Debridement, antibiotics and implant retention (DAIR) is the recommended treatment for all acute prosthetic joint infections (PJI). However, the efficacy of DAIR and identification of risk factors for failure in patients with late acute PJI, is not well described. Patients diagnosed with late acute PJI between 2005 and 2015 were retrospectively evaluated. Late acute PJI was defined as the development of acute symptoms (≤ 3 weeks) occurring ≥ 3 months after arthroplasty. Failure was defined as: i) the need for implant removal, ii) infection related death, iii) the need for suppressive antibiotic therapy due to persistent signs of infection and/or iv) relapse or reinfection during follow-up.Aim
Method
Debridement, antibiotics and implant retention (DAIR) is a widely used treatment modality for early acute prosthetic joint infection (PJI). A preoperative risk score was previously designed for predicting DAIR failure, consisting of chronic renal failure (K), liver cirrhosis (L), index surgery (I), cemented prosthesis (C) and C-reactive protein >115mg/L (KLIC). The aim of this study was to validate the KLIC score in an external cohort. We retrospectively evaluated patients with early acute PJI treated with DAIR between 2006 and 2016 in three Dutch hospitals. Early acute PJI was defined as less than 21 days of symptoms and DAIR performed within 90 days after index surgery. Failure was defined as the need for 1) second DAIR, 2) implant removal, 3) suppressive antimicrobial treatment or 4) infection-related death within 60 days after debridement.Aim
Method
Diagnosing a prosthetic joint infection (PJI) can be difficult. Several imaging modalities are available, but the choice which technique to use is often based on local expertise, availability and costs. Some centers prefer to use 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as first imaging modality of choice, but due to a lack of accurate interpretation criteria, FDG-PET is currently not routinely applied for diagnosing PJI. With FDG-PET it is difficult to differentiate between FDG uptake due to reactive inflammation and uptake due to an infection. Since the physiological uptake pattern around a joint prosthesis is not fully elucidated, the aim of this study was to determine: i) the FDG uptake pattern in non-infected total hip prostheses and, ii) to evaluate whether there is a difference in uptake between cemented and non-cemented prostheses. Patients with a primary total hip arthroplasty (1995–2016) without clinical signs of an infection that underwent a FDG-PET for another indication (mainly suspicion of malignancy) were included and retrospectively analysed. Patients in whom the prosthesis was implanted < 6 months prior to FDG-PET were excluded, to avoid post-surgical effects. Scans were visually and quantitatively analysed. Quantitative analysis was performed by calculating maximum and peak standardized uptake values (SUVmax and SUVpeak) by volume of interests (VOIs) at eight different locations around the prosthesis, from which the mean SUV was calculated. SUV was standardized by the liver SUV that was taken as background.Aim
Method
In the last couple of years, several synovial biomarkers have been introduced in the diagnostic algorithm for a prosthetic joint infection (PJI). Alpha defensin-1 proved to be one of the most promising, with a high sensitivity and specificity. However, a major disadvantage of this biomarker is the high costs. Calprotectin is a protein that is present in the cytoplasm of neutrophils, and is released upon neutrophil activation. Its value has been established for decades as a (fecal) marker for inflammatory bowel disease. To determine the efficacy of synovial calprotectin in the diagnosis of a prosthetic joint infection.Introduction
Aim
