The continual cycle of bone formation and resorption is carried out by osteoblasts, osteocytes, and osteoclasts under the direction of the bone-signaling pathway. In certain situations the host cycle of bone repair is insufficient and requires the assistance of bone grafts and their substitutes. The fundamental properties of a bone graft are osteoconduction, osteoinduction, osteogenesis, and structural support. Options for bone grafting include autogenous and allograft bone and the various isolated or combined substitutes of calcium sulphate, calcium phosphate, tricalcium phosphate, and coralline hydroxyapatite. Not all bone grafts will have the same properties. As a result, understanding the requirements of the clinical situation and specific properties of the various types of bone grafts is necessary to identify the ideal graft. We present a review of the bone repair process and properties of bone grafts and their substitutes to help guide the clinician in the decision making process.

Cite this article: Bone Joint J 2016;98-B(1 Suppl A):6–9.

Corrosion at metal/metal modular interfaces in total hip arthroplasty was first described in the early 1990's, and the susceptibility of modular tapers to mechanically assisted crevice corrosion (MACC), a combination of fretting and crevice corrosion, was subsequently introduced. Since that time, there have been numerous reports of corrosion at this taper interface, documented primarily in retrieval studies or in rare cases of catastrophic failure.

We have reported that fretting corrosion at the modular taper may produce soluble and particulate debris that can migrate locally or systemically, and more recently reported that this process can cause an adverse local tissue reaction. Based on the type of tissue reaction and the presence of elevated serum metal ion levels, this process appears quite similar to adverse local tissue reactions secondary to metal-on-metal bearing surfaces. While modularity in THR has demonstrable clinical benefits, modular junctions increase the risk of corrosion and the types of adverse soft tissue reactions seen in patients with accelerated metal release from metal-on-metal bearing THRs.

Controversy remains regarding the optimal treatment for iatrogenic injury to the medial collateral ligament (MCL) during primary total knee arthroplasty (TKA). Some authors have recommended converting to a prosthesis that provides varus/valgus constraint while others have recommended primary repair. In this study we report the results of a 45 patients who sustained intraoperative MCL injuries during primary TKA that were treated with primary repair.

Of 3922 consecutive primary TKA there were 48 (1.2%) intraoperative MCL lacerations or avulsions. One patient was lost and one died before 24 months follow up. All but one patient underwent primary repair with placement of components without varus/valgus constraint. This left 45 knees with a mean follow up of 89 months (range, 24–200). The mean HSS knee scores increased from 46.8 to 84.8 points (p<0.001). No patients had subjective complaints of instability. No patients had excessive varus/valgus laxity when tested in full extension and 30 degrees of flexion. The range of motion at the time of final follow-up averaged 110 degrees (range, 85 degrees to 130 degrees). Five knees required treatment for stiffness with 4 knees undergoing manipulation under anesthesia and 1 knee undergoing open lysis of adhesions with polyethylene articular surface exchange. Two knees underwent revision for aseptic loosening of the tibial component. In the three knees that underwent open revision, the MCL was noted to be in continuity and without laxity.

Primary repair with 6 weeks of postoperative hinged bracing after iatrogenic injury to the MCL during primary TKA was successful at preventing instability although stiffness was seen in approximately 10% of patients. The increased morbidity associated with implantation of a semiconstrained or constrained implant may be unwarranted in this situation.

Bone is a dynamic organ with remarkable regenerative properties seen only otherwise in the liver. However, bone healing requires vascularity, stability, growth factors, a matrix for growth, and viable cells to obtain effective osteosynthesis. We rely on these principles not only to heal fractures, but also achieve healing of benign bone defects. Unfortunately we are regularly confronted with situations where the local environment and tissue is insufficient and we must rely on our “biologic tool box.” When the process of bone repair requires additional assistance, we often look to bone grafting to provide an osteoconductive, osteoinductive, and/or osteogenic environment to promote bone healing and repair.

The primary workhorses of bone grafting includes autogenous bone, cadaver allograft, and bone graft substitutes. Among the first types of bone graft used and still used in large quantities today include autogenous and cadaver allograft bone. Allografts are useful because it is present in multiple forms that conform to the desired situation. But autogenous bone graft is considered the gold standard because it possesses all the fundamental properties to heal bone. However, it has been associated with high rates of donor site morbidity and typically requires an inpatient hospitalization following the procedure only adding to the associated costs.

