Aims. Tranexamic acid (TXA) has been shown to reduce
Our aim was to determine the total
Tranexamic acid is a fibrinolytic inhibitor which reduces
There is currently no consensus about the mean
volume of blood lost during spinal tumour surgery and surgery for metastatic
spinal disease. We conducted a systematic review of papers published
in the English language between 31 January 1992 and 31 January 2012.
Only papers that clearly presented
Aims. The purpose of the present study was to evaluate the impact of
intravenous tranexamic acid on the reduction of
Aims. In total knee arthroplasty (TKA),
Tranexamic acid (TXA), an inhibitor of fibrinolysis,
reduces
Aims. A typical pattern of
Following total hip arthroplasty (THA) and total knee arthroplasty (TKR) only the ‘visible’ measured
Aims. The aim of this study was to investigate the hypothesis that a single dose of tranexamic acid (TXA) would reduce
We performed a randomised, controlled trial involving 150 patients with a pre-operative level of haemoglobin of 13.0 g/dl or less, to compare the effect of either topical fibrin spray or intravenous tranexamic acid on
We carried out a prospective randomised study to evaluate the
Aims. Cementless primary total hip arthroplasty (THA) is associated with risks of bleeding and thromboembolism. Anticoagulants are effective as venous thromboprophylaxis, but with an increased risk of bleeding. Tranexamic acid (TXA) is an efficient antifibrinolytic agent, but the mode and timing of its administration remain controversial. This study aimed to determine whether two intravenous (IV) TXA regimens (a three-hour two-dose (short-TXA) and 11-hour four-dose (long-TXA)) were more effective than placebo in reducing perioperative real
In an initial randomised controlled trial (RCT)
we segregated 180 patients to one of two knee positions following total
knee replacement (TKR): six hours of knee flexion using either a
jig or knee extension. Outcome measures included post-operative
blood loss, fall in haemoglobin, blood transfusion requirements,
knee range of movement, limb swelling and functional scores. A second
RCT consisted of 420 TKR patients randomised to one of three post-operative
knee positions: flexion for three or six hours post-operatively,
or knee extension. Positioning of the knee in flexion for six hours immediately
after surgery significantly reduced
Despite advances in contemporary hip and knee
arthroplasty,
We have investigated in a prospective, randomised placebo-controlled study the effect of high-dose aprotinin on
We measured the
Aims. We chose unstable extra-capsular hip fractures as our study group
because these types of fractures suffer the largest
We undertook a prospective, randomised study in order to evaluate the efficacy of clamping the drains after intra-articular injection of saline with 1:500 000 adrenaline compared with post-operative blood salvage in reducing