Abstract. Background. Around 5–15% of patients will experience chronic postoperative pain after total knee replacement (TKR) surgery but the source of the pain is unknown. The aim of this study was to assesses patients six months after TKR using magnetic resonance imaging (MRI) of the knee, pain sensory profiles and assessments of pain catastrophizing thoughts. Methods. Forty-six patients had complete postoperative data and were included. MRI findings were scored according to the MRI Osteoarthritis Knee Score (MOAKS) recommendation for Hoffa synovitis, effusion size and bone marrow lesions. Pain sensory profiles included the assessment of pressure pain thresholds (PPTs), temporal summation of pain (TSP) and conditioned pain modulation (CPM). Pain catastrophizing was assessed using the pain catastrophizing scale (PCS). Clinical pain was evaluated using a visual analog scale (VAS, 0–10cm) and groups of moderate-to-severe (VAS>3) and non-to-mild postoperative pain (VAS≤3) were identified. Results. Patients with moderate-to-severe postoperative pain demonstrated higher grades of Hoffa synovitis (P<0.001) and effusion size (P<0.001), lower PPTs (P=0.039), higher TSP (P=0.001) and lower CPM (P=0.014) when compared to patients with non-to-mild postoperative pain. No differences were found in PCS scores. Linear regression models found TSP (P=0.013), PCS (P<0.001), Hoffa synovitis (P=0.036) and effusion size (P=0.003) as independent parameters contributing to the postoperative pain severity. Conclusion. These finding indicate that chronic postoperative after TKR is a combination of joint-related synovitis and effusion in combination with sensitization of central pain mechanisms and pain catastrophizing thoughts

Chronic postoperative pain (CPP) can occur in elective mid/hindfoot and ankle surgery patients. Multimodal pain management has been reported to reduce postoperative pain and opioid use, which may prevent the development of CPP. However, few studies have examined the impact of multimodal pain management strategies on CPP following complex elective mid/hindfoot and ankle surgery. The purpose of this study was to 1) evaluate current pain management strategies and 2) determine current definitions, incidence, and prevalence of CPP after elective mid/hindfoot and ankle surgery. Three databases (MEDLINE, Embase and Cochrane Library) were manually and electronically searched for English language studies published between 1990 and July 2017. For the first aim, we included comparative studies of adults undergoing elective mid/hindfoot and ankle surgery that investigated pre-, peri- or postoperative pain management. For the second aim, we included observational studies examining CPP definition, incidence, and prevalence. Two reviewers independently screened titles and abstracts, followed by full texts. Conflicts were resolved through discussion with a third reviewer. Reviewers also independently assessed the quality of studies meeting inclusion criteria using the Joanna Briggs Institute Critical Appraisal Checklist. For the first aim, 1159 studies were identified by the primary search, and seven high quality randomized controlled trials were included. Ankle arthroplasty or fusion and calcaneal osteotomy were the most common procedures performed. The heterogeneity of study interventions, though all regional anesthesia techniques, precluded meta-analysis. Most investigated continuous popliteal, sciatic and/or femoral nerve blockade. Participants were typically followed up to 48 hours postoperatively to examine postoperative pain levels and morphine consumption in hospital. Interventions effective at reducing postoperative pain and/or morphine consumption included inserting popliteal catheters using ultrasound instead of nerve stimulation guidance, perineural dexamethasone, and adding continuous femoral blockade to continuous popliteal blockade. Using more than one analgesic was generally more effective than using a single agent. Only two studies examined longer term pain management. One found no difference in pain levels and opioid consumption at two weeks with perineural or systemic dexamethasone use. The other found that pain with activity was significantly reduced at six months postoperatively with the addition of a femoral catheter infusion to a popliteal catheter infusion. For the second aim, only two studies of the 747 identified were selected. One prospective observational study defined CPP as moderate-to-severe pain at one year after foot and ankle surgery, and reported 21% and 43% of patients as meeting their definition at rest and with activity, respectively. The other study was a systematic review that reported 23–60% of patients experienced residual pain after total ankle arthroplasty. There is no standardized definition of CPP in this population, and incidence and prevalence are rarely reported and vary largely based on definition. Although regional anesthesia may be effective at reducing in-hospital pain and opioid consumption, evidence is very limited regarding longer-term pain management and associated outcomes following elective mid/hindfoot and ankle surgery

