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Orthopaedic Proceedings
Vol. 96-B, Issue SUPP_11 | Pages 98 - 98
1 Jul 2014
Palmer A Fernquest S Hamish L Pollard T McNally E Wilson D Wilson D Madler B Carr A Glyn-Jones S
Full Access

Summary

The dGEMRIC index correlates more strongly with the pattern of radiographic joint space narrowing in hip osteoarthritis at five year follow-up than morphological measurements of the proximal femur. It therefore offers potential to refine predictive models of hip osteoarthritis progression.

Introduction

Longitudinal general population studies have shown that femoroacetabular impingement increases the risk of developing hip osteoarthritis, however, morphological parameters have a low positive predictive value. Arthroscopic debridement of impingement lesions has been proposed as a potential strategy for the prevention of osteoarthritis, however, the development of such strategies requires the identification of individuals at high risk of disease progression. We investigated whether delayed Gadolinium-Enhanced MRI of Cartilage (dGEMRIC) predicts disease progression. This imaging modality is an indirect measure of cartilage glycosaminoglycan content.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVI | Pages 6 - 6
1 Aug 2012
Alsousou J Handley R Hulley P Thompson M McNally E Harrison P Willett K
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Purpose

Platelet Rich Plasma (PRP) has been shown to have positive effect in tendon regeneration in in-vitro and limited in-vivo animal studies. We aim to study PRP use in acute Achilles tendon rupture (ATR) regeneration in a purposely designed clinical trial.

Methods

This is a prospective double-arm patient-blinded randomized controlled trial. ATR patients were randomized into PRP treatment or control groups. Non-operatively treated patients received PRP or control injection in clinic. In operatively treated patients, PRP gel was applied in the ruptured gap during percutaneous repair. Standard rehabilitation protocol was used and patients were followed up for 24 weeks. ATR, VISA-A and FAOS scores were used as subjective outcome measures. Functional ultrasound Elastography (FUSE) was performed at each follow-up to assess the mechanical properties of tendons. PRP analysis and tendon needle-biopsy were performed to study the histological differences during healing in both groups.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVIII | Pages 47 - 47
1 May 2012
Bottomley N McNally E Jones L Javaid M Arden N Gill H Dodd C Murray D Beard D Price A
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Introduction

Anteromedial osteoarthritis of the knee (anteromedial gonarthrosis-AMG) is a common form of knee arthritis. In a clinical setting, knee arthritis has always been assessed by plain radiography in conjunction with pain and function assessments. Whilst this is useful for surgical decision making in bone on bone arthritis, plain radiography gives no insight to the earlier stages of disease. In a recent study 82% of patients with painful arthritis had only partial thickness joint space loss on plain radiography. These patients are managed with various surgical treatments; injection, arthroscopy, osteotomy and arthroplasty with varying results. We believe these varying results are in part due to these patients being at different stages of disease, which will respond differently to different treatments. However radiography cannot delineate these stages. We describe the Magnetic Resonance Imaging (MRI) findings of this partial thickness AMG as a way of understanding these earlier stages of the disease.

Method

46 subjects with symptomatic partial thickness AMG underwent MRI assessment with dedicated 3 Tesla sequences. All joint compartments were scored for both partial and full thickness cartilage lesions, osteophytes and bone marrow lesions (BML). Both menisci were assessed for extrusion and tear. Anterior cruciate ligament (ACL) integrity was also assessed. Osteophytes were graded on a four point scale in the intercondylar notch and the lateral margins of the joint compartments. Scoring was performed by a consultant radiologist and clinical research fellow using a validated MRI atlas with consensus reached for disagreements. The results were tabulated and relationships of the interval data assessed with linear by linear Chi2 test and Pearson's Correlation.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XVIII | Pages 53 - 53
1 May 2012
Alsousou J Larry L McNally E Noble A Willett K
Full Access

Purpose

Functional ultrasound Elastography (FUSE) of Tendo Achilles is an ultrasound technique utilising controlled, measurable movement of the foot to non-invasively evaluate TA elastic and load-deformation properties. The study purpose is to assess Achilles tendons, paratenon and bursa mechanical properties in healthy volunteers and establish an outcome tool for TA treatment.

