Aims

The objective of this systematic review was to describe trapeziectomy outcomes and complications in the context of osteoarthritis of the base of the thumb after a five-year minimum follow-up.

Purpose: Isolated tumours of the peripheral nerves are exceptional and benign in 90% of the cases. They develop from the constitutive elements of the nerve and correspond to schwannomas in 80% of cases. Other tumours are much more rare and exhibit wide histological variability.

Material and methods: Fifty-one patients were reviewed at mean 4.6 years. Forty-one had a resectable tumour: schwannoma (n=39), intranervous lipoma (n=2). Ten an unresectable tumour: solitary neurofibroma (n=5), peri-nervous hemangioma (n=3), neurofibrolipoma (n=2). We detailed the type of lesion, diagnostic elements, and results of complementary explorations. Enucleation was performed for resectable tumours. Epineurotomy for decompression with systematic interfascicular biopsy was performed in the event of an unresectable tumour.

Results: Postoperative neurological deficits were exceptional and transient. In a first case, prognosis was excellent due to the absence of recurrence or degeneration. In the second, neurological disorders persisted but decreased (paraesthesia). The course remained stable.

Discussion: Our findings are in line with reports in the literature. The diagnosis of nerve tumour should be entertained in the event of tumefaction along a nerve trajectory or if palpation triggers pain. MRI is the most powerful complementary exploration, particularly for deep tumours. The nature of the tumour, its benignity, and the possibility for resection can be suspected on the basis of clinical and complementary findings, but surgery and pathology examination of the surgical specimen are required for confirmation. Preservation of nerve continuity is the key to the therapeutic approach. For resectable tumours, exceptional persistence of symptoms should be followed by a new exploration to search for small unrecognised tumour(s) at the same operative site. For all other cases, recent and rapid changes in the clinical presentation is a sign of recurrence and requires appropriate intervention. To our knowledge, malignant degeneration has never been observed.

Conclusion: First-intention resection of a nerve with a nerve tumour is never indicated.

Solitary tumors of the peripheral nerves are uncommon and found to be benign in 90 p. 100 of the cases. They develop from the elements constituting the nerve and are generally schwannomas (80 p. 100). Other tumors are much more exceptional and exhibit wide histological variability.

The diagnosis of a tumor of the peripheral nerve must be envisaged for all cases with tumefaction or pain on the path of a nerve exacerbated at percussion. Magnetic resonance imaging is the preferred exploration technique, particularly useful in case of a deep tumor.

Preservation of nerve continuity is the underlying goal of the therapeutic strategy, irrespective of the type of tumor. Extricable tumors are to be distinguished from inextricable tumors. Extricable tumors (schwannomas, intranervous lipomas) displace nerve fiber bundles without penetrating into the bundle itself and can thus be resected without interrupting nerve continuity. Prognosis is excellent if no recurrence or degeneration occurs. In case of persistent symptoms, a new exploration may be required to search for other localized tumor(s) unperceived at the first procedure. Inextricable tumors (solitary neurofibromas, hemangiomas of the Schwann sheath, neurofibrolipomas) infiltrate the structural elements of the nerve fibers making complete excision impossible without altering the nerve fibers. Epineurotomy (associated with an interfascicular biopsy for pathology examination) allows decompression and can often provide symptom relief although moderate paresthesia may persist. Patients must be informed of this possibility prior to surgery. Any recent and rapidly evolving modification in the clinical findings is suggestive of recurrence and should be followed by revision exploration. Malignant degeneration has not been observed in solitary tumors to our knowledge. Our own experience with 51 cases is generally in agreement with reports in the literature.