The first bone graft substitute use was calcium sulfate in 1892, and over the past 122 years advancements have achieved improved material properties of calcium sulfate and helped usher in additional bioceramics for bone grafting. Today there are predominantly 4 types of bioceramics available, which include calcium sulfate, calcium phosphate, tricalcium phosphate, and coralline hydroxyapatite. They come in multiple forms ranging from pellets and solid blocks to injectable and moldable putty. In comparison to autogenous bone graft, the primary limitation of bioceramics are the lack of osteogenic and osteoinductive properties. Bioceramics work by creating an osteoconductive scaffold to promote osteosynthesis. The options of bone graft substitutes don't end with these four types of bioceramics. Composite bioceramics take advantage of the differing biomechanical properties of these four basis types of bioceramics to develop improved materials. To overcome the lack of osteoinductive and osteogenic properties growth factors or bone marrow aspirate can be added to the bioceramic. As a result, the list of combinations available in our “biologic tool box” continues to expand. More than 20 BMPs have been identified, but only BMP-2 and BMP-7 have FDA approval.

As we look forward to areas of future research and need within orthobiologics, some will likely come in the near future while others are much further in the future. We will continue to strive for the ideal bone graft substitute, which will have similar osteoinductive properties as autograft. The ultimate bone graft substitute will likely involve stem cells because it will allow an alternative to autogenous bone with the same osteogenic potential.

Corrosion at metal/metal modular interfaces in total hip arthroplasty was first described in the early 1990's, and the susceptibility of modular tapers to mechanically assisted crevice corrosion (MACC), a combination of fretting and crevice corrosion, was subsequently introduced. Since that time, there have been numerous reports of corrosion at this taper interface, documented primarily in retrieval studies or in rare cases of catastrophic failure.

We have reported that fretting corrosion at the modular taper may produce soluble and particulate debris that can migrate locally or systemically, and more recently reported that this process can cause an adverse local tissue reaction. Based on the type of tissue reaction and the presence of elevated serum metal ion levels, this process appears quite similar to adverse local tissue reactions secondary to metal on metal bearing surfaces. While modularity in THR has demonstrable clinical benefits, modular junctions increase the risk of corrosion and the types of adverse soft tissue reactions seen in patients with accelerated metal release from metal-on-metal bearing THRs.

Introduction

Recurrent dislocation following total hip arthroplasty (THA) is a complex, multifactorial problem that has been shown to be the most common indication for revision THA. The purpose of this study was to classify causes of instability and evaluate outcomes based on an algorithmic approach to treatment.

Corrosion at metal/metal modular interfaces in total hip arthroplasty was first described in the early 1990's, and the susceptibility of modular tapers to mechanically assisted crevice corrosion (MACC), a combination of fretting and crevice corrosion, was subsequently introduced. Since that time, there have been numerous reports of corrosion at this taper interface, documented primarily in retrieval studies or in rare cases of catastrophic failure.

We have reported that fretting corrosion at the modular taper may produce soluble and particulate debris that can migrate locally or systemically, and more recently reported that this process can cause an adverse local tissue reaction. Based on the type of tissue reaction and the presence of elevated serum metal ion levels, this process appears quite similar to adverse local tissue reactions secondary to metal on metal bearing surfaces. While modularity in THR has demonstrable clinical benefits, modular junctions increase the risk of corrosion and the types of adverse soft tissue reactions seen in patients with accelerated metal release from metal-on-metal bearing THRs.

Ludloff’s medial approach has never been used for other hip surgeries especially not for THR.

47 patients (26 men/21 women) provided informed consent to participate in the study. The inclusion criterion for the study was the diagnosis of osteoarthritis of the hip joint. The average age at operation was 53.7±10.4years. All patients were provided with a CUT^® prosthesis.

All patients were examined clinically and X-rayed preoperatively as well as postoperatively at three days, two weeks, six weeks and six months. The functional hip scores according to Harris and the Oxford hip score were obtained preoperatively and at the defined intervals postoperatively. The surgical duration and the intraop-erative as well as the postoperative blood loss were measured for each patient. Abductor muscle function and the number of steps a patient was able to walk without walking aids on a treadmill at a velocity of 5km/h (a maximum of 100steps was measured) were assessed.