Orthopaedic surgeons prescribe more opioids than any other surgical speciality. Opioids remain the analgesic of choice following arthroscopic knee and shoulder surgery. There is growing evidence that opioid-sparing protocols may reduce postoperative opioid consumption while adequately addressing patients’ pain. However, there are a lack of prospective, comparative trials evaluating their effectiveness. The objective of the current randomized controlled trial (RCT) was to evaluate the efficacy of a multi-modal, opioid-sparing approach to postoperative pain management in patients undergoing arthroscopic shoulder and knee surgery. The NO PAin trial is a pragmatic, definitive RCT (NCT04566250) enrolling 200 adult patients undergoing outpatient shoulder or knee arthroscopy. Patients are randomly assigned in a 1:1 ratio to an opioid-sparing group or standard of care. The opioid-sparing group receives a three-pronged prescription package consisting of 1) a non-opioid prescription: naproxen, acetaminophen and pantoprazole, 2) a limited opioid “rescue prescription” of hydromorphone, and 3) a patient education infographic. The control group is the current standard of care as per the treating surgeon, which consists of an opioid analgesic. The primary outcome of interest is oral morphine equivalent (OME) consumption up to 6 weeks postoperatively. The secondary outcomes are postoperative pain scores, patient satisfaction, quantity of OMEs prescribed and number of opioid refills. Patients are followed at both 2 and 6 weeks postoperatively. Data analysts and outcome assessors are blinded to the treatment groups. As of December 1, 2021 we have enrolled 166 patients, reaching 83% of target enrolment. Based on the current recruitment rate, we anticipate that enrolment will be completed by the end of January 2022 with final follow-up and study close out completed by March of 2022. The final results will be released at the Canadian Orthopaedic Association Meeting in June 2022 and be presented as follows. The mean difference in OME consumption was XX (95%CI: YY-YY, p=X). The mean difference in OMEs prescribed was XX (95%CI: YY-YY, p=X). The mean difference in Visual Analogue Pain Scores (VAS) and patient satisfaction are XX (95%CI: YY-YY, p=X). The absolute difference in opioid refills was XX (95%CI: YY-YY, p=X). The results of the current study will demonstrate whether an opioid sparing approach to postoperative outpatient pain management is effective at reducing opioid consumption while adequately addressing postoperative pain in patients undergoing outpatient shoulder and knee arthroscopy. This study is novel in the field of arthroscopic surgery, and its results will help to guide appropriate postoperative analgesic management following these widely performed procedures

Background. Tranexamic acid (TXA) decreases blood loss and therefore, may minimize painful postoperative hematomas after total hip arthroplasty (THA). This study evaluated early postoperative pain and blood loss in THA patients with and without the use of topical TXA. Methods. A consecutive series of 174 THAs performed without TXA were compared to a consecutive series of 156 THAs performed with topical TXA. Procedures were performed by a single surgeon using identical perioperative medical and pain control protocols. Inpatient pain scores (VAS 0 to 10), opioid consumption (morphine equivalents, Meq), time to first opioid, and drop in hemoglobin (Hgb) were evaluated. Univariate analysis of topical TXA and 20 potential covariates of pain and blood loss was performed, followed by logistic and linear regression with p≤0.250. Results. In multivariate analysis, THAs with TXA were independently associated with less hemoglobin loss than THAs without TXA (2.98 g/dL vs. 3.39 g/dL; p=0.001). Topical TXA use was associated with greater pain (3.41 vs. 1.71, p=0.001) and increased opioid consumption (44.2 vs. 24.2 Meqs, p<0.001) during the first 24 hours, and decreased time to first opioid (182 vs 422 minutes, p=0.008). 33% of patients receiving TXA compared to 9% without TXA reported moderate-severe pain (p=0.021). Preoperative narcotic use (p=0.055 to 0.008) and fentanyl rather than morphine spinals (p=0.034 to 0.008) also independently increased postoperative pain. Conclusion. Findings continue to support TXA in minimizing blood loss in THA; however, increased early postoperative pain with topical TXA was an unexpected discovery. This finding is reinforced by TXA affecting GABA and glycine receptors in the spinal dorsal horn, and TXA causing periarticular cell death in vivo at clinical concentrations. We currently avoid topical TXA use clinically, particularly in the outpatient early discharge setting, and are exploring whether similar findings are observed with intravenous TXA. For any tables or figures, please contact the authors directly

