In 2015, we published the results of our ceramic-on-metal (CoM) total hip arthroplasties (THAs) performed between October 2007 and July 2009 with a mean follow-up of 34 months (23 to 45) and a revision rate of 3.1%. The aim of this paper is to present the longer-term outcomes. A total of 264 patients were reviewed at a mean of 5.8 years (4.6 to 7.2) and 10.1 years (9.2 to 10.6) to determine revision rate, pain, outcome scores, radiological analysis, and blood ion levels. Those who were unwilling or unable to travel were contacted by telephone.Aims
Methods
Internet delivered interventions may provide a route to rapid support for behavioural self-management for low back pain (LBP) that could be widely applied within primary care. Although evidence is emerging that more complex technologies (mobile apps linked to digital wristbands) can have some impact on LBP-related disability, there is a need to determine the effectiveness of highly accessible, web-based support for self-management for LBP. We conducted a multi-centre pragmatic randomised controlled trial, testing ‘SupportBack’, an accessible internet intervention developed specifically for primary care. We aimed to determine the effectiveness of the SupportBack interventions in reducing LBP-related physical disability in primary care patients. Participants were randomised to 1 of 3 arms: 1) Usual care + internet intervention + physiotherapy telephone support, 2) Usual care + internet intervention, 3) Usual care alone. Utilising a repeated measures design, the primary outcome for the trial was disability over 12 months using the Roland Morris Disability Questionnaire (RMDQ) at 6 weeks, 3, 6 and 12 months. Results: 826 were randomised, with follow-up rates: 6 weeks = 83%; 3 months = 72%; 6 months = 70%; 12 months = 79%. Analysis is ongoing, comparing each intervention arm versus usual care alone. The key results will be presented at the conference.Background
Methods and results
The association between body mass index (BMI) and venous thromboembolism (VTE) is well studied, but remains unclear in the literature. We aimed to determine whether morbid obesity (BMI≥40) was associated with increased risk of VTE following total knee arthroplasty (TKA) or unicompartmental knee arthroplasty (UKA), compared to those of BMI<40. Between January 2016 and December 2020, our institution performed 4506 TKAs and 449 UKAs. 450 (9.1%) patients had a BMI≥40. CT pulmonary angiography (CTPA) for suspected pulmonary embolism (PE) and ultrasound scan for suspected proximal deep vein thrombosis (DVT) were recorded up to 90 days post-operatively.Abstract
Aims
Methods
With respect to survivorship following total knee arthroplasty (TKA), joint registries consistently demonstrate higher revision rates for both sexes in those less than 55 years. The current study analyses the survivorship of 500 cementless TKAs performed in this age group in a high-volume primary joint unit where cementless TKA has traditionally been used for the majority of patients. This was a retrospective review of 500 consecutive TKAs performed in patients under the age of 55 between March 1994 and April 2017. The primary outcome measure for the study was all-cause revision. Secondary outcome measures included clinical, functional and radiological outcomes.Abstract
Introduction
Methods
Tranexamic Acid (TXA) is now commonly used in major surgical operations including orthopaedics. The TRAC-24 randomised control trial aimed to assess if an additional 24 hours of TXA post – operatively in primary total hip (THA) and total knee arthroplasty (TKA) reduced blood loss. Contrary to other orthopaedic studies to date this trial included high risk patients. This paper presents the results of a cost analysis undertaken alongside this RTC. TRAC-24 was a prospective randomised controlled trial on patients undergoing TKA and THA. Three groups were included, Group 1 received 1 g intravenous (IV) TXA perioperatively and an additional 24-hour post-operative oral regime, group 2 received only the perioperative dose and group 3 did not receive TXA. Cost analysis was performed out to day 90. Group 1 was associated with the lowest mean total costs, followed by group 2 and then group 3. The difference between groups 1 and 3 −£797.77 (95% CI −1478.22, −117.32) were statistically significant. Extended oral dosing reduced costs for patients undergoing THA but not TKA. The reduced costs in groups 1 and 2 resulted from reduced length of stay, readmission rates, Accident and Emergency (A&E) attendances and blood transfusions. This study demonstrated significant cost savings when using TXA in primary THA or TKA. Extended oral dosing reduced costs further in THA but not TKA.
