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Bone & Joint 360
Vol. 6, Issue 2 | Pages 2 - 6
1 Apr 2017
Singh A Collins R Wimhurst J


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XLII | Pages 15 - 15
1 Sep 2012
Macnair R Wimhurst J Jones HW Cahir J Toms A
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ARMD (Adverse Reaction to Metal Debris) is an increasingly recognised complication of metal on metal hip replacements. The MHRA (Medical and Healthcare Related Devices Agency) have advised a blood cobalt or chromium level above 7 mg/L is a threshold for further investigation, stating that “low levels are reassuring and strongly predict not having an adverse outcome”. Cross-sectional imaging should be performed when levels are above 7 mg/L. We have performed a study investigating the specificity and sensitivity of chromium and cobalt metal ion levels as a screening measure for ARMD.

79 ASR hip replacements were performed at our hospital and 75 (95%) of these underwent a Metal Artefact Reduction Sequence (MARS) MRI scan. All patients (64 hips) who had not undergone revision were invited to take part in this study. 57 patients with 62 hip replacements completed hip and activity scores, had blood cobalt and chromium ion level measurements and 3D-CT to measure acetabular component position.

Acetabular component inclination (>50 degrees), small head size (< 51mm) and female gender were significantly correlated with raised chromium (Cr) and cobalt (Co) ion levels. An ARMD was detected using MRI in 18 (29%) of the hips in this study. The incidence of ARMD was significantly higher when chromium concentration was above 7 mg/l (p = 0.02). Chromium ion levels >7 mg/L had a sensitivity of 56% and specificity of 83% for ARMD, and cobalt ion levels >7 mg/L 56% and 76% respectively. 40 patients had cobalt levels <7 mg/L and 33 had chromium levels <7 mg/L, but 8 of these had an ARMD on MRI. All 8 patients had minimal symptoms (Oxford Hip Score ≥ 44 out of 48).

The Medicines and Healthcare Products Regulatory Agency (MHRA) has recommended that cobalt and chromium levels be measured in patients with a metal-on-metal hip replacement and cross-sectional imaging performed when these levels are above 7 μg/L. This study has shown that by using this threshold, in patients with this implant combination, the sensitivity and specificity for the detection of ARMD is low and patients with soft tissue disease may be missed. Furthermore the presence of MRI detected ARMD, in the absence of significant clinical symptoms and with metal ion levels <7 μg/L is of concern.

MoM implants at risk of failure are associated with raised cobalt and chromium levels. However metal ion analysis alone is not reliable as a screening tool for ARMD, which is often clinically “silent”. We recommend the routine use of MARS MRI as the safest method of ARMD diagnosis in patients with MoM implants.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 545 - 545
1 Nov 2011
Jones HW Wimhurst J Macnair R Derbishire B Chirodian N Toms A Cahir J
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Introduction: Although good mid-term results have been reported with some metal on metal hip replacements, reported complications due to metal on metal (MOM) related reactions are a cause for concern. We have assessed the clinical outcome and MRI metallic artefact reduction sequence (MARS) findings in a consecutive series of patients with a large head metal on metal hip replacement.

Methods: 62 ASR XL Corail THRs and 17 ASR resurfacings were performed at our hospital between 2005 and 2008. All patients were reviewed and assessed with an Oxford hip score (OHS), a plain radiograph and a MRI imaging was obtained on 76 (96%) hips. Implant position was assessed using Wrightington cup orientation software.

Results: At a mean follow up of 32 months, 9 (15%) ASR XL Corail THRs, and 2(12%) ASR resurfacings had been revised. 10 revisions were performed for MRI confirmed MOM related pathology. Histology confirmed a MOM reaction in all 10 cases.

Of the 76 hips that were MRI scanned, 27 (36%) had typical features of a MOM reaction. These were classified as mild in 10 (13%), moderate in 13 (17%) and severe in 4 (5%).

78 patients completed an OHS and the mean score was 21. The mean OHS was 29 pre-operatively in those that had been revised, 25 in patients with abnormal MRI findings and 20 in those with a normal MRI. 10 patients with abnormal MRIs had a near perfect OHS (15 or less)

Conclusions: The ASR XL Corail THR has an unacceptably high early failure rate. MARS MRI is able to detect metal debris related soft tissue pathology around metal on metal THRs. These lesions are sometimes asymptomatic. We suggest that MARS MRI evaluation should form part of the routine evaluation of all metal on metal THRs, and in particular of this implant.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_III | Pages 299 - 299
1 Jul 2011
Ollivere B Darrah C Evans-Gowing R Donell S Wimhurst J Clark I
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Classification of osteoarthritis of the hip is fraught with difficulty Although different patterns of disease are recognised, there is no accepted classification or grading system. We aim to develop a classification system that reflects both the radiological changes, and the local disease process within the joint.

