Background

An increased incidence of periprosthetic osteolysis, resulting in loss of biologic fixation, has been recently reported in contemporary THAs with low-carbide metal-on-metal compared to metal-on-polyethylene couple bearings. A hypersensitivity reaction due to Co and Cr debris is reported as a potential cause for failure of THAs with high-carbide bearings, but there are no evidence-based data for this reaction in low-carbide metal-on-metal bearings.

Most studies on LBP have focused on adults although many investigations have shown that the roots of LBP lie in adolescence. Several mechanical, physical and behavioral factors have associated with non-specific LBP in adolescents. To our knowledge no previous study has investigated using advanced statistics all previously reported parameters together with psychological and psychosocial factors on LBP in adolescents aged 15–19 years.

688 students aged 16± 1 years from 5 randomly selected high schools participated in this multifactorial study and completed a questionnaire containing questions on daily activity, backpacks carrying, psychological and psychosocial behavior. Anthropometric data as well biplane spinal curvatures together with questionnaire results were included in the analysis using advanced statistics.

LBP reported 41% of the participants. Generally, statistically significant correlations were found between LBP(0.002), physical activity(P< 0.001), physician consultation(P=0.024) and depression (P< 0.001) Gender-related differences were shown regarding LBP intensity(P=0.005) and frequency(P=0.013), stress(P< 0.03), depression (P=0.005) and nervous mood(P=0.036) in favor of male students. Male adolescents had continuously energy (P=0.0258) and were calm (P=0.029) in contrast to female counterparts.

LBP was gender-related and was less common in adolescents with frequent activity. Adolescent girls with stress, depressive mood and low energy have more LBP than boys that makes physician consultation for LBP more common in female adolescents.

Systematic physical activity and control of psychological profile should decrease LBP frequency and intensity

Study design: Prospective multifactorial study on low back pain (LBP) in adolescents.

Background data: Most studies on LBP have focused on adults although may investigations have shown that the roots of LBP lie in adolescence. Several mechanical, physical and behavioral factors have associated with non-specific LBP in adolescents. To our knowledge no previous study has investigated using advanced statistics all previously reported parameters together with psychological and psychosocial factors on LBP in adolescents aged 15–19 years.

Material and Methods: 688 students aged 16± 1 years from 5 randomly selected high schools participated in this study and completed a questionnaire containing questions on daily activity, backpacks carrying, psychological and psychosocial behavior. Anthropometric data as well biplane spinal curvatures together with questionnaire results were included in the analysis using advanced statistics.

Results: LBP reported 41% of the participants. Generally, statistically significant correlations were found between LBP(0.002), physical activity(P< 0.001), physician consultation(P=0.024) and depression (P< 0.001) Gender-related differences were shown regarding LBP intensity(P=0.005) and frequency(P=0.013), stress(P< 0.03), depression (P=0.005) and nervous mood(P=0.036) in favor of male students. Male adolescents had continuously energy (P=0.0258) and were calm (P=0.029) in contrast to female counterparts.

Discussion: LBP was gender-related and was less common in adolescents with frequent activity. Adolescent girls with stress, depressive mood and low energy have more LBP than boys that makes physician consultation for LBP more common in female adolescents.

Conclusion: Systematic physical activity and control of psychological profile should decrease LBP frequency and intensity.

Objective. To evaluate the outcomes of the treatment of acute thoracolumbar burst fractures by transpedicular balloon kyphoplasty with Calcium phosphate cement and posterior instrumented fusion.

Methods: Twenty-three consecutive patients (average age 48 years) who sustained thoracolumbar A3-type burst fracture with or without neurologic deficit were included in this prospective study. Twenty-one out 23 patients had single fractures and the left 2 had each one additional A1 compression contiguous fracture. On admission 5(26%) out 23 patients had neurologic lesion (5 incomplete, one complete). Bilateral transpedicular balloon kyphoplasty was performed with quick hardening calcium phosphate cement to reduce segmental kyphosis and restore vertebral body height and supplementary pedicle screw instrumentation (long including 4 vertebrae for T9-L1 fractures and short (3 vertebrae) for L2 to L4 fractures. Gardner kyphosis angle, anterior and posterior vertebral body height ratio and spinal canal encroachment were calculated pre–to postoperatively.

