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Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_9 | Pages 2 - 2
1 Sep 2019
Nijeweme - d'Hollosy WO Poel M van Velsen L Groothuis-Oudshoorn C Hermens H Stegeman P Wolff A Reneman M Soer R
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Aims

Clinical decision support systems (CDSS) can support clinicians in selecting appropriate treatments for patients. The objective of this study was to examine if triaging patients with LBP to the most optimal treatment can be improved by using a data-driven approach with the help of machine learning as base of such a CDSS.

Methods

A clinical database of the Groningen Spine Center containing patient-reported data from 1546 patients with LBP was used. From this dataset, a training dataset with 354 features was labeled on eight different treatments actually received by these patients. With this dataset, models were trained. A test dataset with 50 cases judged on treatments by 4 experts in LBP triage was used to test these models with data not used to train the models. Prediction accuracy and average area under curve (AUC) were used as performance measures for the models.


Background

There is growing evidence for an important role of central sensitization (CS) in the development and maintenance of chronic pain. Consequently, alleviation of CS might be helpful, as was demonstrated for pregabalin. For tapentadol this is unknown.

Tapentadol is a drug with a dual mechanism: 1) it acts on the mu-opioid receptor (µ-OR) and 2) it inhibits the reuptake of noradrenalin in the central nervous system3. The noradrenergic effect might involve a modulation of descending pain pathways and thereby reduce or alleviate CS.

Aim

The aim of the present study is to determine the alterations in CS parameters by tapentadol in patients with chronic visceral (endometriosis) pain and deep somatic (low back) pain, using pregabalin as comparator.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_9 | Pages 28 - 28
1 Sep 2019
Soer R Buwalda N Mireau J Coppes M Wolff A Preuper HS Reneman M
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Aims

The aims of this study were to investigate whether 1) multispecialist tertiary intervention for complex spinal pain lead to reductions in spine-related healthcare costs and 2) baseline characteristics are related to health care consuming costs.

Patients and methods

A cost study in a natural prospective cohort was carried out to investigate healthcare data of patients admitted to the Groningen Spine Center (GSC) ranging from two years prior to referral until two year after discharge. GSC intervention consisted of a multi-professional and -specialist based diagnosis and treatment. Patients (18 and 80 years) were included, suffering from specific as well as multifactorial spinal pain. Clinical data was merged with Health Care Insurance data and included questionnaires on demographics, work, pain, disability, quality of life and psychosocial functioning. Univariable (paired sample t-tests) and multivariable analyses (pooled OLS Regression and fixed effects models) were carried out.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_9 | Pages 54 - 54
1 Sep 2019
Schuttert I Timmerman H Groen G Wolff A
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Background

There is growing evidence for an important role of central sensitization (CS) in the development and maintenance of chronic pain. This accounts for patients with chronic low back pain radiating to the leg (CLBPr) as well. Care as Usual (CaU) in these patients consists of diagnostic segmental nerve root blocks (dSNRB) followed by therapeutic interventions, i.e. a therapeutic segmental nerve root block (tSNRB) or pulsed radiofrequency (pRF). However, it is unknown if these procedures affect the amount of CS in these patients.

Aim

The aim of the present study is to determine the alterations in the presentation of CS in CLBPr patients during care as usual.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_9 | Pages 60 - 60
1 Sep 2019
Stegeman P Speijer L Hamelink J Sterken M Soer R Wolff A Preuper HS Reneman M Nijeweme - d'Hollosy WO
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Aims

The aim of this study was to investigate the agreement of physician assistants (PAs) in the triaging of patients with Low Back Pain (LBP) based on self-reported data.

Patients and methods

A cross sectional vignette study among four PAs was carried out. Vignettes (cases) were constructed including 26 factors that can be self-reported, identified in literature that have predictive value in treatment outcomes (for example red flags indicating serious underlying conditions and yellow flags indicating psychosocial factors). All vignettes were randomly assigned to the PAs who should determine what intervention would be most optimal to the patient (rehabilitation, injections, medications, surgery, primary care psychology, primary care physical therapy). PAs were allowed to advise more than one intervention. Per vignette, 3 PAs were assigned randomly to advise on intervention. Fleish kappas were calculated to determine the interrater reliability.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_9 | Pages 33 - 33
1 Sep 2019
Dutmer A Reneman M Wolff A Soer R Preuper HS
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Introduction

A minority of patients with chronic low back pain (CLBP) account for a majority of disability and costs. This subgroup has potentially most to gain from effective treatment. The Groningen Spine Cohort will provide a 10-year prospective insight into the burden of CLBP for patients referred to multispecialty tertiary spine care in the Netherlands. This study reports first baseline results.

Objective

To study the personal and societal impact of CLBP in patients visiting the UMCG tertiary spine center.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 545 - 545
1 Sep 2012
Adib F Reddy C Guidi E Nirschl R Ochiai D Wolff A Wellborn C
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Introduction

Superior Labral Anterior Posterior Tears are being treated surgically in increasing numbers. Stiffness is the most common complication. We reviewed 115 cases of SLAP repairs to try and identify preoperative risk factors if any for stiffness.

Methods

Retrospective cohort study of 115 patients who underwent SLAP repair. All patients failed attempts at conservative therapy including NSAIDS, Physical Therapy and cortisone injections.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 289 - 289
1 Jul 2008
LUBBEKE-WOLFF A GARAVAGLIA G HOFFMEYER P PERNEGER T
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Purpose of the study: Revision total hip arthroplasty (rTHA) is associated with higher mortality than primary total hip arthroplasty (pTHA). The functional outcome after rTHA is globally satisfactory but less so than with primary implantation. Nevertheless, data are scarce. Patients undergoing revision procedures are older and have more co-morbid conditions. In this context, we evaluated quality-of-life and patient satisfaction five years after implantation, comparing rTHA versus pTHA. We analyzed the impact of age, obesity, and co-morbid conditions.

Material and methods: The study cohort included all patients undergoing pTHA (n=471) OR rTHA (n=124) in our unit between 1996 and 2000. Five years postoperatively, we noted the Harris hip score (HHS) and patient satisfaction, assessed on a visual analog scale (VAS) from 1 to 10.

Results: The rTHA patients were older (72 yeras versus 68 years, p=0.004), more frequently obese (BMI30: 33% versus 19%, p=0.003) and presented more co-morbid conditions involving medical ( 2: 46% versus 21%, p< 0.001) and orthopedic ( 2: 13% versus 7%, p=0.053) problems. Five years after surgery, quality-of-life and patient satisfaction were much lower after rTHA than after pTHA (HHS < 70; 31% versus 9%, p< 0.001; satisfaction score 8: 68% versus 85%, p< 0.001). Adjustment for the preoprative status (ASA, medical and orthopedic comorbidity, BMI, gender, age) attenuated these differences which nevertheless remained significant [non-adjusted HHS difference: 11.5 (95%CI: 7.4–15.7); adjusted difference: 8.8 (95%CI: 5.5–12.1)]. In both groups, a low HHS was associated with BMI ≥ 30, poor preoperative function, 2 joints affected, elderly age. Obesity was associated with even poorer results after rTHA than after pTHA (non-adjusted difference, p=0.026).

Discussion: Quality-of-life and patient satisfaction at five years were clearly poorer after rTHA than after pTHA. This is in agreement with data in the literature. The difference is explained in particular by greater patient age and more associated comorbidities for rTHA. Obesity is a prognostic factor which is more unfavorable after rTHA than after pTHA.

Conclusion: Considering the risks and benefits of revision surgery, it is important to recognize not only the surgical factors but also the characteristic features of the patients.