Septic Arthritis (SA) is considered a surgical urgency/ emergency by physicians around the world. As our understanding grows, and improved diagnostic algorithms are developed, it has become apparent that competing interests in terms of accurately diagnosing concurrent osteomyelitis may supercede rapid surgical intervention when the imaging is timely. Nevertheless, even in cases of isolated SA, many patients will require repeat surgery. We aimed to assess factors which could predict this. A multicenter retrospective redcap database was created involving 20 pediatric centers from the CORTICES study group with the goal of better understanding pediatric musculoskeletal infection (PMSKI). All patients who met inclusion for the database were considered, surgeons for each site determined through imaging and chart review which patients met the diagnosis of isolated SA. Patients with concomitant abscesses or osteomyelitis were expressly excluded. Appropriate non parametric statistics were used to assess univariate significance. Multivariable logistic regression was used to assess clinical factors associated with an increased likelihood of more than one surgery. Receiver characteristics operating curve (ROC) analysis was used to determine optimal cutoffs to discriminate between children who required more than one surgery compared to those who required only one surgery. A probability algorithm was developed for the number of clinical factors present and the likelihood requiring more than one surgery following SA diagnosis. “Four hundred and fifty-four patients with isolated SA were analyzed from 20 US hospitals. Patients were 5.4 +/− 4.8 years old at admission, and the cohort was 56% male. Of the 454 patients, 47 (10.4%) needed more than one surgery. Bivariate comparisons across surgery groups found significant differences in minimum platelet count (pplatelet, a patient has a 0.3% reduction in the odds of needing more than one surgery (OR=.997; p=0.04). For each additional ten units of Higher CRP values and lower platelet values indicate more severe disease in isolated SA with a greater likelihood of repeat surgery. Higher CRP and lower platelet counts may portend multiple surgeries and caregivers of children with isolated SA should be advised as such.
91% of blood loss in Total Hip Replacement (THR) occurs in the period after skin closure and the first 24 post-operative hours. TRAC-24 was established to identify if an additional 24-hour post-operative oral regime of Tranexamic acid (TXA) is superior to a once-only intravenous dose at surgery. This was a prospective, phase IV, single centered, open label, parallel group controlled trial on patients undergoing primary elective THR. A history of thromboembolic or cardiovascular disease were not exclusion criteria. The primary outcome was indirect calculated blood loss at 48 hours (IBL). 534 patients were randomized on a 2:2:1 ratio over three different groups. Group 1 received an intravenous dose of TXA at the time of surgery and an additional 24-hour post-operative oral regime, Group 2 only received the intra-operative dose and Group 3 did not receive any TXA.Background
Methods
The EU-funded Back-UP project aims to develop a cloud computer platform to guide the treatment of low back and neck pain (LBNP) in first contact care and early rehabilitation. In order to identify evidence-based treatment options that can be recommended and are accessible to people with LBNP across Europe, we conducted a systematic review of recently published guidelines. Electronic databases, including Medline, Embase, CINAHL, PsycINFO, HMIC, Epistemonikos, PEDro, TRIP, NICE, SIGN, WHO, Guidelines International Network (G-I-N) and DynaMed Plus were searched. We searched for guidelines published by European health professional or guideline development organisations since 2013, focusing on the primary care management of adult patients presenting with back or neck pain (including whiplash associated symptoms, radicular pain, and pregnancy-related LBP). The AGREE-II tool was used to assess the quality of guideline development and reporting.Background and aims
Methods
Improving primary care management of musculoskeletal (MSK) pain is a priority. A pilot cluster RCT tested prognostic stratified care for patients with common MSK pain presentations, including low back pain, in 8 UK general practices (4 stratified care; 4 usual care) with 524 patients. GPs in stratified care practices were asked to use i) the Keele STarT MSK tool for risk-stratification and ii) matched treatment options for patients at low-, medium- and high-risk of persistent pain. A linked qualitative process evaluation explored patients' and GPs' views and experiences of stratified care. Individual ‘stimulated-recall’ interviews with patients and GPs in the stratified care arm (Background
Methods
