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The Bone & Joint Journal

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The Journal of Bone & Joint Surgery British Volume
Vol. 70-B, Issue 4 | Pages 600 - 602
1 Aug 1988
Cannon Dyson P Sanderson P

We report 16 orthopaedic patients who had antibiotic-associated diarrhoea (pseudomembranous colitis) after operation. There was an association with the use of cephradine and with the prolongation of prophylaxis for more than three peri-operative doses. Five cases occurred as a cluster, suggesting that the causative agent, Clostridium difficile, may be infectious in some situations.