The postoperative pain after hip arthroscopy remains a major challenge in the immediate postoperative period. Adequate postoperative analgesia has been associated with increased patient satisfaction and decreased consumption of opioids. We evaluated the efficacy of pericapsular nerve group block (PENG) versus fascia iliaca block (FIB) in reducing post-operative pain and analgesic consumption within the first 24 hours following arthroscopic management of femoroacetabular impingement (FAI). Thirty-nine patients (17 females and 25 males, ages 18–42 years, mean ± SD (27.9 ± 6.2), and mean BMI of 25.13±5.08 kg/m2 were scheduled for primary arthroscopic management of FAI. Included patients were randomized into two groups according to the block used in each. Group (A) 19 patients were included and had FIB and group (B) 20 patients were included and received PENG block. The efficacy of both techniques was clinically and statistically valuated using VAS score and quadriceps muscle power. There was a statically significance difference in the mean at rest between the two groups at all measured time points following surgery (6, 12, 18 and 24 h). Also, in dynamic pain scores (with hip flexion) scores were statistically significant at 24 hours post-operative (P = .001). Total opioid consumption in the first 24 hours postoperative was lower in the PENG group with significant difference of mean 16.5 ±9.9 mg for PENG group versus 27.5±9.6 mg for FIB group (P < .005). Five patients (26.31%) in FIB group had weaker quadriceps muscle power while none in PENG group patients had quadriceps weakness. PENG block might be considered as an ideal regional anesthesia modality for hip arthroscopy. As an alternative to more conventional regional nerve blocks such as a fascia iliaca block. PENG block is easily performed in the preoperative setting, and appears to spare motor function while providing a prolonged sensory pain relief

Background. The degree of postoperative pain is usually moderate to severe following Total Hip Arthroplasty (THA). Comfort and lack of pain are important for optimal mobilization and earlier home discharge. Aim. To evaluate the efficacy and safety of Ropivacaine, a long- acting local anaesthetic, when infiltrated in the wound at the end of operation of THA. Methods. Seventy patients, 39 women and 31 men, ASA I-III, underwent Total Hip Arthroplasty in our clinic from January 2008 to June 2009. Patients were randomized into two groups. In group A, a solution of 100 ml Ropivacaine 2mg/ml (Naropeine 0,2%) was infiltrated in the deep tissues (capsule, gluteus medius, gluteus maximus and rotators) (50 ml) while the fascia, subcutaneous tissues and skin were infiltrated with the remaining 50ml. Group B was the control group. All patients received standardized general anesthesia or spinal anesthesia and a PCA morphine using a self-administered pain pump was applied in the recovery room for 48 hours. All patients took 1gr x 3 Apotel i.v., 40mg x2 Dynastat i.v., and 4mg x2 Zofron i.v. for 48 hours postoperative. Pain scores with Visual Analogue Scale (0–10) at 1, 2, 4, 8, 12, 24 and 48 hours postoperatively, time to the first analgesic requirement and side effects were recorded. Results. There were no significant differences in demographic characteristics of the patients and duration of the surgery between two groups. Morphine consumption was statistically significantly lower in group A for the first 48 hours, resulting in a lower frequency of nausea, itching and sedation. Postoperative pain levels at rest and during mobilization were statistically significantly lower in group A while median hospital stay was similar in both groups. Conclusion. Operative wound infiltration with ropivacaine reduces pain and the requirement for analgesics after hip replacement, leading to faster postoperative mobilization