Healthcare for sciatica is usually ‘stepped’ with initial advice and analgesia, then physiotherapy, then more invasive interventions if symptoms continue. The SCOPiC trial tested a stratified care algorithm combining prognostic and clinical characteristics to allocate patients into one of three groups, with matched care pathways, and compared the effectiveness of stratified care (SC) with non-stratified, usual care (UC). Pragmatic two-parallel arm RCT with 476 adults recruited from 42 GP practices and randomised (1:1) to either SC or UC (238 per arm). In SC, participants in group 1 were offered up to 2 advice/treatment sessions with a physiotherapist, group 2 were offered up to 6 physiotherapy sessions, and group 3 was ‘fast-tracked’ to MRI and spinal specialist opinion. Primary outcome was time to first resolution of sciatica symptoms (6-point ordinal scale) collected via text messages. Secondary outcomes (4 and 12 months) included leg and back pain intensity, physical function, psychological status, time-off-work, satisfaction with care. Primary analysis was by intention to treat.Background and Purpose
Methods
The Keele STarT Back approach is effective for stratifying patients with low back pain in primary care, but a similar approach has not been tested with a broader range of patients with musculoskeletal (MSK) pain. We report a feasibility and pilot trial examining the feasibility of a future main trial of a primary care based, risk-stratification (STarT MSK) approach for patients with back, neck, knee, shoulder or multi-site pain. A pragmatic, two-parallel arm, cluster randomised controlled trial (RCT) in 8 GP practices (4 stratified care involving use of the Keele STarT MSK tool and matched treatment options: 4 usual care). Following screening, adults with one of the five most common MSK pain presentations were invited to take part in data collection over 6 months. Feasibility outcomes included exploration of selection bias, recruitment and follow-up rates, clinician engagement with using the Keele STarT MSK tool and matching patients to treatments.Background and aims
Methods
The STarT Back risk-stratification approach uses the STarT Back Tool to categorise patients with low back pain (LBP) at low, medium or high-risk of persistent disabling pain, in order to match treatments. The MATCH trial (NCT02286141) evaluated the effect of implementing an adaptation of this approach in a United States healthcare setting. This was a pragmatic cluster randomised trial with a pre-intervention baseline period. Six primary care clinics were pair-randomised, three to an intensive stratified care quality improvement intervention and three as controls. LBP patients were invited to provide outcomes two weeks after their primary care visit, and two and six months later. Primary outcomes were physical function (RMDQ) and pain (0–10 NRS), and secondary outcomes including healthcare use and treatments provided received. Analysis was intention-to-treat.Purpose & Background
Methods
Population ageing will facilitate an increase in health problems common in older adults, such as musculoskeletal conditions. Musculoskeletal conditions are the fourth largest contributor to disease burden in older adults; affecting quality of life, physical activity, mental wellbeing and independence. Therefore primary care health services must provide appropriate and efficacious management and treatment. However there are a number of complexities specific to older adults that are essential to address. In order to identify these complexities, a review of the background literature was undertaken in addition to a Patient and Public Involvement and Engagement (PPIE) session. The PPIE group consisted of eight older adults who experience chronic musculoskeletal pain. This session was used to discuss and explore what factors are important to consider in GP consultations for musculoskeletal pain for older adults, in addition to those identified through background literature. A number of factors were highlighted through these methods, including the difference in mood and aspirations for older adults; taking a holistic approach; the impact of comorbidities; whether the GP is listening and ‘on the same wavelength’, and older adults' expectations regarding their pain and the consultation.Purpose of Study and Background
Methods and Results
This study aimed to assess the effect of flexion and external rotation on measurement of femoral offset (FO), greater trochanter to femoral head centre (GT-FHC) distance, and neck shaft angle (NSA). Three-dimensional femoral shapes (n=100) were generated by statistical shape modelling from 47 CT-segmented right femora. Combined rotations in the range of 0–50° external and 0–50° flexion (in 10° increments) were applied to each femur after they were neutralised (defined as neck and proximal shaft axis parallel with detector plane). Each shape was projected to create 2D images representing radiographs of the proximal femora. As already known, external rotation resulted in a significant error in measuring FO but flexion alone had no