Methods

Forty asymptomatic Achilles tendons of 20 healthy volunteers were recruited (10 men and 10 women, age range 18-55). One patient with Acute Achilles rupture scanned to evaluate the tendon gap. Each volunteer answered the Foot and Ankle Outcome Score (FAOS) and Victorian Institute Sport Assessment score (VISA-A) questionnaires. The Achilles Tendons were divided into three thirds (total 120 Proximal, middle and distal thirds). Three longitudinal images of each third were obtained using portable US scan device (Z.one, Zonare Medical System Inc., USA, 8.5 MHz). Images processing was achieved using a MatLAb software (developed by the research team) in parallel Oxford university computers. Each 1/3rd Achilles tendon under went the following scans:

Free hand US scan

Free hand Compression decompression Elastography scan

Dorsal Flexion elastography

Planter flexion elastography

Zonare real-time Elastography

Elastography scan with the Oxford isometric dynamic foot and Ankle mover (OIDFA)

B mode and elasticity images were derived from the raw ultrasound radio frequency data. The anatomical structures mechanical properties were evaluated by a quantitative score of different colours representing stiff tissue (blue) to more soft tissue (green, yellow, red).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 73 - 73
1 Jan 2011
Bottomley N McNally E Ostlere S Kendrick B Murray D Dodd C Beard D Price A
Full Access

Introduction: This study explores whether modern magnetic resonance imaging (MRI) with improved cartilage sequencing is able to show a more detailed view of antero-medial osteoarthritis of the knee (AMOA) than previously, so enabling a radiographic description of this common phenotype of disease. Modern MRI technology allows us to visualize in great detail the structures and cartilage within the knee, providing a better understanding of the pathoanatomy of AMOA. This description of the end stage of disease is useful as a baseline when investigating the progression of arthritis through the knee. Preoperative assessment of patients and selection of intervention is very important and preoperative imaging forms an integral part of this. This will also be useful in preoperative assessment and surgical management of patients.

Methods: 50 patients with a radiographic diagnosis of anteromedial osteoarthritis of the knee and had been listed for unicompartmental knee arthroplasty (UKA) had MRI as part of their pre-op workup. At operation all were deemed suitable for UKA using the current Oxford indications. The image sequences were coronal, axial and sagittal with a predetermined cartilage protocol. The state of the ACL, cartilage wear degree and location, presence and pattern of osteophytes, meniscal anatomy and subchondral high signal were assessed.

Results: All the ACLs were visualized and in continuity, however 40% showed intrasubstance high signal. 100% of medial compartments showed full thickness anteromedial loss with preservation of the posteromedial cartilage. When present, the meniscus was extruded in 75% of cases.

90% of lateral compartments were normal and none had full thickness cartilage loss. However 10% showed high signal in the tibial plateau. There was a highly reproducible pattern of osteophyte formation; 94% posteromedial and posterolateral aspect of medial femoral condyle; 90% medial tibial; 80% medial femoral and 84% lateral intercondylar notch.

Discussion: This study maps the pattern of anteromedial osteoarthritis using modern MRI techniques. This creates a baseline description of disease which is useful when investigating disease progression. This also has importance in determining preoperative indications (preservation of ACL and posteromedial cartilage); surgical technique (determine pattern of osteophytes requiring resection) and potentially important for long-term outcome (early lateral compartment changes).


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 80 - 80
1 Jan 2011
Dean BJF Matthews JJ Reed DW Pandit H McNally E Athanasou N Gibbons CMLH
Full Access

Introduction: Hoffa’s fat pad (HFP) of the knee is affected by a variety of tumours and tumour-like conditions. HFP can be affected by diffuse or solitary, focal disease. Solitary tumours are relatively uncommon but with widespread uptake of Magnetic Resonance Imaging Scans (MRI) an increasing number of Hoffa’s fat pad tumours (HFP) are being recognized.

Methods: This paper reports a consecutive series of 20 cases of solitary symptomatic HFP tumours referred to Oxford bone and soft tissue tumour service between 1999 and 2008. The commonest presenting symptom was anterior knee pain. All patients underwent open excision after diagnostic magnetic resonance imaging (MRI).

