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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 572 - 572
1 Nov 2011
Pegreffi F Belletti L Esposito M
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Purpose: The purpose of this study was to evaluate the long-term results of arthroscopic treatment in patients affected by triangular fibrocartilage complex (TFCC) type 1b lesions associated with distal radio ulnar joint (DRUJ) instability.

Method: 138 patients affected by TFCC type 1b lesions: Group A (117 patients, 27±7 yrs) were treated using an out-in arthroscopic technique and Group B (21 patients, 24±4 yrs) with an associated total DRUJ instability, were treated using an out-in arthroscopic technique in addition to an anchor placement. Inclusion criteria were: TFCC tears, type 1b lesions and no previous wrist fractures. SF-36, DASH, VAS, and ROM were accessed preoperatively and at four years follow-up.

Results: All the patients have a significant improvement in terms of SF-36 (p0.05).

Conclusion: Arthroscopy is a tool of paramount importance in both diagnosis and treatment of TFCC injuries even associated with DRUJ. Furthermore, type 1b lesions associated with total DRUJ instability should be managed combining an out-in arthroscopic technique with the use of an anchor to completely relieve pain and restore wrist function.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_IV | Pages 574 - 574
1 Oct 2010
Porcellini G Campi F Lollino N Paladini P Pegreffi F
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Aims: Displaced proximal humeral fractures are considered a real challenge. Malunion, nonunion, avascular necrosis, arthritis are frequent complications. Thus revision surgery, using reverse shoulder prosthesis, is mandatory both to restore shoulder function and to relieve pain.

Our purpose was to understand if clinical outcomes after revision surgery are influenced by the first surgical procedure performed to fix the fracture.

Methods: 15 patients, mean age 67±2 yrs, sustained a complex humeral fracture. Group A (8 patients) was treated with reduction and fixation with K-wires, while in Group B (7 patients) a cemented hemiarthroplasty was performed. After primary surgical treatment, both groups required revision surgery and a shoulder reverse prosthesis was implanted.

Constant score, Flexion, VAS scale and Dash questionnaire were evaluated preoperatively and at 1 year after revision surgery,

Results: Constant Score improved from 7 to 42 points in Group A, while in Group B from 15 to 41 points (n.s.). Flexion in Group A improved from 30° to 106°, while in Group B from 44° to 94° (n.s.). VAS value decreased from 9 to 2 in Group A and from 8 to 5 in Group B (n.s.). Dash value decreased from 82 to 49 points in Group A and from 75 to 55 points in Group B (n.s.).

Conclusions: This study demonstrates that reverse shoulder prosthesis offers a salvage-type solution in revision surgery reguardless the surgical treatmet performed previously. In conclusion reverse shoulder prosthesis is an important tool the surgeon can use in shoulder revision surgery.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 64 - 64
1 Mar 2009
Moroni A Romagnoli M Cadossi M Pegreffi F Giannini S
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INTRODUCTION Metal-on-metal hip resurfacing (MOMHR) has recently been reintroduced as a viable treatment option for young active patients. A short femoral neck and insufficient head are common deformities following CDH, Perthes disease and SFCE. Therefore, severity of these deformities is a contraindication for MOMHR, as contact between the femoral resurfacing component and the femoral head would be inadequate and off-set insufficient.

METHODS 32 patients with severe deformity of the hip were treated with Birmingham hip resurfacing and head lengthening. We used a standard acetabular component in 18 patients and a CDH acetabular component and supplementary screw fixation in 14. Bone chips produced while reaming the acetabulum were impacted on the femoral head to achieve the desired length, as evaluated on pre-op x-rays. Rehabilitation included no weight-bearing for 1 month and partial weight-bearing for another month.

RESULTS Median patient age was 44 years. Median head lengthening was 1.2 cm. Minimum follow-up was 3.1 years, maximum 5.2. Mean Harris Hip Score was 98. At follow-up 82% of the patients were involved in heavy or moderately heavy work. 34% of the patients practiced sports. Co and Cr serum concentrations at 25 months were respectively ng/ml 1.76, and 0.75. DXA analysis of the proximal femur showed complete recovery of BMD in Gruen zone 1 and increased in zone 7 (p= 0.05). There were no major complications.