Results: All 23 patients were operated within two days after admission and were followed for at least 24 months after index surgery. Operating time and blood loss averaged 70 minutes and 250 cc respectively. The 5 patients with incomplete neurologic lesions improved by at least one ASIA grade, while no neurological deterioration was observed in any case. Overall sagittal alignment was improved from an average preoperative 16o to one degree kyphosis at final follow up observation. The anterior vertebral body height ratio improved from 0.6 preoperatively to 0.9 (P< 0.001) postoperatively, while posterior vertebral body height was improved from 0.95 to 1 (P< 0.01). Spinal canal encroachment was reduced from an average 32% preoperatively to 20% postoperatively. No differences in preoperative values and postoperative changes in radiographic parameters between short and long group were shown. Cement leakage was observed in 4 cases: three anterior to vertebral body and one into the disc without sequalae. In the last CT evaluation, continuity was shown between calcium phosphate and cancellous vertebral body bone. Posterolateral radiological fusion was achieved within 6–8 months after index operation. There was no instrumentation failure or measurable loss of sagittal curve and vertebral height correction in any group of patients.

Conclusions: Balloon kyphoplasty with calcium phosphate cement secured with posterior long and short fixation in the thoracolumbar and lumbar spine respectively provided excellent immediate reduction of posttraumatic segmental kyphosis and significant spinal canal clearance and restored vertebral body height in the fracture level in an equal amount both in short and long instrumentation.

Several methods of surgical treatment for pyogenic spondylitis have been reported including anterior approach, staged and simultaneous anterior decompression and posterior stabilisation. The use of anterior implants in the presence of infection presents still a challenge for spine surgeons.

Retrospective analysis of the clinical and radiological outcome of patients suffering from pyogenic spondylitis of the cervical and lumbar spine necessitating surgical treatment for intractable pain, instability and neurologic impairment.

Seventeen patients with spondylitis associated or not with paravertebral abscess were treated by one stage surgery (first: anterior decompression and placement of titanium mesh cage, filled with autologous iliac bone graft; second: posterior transpedicular instrumentation and fusion). The age of the patients was 54 ±15 years. Most of the patients had systematic problems such as lung tuberculosis, hepatic cirrhosis, diabetes mellitus or chronic renal failure. Patients were evaluated before and after surgery in terms of pain and neurological level, sagittal spinal balance and radiological fusion. All 17 patients were followed for 45 months.

Average duration of both surgeries was 4.5 hours. The VAS score improved from 7 (preoperatively) to 2 (postoperatively). The correction of the segmental kyphotic deformity was 6o, without loss of correction or cage migration or instrumentation failure. All patients with incomplete neurologic impairment improved postoperatively. There was neither migration of mesh cage nor posterior instrumentation failure at the follow up observation. There was an approach-related abdominal hernia.

This clinical study showed that patients with cervical and thoracolumbar osteomyelitis necessitating surgery for certain indications can successfully undergo instrumented combined, one-stage, same-day surgery. The presence of the mesh cage anteriorly at the site of infection had not negative but beneficial influence on the course of infection healing, and it additionally stabilised the affected segment, maintaining sufficient sagittal profile.

Background. Balloon kyphoplasty has been established as an effective minimal invasive method to treat vertebral fractures of osteoporotic and pathologic etiology.

Objectives. Comparative analysis of the clinical and radiographic outcomes of balloon kyphoplasty for treatment of osteoporotic and pathologic vertebral fractures.

Study design. Prospective comparative study.

Materials-Methods. Twenty five patients (14 women and 11 men) aged (average + SD) 73 + 8 years (range 52–83 years) with vertebral fracture were treated with kyphoplasty and were sampled into three groups: 14 patients (Group A) suffered from osteoporotic fractures and underwent percutaneous kyphoplasty, 5 patients (Group B) suffered from fractures caused from malignancy were treated with percutaneous kyphoplasty, and 6 patients (Group C, hybrid) who underwent combined operation (open kyphoplasty plus instrumented fusion). These patients underwent 25 operations to treat 38 vertebral fractures located between T11 and L5. Preoperative and postoperative radiographs were compared to calculate the changes of vertebral body height ratio (AVBHr, PVBHr) and Gardner kyphotic deformity angle. Sagittal spine alignment was analyzed on whole spine standing radiographs. The VAS, the Oswestry Disability Index (ODI) and the SF-36 surveys were used to evaluate the clinical results. The average time of follow-up was 31.5 + 7 months (range 25–40 months). The average preoperatively SF-36 score (Domain Bodily pain) was 8+ 16, The VAS was 9+1.3 while the ODI was 28+ 17.