impact. Individually, neither flexion nor external rotation had any impact on GT-FHC but, for example, 30° of flexion combined with 50°of external rotation resulted in an 18.6mm change in height. NSA averaged 125° in neutral with external rotation resulting in a moderate increase and flexion on its own a moderate decrease. However, 50° degrees of both produced an almost 30 degree increase in NSA. In conclusion, although the relationship between external rotation and FO is appreciated, the impact of flexion with external rotation is not. This combination results in apparent reduced FO, a high femoral head centre and an increased NSA. Femoral components with NSAs of 130° or 135° may historically have been based on X-ray misinterpretation. This work demonstrates that 2D to 3D reconstruction of the proximal femur in pre-op planning is a challenge.
Unknown femur orientation during X-ray imaging may cause inaccurate radiographic measurements. The aim of this study was to assess the effect of 3D femur orientation during radiographic imaging on the measurement of greater trochanter to femoral head centre (GT-FHC) distance. Three-dimensional femoral shapes (n=100) of unknown gender were generated using a statistical shape model based on a training data of 47 CT segmented femora. Rotations in the range of 0° internal to 50° external and 50° of flexion to 0° of extension (at 10 degree increments) were applied to each femur. A ray tracing algorithm was then used to create 2D images representing radiographs of the femora in known 3D orientations. The GT-FHC distance was then measured automatically by identifying the femoral head, shaft axis and tip of greater trochanter. Uniaxial rotations had little impact on the measurement with mean absolute error of 0.6 mm and 3.1 mm for 50° for pure external rotation and 50° pure flexion, respectively. Combined flexion and external rotation yielded more significant errors with 10° around each axis introducing a mean error of 3.6 mm and 20° showing an average error of 8.8 mm (Figure 1.). In the cohort we studied, when the femur was in neutral orientation, the tip of greater trochanter was never below the femoral head centre. Greater trochanter to femoral head centre measurement was insensitive to rotations around a single axis (i.e. flexion or external rotation). Modest combined rotations caused the tip of greater trochanter to appear more distal in 2D and led to deviation from the true value. This study suggests that a radiograph with the greater trochanter appearing below femoral head centre may have been acquired with 3D rotation of the femur.
Anterior-posterior (AP) x-rays are routinely taken following total hip replacement to assess placement and orientation of implanted components. Pelvic orientation at the time of an AP x-ray can influence projected implant orientation.1However, the extent of pelvic orientation varies between patients.2Without compensation for patient specific pelvic orientation, misleading measurements for implant orientation may be obtained. These measurements are used as indicators for post-operative dislocation stability and range of motion. Errors in which could result in differences between expectations and the true outcome achieved. The aim of this research was to develop a tool that could be utilised to determine pelvic orientation from an AP x-ray. An algorithm based on comparing projections of a statistical shape model of the pelvis (n=20) with the target X-ray was developed in MATLAB. For each iteration, the average shape was adjusted, rotated (to account for patient-specific pelvic orientation), projected onto a 2D plane, and the simulated outline determined. With respect to rotation, the pelvis was allowed to rotate about its transverse axis (pelvic flexion/extension) and anterior-posterior axis (pelvic adduction/abduction). Minimum root mean square error between the outline of the pelvis from the X-ray and the projected shape model outline was used to select final values for flexion and adduction. To test the algorithm, virtual X-rays (n=6) of different pelvis in known orientations were created using the algorithm described by Freud et al.3The true pelvic orientation for each case was randomly generated. Angular error was defined as the difference between the true pelvic orientation and that selected by the algorithm. Initial testing has exhibited similar accuracy in determining true pelvic flexion ( Although the algorithm is still under development, the low mean, maximum, and standard deviations of error from initial testing indicate the approach is promising. Ongoing work will involve the use of additional landmarks for registration and training shapes to improve the shape model. This tool will allow surgeons to more accurately determine true acetabular orientation relative to the pelvis without the use of additional x-ray views or CT scans. In turn, this will help improve diagnoses of post-operative range of motion and dislocation stability.
