demonstration of the standard precautions and infection control procedures with post test, in the beginning of their carriers.

Aim: To determine retrospectively the post-operative mortality and fatal pulmonary embolism (PE) rates in 936 consecutive primary total knee replacements (TKR) in the three month period after surgery where chemical thromboprophylaxis was not routinely used.

Methods: Operations were performed over a period of eleven years by eight different senior orthopaedic surgeons on 248 men and 525 women. One hundred and sixty three patients had bilateral TKRs and the mean age at the time of operation was similar (69.4 and 72.2 years respectively). Patients were traced by out-patient appointments, telephone and through their general practitioners (GPs). Post-mortem examinations were used to verify cause of death in all save three of the cases. All but one of the patients were followed up.

Results: There were no deaths from PE confirmed by post-mortem examinations. As three patients were certified dead without post-mortem examination and one patient could not be traced this meant that, at worst, our fatal PE rate was 0.43% (4/936; CI 0.14%–1.17%). The all-cause mortality rate was 0.64% (6/936; CI 0.26%–0.46%) (Table 1). The patient mortality was compared with the population mortality of England and Wales using standardised mortality ratios (SMRs). The SMR for both sexes combined was 0.74 (CI 0.29–1.52). We observed a lower mortality in females SMR = 0.67 and males SMR = 0.84 during the first three post-operative months than compared to the general population.

Conclusion: Fatal pulmonary embolism after total knee replacement without routine chemical thromboprophylaxis is uncommon. The overall death rate in this series of patients undergoing total knee replacement appears to be lower than that in the general population.