Multifactorial analyses of variance and Chi-square tests were performed.

Based on the numbers available there were no significant differences between the two groups in the distribution of patient age (p=0.604), gender (p=0.654), weight (p=0.180) and height (p=0.295). No significant differences in the calculated Harris score (p=0.723) were found pre-operatively. The amount of steps the patient was able to walk was not different between the approach groups (p=0.636).

The total amount of blood loss (intra- + post-OP) was even significantly lower in the medial approach group (p=0.009).

Three days post-operatively the leg lengths were assessed. The difference was not statistically significant based on the numbers available (p=0.926). The overall correlation between Harris and Oxford score was significant (r²=0.63, p< 0.001).

Three days post-operatively a slight, but significant better Harris (p< 0.001) and Oxford scores (p=0.001) could be observed in the medial approach group. The number of steps the patient was able to walk without help or crutches was significantly higher in the medial approach group (p=0.001). The Trendelenburg sign (p< 0.001) and the limping criterion (p< 0.001) were significantly less in the medial approach group.

Two weeks post-operatively the Harris (p=0.001) and the Oxford (p=0.046) scores were significantly better for the medial approach group. The number of steps the patient was able to walk without help or crutches was significantly higher in the medial approach group (p< 0,001).

The medial approach is clinically feasible to perform the implantation of a femoral neck prosthesis. The accuracy of the stem implantation reflected in both the leg lengths and the postoperative X-ray alignment was not different between the groups.

After six months there was no significant difference between the conventional anterolateral approach and the medial approach in the presented study.

There is a renewed interest in unicompartmental knee arthroplasty. The present report describes the minimum ten-year results associated with a – unicompartmental knee arthroplasty design that is in current use.

Sixty-two consecutive unicompartmental knee arthroplasties that were performed with cemented modular Miller-Galante implants in 51 patients were studied prospectively both clinically and radiographically. All patients had isolated unicompartmental disease without patellofemoral symptoms. No patient was lost to follow-up. Thirteen patients (13 knees) died after less than 10 years of follow-up, leaving 38 patients (49 knees) with a minimum of 10 years of follow-up. The average duration of follow-up was 12 years.

The mean Hospital for Special Surgery knee score improved from 55 points preoperatively to 92 points at the time of the final follow-up. Thirty-nine knees (80%) had an excellent result, six (12%) had a good result, and four (8%) had a fair result. At the time of final follow-up, 39 knees (80%) had flexion to at least 120 degrees. Two patients (two knees) with well-fixed components underwent revision to total knee arthroplasty, at seven and 11 years, because of progression of patello-femoral arthritis. At the time of the final follow-up, no component was loose radiographically and there was no evidence of peri-prosthetic osteolysis. Radiographic evidence of progressive loss of joint space was observed in the opposite compartment of nine knees (18%) and in the patello-femoral space of seven knees (14%). Kaplan-Meier analysis revealed a survival rate of 98.0% +/−2.0% at ten years and of 95.7% +/− 4.3% at 13 years, with revision or radiographic loosening as the end point. The survival rate was 100% at 13 years with aseptic loosening as the end point.

After a minimum duration of follow-up of 10 years, this cemented modular uni-compartmental knee design was associated with excellent clinical and radiographic results. Although the 10 year survival rate was excellent, radiographic signs of progression of osteoarthritis in the other compartments continued at a slow rate. With appropriate indications and technique, this uni-compartmental knee design can yield excellent results into the beginning of the second decade of use.

A post-clinical retrieval analysis was performed on 43 polyethylene tibial components of a contemporary total knee arthroplasty system with implantation duration between 12 and 80 months. Components were scored for eight potential modes of surface wear or damage on the top and back surfaces. Moderate backside wear of 4.1μm per year was documented by measuring the extent of manufacturer’s engraved lettering removal. Neither the topside nor backside score correlated with duration of in vivo function. No component experienced topside or backside delamination, cracking, or significant deformation. The greatest contribution to wear and damage score was pitting and scratching secondary to bone cement debris. The extent of both wear and damage experienced by these components was moderate, in comparison with that previously reported with older implant systems.