Introduction. Prosthetic designs that use porous metals possess an extremely high surface area and through capillary effect may potentially ‘absorb’ and later elute analgesic solution, serving as a surgical site drug depot. This study aimed to determine if a highly porous acetabular component submerged in an aqueous-based analgesic solution prior to implantation reduced postoperative pain scores and opioid consumption in the early post-operative period. Methods. Using our IRB approved database, 200 consecutive opioid naïve primary THA patients operated on by a single surgeon at two institutions using the same acetabular component were identified. 100 patients had a standard volume/concentration of an analgesic cocktail soft-tissue injection at closure (control). 100 patients had their acetabular components submerged into the same cocktail prior to implantation (treatment) and the balance of the volume injected. Postoperative protocols were otherwise identical. Groups were compared for visual analog pain scores (VAS), opioid consumption, 1-year radiographic findings and surgical revision rates. Results. VAS were lower in the treatment group at 6hrs (2.35±1.8 v. 3.31±2.3, p<0.01), 12hrs (2.00±1.6 v. 3.61±2.3, p<0.01), 18hrs (2.36±1.7 v. 3.44±1.9, p<0.01), and 24 hrs (2.20±1.6 v. 3.82±1.9, p<0.01). Opioid consumption was lower in the treatment group at all time point in the first 24 hours and significantly lower in the first 6 hours (7.18±9.42 MME v. 10.76±11.37 MME, p<0.05) and between 12 and 24 hours postoperatively (10.43±15.94 MME v. 17.08±22.75 MME, p<0.05). The total MME administered to the treatment group was significantly lower than the control group (48.3±59.7 MME vs. 76.1±78.6 MME, respectively; p<0.01). At one-year, there was no radiographic evidence of periacetabular lucencies and no revisions for loosening. Conclusion. The use of a highly porous component commonly used in THA as a potential analgesic drug depot in combination with soft-tissue injections may reduce postoperative pain scores and opioid consumption compared to soft-tissue injections alone

Introduction. Even as the outcomes of primary total knee arthroplasty (TKA) continue to improve, there remain increasing concerns about pain control after surgery and prolonged narcotic use. Cryoneurolysis has been demonstrated to reduce osteoarthritis knee pain for up to 90 days. We hypothesized that postoperative narcotic use could be reduced following preoperative cryoneurolysis of the superficial genicular nerves. Methods. Primary TKA patients were randomized into either a control or cryoneurolysis treatment group. Both followed the same preoperative, intraoperative, and postoperative pain management protocol, except the treatment group had cryoneurolysis of their superficial genicular nerves 3–7 days prior to surgery. All patients were prescribed 40 narcotic pills at discharge and pills were counted at 72 hours and at 2,6, and 12 weeks postoperatively. The primary endpoint was daily morphine equivalent (DME) based on pill count and secondary endpoints were changes in pain and Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS, Jr.) scores. Results. Per-protocol results demonstrated that the DME for the treatment group was significantly lower at 72 hours (10.9 mg vs. 14.9 mg, p=0.0389), 6 weeks (4.2 mg vs. 5.9 mg, p=0.0186) and 12 weeks (2.4 mg vs 3.4 mg p=0.0234). Overall, there was a 29% reduction in the DMEs over the entire 12-week postoperative period. Only 14% of the treatment group consumed opioids past 6 weeks compared to 44% of the control group (p=0.0005). The treatment group demonstrated a greater reduction in pain scores from baseline at 72 hours and 12 weeks. The treatment group also showed significant improvements in KOOS Jr. scores compared to the control group at all timepoints. Conclusions. The results demonstrate that preoperative cryoneurolysis can reduce opioid consumption after TKA. The early cessation of opioid consumption is especially encouraging given the association of prolonged narcotic use with increased complications following surgery. Preoperative cryoneurolysis should be considered as part of a multimodal protocol to reduce opioid consumption and pain and improve function after TKA. For figures, tables, or references, please contact authors directly