Results: Histology revealed varied diagnoses with the commonest being pigmented villonodular synovitis (PVNS) and ganglia. American Knee Society scores improved from 76 pre-operatively to 96 post-operatively with an improvement in functional scores from 92 to 100. In one patient, MRI identified the cause of hypo-phosphataemic osteomalacia as an HFP phosphaturic mesenchyma tumour despite the lack of local symptoms.

Discussion In conclusion the majority of solitary HFP tumours are benign and may be either cystic or solid. MRI and plain radiographs are the imaging of choice. The definitive treatment of both cystic and solid tumours should be selective arthrotomy and excision biopsy. Arthroscopic resection is not advised, as complete excision is not always possible. None of the 20 patients in this series had a malignant tumour but this has been reported in the literature. Calcification on plain radiographs may indicate a malignant lesion. All patients in our series reported substantial improvement in symptoms following open tumour resection.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 386 - 386
1 Jul 2010
Pollard T McNally E Wilson D Maedler B Wilson D Watson M Carr A
Full Access

Introduction: Subtle deformity of the hip joint may cause osteoarthritis. In femoroacetabular impingement (FAI), cam deformities damage acetabular cartilage. Whether surgical removal of cam lesions halts progression is unknown. Sensitive, non-invasive assays of chondral damage are required to evaluate early treatment efficacy.

Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) permits inference of glycosaminoglycan (GAG) distribution. We aimed to determine whether hips with cam deformities have altered GAG content, using dGEMRIC.

Methods: Subjects were recruited from a prospective cohort study. All were clinically and radiographically assessed. Hips with a normal joint space width (> 2.5mm) were eligible for dGEMRIC. 32 Hips (18 male, 14 female, mean age 51.7 years, none of whom had been investigated for hip pain) with (n=21) and without (n=11) cam deformities were scanned.

2 regions of interest (ROI) were studied:

acetabular cartilage from 12 to 3 O’Clock (T1-Index-acet).

total cartilage (femoral and acetabular) for the joint from 9 to 3 O’Clock (T1-Indextotal).

The average of all pixels within the given ROI defined the T1-index.

For each hip, the ratio of the GAG content T1-Index-acet/T1-Indextotal was calculated. Mean T1-Indexto-tal and T1-Indexacet/T1-Indextotal were compared.

Results: T1-Indextotal were similar (689ms v 700ms, p=0.79) but T1-Indexacet/T1-Indextotal was lower in cam hips (0.93 v 1.01, p=0.017), indicating localised depletion of GAG content. Cam hips with positive clinical signs had lower T1-Indextotal than cam hips without (629ms v 717ms, p=0.055), and non-cam hips (629ms v 722ms, p=0.049).

Discussion: Cam hips have lower GAG content of their anterosuperior acetabular cartilage. dGEMRIC identified more generalised disease in cases with positive clinical findings. Ratios of GAG content for specific ROIs enable mapping of chondral damage. This may aid understanding of early disease mechanisms, track progression, and facilitate assessment of the efficacy of surgical procedures.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 417 - 417
1 Jul 2010
Dean B Matthews J Reed D Pandit H McNally E Athanasou N Gibbons C
Full Access

The infrapatellar (Hoffa’s) fat pad can be affected by a variety of tumours and tumour-like conditions which can occasionally present a diagnostic and therapeutic challenge to the treating surgeon. The fat pad can be affected by diffuse or solitary disease. Solitary tumours are relatively uncommon but with widespread uptake of Magnetic Resonance Imaging Scans (MRI) an increasing number of Hoffa’s fat pad tumours (HFP) are being recognized.

Between 1999 and 2008, 20 patients with HFP pathology referred to Oxford bone and soft tissue tumour service underwent resection and histological examination. Clinical records, imaging and histological findings were reviewed. Histology showed eight different diagnoses with Pigmented Villonodular Synovitis (PVNS) and ganglia being the most common pathology.

In one patient, MRI identified the cause of hypophosphataemic osteomalacia as an HFP phosphaturic mesen-chyma tumour despite the lack of local symptoms.

