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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 147 - 147
1 Jun 2012
Controlled Release of Antibiotics From Beta-TCP Mixed in HA in IBBC as Prevention of Infection in Joint Replacement
Mizokawa S Arita T Tachibana A Tanabe T Oonishi H
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INTRODICTION

Since 1985, not resorbable crystalline osteoconductive hydroxyapatite (HA) granules were interposed on the interface between bone and bone cement at the cementation (Interface Bioactive Bone Cement: IBBC) of total hip arthoplasty (THA) to prevent generation of connective tissue and osteolysis for the longevity of cemented THA. To prevent the patients from infection, we are planning to use b-tricalcium phosphate (Beta-TCP) impregnated with antibiotics along with HA granules. However, there have been no reports on the loading and release of antibiotics from fine granules of Beta-TCP. Here, we have investigated the loading of antibiotics on Beta-TCP and their release in vivo.

MATERIALS AND METHODS

Beta-TCP was impregnated with antibiotics such as flomoxef sodium (F), vancomycin hydrochloride (V) cefotiam dihydrochloride (C) and cefozopran hydrochloride (CE) under normal or reduced pressure. After washing with PBS three times, Beta-TCP loaded with the antibiotic was placed in PBS. An aliquot of solution was sampled at appropriate time intervals and the amount of the released antibiotic was estimated based on the anti-bacterial activity.