The results of cementless total hip arthroplasty (THA) vary with data from the UK national Joint Registry being less favourable than that from the Australian registry. The senior author started using a fully cementless THA in 2005 and we aimed to gauge the performance of the implants based on their revision data. Between August 2005 and March 2015, 4,802 primary THA (4,309 patients) were performed with a cementless Corail® stem and a cementless Pinnacle® cup. There were 2,086 (43.4%) males and 2,716 (56.6%) females with a median age of 70 years (IQR 13, Range 16–95). There were a number of changes to the surgical technique with respect to the Corail® stem during the ten-year period, which we have categorised as phase 1 and phase 2. We compared the data in the two phases. Data were extracted from a prospectively maintained patient information database.Introduction
Patients and methods
To identify treatment effect modifiers within the STarT Back Trial which demonstrated prognostic stratified care was effective in comparison to standard care for patients with low back pain. Secondary analysis of the STarT Back Trial using 688 patients with available 4-month follow-up data. Disability (baseline and 4 months) was assessed using the Roland Morris Disability Questionnaire (RMDQ) using continuous and dichotomized (>7) outcome scores. Potential treatment effect modifiers were evaluated with group x predictor interaction terms using linear and logistic regression models. Modifiers included: age, gender, education, socio-economic status (SES), employment status, work satisfaction, episode duration, general health (SF-12), number of pain medications, and treatment expectations.Purpose and Background:
Methods:
Internet interventions provide an opportunity to encourage patients with LBP to self-manage and remain active, by tailoring advice and providing evidence-based support for increasing physical activity. This paper reports the development of the ‘SupportBack’ internet intervention, designed for use with usual primary care, as the first stage of a feasibility RCT currently underway comparing: usual primary care alone; usual care plus the internet intervention; usual care plus the internet intervention with physiotherapist telephone support. The internet intervention delivers a 6-week, tailored programme focused on graded goal setting, self-monitoring, and provision of tailored feedback to encourage physical activity/exercise increases or maintenance. 22 patients with back pain from primary care took part in ‘think aloud’ interviews, to qualitatively explore the intervention, provide feedback on its relevance and quality and identify any extraneous content or omissions.Background:
Methods:
Joint aspiration is a useful tool during preoperative workup in suspected periprosthetic infection. The aim of this study was to review efficacy of joint aspiration in our unit and compare results with the published literature. We undertook a retrospective review of 153 consecutive patients who underwent joint aspirations for suspected periprosthetic infection between 03/2011 and 10/2012 who were identified from the hospital electronic database. As per protocol, joint fluid was sent in an EDTA tube for cell count, Paediatric blood culture bottle and the remainder in a specimen pot. 105 (69%) were TKRs and 48 (31%) were THRs. Intraoperative samples were sent as per protocol in only 40 (26%) cases. The hit rate of positive cultures was 11/153 (7%) and specimens sent in paediatric culture bottles identified more positives than if it was omitted (10.5 Vs 5.5%). In conclusion, the hit rate of positive cultures is low in this study compared to the literature (7% Vs 33%) and this is likely due to blanket aspiration of all patients who are undergoing revision. In addition, specimens sent in paediatric culture bottles seem to identify more positives. We recommend cases are selected for aspiration according to AAOS guidelines.