Introduction. Chronic pain is one of the adverse outcomes in surgery for degenerative lumbar pathology (DLP). Postoperative complications as DVT, and chronic pain in pathologies as thoracotomy or breast cancer have been associated with poor control of postoperative pain. Study design. Prospective study of patients undergoing surgery for DLP. Purpose. To evaluate the relationship of postoperative pain with final outcomes in terms of chronic pain and quality of life. Outcome measures. Visual analogue scales (VAS) to assess lumbar and leg pain, Short Form-36v2 (SF-36), Oswestry Disability Index (ODI) and Core Outcome Measures Index (COMI). Method. 263 patients with a mean age of 54.0 years (22–86 y) were reviewed and 131 patients were women (49.8%). Pain, quality of life and disability of patients were assessed in the immediate preoperative and 2 years after surgery. Epidemiological data collected were age, sex, educational level, employment status, diagnosis, treatment, and comorbidity (ASA). An external nurse evaluated postoperative pain four times every day and we selected the worst value of day. The reference value of postoperative pain was the VAS of third day when patient starts standing and PCA is removed. To compare means we used t-Student and Pearson's coefficient or Spearman's test was used to assess the correlation, and, finally, linear regression study (ANOVA) was performed with variables that showed statistically significant correlation. SPSS 15.0 statistical package. Results. The mean value of VAS on 3rd day (VAS-3) was 2.86 ± 2.2. Postoperative pain showed a moderately positive correlation with final pain, measured by Bodily Pain (r=0.310, p <0.05) and final VAS (r=0.318, p <0.001), and moderately negative with the Physical Component Scale of the SF36 (r=−0.269, p <0.05). No significant correlations existed with the other instruments. Preoperative pain, sex and MSC-SF36 was correlated with postoperative pain (r=0.262 p <0.05; r=− 0.261 p <0.003, r=− 0.306 p <0.001). According to linear regression studies each point in the VAS-3 will be an increase of 0.522 points in the final VAS (p <0.01). Conclusions. Postoperative pain has moderate but statistically significant influence in the final lumbar pain perception, assessed by VAS and Bodily Pain. Postoperative pain has an inverse relationship to the physical component of SF-36. However, postoperative pain is not correlated with disability measured by ODI or COMI

Background: Control of acute postoperative pain remains a serious problem. Postoperative pain is associated with an increase in thrombotic or respiratory complications. In the other hand the association between surgery, acute postoperative pain and ongoing chronic pain is well defined. Target: To evaluate the incidence of severe pain after surgery for degenerative lumbar pain, with two analgesic techniques; intravenous analgesia (i.v.) (group 1) and patient controlled analgesia (PCA) (group 2). Study design: Retrospective study with dates obtains prospectively. Patient sample: We studied 206 patients operated between january 04 and june 05. Group 1 (intravenous) 80 patients and 126 in group 2 (PCA). Outcomes mesasures: Percentage of patients with severe pain, number of rescues and complications. Materials and methods: The type of postoperative analgesia administrated was decided by the anaesthesiologist. To measure pain intensity the VAS was assessed every 6 hours and worst score was used, excluding recovery room. Type of rescue analgesia was the same in all patients and these was recommended in VAS > 3. We evaluate sex, age and comorbidity by ASA. We have defining analgesic ‘failure’ by the overall incidence of pain intensity in two categories: the percentage of patients who experienced moderate-severe pain (VAS > 3) and severe pain (VAS> or = 7). As the pain scores were not normally distributed we not used mean and SD of VAS. The number of rescues and complications were also evaluated. Results: There was not differences in median age (group 1 50’85 sd 15’4; group 2 52’44 sd 15’4 p=0’47), ASA (group 1 1’89 sd 0’75; group 2 1’90 sd 0’57 p=0’88) or diagnosis between two groups. There were differences in percentages of sexes, group 1 with 40% of women and 62’69% in group 2 (p=0’013). There were not differences in incidence of patients with moderate-severe pain (group 1 15/80; group 2 30/126. p=0’392) neither in incidence of patients with severe pain (group 1 33/80; group 2 51/126. p=0’912). There were not differences in number of rescues (p=0’912) neither in number of complications between groups. Global incidence of VAS > 3 were 40’8 but the incidence of rescues were 25’2%. Conclusions: Our findings suggest that both techniques have similar effectiveness, although the global incidence of severe pain was not optimal (21’8%). It is important to remark the different between incidence of patients with VAS > 3 and number of rescues administrated

