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The Journal of Bone & Joint Surgery British Volume
Vol. 90-B, Issue 11 | Pages 1451 - 1456
1 Nov 2008
Morris C Doll HA Wainwright A Theologis T Fitzpatrick R

We developed the Oxford ankle foot questionnaire to assess the disability associated with foot and ankle problems in children aged from five to 16 years. A survey of 158 children and their parents was carried out to determine the content, scaling, reliability and validity of the instrument. Scores from the questionnaire can be calculated to measure the effect of foot or ankle problems on three domains of children’s lives: physical, school and play, and emotional. Scores for each domain were shown to be internally consistent, stable, and to vary little whether reported by child or parent. Satisfactory face, content and construct validity were demonstrated. The questionnaire is appropriate for children with a range of conditions and can provide clinically useful information to supplement other assessment methods. We are currently carrying out further work to assess the responsiveness of questionnaire scores to change over time and with treatment.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 322 - 322
1 Jul 2008
Muir F Palmer SH Hollinghurst D Theologis T
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Purpose of Study:

To describe the degree and type of disability experience by patients with combined postero-lateral corner and posterior cruciate ligament knee injuries

To document any dynamic abnormalities of the lower limbs through the gait cycle using kinematic and kinetic gait analysis

To identify abnormal electromyographic signals of the quadriceps, hamstring and gastrocnemius muscles through normal gait.

Methods and Results: After rigorous exclusion criteria were instituted twelve patients were identified as having the required combined knee ligament injuries. These patients underwent functional assessment, clinic examination and gait analysis at the Oxford Gait Laboratory.

Significant functional disability was noted in all patients. Characteristic gait abnormalities identified included hyperextension and dynamic varus deformity with a corresponding increase in the internal valgus knee moment. Electromyographic data revealed early and prolonged contraction of the medial hamstrings and gastrocnemius muscles.

Conclusion: These results suggest the presence of compensatory mechanisms of the musculature around the knee and suggest direction in rehabilitation programs in patients with combined injuries to the posterior cruciate ligament and posterolateral corner of the knee. The results also provide baseline data that will be useful when evaluating the post-operative outcomes in patients undergoing knee ligament reconstruction in the future.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 400 - 401
1 Jul 2008
Theologis T Matthews S Gibbons CLMH Wainwright A Kamboroglou G
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The management of pathological fractures in children remains controversial. The indications for surgical treatment are unclear and the need for histological diagnosis before or after definitive treatment is not clearly defined.

We reviewed retrospectively the records of all patients under the age of 16 years who presented over the past 7 years with a fracture as the first manifestation of bone pathology. There were 26 patients (19 boys and 7 girls) of an average age of 12 years and 2 months (range 4.1–15.8 years).

There were 9 cases of fracture through a simple bone cyst, 6 in the humerus and 3 in the femur. In all cases the fracture was treated conservatively initially. Subsequent management included needle biopsy in all, followed by bone marrow injection under the same anaesthetic. The patients suffered a refracture and were treated with flexible intra-medullary nail fixation.

There were 5 cases of fibrous dysplasia, of which 2 in the femur, 2 in the tibia and one in the proximal radius. Histological diagnosis was obtained in all cases prior to definitive treatment. This included a locked intra-medullary nail in one patient and flexible nailing in another two. The remaining two patients are still under observation.

There were 2 patients with giant cell tumour, 3 patients with aneurysmal bone cyst and one patient with chondroblastoma. Histological diagnosis preceded treatment with curettage and grafting in all these cases. There were 6 patients with malignant primary bone tumour, 1 adamantinoma, 2 osteosarcoma, and 3 with Ewings Sarcoma.

The 3 patients with Ewing’s sarcoma involved the femur. One had extensive local disease and early intra-medullary nailing was performed for palliative reasons. The second patient was treated conservatively initially. Definitive surgery was performed after fracture healing and included segmental resection and vascularised fibular graft. The third patient was initially treated elsewhere. She was thought to have a benign lesion and internal fixation with a screw/plate device was performed. Histology from intra-operative specimens confirmed Ewing’s sarcoma. Definitive surgery required extensive resection and prosthetic replacement.

