Introduction: Surgical treatment options of malignant tumors of the pelvis were traditionally very limited, and often resulted in an amputation. With development of neo/-adjuvant therapies, limb-salvage surgery has become the treatment of choice. Still, the treatment remains challenging, and options for pelvic reconstruction after resection such as allografts, radiated autografts, saddle-prosthesis, custom made prosthesis and modular reconstruction systems are all associated with high complication rates. Aim of our retrospective study was to evaluate the results after reconstruction of the pelvis with a custom-made pelvic megaprosthesis.

Materials and Methods: From 1977 to 2008, a total of 92 patients with malignant tumors or metastases of the pelvis were treated by resection and reconstruction with custom-made pelvic megaprostheses at our institution. Mean age was 56.2 years [17–77] with 43 male patients and 59 female. We treated 45 primary tumors and 47 metastases. Primary tumors included chondrosarcoma (45,4%), Ewing’s sarcoma (18,2%), malignant fibrous histiocytoma (9,1%), osteosarcoma (4,5%) and others. In the group with metastases we found renal cell carcinoma (52,4%), mamma-carcinoma (14,3%), thyroid carcinoma (9,5%), oropharyngeal carcinomas (9,5%), and others. Wide resection was performed in 11 patients, marginal-resection in 47, and intralesional-resection in 34 patients. Depending on the bone defect after tumor resection, pelvic megaprostheses were implanted either in the superior part of the iliac wing, the sacrum and/or the lower lumbar spine.

Results: Patients were reassessed repeatedly at two different time points resulting in a mean follow-up of 3,6 years [range 0,5 to 8,4years]. A total of 55 patients were available for follow-up, 29 had died and 6 Patients were not available for evalutation (living abroad). In the group with malignant tumors 50% of the patients were alive after 5 years; 50% of patients with metastasis survived at least 2 years. The local recurrence rate was 15%. In 2 of these patients local re-resection was possible, and 5 patients were treated with secondary external hemi-pelvectomy. Aseptic failure of the megaprosthesis was observed in 3%. The MSTS-Score showed good results in 34%, fair results in 42% and poor results in 23%. We found infections in 14%. Nerve palsy occurred in 11%, thombosis in 5%, and dislocation of the prosthesis in 15% of patients.

Discussion: Our study demonstrates that reconstruction of pelvic bone defects after tumor resection with custom-made megaprosthesis allows limb-salvage surgery with satisfying functional results. In spite of the relatively high complication rates-which are comparable or even favorable to other reconstruction techniques-we consider the custom-made megaprosthesis our treatment of choice to reconstruct pelvic bone defects.

Goal: Evaluation of prognostic factors on the long term survival of soft tissue sarcomas after resection.

Methods: Between 1991–2003

a) 29 synovial sarcomas males:femals 15:14 (mean age 36),

R0 resection was archived by 71% of the synovialsarcomas, 60% of leiomyosarcomas and 73% of MFHs’. The histological garding of synovialsarcomas was: G1: 0%, G2:21%, G3:73% and Gx: 6%. The histological garding of leiomyosarcomas was: G1:7%, G2:20%, G3:73% with 11 primary recurrences and the grading of the MFHs’ was G1: 7,7%, G2: 15,4%, G3: 69,2% und Gx: 7,7%.

Results:

Synovial sarcomas:

After a follow-up of 8 (2–14) years the overall survival was 57%, after R0-resection 65% and after R1 resection 0%. The survival of G2 und G3 was 67% and 53% respectively. The survival of T1 and T2-tumors was 100% and 39% respectively. The 2- and 4 year survival of patients with primary metastases and local recurrence was 50% und 28%. 55% of the patients developed local recurrence.

Scores for function and quality of life after treatment were 79% (37%–100%) for synovial- and 76% (53%–93%) for leiomyosarcomas and 76% (44%–100%) for MFHs

Conclusions: The investigated soft tissue sarcomas are highly malignant tumors. Bad prognostic factors for reduced long term survival are T2-tumors and G3-tumors (except MFHs’), local recurrence, metastases at the time of diagnosis and tumors after R1-resection, requiring aggressive multimodal treatment with chemotherapy, radiation and wide or even radical surgery.

Introduction: During the last years minimal-invasive augmentation techniques of vertebral bodies have been established to stabilize painful height losses. Kyphoplasty was described in osteoporotic fractures for stabilisation and high restoration of the collapsed vertebral body. Kyphoplasty intends to achieve a reduction of kyphosis prior to cementing.

Aim: The study was performed to analyze the Kyphoplasty technique in patients with tumour induced back pain due to affected vertebral bodies.

Method: 7 Patients with Tumour induced back pain were enrolled. MRI, CT and x-ray were performed to confirm the diagnosis and for staging. All patients have severe and significant back pain. Primary spine tumours were excluded. To evaluate the clinical outcome the Oswestry

Score and McNab Score were used. CT scans after procedure were performed to detect cement extrusion. The follow up examinations 12 weeks after Kyphoplasty were performed by an independent blinded observer.

Results: 6 patients complete 12 week follow up. All subjects reported significant subjective improvement on the McNab Score (2 excellent, 3 good,1 moderate outcome.) Oswestry Score showed the same results (74±12 Pts at Baseline and 28±9 at 12 week follow up).