Introduction: Hospital accrediting organizations have recently emphasized the evaluation of and response to postoperative pain as the “fifth vital sign”. However, there are no prospective studies describing normal pain patterns after TKA to guide appropriate clinical responses. Similarly, there are no studies describing those at risk for unusual pain. Purpose: To outline the pattern of normal recovery and identify factors predictive of significant pain after TKA. Method: Prospective, observational, single surgeon design. Inclusion criteria: primary, cemented TKA for osteoarthritis. Clinical & radiographic measures obtained pre-op and at 1,3,6 and 12 months post-operatively. Predictive factors and post-operative outcomes included body mass index visual analogue scale (VAS), demographics, physical therapy, and component design, alignment and fixation. Psychometric testing included the Beck Depression Inventory and McGill Pain Questionnaire. Results: 96 patients, 125 knees (mean age = 66, 55.2% women). Mean VAS at pre-op, 1,3, 6 and 12 month visits were 51.1(SD 23.8), 37.4(21.8), 27.0(22.2), 20.8(20.3), and 18.0(21.0), respectively. significant pain (VAS> 40) was reported by 61.51% of patients pre-op, 41.7% at 1 month, 24.0% 3 months, 16.7% 6 months, and 8.3% 12 months. There were no differences in pain based on the type of anesthesia, weight, age or gender. Preoperative elevated depression, anxiety and pain-related suffering descriptors predicted greater pain during the first 6 months after surgery, but did not ultimately affect recovery. Patients who had greater pain (VAS> 40) used more home and outpatient physical therapy (p=0.25). Conclusion: Contrary to common beliefs, many patients (22%) still experience significant pain up to six months after TKA, despite absence of clinical or radiographic abnormalities. significant pain (VAS > 40mm) after six months may be indicative of an abnormal pain experience. Preoperative pain, depression and suffering are associated with increased early pain andutilization of therapy

Chronic low back pain (CLBP) is the most common cause of disability worldwide, and lumbar spine fusion (LSF) is often chosen to treat pain caused by advanced degenerative disease when clinical treatment failed certain cases, the post-surgical outcomes are not what was expected. Several studies highlight how important are. In psychological variables during the postoperative spine surgery period. The aim of this study is to assess the role of preoperative depression on postoperative clinical outcomes. We included patients who underwent LSF since December 2021. Preoperative depression was assessed administering Beck Depression Inventory questionnaire (BDI). And pain and disability were evaluated at 1, 3, and 6 months, administering respectively Visual Analogic Scale (VAS) and Oswestry Disability Index (ODI). As statistical analysis Mann-Whitney test was performed. We included 46 patients, 20 female (43,5%) and 26 male (56,5%) with an average age of 64,2. The population was divided in two groups, fixing the BDI cut-off point at 10. Patients with BDI < 10 points (N=28) had normal mental health status, instead patients with BDI > 10 points (N=16) had depressive disorders. At 3 months patients with healthy mental status reported statistically significant reduction of pain (U = 372,5, p = .006) and improvement of disability but without statistical significancy (U = 318, p = 0,137). At 6 months patients without psychological disease reported statistically significant reduction of pain (U = 342, p = 0,039) and disability (U = 372,5, p = 0,006).

