Cementless femoral component designs supplemented with hydroxyapatite (HA) coating have been hypothesised to enhance osseointegration, thereby improving stability and clinical outcomes. We herein offer interim results at 5 years from a prospective, multi-centre study of a femoral stem (SL-PLUS™ Hip Stem Prosthesis), forged from titanium alloy (Ti6Al7Nb) and consisting of a titanium plasma sprayed coating (0.3mm) with an additional 0.05mm layer of HA. Investigators at 2 centres enrolled patients between 18–75 years of age who underwent primary total hip arthroplasty (THA) with this HA-coated stem. The study's primary outcome was the clinical efficacy of the stem, as measured by the Harris Hip Score (HHS), Western Ontario & McMaster Universities Osteoarthritis (WOMAC) Score calculated out of Hip Disability and Osteoarthritis Outcome Score (HOOS), and the EuroQol EQ-5D-3L index score and visual analogue scale (VAS). Its secondary outcomes included a radiographic assessment of implant position and fixation, and overall safety, as measured by intraoperative/early postoperative complications and survivorship calculated using Kaplan-Meier estimates.INTRODUCTION
METHODS
Bumps and lumps of the hand are a common cause for consultation in general practice. However not all of these lesions are of true neoplastic nature and malignant tumours are a rarity in this location. The records of all tumours of the hand and wrist treated surgically at our institution in the period 1994 to 2009 were reviewed. Because of their non-neoplastic nature typical lesions of the hand such as ganglion cysts or palmar fibromatosis and the like were not included in this study. Histological entity, location, radiographic and clinical findings were analysed; malignant tumours were followed up by X-ray and MRI.Aim
Method
There were nineteen malignant lesions, nine of which were bone tumours; the most common being chondrosarcoma (3) and osteosarcoma (3). Malignant soft tissue tumours (10) were very heterogeneous, clear cell sarcoma being the only tumour appearing at least twice. Out of thirty-four benign soft tissue tumours, pigmented villonodular synovitis (11), fibrous (9) and lipomatous (5) tumours have been the most frequent. Thirty five benign bone tumours included chondroma (10), solitary bone cyst (10), aneurysmatic bone cyst (3), osteoid-osteoma (3) and giant cell tumour (3).
Fifty patients (53 hips) died post revision 0.0 to 13.5 (mean, 6.8) years. Their implants had been followed-up radiographically for 0.0 to 9.2 (mean, 3.6) years. At the time of revision these patients had been 48.9 to 89.3 (mean, 76.7) years old. One of them had undergone stem revision for aseptic loosening one year post surgery. Another 6 were revised 1.4 to 13.9 years post surgery, 5 for low grade infection and 1 for peri-implant fracture. Seven patients refused to present for follow-up because of advanced age and poor cooperation. Eight were contacted by telephone. These 15 patients were not re-operated. Five patients were altogether lost to follow-up, thus leaving a total of 53 hips (49 patients) for analysis at a follow-up time of at least 10 years. The follow-up time was 10.0 to 16.1 (mean, 11.6) years. For radiographic follow-ups monitor-guided a.-p. and axial radiographs were recorded. These were analyzed by Gruen zones.
Harris Hip Score (HHS) was used for clinical evaluation (preoperative scores were retrospectively ascertained from patients’ charts). For radiological follow up plain X-rays of the pelvis a.p. and targeted views of the cup were used. Radiolucency, osteolysis (around cup, caudal hook, screws), migration (medial, cranial) and dumping was noted and the results divided into 3 groups: stable (no migration) at risk (cranial or medial migr.), loosened (cranial and medial migr.).
HHS improved from 36,4 to 69,3 points (max. 100). Pain: 15,5 to 36,8 pts (max. 44). Activity of daily living:14,3 to 36,8pts (max. 47). Walking distance 3,6–5,8 pts (max.11). Radiological results (n=19, patient who died included in rad. FU): Radiolucency and osteolysis: Cup 5, hook 12, screws 10. Migration: medial:7 (all of those had medial bone defects), cranial:4, angulation >
4°:4 Outcome: stable: 11, at risk: 3, loosened 5 (1 died, 1 explanted, 3 control every 3 months)
A second follow up is starting recently with an average FU time of about 36 months.