Orthopaedic implants are often fixed into place using bone cement. The degradation of the cement mantle has been implicated as playing a major role in the loosening of these implants, and this often necessitates revision surgery. The present work has used the non-destructive acoustic emission (AE) technique to monitor the initiation and evolution of fatigue damage in bone cement constructs. Using this technique, it should be possible to gain an understanding of failure progression in cemented orthopaedic devices. Previous work in this area has focused on AE activity originating from the eventual failure location in order to identify those signatures associated with critical fatigue cracks. This usually involves analysing AE signatures associated with the final stages of failure; however, there have been limited investigations that have looked at the damage that takes up most of the crack propagation life of the sample, (i.e. microcracking formation and development), that occurs away from the failure site, but could still play a role in final failure. In this study, dog-bone-shaped specimens of bone cement were subjected to uniaxial tensile fatigue loading, with damage monitored along the length of specimens using AE. Where specimens exhibited AE activity at locations away from the fracture site, they were sectioned and subjected to synchrotron tomography, which enabled high resolution images of these regions to be obtained. Microcracks of the order of 20 microns were observed in areas where AE had identified early, non-critical damage; in contrast, no microcracking was observed in areas that either remained unloaded or exhibited no AE. To further corroborate these observations, and characterise the damage mechanisms involved, scanning electron microscopy (SEM) was applied to the sectioned samples. In those locations where significant yet non-critical AE occurred, there was evidence of crack-bridging, suggesting that crack closure mechanisms may have slowed down or even arrested crack propagation within the bone cement. These findings further validate the use of AE as a passive non-destructive method for the identification and understanding of damage evolution in cemented orthopaedic devices.
Uncemented porous-coated total hip prostheses rely on osseointegration or bone ingrowth into the pores for a stable interface and long term fixation. One of the criteria for achieving this is good initial stability, with failure often being associated with migration and excessive micromotion. This has particularly been noted for long stem prostheses. To minimize micromotion and increase primary stability, a short stemmed implant ‘PROXIMA’(DePuy; Leeds, UK) with a prominent lateral flare was developed with the aim of providing a closer anatomical fit, more physiological loading and limiting bone resorption due to stress shielding. This study aims to simulate bone ingrowth and tissue differentiation around a well fixed porouscoated short stemmed implant using a mechanoregulatory algorithm and finite element analysis (FEA). Specific emphasis is made on the design of the implant and its effect on osseointegration. An FE model of the proximal femur was generated using computer tomography (CT) scans. The PROXIMA was then implanted into the bone maintaining a high neck cut and adequate cancellous bone on the lateral side to accommodate the lateral flare and for osseointegration. A granulation tissue layer of 0.75mm was created around the implant corresponding to the thickness of the porous coating used. The mechanoregulatory hypothesis of Carter et al (J. Orthop, 1988) originally developed to explain fracture healing was used with selected modifications, most notably the addition of a quantitative module to the otherwise qualitative algorithm. The tendency of ossification in the original hypothesis was modified to simulate tissue differentiation to bone, cartilage or fibrous tissue. Normal walking and stair climbing loads were used for a specified number of cycles reflecting typical patient activity post surgery. The majority of the tissue type predicted to be formed, simulating a month in vivo, is fibrous and indicates a weak interface proximally after this period. The stronger tissues, bone and cartilage occupy the mid-lower regions, indicating a strong interface distally. This can be explained by the unique lateral flare that provides extra stability to the distal regions of the implant, especially on the lateral side. The percentage of bone ingrown around the implant at different stages is also important and there was a significant rise from 15% after 10 cycles to about 30% after 30 cycles, simulating a month in vivo. It was also noted that initial bone formation was very high, even after a few cycles, which leads to a stronger interface early on. Fibrous tissue occupied around 45% at almost all stages and did not vary considerably. Cartilage however, was replaced by bone as tissue differentiation occurred, reducing from about 30% after 10 cycles to 20% after 30 cycles. This further indicates the trend of tissue ossification through the regions of stronger tissues, gradually proceeding in the direction of the weaker tissues. The unique lateral flare design and the seating of the implant entirely in the cancellous bed without any diaphyseal fixation provides contrasting results in terms of bone ingrowth around the implant. The lateral flare minimises micromotion and provides better stress distribution at the interface under the region. This accounts for a large percentage of the mid to distal regions under the flare being covered with either bone or cartilage. From the predictions of the algorithm, the significant lateral flare of the PROXIMA helps in stabilizing the implant and provides better osseointegration in the distal regions around the implant.