This study demonstrates the correlation between pre-existing depressive state and poorer clinical outcomes after spine surgery. These results are consistent with the literature. Therefore, during the surgical decision making it is crucial to take psychological variables into account in order to predict the results after surgery and inform patients on the potential influence of mental status.

To assess whether by improving patient’s knowledge about the wrist arthroscopy procedure would positively affect the amount of postoperative pain. We tested the effect of a fact sheet that contained detailed information about the procedure on the outcome of such a surgery. Fifty-five patients undergoing diagnostic wrist arthroscopy were randomly allocated into 2 groups. Group 1 included 28 patients to whom an explanatory form named fact sheet was provided prior to the procedure. 27 patients in the second group did not have the fact sheet. However both groups had the usual preoperative verbal instructions during consenting and all patients had Visual analogue scale pain assessment before surgery. Pain scores were recorded over a 10 day period postoperatively, the end point being the day on which the patient returned to the preoperative pain status. There were 34 females and 21 males with 47 right and eight left wrists but all were the dominant side. The mean age of the patients was 35 years (range of 16 to 54 years). In the first 48 hours all patients had flare up of pain in their wrists but by day five, 75% of patients who had the fact sheet, recovered to their preoperative pain status whereas only 22% of patients in the control group had done so. Furthermore, Patients in group 1 resumed their routine daily activities on average three days earlier (day seven) when compared to the control group in whom this return was not complete up to day 10. Supplying a fact sheet prior to wrist arthroscopy has a positive influence in terms of decreasing the preoperative pain score and reducing the time patients required off work. Given the clear benefits demonstrated by this simple manoeuvre, it is now our practice to provide such a fact sheet to all patients

To determine the effect of Dexamethasone on post-operative pain management in patients undergoing Total Knee Arthroplasty in terms of numerical pain rating scale and total opoid consumption.

This Randomized Controlled Trail (RCT) was conducted for 02 years (7th September 2015 to 6th September 2017). All patients undergoing primary Unilateral Total Knee Replacement (TKR) for Osteoarthritis knee were included in the study. Patients with poor glycemic control (HbA1c > 7.6), Hepatic/Renal failure, corticosteroids/ Immunosuppression drug usage in the last 06 months, known psychiatric illnesses were excluded from the study. All patients were operated by consultant Orthopaedic surgeon under Spinal Anaesthesia and tourniquet control using medial para-patellar approach. Patients were randomly divided into 02 groups, A and B. 79 patients were placed in each group. Group A given 0.1mg/kg body weight Dexamethasone Intravenously 15 minutes prior to surgery and another dose 24 hours post-operatively while in group B (control group) no Dexamethasone given. Post-operative pain using the numerical pain rating scale (NRS) and total narcotics consumed converted to morphine dose equivalent noted immediately post-op, 12-, 24- and 48-hours post-operatively. Data analysis done using SPSS version 23.

A total of 158 patients were included in the study. Of the total, 98 (62.02%) were females and 60 (37.98%) males. Average BMI of patients 26.94 ±3.14 kg/m2. Patients in group A required less post-operative analgesics (p < 0 .01) and had a better numerical pain rating scale score (p < 0 .01) as compared to group B. Pain scores at 24- and 48-hours post-op were significantly less for Dexamethasone group (p < 0 .01).

Use of Dexamethasone per- and post-operatively reduces the pain and amount of analgesics used in patients undergoing TKA.

For any reader queries, please contact drjunaidrmc@gmail.com

Abstract

Background: To assess the safety and efficacy of intrathecal diamorphine for the postoperative pain relief in patients having lumbar decompressive surgery. Methods: Retrospective study of case records of 39 consecutive patients who underwent lumbar decompression surgery, carried out by the same surgeon. There were 39 (24 males & 15 females, age range 19–75 years) healthy patients (23 ASA 1, 13 ASA 2 and 3 ASA 3). All patients having lumbar microdiscetomy or decompression for spinal stenosis were treated by a single intrathecal injection of diamrphine, performed by the surgeon prior to wound closure. All were prescribed regular paracetamol, and a NSAID if there were no contraindications. Oral opiates were prescribed for “rescue” analgesia. Retrospective analysis of the case notes of these patients was carried out and visual analogue pain scores, sedation scores and side effects/complications were evaluated. Results: Five patients required rescue analgesia in the first six hours after surgery. None was required subsequenty. Nausea occurred in 2 patients, 1 patient had vomiting and one pruritus requiring piriton. Respiratory depression and sedation were not found in any of the patients. None of the patients had neurological complications. Conclusion: Intrathecal diamorphine proved to be safe, effective and eliminated the need for opioid infusions following lumbar decompression surgery