After ethical permission and consent tissue was taken from 20 patients undergoing primary hip replacement surgery. Intra-operative tissue samples were taken from each patient and the steady state gene expression of several cytokines (TNF-α, IL1-β, IFN-γ, IL-6, RANKL and OPG) measured quantitatively using Taqman RT-PCR. Relative expression was calculated for each sample using standard curves and normalised to 18S expression. The technique was consistent with high correlations for repeated measures from the same tissue type (κ=0.99) and from different tissue types in the same joint (κ=0.92). Intra-observer (κ=0.93) and inter-observer (κ=0.89) reliability for the technique were also found to be high.

Preoperative radiographs were scored by two independent observers and joint space narrowing, cysts, osteophytes and sclerosis noted in each of the DeLee-Charnley zones on the femoral and acetabular side. Based on these scores patients were then classified to either lytic or sclerotic type and subclassified into either hypertrophic or atrophic.

Subgroup analysis of cytokine expression by radiographic type was performed. There were statically significant differences in expression of macrophage stimulating cytokines (IL-1γ and OPG) in the lytic group as compared to the sclerotic group (p< 0.05). Conversely, the sclerotic group expressed significantly higher levels of IL-6. Individuals with atrophic subtype demonstrated significantly higher levels of IL-1β and IL-6, but lower levels of IFN-γ

Our results demonstrate greatly differing patterns of disease within osteoarthritic hip joints. These changes are reflected in radiographic appearances of osteoarthritis. Our proposed classification system can be used grade and classify osteoarthritis in a manner that reflects the disease process.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 531 - 531
1 Aug 2008
Nolan JF Darrah C Donell ST Wimhurst J Toms A Marshall T Barker T Case CP Peters C Tucker JK
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60 out of total series of 643 metal-on-metal hip replacements, carried out over the last nine years, have so far required revision, 13 for peri-prosthetic fracture and 47 for extensive, symptomatic, peri-articular soft-tissue changes.

Dramatic corrosion of generally solidly fixed, cemented stems has been observed and is believed to have resulted in the release of high levels of cobalt chrome ions from the stem surface. The contribution of the metal-to-metal articulation is, as yet, unclear.

Not including the fracture cases, plain films have demonstrated little or no abnormality to account for patients’ progressive symptoms. MRI scanning, on the other hand, utilising a technique designed to minimise implant artefact, has correlated very closely with findings at the time of revision surgery.

The histological changes, typified by extensive lymphocytic infiltration and a severe vasculitis leading to, in some cases, extensive tissue necrosis are demonstrated and discussed.

The failure of any of the existing protective mechanisms or regulatory restrictions to identify and limit the exposure of large numbers of patients to unsatisfactory implants has again been demonstrated.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 307 - 307
1 Jul 2008
Jones M Oddy M Pendegrass C Pilling J Wimhurst J
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Introduction: Templating of radiographs is part of pre-operative planning in Total Hip Replacement (THR). Digital radiograph technology allows the manipulation of images, altering magnification and therefore affecting accuracy and reproducibility in templating. We have performed a study to investigate templating for hybrid total hip arthroplasty comparing digital hard copies with three computer methods to scale for magnification, in order to assess whether on-screen images can be templated directly with existing acetate templates.

Methods: 20 patients undergoing hybrid THR had pre-operative radiographs taken with a 10 pence coin attached to the skin overlying their greater trochanter. On-screen computer images were manipulated using either the 10p coin as a marker to scale for magnification, or two digital line methods using computer software against external ruler scales. Templating were performed for acetabular size, femoral offset, stem offset and stem size by three grades of observer, and the on-screen images were compared with hard copy digital prints. Intraclass Correlation (ICC) analyses were performed to assess intra-observer and inter-observer variability for the four methods. Comparisons were also made between templated results and the sizes of the inserted prostheses.

Results: All methods showed good reproducibility with all ICC values for intra-observer variability greater than 0.7. Inter-observer variability was less consistent, and the two digital line methods were the least reliable, with accuracy of sizing compared with the inserted prostheses varying between −1.6% to +10.2%. The hard copy radiographs showed better reproducibility than the 10p method, but less accuracy with 3.7% under-sizing. The 10p method was most accurate, with no significant differences for offset or acetabulum compared with the inserted prostheses, and templated under-sizing of only 0.9%.