DISCUSSION AND CONCLUSIONS The absence of major complications and the quality of our results support this technique in young active patients with severe deformity of the hip.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 97 - 97
1 Mar 2009
Moroni A Faldini C Hoang-Kim A Pegreffi F Tesei F Giannini S
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Introduction: Screw loosening is a common complication of osteoporotic fracture fixation leading to implant loosening, fracture malunion and non-union. Because recent animal studies have shown that bisphosphonates improve implant fixation we wanted to assess whether alendronate (ALN) improves screw fixation in a clinical setting of osteoporotic fractures.

Methods: Sixteen consecutive patients with AO/OTA A1 pertrochanteric fractures were selected. Inclusion criteria were: female over the age of 65, BMD T-score less than −2.5 SD. Fractures were fixed with a pertrochanteric fixator and 4 hydroxyapatite (HA)-coated screws. Two screws were implanted in the femoral head (screw positions 1 and 2) and two in the femoral diaphysis (screw positions 3 and 4). Patients were randomized to either postoperative systemic administration of ALN, 70 mg per week for 3 months (Group A) or no ALN. Fixators were removed at 3 months post-op in all patients.

Results: All the fractures healed. No differences in screw insertion torque between the two groups were found. No pin loosening or infection occurred. The combined mean extraction torque of the screws implanted at positions 1 and 2 (cancellous bone) was 3181 ± 1385 N/mm in Group A and 1890 ± 813 N/mm in Group B (p < 0.001). The combined mean extraction torque of the screws implanted at positions 3 and 4 (cortical bone) was 4327 ± 1720 N/mm in Group A and 3785 ± 1181 N/mm in Group B (ns).

Discussion and Conclusion: This is the first study to demonstrate in a clinical setting improved screw fixation following post-operative ALN treatment. We observed a two-fold fixation increase in the screws implanted in cancellous bone. With cortical bone, the difference in screw fixation was less marked. Besides its bone preserving ALN should be recommended as an effective solution to improve fixation in osteoporotic bone.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_I | Pages 167 - 167
1 Mar 2009
Moroni A Pegreffi F Romagnoli M Hoang-Kim A Tesei F Giannini S
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INTRODUCTION: This prospective randomized study investigated short-term outcomes of cemented vs. HA-coated hip arthroplasty in elderly osteoporotic patients with femoral neck fractures.

METHODS: Forty consecutive patients with femoral neck fractures (AO/OTA fracture type B2 and B3) were randomized to receive either an AHS prosthesis (Group A, n = 22, cemented implant) or a Furlong prosthesis (Group B, n = 18, HA-coated implant). Inclusion criteria were: female age ≥75, fracture resulting from minor trauma, ability to communicate and bone mineral density (BMD) T-score at the contralateral hip lower than −2.5 SD. Subjective assessment was evaluated according to a rating system 0-(unsatisfactory) to 10(satisfactory). Average follow-up was 29 months for Group A and 27 months for Group B.

RESULTS: Average patient age was 75 ± 5 in both groups. There were no differences in ASA scores between the two groups. Surgical time was 77 ± 12 minutes for Group A, and 72 ± 13 minutes for Group B (ns). Harris hip score was 46 ± 36 in Group A and 62 ± 33 in Group B. (p < 0.05). SF-36 was 35 ± 32 in Group A and 54 ± 32 in Group B (ns). Subjective assessment was 5 ± 4 in Group A and 7 ± 3 in Group B (ns). The incidence of death during the follow-up period was 33% in Group A and 15% in Group B. (p < 0.05). One Group A patient underwent revision due to implant loosening. A Furlong prosthesis was successfully implanted in this patient.

DISCUSSION: Although femoral neck fractures in elderly osteoporotic patients are usually treated with cemented arthroplasty, our comparative study showed better results with the Furlong prosthesis, even if statistical significance was reached in only two parameters. The outcomes obtained with the Furlong prosthesis are due to the ability of the HA-coating to bind with osteoporotic bone, thus establishing a stable fixation. Fixation failed in only one cemented implant, but our case number was limited and the follow-up short. Post-op mortality at the time of follow-up was high. This was not unexpected, given the age level and health status of the study groups. This study shows that the HA-coated Furlong prosthesis is a viable option for the treatment of elderly osteoporotic femoral neck fracture patients.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_I | Pages 30 - 31
1 Mar 2006
Moroni A Pegreffi F Frizziero A Hoang-Kim A Giannini S
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Purpose: Four external fixation pin types differing in coating, design and implantation technique were tested in an animal study.