Introduction

Achieving a well-balanced midflexion and flexion soft tissue envelope is a major goal in Total Knee Arthroplasty (TKA). The definition of soft tissue balance that results in optimal outcomes, however, is not well understood. Studies have investigated the native soft tissue envelope in cadaveric specimen and have shown loosening of the knee in flexion, particularly on the lateral side. These methods however do not reflect the post TKA environment, are invasive, and not appropriate for intra-operative use. This study utilizes a digital gap measuring tool to investigate the impact of soft tissue balance in midflexion and flexion on post-operative pain.

Controlling postoperative pain and nausea after total joint arthroplasty remains an important challenge. We conducted a prospective, randomized controlled trial with 120 patients to determine if the addition of perioperative dexamethasone to a multimodal regimen improves antiemetic and analgesic control, enhances mobility, and shortens hospital length of stay after total hip and knee arthroplasty. Patients administered 10 mg of intravenous dexamethasone intraoperatively consumed less daily rescue anti-emetic and analgesic medication, reported superior VAS nausea and pain scores, ambulated further distances, and had a significantly shorter length of stay compared to the control group (p < 0.05). A second, 24-hour postoperative dose of 10 mg intravenous dexamethasone provided significant additional pain and nausea control and further reduced length of stay (p < 0.05). No adverse events were detected with the administration of the intraoperative and/or postoperative dexamethasone

Background/Introduction

As a new generation of robotic systems is introduced into the world of arthroplasty, Robotic-Assisted Total Knee Arthroplasty (TKA) represents a growing proportion of a reconstructive surgeon's operative volume. This study aims to compare the post-operative readmission rate, pain scores, costs, as well as the effects on surgeon efficiency one year after adoption of these technologies into clinical practice.

Introduction and Objectives: Orthopaedic surgery is associated with significant pain in the immediate postoperative period. Management of this pain often requires the administration of opiates. The goal of this study is to evaluate the efficacy of analgaesic treatment with intravenous morphine hydrochloride in a nurse-controlled analgaesia (NCA) system during the first day postoperative in children in general hospital wards.

Materials and Methods: The study included 69 consecutive patients, all under 6 years of age, who underwent scheduled orthopedic surgery. All patients were treated postoperatively using intravenous morphine hydrochloride using the NCA system according to the following protocol: loading dose: 50–100 μg/kg; continuous infusion: 10–20 μg/kg/h; bolus dosage: 4- μg/kg: closure time: 20”; maximum dose: 400 μg/kg/4h. The following variables were evaluated: 1). Intensity of pain: none = 0 / mild = 1 / moderate = 2 / very intense = 3; 2). Side effects: a) nausea and vomiting: none =0 / 1 episode in 4 hours = 1 / more than 1 episode in 4 hours = 2. b) Urinary retention: none = 0 / spontaneous micturition after less than 8 h = 1/ draining catheter required = 2; 3). Average morphine chloride dose/kg of weight.

Results: Average age was 24.3 months (range: 4 months – 6 years). Average weight: 12.7 kg. Results showed no case of excessive sedation or respiratory depression. Average morphine hydrochloride dosage per kg body weight was 365.5 μg (± 402.5 μg).

Discussion and Conclusions: The guidelines of our I.V. morphine hydrochloride protocol for NCA yielded satisfactory control of post-operative pain after trauma surgery in children under 6 years old. No major side effects were noted in our patients, and the protocol may be safely used.