Discussion: On-screen templating of digital radiographs with standard acetate templates is accurate and reproducible if a radio-opaque marker such as a 10p coin is included when taking the original radiograph.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 357 - 357
1 Sep 2005
Howie D Wimhurst J Wallace R Knight T McGee M Costi K
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Introduction and Aims: This paper presents a treatment plan for femoral stem revision that has been developed based on long-term studies of revision total hip replacement (THR) using cemented stems, cementless proximal fixation stems, cemented stems with impaction grafting and modular titanium long stems.

Method: The clinical and radiographic results of femoral stem revision were compared using the following techniques: 1) a standard or long cemented collarless double taper Exeter or CPT stems (CCDT stems) [n=190]; 2) a proximally porous coated mid to long cementless stem [n=56]; 3) two series of CCDT stems with impaction grafting n=34]; and 4) a modular grit-blasted titanium taper stem [n=13] used for severe cortical damage. Treatment decisions were made based on the age of the patient, the appearance of the pre-operative radiograph and the extent of bone deficiency at surgery. Follow-up was from 17 to two years.

Results: Only one hip was lost to follow-up. In the CCDT group, at a median follow-up of five years (range 2–17 years), two standard length stems and one long stem had been re-revised for loosening (1.5%) and seven stems had been re-revised for other reasons. Survivorship to re-revision for loosening at eight years was 95% (95%CI=85–100%) for both standard and long stems. There was a trend for better longer-term results for long stems. The extent of pre-operative bone loss did not influence results. For the cementless proximal fixation group, at a median follow-up of 10 years, re-revision of the stem for loosening occurred in 20%. Importantly, these poor results could have been predicted from short-term results. The initial series of femoral impaction grafting with CCDT stems and irradiated bone had a small incidence of stem loosening and periprosthetic fracture. The majority of stems subsided, but at a median follow-up of eight years there were no further re-revisions. In the second series, usually with non-irradiated allograft with mesh containment, there was minimal stem subsidence and no re-revision. The grit blasted titanium taper stem has dealt with periprosthetic fratures and severe proximal cortical loss, but with some cases of subsidence and femoral fracture.

Conclusion: Based on these results, our treatment plan for routine femoral revision in middle-aged and elderly patients without severe proximal deficiency is a polished CCDT long stem. In younger patients, impaction grafting is recommended, provided deficient bone is protected. Cementless modular stems are reserved for femurs with severe proximal cortical deficiency.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 356 - 357
1 Sep 2005
Howie D Wallace R Wimhurst J MacDowell A
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Introduction and Aims: To aid the comparison of results of different techniques of femoral revision at total hip replacement and in choosing types of revision, a number of radiographic classifications have been proposed. We aimed to determine the reliability of five popular radiographic classification systems for grading the extent of femoral bone deficiency.

Method: Twenty pre-revision total hip replacement femoral radiographs were assessed by a senior consultant specialist in revision surgery, a junior consultant, a fellow and a trainee registrar. The femoral bone deficiency was classified using the systems of the American Academy of Orthopaedic Surgeons (AAOS) and EndoKlinik, and those described by Paprosky, Gross and Gustillo. Intra-observer agreement and inter-observer agreement between assessors were determined using the kappa coefficient. Radiographs were reassessed after a minimum of two weeks. Kappa coefficients of 0.6–0.8 (substantial) or > 0.8 (almost perfect) were considered to indicate acceptable agreement. Intra-operative measurement of deficiency was also undertaken.

Results: Intra-oberser agreement was rated as acceptable for the Paprosky, Gross and Gustillo systems, each giving substantial agreement, but was unacceptable for the AAOS and EndoKlinik systems. Inter-observer agreement was unacceptable for all systems except the Gross classification system, which was rated as having substantial agreement.

Conclusion: Comparing results of femoral revision between different surgeons based on bone deficiency according to the most popular radiographic classification systems is doubtful because of poor reliability. These classifications can be used by an individual surgeon as a guide to management, but most classifications should not be used to recommend the type of femoral revision to other surgeons.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_IV | Pages 465 - 465
1 Apr 2004
Howie D Wimhurst J McGee M Knight T Badaruddin B
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Introduction This study reviews the mid to long term results of revision THR with cemented, collarless double-tapered (CCDT) stems.