Purpose of study: This study assessed the current availability of “out of hours” MRI scans for patients who present with symptoms suggestive of cauda equina syndrome to trauma units across the United Kingdom (UK).

Methods: 98 trauma units in 212 hospitals across the UK were identified. Senior house officers and registrars were questioned about the availability of emergency MRI scans after 5pm and midnight and at weekends. All units responded to the survey.

Results: 88 of 98 units had an on-site MRI scanner. In 32 hospitals, an MRI scan could be obtained after 5pm. In only 27 hospitals was this possible after midnight. In 58 units (65%) of cases, consultant to consultant contact was required to arrange the scan. 67 units found it “very difficult” or “impossible” to obtain an MRI scan at the weekend producing a potential delay of 64 hours from presentation at 5pm on a Friday night to 9am on a Monday morning.

Conclusions: The availability of urgent MRI scans in cases of suspected cauda equina syndrome currently represents a “postcode lottery” across the UK. This may mean that patients requiring urgent surgical decompression face a significant delay in diagnosis. Delayed or missed cases of cauda equina syndrome have huge personal, social and economic impact. On-site MRI facilities, which are available 24 hours a day for such cases are recommended in all units receiving an acute trauma on call.

We compared the orientation of the acetabular component obtained by a conventional manual technique with that using five different navigation systems.

Three surgeons carried out five implantations of an acetabular component with each navigation system, as well as manually, using an anatomical model. The orientation of the acetabular component, including inclination and anteversion, and its position was determined using a co-ordinate measuring machine.

The variation of the orientation of the acetabular component was higher in the conventional group compared with the navigated group. One experienced surgeon took significantly less time for the procedure. However, his placement of the component was no better than that of the less experienced surgeons. Significantly better inclination and anteversion (p < 0.001 for both) were obtained using navigation. These parameters were not significantly different between the surgeons when using the conventional technique (p = 0.966).

The use of computer navigation helps a surgeon to orientate the acetabular component with less variation regarding inclination and anteversion.

Background: Metal-metal bearings are frequently implanted in young, active patients. The relationship between patient activity and Co and Cr ion levels has not been scientifically investigated.

Methods: Seven patient subjects with well-functioning metal-metal bearing hip prostheses and one control subject (no implants), all with normal renal function, were monitored during a two-week long activity protocol. Lower extremity activity was continuously assessed by a computerized, two-dimensional accelerometer (Step Activity Monitor; SAM). During the first week, subjects were requested to limit physical activity. Subjects then completed an hour-long treadmill test followed by a week where they were encouraged to be as physically active as possible. Serum Co and Cr ion levels and urine Cr levels were assessed at 10 different time points during these two weeks.

Results: Regardless of activity, the serum ion levels for a given patient were essentially constant and there was no correlation between patient activity and serum or urine ion levels. A mean increase in activity of 28% (95% CI, 13 to 43%; SE, 6%) during the high-intensity activity week resulted in a mean decrease of 2.6% (95% CI, −14.2 to 8.9%; SE, 4.7%) in serum Co and a mean increase of 2.0% (95% CI, −5.3 to 9.3%; SE, 3.0%) in serum Cr. During the treadmill test, a mean activity increase of 1,621% (16-fold) (95% CI, 972 to 2,271%; SE, 265%) resulted in a mean increase of 3.0% (95% CI, −5.7 to 11.7%; SE, 3.6%) in serum Co and a mean increase of 0.8% (95% CI, −3.5 to 5.0%; SE, 1.7%) in serum Cr. This effectively constitutes no change in serum ion levels for these changes in activity because the differences are within the variability for the measurement accuracy of these tests.

Conclusions: In patients with normal renal function and a well-functioning metal-metal bearing, ion levels are not affected by patient activity. Periodic measurements of serum ion levels can be used to monitor the tribologic performance of prosthesis with a metal-metal bearing without adjusting for patient activity.

Introduction and Aims: Due to relative motion that can occur between the polyethylene articular surface and tibial tray, backside wear of modular tibial components can be a significant contributor to wear in TKR. This study examines the backside wear performance of a tibial component system from both a laboratory and clinical perspective.