The 2 patients with osteosarcoma had fracture of proximal humerus and distal femur. The former was treated by forequarter amputation as there was tumour involvement of brachial plexus and remains AWND at 7 years. The latter had resection and EPR of the distal femur.

One patient with adamantinoma underwent segmental resection and reconstruction with VFFG

We recommend that primary fixation of pathological fractures should be avoided until histological diagnosis is obtained. However, if radiographic appearances are reassuringly benign, biopsy can be delayed until conservative fracture management is completed. Definitive treatment of benign lesions with protective intramedullary nailing or curettage and grafting can follow frozen section under the same anaesthetic.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 292 - 292
1 May 2006
Theologis T Ostlere S Gibbons CLM Athanasou NA
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Aim: To describe the clinical, radiological and pathological features of this rare subtype of osteoblastoma diagnosed pre-operatively and treated by excision.

Conclusion: Toxic osteoblastoma is a benign bone forming tumour that presents with systemic symptoms of fever, anorexia and weight loss.

It has a characteristic radiographic appearance with marked periostitis in the involved bone mimicking osteosarcoma and associated focal abnormality in juxtaposed skeletal sites.

With the help of two previously reported cases from the literature of aggressive bone forming tumours in children who presented with marked anorexia and cachexia diagnosed as osteomyelitis and osteosarcoma and treated by ablative surgery this tumour was correctly diagnosed with planned subtotal scapulectomy and reconstruction enabling a good functional result. The systemic symptoms fully resolved following surgery with return of appetite and weight gain.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 122 - 122
1 Mar 2006
Kotnis R Spiteri V Little C Theologis T Wainwright A Benson M
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Aims: To assess the value of hip arthrography in planning definitive treatment for children with DDH and Perthes’ disease.

Background: It is sometimes unclear whether children with DDH and Perthes’ disease need an operation. Surgeons are guided by the clinical symptoms and signs together with the radiographic appearances of the affected hip. In our Unit children on whom an operation is considered undergo an examination under anaesthetic (EUA) and a hip arthrogram. This prospective study was developed to assess whether treatment was modified by the arthrogram.

Methods: All patients who underwent an EUA and hip arthrogram for DDH or Perthes’ disease over a 10 month period were entered into this prospective study. Prior to arthrography a Consultant Children’s Orthopaedic Surgeon formulated a treatment plan. A standard arthrogram was performed which included anteroposterior, frog lateral, Von Rosen and oblique views. Traction axial loading views were taken to assess stability. Following EUA and arthrogram the Consultant Surgeon formulated a definitive treatment plan. Three Children’s Consultants were then invited subsequently to review the preoperative and arthrographic appearances blindly to monitor reproducibility. Twenty-one patients with DDH and 19 with Perthes’ disease were entered into the study.

Results: In the DDH group of patients the treatment plan was modified in 12 of the 21 patients as a consequence of the arthrogram. Six of the 19 patients (31.6 %) of the Perthes’ affected patients had their treatment modified. When it was felt likely prior to EUA a conservative treatment was indicated. The correlation of intra-observer Consultant agreement was high but inter-observer Consultant agreement was moderate only. In both groups of patients the range of hip motion was significantly greater under anaesthesia.

Conclusion: Static and dynamic arthrography helps decision making in patients with DDH and Perthes’ disease.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 304 - 305
1 Sep 2005
Hollinghurst D Palmer S Annetts N Dodd C Theologis T
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Introduction and Aims: The effects of injury to the posterior cruciate ligament (PCL) and posterior-lateral corner (PLC) on physical function are not as well documented compared to the more common injury to the anterior cruciate ligament. This study aimed at improving our understanding of PCL/PLC injury through gait analysis and electromyographic (EMG) testing.

Method: We studied 19 patients, average age 30 years (20–55) with clinically and radiologically confirmed PCL/PLC deficiency in isolation. Ninety percent of patients complained of instability when performing the activities of daily living and all complained of pain. All patients were assessed using the Lysholm and Gillquist functional knee score as well as gait analysis, including Kinematics, Kinetics and EMG of the quadriceps, hamstrings and gastrocnemius muscles. Findings were compared to our normal database. The mean Lysholm score was 51/100 (24–90). Those with a Lysholm greater than 50 were designated as ‘copers’.