Results. The average SF-36 (Bodily Pain) score did not significantly differ among the groups and was improved postoperatively to (average, SD) 40+14. VAS improved postoperatively in an similar way in all three groups to 4+1.4 and the ODI was improved in all three groups to 49+ 17, without significant differences among groups. The AVBHr improved significantly only in group A (p=0.01), while there was no change in PVBHr in any group. The Gardner angle improved significantly in groups A (p=0.006) and C (p=0.05) respectively.

Discussion. The inflatable bone tamp placed percutaneous or open in combination with spinal instrumentation was efficacious in the treatment of osteoporotic and pathologic vertebral fractures. Kyphoplasty alone or as hybrid was associated with early clinical improvement of pain and function in the treatment of painful pathologic compression fractures, as well as with reduction of Gardner angle.

Background data. The clinical outcome of decompression and posterolateral spinal fusion for patients with degenerative lumbar spinal stenosis may be influenced by a variety of pathophysiologic factors. Among them, sagittal balance of the spine has gained new interest regarding its correlation with low back pain following lumbar spine surgery.

Objectives. To study the effect of sagittal spinal alignment on low back pain in patients operated for degenerative lumbar spinal stenosis.

Study design. Multifactorial analysis.

Materials and Methods. In this prospective randomized comparative study 45 consecutive patients were included, who underwent decompression for symptomatic degenerative lumbar spinal stenosis and two-, three- or four levels posterior transpedicular fixation with three instrumentations of different stiffness (dynamic, semirigid and rigid) plus posterolateral fusion. All patients were followed up for an average period of four-year radiologically and with SF-36 (domain Bodily pain) to investigate possible correlations between anthropometric parameters, stiffness and extension of instrumentation, roentgenographic sagittal balance, motion in adjacent free level and low back pain.

Results. Bodily pain scores improved with the time lapsed from index operation (P< 0.0001). As the distance of the apical lumbar vertebra from plumbline increased, bodily pain score improved significantly (P=0.0006). At the last observation following surgery patients had better Bodily pain score than that they had preoperatively (P=0.0001) and six months postoperatively (P< 0.0001) respectively. Patients, who received four levels instrumentation had higher Bodily pain score (P=0.0245) than their counterparts who received two levels instrumentation.

Discussion. Maintenance or even improvement of lumbar lordosis, instrumentation of three and four vertebrae, and time lapsed from index operation was associated with improvement of back pain. On contrary, patients’ age, gender, instrumentation stiffness, vertebral inclination, thoracic kyphosis and sagittal lumbar flexibility did not affect the surgical outcome regarding back pain in adult patients who underwent decompression and stabilization 2 to 4 levels for degenerative lumbar spinal stenosis.

Background: Recent studies have reported early periprosthetic osteolysis in patients who have been treated with a contemporary metal-on-metal total hip arthroplasty and suggested that metal hypersensitivity associated with an immunologic response to metal may be of etiologic importance. We evaluated the results and histologic findings in patients who underwent revision surgery for a failed contemporary metal-on-metal total hip arthroplasty.

Material and Methods: Two hundred and seventeen total hip arthroplasties (SL-Plus stem and Bicon-Plus cup) with a Sikomet metal-on-metal articulation were implanted in one hundred and ninety four consecutive patients and retrospectively reviewed at mean of 77 months postoperatively. Clinical follow up was performed with the Harris hip score and plain radiographic evaluation was performed. Histologic analysis was performed on the periprosthetic tissues of 14 hips that underwent revision arthroplasty.

Results: The mean Harris hip score improved from 45 preoperatively to 96 at final evaluation. Fourteen (6.4%) hips were revised: 9 for aseptic loosening, 2 for technical failure and three for septic failure. Histologic examination of the retrieved periprosthetic tissues from the eleven patients who underwent revision for aseptic loosening or technical failure showed microscopic metallosis and extensive lymphocytic and plasma cell infiltration around the metal debris. With an endpoint of removal of a component with aseptic loosening, endpoint survivorship was 93% for the stem and 98% for the cup respectively.

Conclusions: Our findings are in agreement with recent publications and support the possibility that periprosthetic osteolysis and aseptic loosening in hips with metal-on-metal articulation are possibly associated with hypersensitivity to metal debris. Prospective, comparative randomized long-term studies are necessary to determine the cause(s) of loosening of this particular articulation.