Method: Polyethylene components, CR and PS, from the NexGen knee system (Zimmer Inc.) were evaluated for backside wear. These components were identified on the back surface by the manufacturer with engraved lettering of a depth ranging from 20 to 30 micrometers. Twenty-seven components retrieved after 24 to 80 months in-situ were evaluated along with six components having undergone three million cycles of laboratory knee function simulation. Backside wear was quantified by engraving mark depth and screw hole recess penetration measurements utilising a New View 5000 scanning white light interferometer (Zygo). The severity of third-body abrasion was also recorded.

Results: This particular knee system utilised a peripheral rail and dovetail polyethylene locking mechanism which demonstrated little relative polyethylene to tibial tray motion during joint function simulation. Simulator testing produced backside wear of 6.4 micrometers/million cycles or 4.5 mm3/million cycles. This backside wear represented 30% of total component wear as measured gravimetrically. Backside wear in the clinically retrieved components was sufficient to completely remove the manufacturer’s engraving marks on only three of 27 components. The remaining 24 components all experienced backside wear insufficient to remove all engraving. The severity of third-body abrasion (typically bone cement) was generally associated with greater backside wear. Two of the three clinically retrieved components with worn-through lettering had evidence of significant third-body wear. In 11 clinically retrieved components (utilised on tibial trays with screw holes), backside wear was measured by comparing engraving mark depth in unworn polyethylene areas over screw recesses with engraving mark depth in areas of polyethylene contact with the tibial tray. These components demonstrated 14 micrometers of wear at an average of 37 months in-situ or 4.4 micrometers per year. None of the retrieved components were clinically associated with osteolysis.

Conclusion: In this particular tibial component system, backside wear was moderate for both the joint simulator and clinically retrieved specimens. Backside wear does not appear to be the major contributor of total polyethylene wear in this implant system. The presence of third-body particles contributed to greater wear.

Aims: Measure serum chromium (SrCr) and cobalt (SrCo) and urine chromium (UCr) levels in patients with metal on metal surface arthroplasty of the hip. Methods: Ion levels were measured prospectively in 22 patients implanted with the Conserve Plusª (Wright Medical, TN) CoCr hip resurfacing. There were 15 males and 7 females with an average age of 49 years (range 28 Ð 62 yr). Serum and urine samples were collected using strict anti-contamination techniques pre-operatively and at 3, 6 and 12 months using graphite furnace atomic absorption spectrophotometry. Results: All postoperative metal levels were increased compared to their pre-operative levels. SrCr and SrCo values are at their highest at 3 months post operative and then begin to decrease. UrCr although elevated at 3 and 6 months postoperatively compared to the preop values, the levels continued to increase after the 6-month interval. These values are approximately 4-fold, 7-fold and 3-fold higher in SrCr, UrCr and SrCo, respectively, compared to the values seen in a group of patients with well functioning conventional metal (CoCr) on polyethylene total hips at 84 months postoperative measured by our group. Conclusions: The present levels are 2-fold lower in both SrCr and UrCr and 3-fold lower in SrCo than a group of patients with older generation surface arthroplasties reported previously by our group, suggesting improved manufacturing techniques and material properties have resulted in reduced component wear and generation of wear particles. 12 and 24 month data are currently being collected and analyzed.

Interfacial membranes collected at revision from 11 failed uncemented Ti-alloy total hip replacements were examined. Particles in the membranes were characterised by electron microscopy, microchemical spectroscopy and particle size analysis. Most were polyethylene and had a mean size of 0.53 micron +/- 0.3. They were similar to the particles seen in the base resin used in the manufacture of the acetabular implants. Relatively few titanium particles were seen. Fragments of bone, stainless steel and silicate were found in small amounts. Most of the polyethylene particles were too small to be seen by light microscopy. Electron microscopy and spectroscopic techniques are required to provide an accurate description of this debris.

We present the case of a 65-year-old man who developed a malignant fibrous histiocytoma at the lesser trochanter five months after a cementless hip replacement. We have reviewed reports of similar cases and discuss them in terms of the possible mechanisms of sarcomatous degeneration and the latency of such changes.