Results: There were 12 ‘non-copers’ and seven ‘copers’. Fifty percent of patients demonstrated a varus thrust through stance. Forty-two percent of patients demonstrated hyperextension of the knee through stance. Sixty-three percent of patients demonstrated premature and prolonged hamstring activity. Thirty-seven percent of patients had premature activity of the gastrocnemius muscle in stance. Fifty-seven percent of the ‘copers’ demonstrated premature and prolonged hamstring activity through the gait cycle compared to forty-five percent of ‘non-copers’ (non-significant p=0.25 Fishers Exact Test). Fifty-five of ‘non-copers’ demonstrated premature activity of the gastrocnemius muscle in stance compared to none of the ‘copers’ (significant p=0.025 Fishers Exact Test).

Conclusion: The observed varus thrust may be responsible for the development of medial and patellofemoral compartment osteoarthritis, a recognised problem in PCL deficient knees. Hyperextension that occurs dynamically during gait could explain failure of PCL/PLC reconstruction over time. The observed abnormal hamstrings activity is unlikely to be a compensatory mechanism.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 395 - 395
1 Sep 2005
Thompson N Seniorou M Harrington M Theologis T
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Introduction: The purpose of this study was to quantify changes in lower limb muscle strength in children with spastic diplegic cerebral palsy 6 months after multi-level orthopaedic surgery.

Method: A consecutive sample of 20 children ( 10 girls and 10 boys, mean age 10.6) with spastic diplegia was studied prospectively. All participants had soft-tissue and bony surgical procedures performed as part of their clinical management. Physiotherapy treatment commenced following surgery. Lower limb muscle strength, pre and 6 months post-surgery, was measured, in addition to routine gait and function assessment. Maximum voluntary isometric strength of 5 muscle groups was measured bilaterally using a digital dynamometer. Paired-samples t-tests were performed.

Results: There was a marked deterioration of muscle strength (p < 0.05) in all muscle groups. Medial hamstrings and hip flexors showed the greatest decline with an average decrease of 54% and 41% respectively. Analysis of gait parameters showed a significant improvement in kinematics (p< 0.05) but a decrease in walking velocity and cadence. Motor function decreased significantly (p< 0.05). There was reduced motor power in 18 of the 20 at 6 months.

Discussion: Our results quantified objectively the magnitude of strength changes after multi-level surgery and show that weakness may be greater and persist longer than expected. This information will be useful for planning treatment after multi-level surgery and is part of a randomised trial investigating strength training. In general there is a decrease in power but an improvement in gait.


The Journal of Bone & Joint Surgery British Volume
Vol. 87-B, Issue 3 | Pages 408 - 409
1 Mar 2005
Thomas S Theologis T Wainwright AM

We present simple but effective retractors used in pairs to expose the sciatic notch during Salter innominate osteotomy. We have found them to be useful for a wide range of procedures requiring similar exposure. We present them here in tribute to the memory of the designer Mercer Rang.


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 264 - 264
1 Mar 2003
Wainwright A Thompson N Harrington M Theologis T
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Introduction: Traditionally, the degree of correction for derotational femoral osteotomies in cerebral palsy has been based on clinical or radiographic measures. Recently, three dimensional gait analysis has been used to plan and evaluate orthopaedic surgery. Our aim was to assess the outcome of derotation osteotomies, where the degree of rotation at surgery was guided by transverse plane kinematics (aiming at reducing peak hip rotations to normal limits).

Method: Pre and post-operative gait analyses were reviewed in a group of these patients (16 legs) and compared with a similar group of 8 patients (16 legs) who had soft tissue procedures only.

Results: Improvement following derotation osteotomy occurred in all but one case; 11/16 osteotomies resulted in peak internal rotation within one standard deviation (SD) of peak normal internal rotation (normal range −6° to +11°), the other 4 were within 1.4 SDs.

Discussion: Objective improvement in hip rotation during gait was measured in 15/16 subjects undergoing dero-tation osteotomy based on gait analysis. There was no rotational change overall in patients who had soft tissue procedures only. Average dynamic correction of internal rotation during gait was slightly less than intra-operative correction, possibly due to tensioning of spastic muscles.