Methods: Forty tapered pins were divided into 4 Groups according to pin design type: Group A consisted of 10 standard self-tapping pins (ø5–6mm, pitch 1.75mm), Group B 10 hydroxyapatite (HA)-coated self-tapping (ø5–6mm, pitch 1.75mm), Group C 10 standard, self-drilling, self-tapping (ø5–6mm, pitch 1.25mm) and Group D 10 HA-coated, self-drilling, self-tapping (ø5–6mm, pitch 1.25mm). Four pins were randomly implanted into the femoral diaphysis of 10 sheep. The pins were implanted at 2-cm intervals apart. Pre-drilling was used for Groups A and B but not for Groups C and D. Sheep were euthanized 6 weeks after surgery.

Results: There were no major complications. Mean pin insertion torque was 3100 ± 915 Nmm in Group A, 2808 ± 852 Nmm in Group B, 2589 ± 852 Nmm in Group C and 2180 ± 652 Nmm in Group D. Mean pin extraction torque was 1570 ± 504 Nmm in Group A, 2128 ± 1159 Nmm in Group B, 1599 ± 809 Nmm in Group C and 2200 ± 914 Nmm in Group D. Insertion torque of the coated groups was lower than insertion torque of the standard groups (p < 0.05). However, extraction torque of Groups B and D was higher than Groups A and C (p < 0.05). No differences in pin fixation were found between the two coated pin groups (Group B and D). Morphologic analysis showed extensive bone to pin contact without fibrous tissue interposition in the coated pin groups and fibrous tissue interposition in the uncoated pin groups.

Conclusion/Significance: This study demonstrated that coating pins with hydroxyapatite is effective regardless of the pin design and the implantation technique.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 247 - 248
1 Sep 2005
Moroni A Faldini C Pegreffi F Hoang-Kim A Giannini S
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Introduction: Deterioration of bone-pin interface, causing pin loosening and infection, is a major cause of postoperative complications following external fixation. This paper presents the results obtained using hydroxyapatite (HA)-coated pins in various bone types, such as osteoporotic bone.

Materials And Methods; In an animal study comparing HA-coated and standard pins, pin insertion and extraction torque were measured. Subsequently, a clinical study compared insertion, extraction torque and pin-tract infection rate of standard and HA-coated pins implanted in healthy and osteoporotic bone.

Results: hi the animal study, mean final insertion torque was 4360±1050Nmm in the standard group and 3420 ± 676 Nmm in the HA-coated group. Mean extraction torque was 253 ± 175 Nmm in the standard group and 3360 ± 1260 Nmm in the HA-coated group (p = 0.002). In the clinical study on healthy bone, the mean insertion torque was 4130 ± 2160 Nmm in the standard group and 3440 ± 1930 Nmm in the HA-coated group (p = 0.03). The mean extraction torque was 1470 ± 1700 Nmm in the standard group and 5130 ± 2300 Nmm in the HA-coated group (p < 0.001). There were 33 pin-tract infections in the standard group and 20 pin-tract infections in the HA-coated group (p < 0.05, power 0.9). The standard pin group had a mean extraction torque of 730 (0–5500) Nmm in the infected pin-tracks and 2110 (0–7000) Nmm in the uninfected pin-tracts (p < 0.0001). The HA-coated group had a mean extraction torque of 5310 (1000–8000) Nmm in the infected pin-tracts and 5080 (0–8000) Nmm in the uninfected pin tracts (NS). In the clinical study on osteoporotic bone, mean final insertion torque was 461 ± 254 Nmm in the standard group and 331 ± 175Nmm in the HA-coated group (p = 0.01). Mean extraction torque was 191 ± 154 Nmm in the standard group and 600 ± 214 Nmm in the HA-coated group (p < 0.0005). Pin infection rate was greater in the standard group (p < 0.05).