In conclusion, the majority of solitary HFP tumours are benign and maybe cystic or solid. MRI and plain radiographs are the imaging of choice. Cystic tumours maybe aspirated but the definitive treatment of both cystic and solid tumours should be open arthrotomy and excision biopsy. Arthroscopic resection is not advised, as complete excision is not always possible. None of the 20 patients in this series had a malignant tumour but this has been reported in the literature. Calcification on plain radiographs may indicate a malignant lesion. All patients in our series reported substantial improvement in symptoms following open tumour resection.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_III | Pages 416 - 416
1 Jul 2010
Bottomley N McNally E Ostlere S Beard D Gill H Kendrick B Jackson W Gulati A Simpson D Murray D Dodd C Price A
Full Access

Introduction: This study explores whether modern magnetic resonance imaging (MRI) with improved cartilage sequencing is able to show a more detailed view of anteromedial osteoarthritis of the knee (AMOA). Preoperative assessment of patients and selection of intervention is very important and preoperative imaging forms an integral part of this. Modern MRI technology may allow us to visualize in great detail the structures and cartilage within the knee, providing a better understanding of the pathoanatomy of AMOA. This will be useful in preoperative assessment and surgical management of patients.

Methods: 50 patients with a radiographic diagnosis of anteromedial osteoarthritis of the knee and had been listed for unicompartmental knee arthroplasty (UKA) had MRI as part of their pre-op workup. At operation all were deemed suitable for UKA using the current Oxford indications. The image sequences were coronal, axial and sagittal with a predetermined cartilage protocol. The state of the ACL, cartilage wear location and pattern, presence of osteophytes and subchondral high signal were assessed.

Results: All the ACLs were visualized and in continuity, however 40% showed intrasubstance high signal.

100% of medial compartments showed full thickness anteromedial loss with preservation of the posteromedial cartilage. When present, the meniscus was extruded in 96% of cases.

90% of lateral compartments were normal and none had full thickness cartilage loss. However 10% showed high signal in the tibial plateau.

There was a highly reproducible pattern of osteophyte formation; 94% posteromedial and posterolateral aspect of medial femoral condyle; 90% medial tibial; 80% medial femoral and 84% lateral intercondylar notch.

Discussion: This study maps the pattern of anteromedial osteoarthritis using modern MRI techniques. This has importance in determining preoperative indications (preservation of ACL and posteromedial cartilage); surgical technique (determine pattern of osteophytes requiring resection) and potentially important for long-term outcome (early lateral compartment changes).


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 218 - 218
1 May 2006
Coltman T Chapman-Sheath P Riddell A McNally E Wilson-MacDonald J
Full Access

Study design: A prospective comparison of MRI findings with surgical findings in patients presenting to our spinal triage service with a prospective diagnosis of a lumbar disc herniation.

Objective: To investigate consistency between radiologists interpretation of MRI scans, and comparison between MRI and surgical findings, in an attempt to identify those patients suitable for percutaneous treatment.

Background: MRI has assumed a preeminent position in the diagnosis of lumbar disc prolapse.

Methods: 87 consecutive patients presenting with signs and symptoms suggestive of a lumbar disc prolapse that underwent an MRI and based on that a discectomy.

Results: Reliability tests show only fair agreement (k=0.36) between the radiologists and at best only moderate agreement (k=0.41) between the radiologists and surgical findings.

Conclusions: MRI is an excellent tool for diagnosis of a disc prolapse but does not appear to help in classifying discs suitable for percutaneous treatment.


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_II | Pages 162 - 162
1 Apr 2005
Harvie P Ostlere S Teh J McNally E Clipsham K Burston B Pollard T Carr A
Full Access

The purpose of this study was to investigate the role that genetics play in the aetiology and symptomatology of full thickness tears of the rotator cuff.

From a retrospective, cohort study of 205 patients diagnosed with full thickness rotator cuff tears, we determined, using ultrasound, the prevalence of full thickness tears in their 129 siblings. Using 150 spouses as controls, the relative risk of full thickness rotator cuff tear in siblings v controls was 2.42 (p< 0.0001, 95 % CI 1.77 to 3.31). The relative risk of symptomatic full thickness rotator cuff tear in siblings v controls was 4.65 (p< 0.0001, 95 % CI 2.42 to 8.63).

The significantly increased risk for tears in siblings implies that genetic factors play a major role in the development of full thickness tears of the rotator cuff.