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Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_9 | Pages 24 - 24
1 Sep 2019
GENETIC LOCUS ON CHROMOSOME 9 ASSOCIATED WITH MODIC CHANGES REVEALED BY GENOME-WIDE META-ANALYSIS
Freidin M Kraatari M Skarp S Määttä J Kettunen J Niinimäki J Karppinen J Männikkö M Williams F
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Objective

Modic changes (MC), a form of intervertebral disc degeneration visible as subchondral and vertebral bone marrow changes on spine magnetic resonance (MR), are known to be associated with low back pain. This study aimed to identify genes contributing to the development of MC using genome-wide association study.

Methods

Presence of MC was evaluated in lumbar MR images in the Northern Finland Birth Cohort 1966 (NFBC1966, N=1182) and TwinsUK (N=647). Genome-wide association analyses were carried out in the cohorts separately using a linear regression model fitted to test for additive effects of SNPs and adjusting for age, sex, BMI, and either family relatedness via a kinship matrix (TwinsUK) or population stratification using principal components (NFBC1966). Meta-analysis of the two studies was carried out using the inverse-variance weighting approach.

Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_I | Pages 26 - 26
1 Jan 2012
DO VERTEBRAL ENDPLATE SIGNAL (MODIC) CHANGES HURT?
Jensen T Kent P Karppinen J Sorensen J Niinimäki J Leboeuf-Yde C
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Purpose

By systematic literature review, to quantify the association between vertebral endplate signal changes (VESC) and non-specific low back pain (NSLBP).

Materials and methods

MEDLINE, EMBASE, and SveMED databases were searched for the period 1984 to June 2009. Articles were included which investigated the association between VESC and NSLBP and reported sufficient data to construct two-by-two tables. Articles on specific low back pain conditions were excluded. A standardised data collection and quality assessment were performed. To estimate the association between VESC and NSLBP, two-by-two tables were created and exact odds ratios were calculated with 95% confidence intervals (CI). Meta-analysis was performed on homogeneous studies.

Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 278 - 278
1 May 2009
GENETIC FACTORS ASSOCIATE WITH LUMBAR MODIC CHANGES
Daavittila I Solovieva S Kuisma M Taimela S Natri A Korpelainen R Niinimäki J Tervonen O Ala-Kokko L Männikkö M Karppinen J
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Introduction: Modic changes are vertebral endplate changes visible in magnetic resonance imaging (MRI), which associate with degenerative intervertebral disc disease. Twin studies suggest that intervertebral disc degeneration and low back pain may be primarily explained by genetic factors. There are, however, no studies on genetic factors in Modic changes.

Materials and methods: Eleven variations in eight genes (COL9A2, COL9A3, COL11A2, IL1A, IL1B, IL6, MMP-3 and VDR) were genotyped in an occupational cohort of 159 male train engineers and 69 male paper mill workers. All the study subjects were MRI scanned and evaluated for Modic changes.

Results: Out of 228 subjects studied, 128 (56%) were found to have Modic change at one or more disc levels. 15% of them had exclusively Modic type I while 32% had exclusively Modic II changes. 10% of the subjects had both type I and type II changes. When single nucleotide polymorphisms (SNPs) were analyzed independently, none of them significantly associated with Modic changes. However, when the gene-gene interactions were evaluated IL1A and MMP-3 polymorphisms together associated with type II Modic changes (OR 3.2, 95% CI 1.2–8.5; p = 0.038). Furthermore, IL-1 gene cluster together with MMP-3 polymorphism associated significantly with type II Modic changes (OR = 8.14, 95% CI 1.72–38.44; p = 0.008).

Discussion: This is the first study evaluating the role of genetic factors in relation to Modic changes. Genetic variations in IL-1 cluster and MMP-3 gene were found together to associate significantly with type II Modic changes.