Conclusion: There was no deterioration of the bone-pin interface strength (measured by torque resistance at the time of pin extraction) with HA-coated pins. The improved strength of fixation of the HA-coated pins was associated with a lower incidence of pin-tract infection.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_I | Pages 55 - 55
1 Mar 2005
Moroni A Faldini C Pegreffi F Hoang-Kim A Giannini S
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Although dynamic hip screw (DHS) is considered the treatment of choice for pertrochanteric fractures, we theorized that external fixation would produce clinical outcomes equal to, if not better than, outcomes obtained with conventional treatment. As external fixation is minimally-invasive, we expected a lower rate of morbidity and a reduced need for blood transfusions. We compared fixation with DHS vs. Orthofix pertrochanteric fixator (OPF) in elderly pertrochanteric fracture patients. Forty consecutive pertrochanteric fracture patients were randomized to receive either 135A1 4-hole DHS (Group A) or OPF with 4 HA-coated pins (Group B). Inclusion criteria were: female, age B3 65 years, AO type A1 or A2 and BMD less than −2.5 T score. There were no differences in patient age, fracture type, BMD, ASA, hospital stay or quality of reduction. Operative time was 64 B1 6 minutes in Group A and 34 B1 5 minutes in Group B (p < 0.005). Average number of post-operative blood transfusions was 2.0 B1 0.1 in Group A, and none in Group B (p < 0.0001). Pain was measured 5 days post-operatively and was lower in Group B (p < 0.005). Fracture varization at 6 months was 6 B1 8A1 in Group A and 2 B1 1A1 in Group B (p = 0.002). In Group B, no pin-tract infections occurred. Pin fixation improved over time, as shown by pin extraction torque (2770 B1 1710 N/mm) greater than insertion torque (1967 B1 1254 N/mm), (p= 0.001). Harris hip score at 2 years was 62 B1 20 in Group A and 63 B1 17 in Group B. This study shows that OPF with HA-coated pins is an effective treatment for this patient population. Operative time is brief, blood loss is minimal, fixation is adequate and the reduction is maintained over time.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 243 - 243
1 Mar 2004
Moroni A Faldini C Pegreffi F Giannini S
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Aims: Our purpose was to determine if DHS fixed with hydroxyapatite (HA)-coated AO/ASIF screws improves fixation and clinical outcomes in osteoporotic trochanteric fracture patients. Methods: 120 osteoporotic patients with trochanteric fractures were randomized to receive 135° 4-hole DHS fixed with either standard lag and cortical stainless-steel AO/ASIF screws (Group A) or HA-coated lag and cortical stainless-steel AO/ASIF screws (Group B). Inclusion criteria were: female; age ≥65 years; AO type A1 or A2; and BMD lower than -2.5 T score. Results: Tip Apex Distance (TAD) was 22±4mm in Group A and 23±5mm in Group B (ns). In Group A there were 4 cut-out cases and none in Group B (p< 0.05, β=0.8). Post-op (ns) and 6 month (p=0.008) femoral neck-shaft angle was 134±5° and 129±7° (Group A) and 134±7° and 133±7° (Group B). At 6 months, Harris Hip Score was 63±22 (Group A) and 71±18 (Group B) (p=0.02). Conclusions: HA-coated AO/ASIF screws prevent fracture varization and lag screw cutout, thus improving clinical outcomes in osteoporotic trochanteric fracture patients.


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 226 - 226
1 Mar 2004
Moroni A Faldini C Pegreffi F Giannini S
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Aims: We compared treatment with external fixation (EF) vs DHS in osteoporotic trochanteric fractures. Methods: 40 patients were randomized to receive either 135° 4-hole DHS (Group A) or an Orthofix trochanteric external fixator with 4 hydroxyapatite-coated Osteotite pins (Group B). Inclusion criteria were: female, age ≥65 years, AO fracture type A1-2 and BMD lower than -2.5T score. Fixators were removed at 3 months. Results: There were no differences in patient age, fracture type, BMD, ASA, hospital stay, or quality of reduction. Operative time was 64±6 minutes in Group A and 34±5 minutes in Group B (p< 0.005). Average number of blood transfusions was 2±0.1 in Group A, and none in Group B (p< 0.0001). Fracture varization at 6 months was 6±8° in Group A and 2±1° in Group B (p=0.002). Harris Hip Score was 62±20 in Group A and 63±17 in Group B (ns). In Group B, no pin-track infections occurred. Pin fixation was maintained over time, as shown by no differences between pin extraction and insertion torque. Conclusions: We consider EF a viable treatment option for this patient population. Operative time is short, postoperative complications are minimized, and fixation is improved.