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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 314 - 314
1 Jul 2014
PREVENTING BONE LOSS AND BONE MARROW ADIPOSITY CAUSED BY METHOTREXATE CANCER CHEMOTHERAPY: SUPPLEMENTARY TREATMENT WITH DIETARY FISH OIL VS FOLINIC ACID
Nadhanan R Fan C Su Y Howe P Xian C
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Summary

Methotrexate chemotherapy (commonly used in treating cancers and rheumatoid arthritis) creates an inflammatory condition in bone, decreasing osteogenesis, enhancing adipogenesis, increasing osteoclastogenesis, leading to bone loss and marrow adiposity; treatment with fish oil or folinic acid counteracts these negative effects and prevents bone loss.

Introduction

Chemotherapy with anti-metabolite methotrexate (MTX) is commonly used in treating cancers and rheumatoid arthritis; however it is known to cause bone loss for which currently there are no adjunct preventative treatments.