Methods We prospectively studied 192 revisions, in 183 patients, of femoral stems using standard (42%) or long (58%) Exeter and CPT CCDT stems. Results were analysed according to the length of stem, extent of pre-operative deficiency (Paprosky I:II:IIIa:IIIb:IV = 4:20:44:20:12%) and intra-operative bone loss. Postoperative radiographs were independently analysed for loosening and stress shielding. Risk factors of poor outcome were examined by multivariate logistic regression. The median follow-up was six years (2 to 17 years) with 55 patients having died (28%) and no cases lost to follow-up.

Results There were four stem re-revisions for sepsis (2%), three for aseptic loosening (1.5%) and three for component malpositioning (1.5%). The survivorship to femoral re-revision for aseptic loosening at eight years was 95% (95%CI=90–100%) for standard and 95% (90 – 100%) for long stems (p=0.674). Migration was less than five millimetre in unrevised stems. Survivorship and outcomes was independent of the Paprosky grade. There was a trend for better longer-term results in hips with long stems. Major stress shielding was not seen and thigh pain was not a problem.

Conclusions CCDT long stems are suitable for most femoral revisions in patients without severe segmental deficiency.

In relation to the conduct of this study, one or more of the authors is in receipt of a research grant from a non-commercial source.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 15
1 Mar 2002
Brooks R Rushton M Wimhurst J Rushton N
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This study investigated the effects of wear particles, produced from a number of implant materials, at the bone-implant interface using a small animal model.

Particles were prepared from metal, ceramic and polymer replacement joint components or implant grade stock by grinding the materials against a diamond embedded grinding pad. The mean diameter of the particles ranged from 1.5mm to 3.2mm. Sterilised particles were suspended in sterile saline containing 2% v/v male Sprague-Dawley serum at a concentration of 109 particles per ml.

Seventy-two male Sprague-Dawley rats were assigned to twelve groups of six animals. A ceramic pin was inserted into the right tibia of each animal. Six groups were assigned a particle type with one group acting as vehicle control. 100ml of particle suspension or vehicle was injected into each knee joint at 8, 10 and 12 weeks following implantation and the animals were killed 2 weeks later. Of the remaining five groups, four were assigned a particle type and one was the vehicle control. These animals were injected with 100ml of particle suspension or vehicle at 20, 22 and 24 weeks following pin implantation and were killed 2 weeks later. The tibia and femora were removed, disarticulated and processed for histology. The total gap between pin and bone, including fibrous tissue, was measured.

Specimens showed no signs of infection either clinically or in the histopathology. All materials tested produced lesions at the bone-implant interface. A significant difference was seen between metal injected vs. vehicle control animals and aluminium oxide injected vs. vehicle controls. Particles of stainless steel produced the greatest response and this finding may have implications for the use of metal on metal articulations aimed at eliminating polyethylene wear.


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 15
1 Mar 2002
Clarke S Brooks R Hobby J Wimhurst J Myer B Shore S Rushton N
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This study investigated the relationship between histological, clinical and radiological features of aseptically loose total joint replacements (TJRs) and synovial fluid levels of interleukin (IL)-1b, IL-6, IL-8 and IL-10.

Tissue and synovial fluid samples were retrieved from patients undergoing primary (hip; n=15: knee; n=13), or revision of aseptically loose TJRs (hip; n=14: knee; n=9). The presence of inflammatory cells, blood vessels and wear debris in the tissue were assessed on a relative scale. Revision TJRs were assessed for sepsis, migration of the implant, gross loosening and the degree of radiolucency. Cytokine levels in the synovial fluid samples were determined by ELISA.

All cytokines were increased in synovial fluid from revision TJRs compared to primary replacements, as were the degree of macrophage and giant cell infiltration (p< 0.01). There was a significant positive correlation between the presence of macrophages and giant cells with the levels of IL-1b, IL-8 and IL-10 (p< 0.05) but not IL-6.

The amount of wear debris was related to the presence of macrophages and giant cells (p< 0.01) but not to any of the cytokines.

There were no relationships between any of the clinical parameters and the presence of wear debris or the levels of any cytokine with the exception of IL-6 and gross loosening (p< 0.01). Similarly there were no differences between hips and knees for any of the parameters except IL-6, for which higher levels were found in hips (p< 0.05).

The results suggest that macrophages and giant cells are responsible for the majority of IL-1b, IL-8 and IL-10 production but another cell type is contributing to IL-6 production. Furthermore, IL-6 does not fit the pattern of the other cytokines as it is upregulated in hip joints compared to knees and correlates with the presence of gross loosening. This may suggest a unique role for IL-6 that requires further investigation.