Two-stage revision surgery for infected total knee replacement offers the highest rate of success for the elimination of infection. The use of articulating antibiotic-laden cement spacers during the first stage to eradicate infection also allows protection of the soft tissues against excessive scarring and stiffness. We have investigated the effect of cyclical loading of cement spacers on the elution of antibiotics. Femoral and tibial spacers containing vancomycin at a constant concentration and tobramycin of varying concentrations were studied The elution of tobramycin increased proportionately with its concentration in cement and was significantly higher at all sampling times from five minutes to 1680 minutes in loaded components compared with the control group (p = 0.021 and p = 0.003, respectively). A similar trend was observed with elution of vancomycin, but this failed to reach statistical significance at five, 1320 and 1560 minutes (p = 0.0508, p = 0.067 and p = 0.347, respectively). However, cyclically loaded and control components showed an increased elution of vancomycin with increasing tobramycin concentration in the specimens, despite all components having the same vancomycin concentration. The concentration of tobramycin influences both tobramycin and vancomycin elution from bone cement. Cyclical loading of the cement spacers enhanced the elution of vancomycin and tobramycin.
Removal of solidly fixed implants is a challenge in revision knee arthroplasty. It is fraught with the risk of intraoperative fractures and bone stock vital for the success of subsequent revision surgery. We describe the double extraction technique for extraction of solidly fixed implants. This technique was first tested in laboratory setting and then replicated in the operation theatre with successful results. In this retrospective study we analysed all our patients in which we used the double extraction technique for the removal of solidly fixed implants. In this procedure, the surgeon and the assistant each place an osteotome on the cement metal interface at symmetric positions, directly opposite each other on the medial and lateral sides. They deliver synchronous blows with a mallet at positions around the interface until the cement fractures. The femoral component can then be easily removed. The technique was tested in a laboratory before it was used clinically. Polyurethane mouldings, representing a suitable substrate for cementing metal components were fixed on to a steel rod of similar weight and length as the lower leg. Stainless steel discs (40mm diameter × 4mm thickness) were cemented on to the polyurethane substrate to form a model of a cemented implant. The discs were instrumented to allow recording of the mechanical processes caused by the double extraction technique and to allow comparison with the single osteotome extraction technique. The methodology successfully demonstrated that the double osteotome technique increases the contact force of the second blow. When the synchronous blows are delivered, less energy is expended in the movement of tibia and more is contributed to the removal of the component. In this study we looked at a total of 206 patients were the solidly fixed tibial and femoral components were removed using the double extraction technique. There were 86 men and 126 women. The mean age of the patients was 66.8 years (range 37–87 years). Only patients with solidly fixed implants were included in this study. Stability of implants was assessed with preopera-tive radiographs and then confirmed intraoperatively. Patients with loose implants intraoperatively were excluded from this study. We present our results with use of this technique in 206 patients with follow up of 1 to 5 years.
During conventional hip arthroplasties, the diseased femur is rigidified using a metallic stem. The insertion of the stem induces a change in the stress distribution in the surrounding femur, and the bone remodels; this stress distribution is a direct result of the stem stiffness characteristics. Healthy healing of the femur requires that the bone be loaded as naturally as possible. If the bone is not loaded appropriately, it can resorb which may result in stem loosening and revision. Although current rigid metallic femoral stems are very successful, a poor stress distribution may become a critical problem for younger patients as the stem/femoral bone construct will be subjected to higher loads for longer times, and since remodelling is faster, loosening can occur earlier. Reduced stiffness stems have therefore been investigated, but early failures have been reported due to increased movements, poor initial stability and the low proximal stiffness of the stem. A novel biocompatible carbon fibre reinforced plastic (CFRP) stem has been developed in light of these past experiences