National Institute of Clinical Excellence guidelines on Metastatic Spinal Cord Compression recommend urgent consideration of patients with spinal metastases and imaging evidence of structural spinal failure with spinal instability for surgery to stabilise the spine and prevent Metastatic Spinal Cord Compression. We aimed to compare neurological outcomes of patients managed operatively and non-operatively. Prospective collection of 397 patients' data over a 4-year period.

Males represented 59.2% of patients. Median age was 69 years. Non-operative intervention in 62.2% of patients. Prostate, lung, Breast, Myeloma, Renal Cell Carcinoma and Lymphoma accounted for over 75% of all primary tumours (n=305). Median Length of hospital stay was longer in the operative group of 15 days compared to 10 days in the non-operative group (p<0.0001). Patients who were ambulating on presentation maintained their ambulation in 70.2% of cases in the operative group compared to 90.9% in the non-operative group (p<0.0001). However, upon discharge 41% of patients managed operatively were ambulatory compared to the non-operative group rate of 36.5% (p<0.0001). In Prostate, Breast, Myeloma, RCC and Lymphoma 100% of patients managed non-operatively maintained ambulation. Lung primaries managed operatively had an 80% chance of maintaining ambulation compared to 76.9% in the non-operative group (p<0.05)

A higher proportion of patients managed non-operatively maintained ambulation than those managed operatively. With operative intervention, more patients regained ambulatory status. Whilst we have mainly focused on ambulatory status in this paper there are other factors to consider including pain relief and spinal stability which may be an indication for surgical intervention.

Bone grafting utilises tissue harvesting from second anatomic location of same patient (autograft) or from a human donor (allograft) to treat bone defects. Limited availability of bone grafts, donor site morbidity and risk of disease transmission led to an alternative strategy for bone grafting as synthetic materials that can promote bone regeneration. Engineered bone grafts are biocompatible and possess sufficient mechanical strength to support fractured bone. Polymer scaffolds lack mechanical stability whereas ceramic scaffolds are stiffer resulting in loosening of implants. Combining polymer and ceramic to form scaffolds can enhance the physical and mechanical properties and can be used for bone tissue engineering. We hypothesised that the nucleation of hydroxyapatite in carboxymethyl cellulose (CMC) matrix would improve scaffold properties physically and mechanically; thus, demonstrating CMC based biomimetic process to synthesise novel CMC/ HA scaffolds with suitable physical, mechanical and biological properties for bone tissue engineering.

CMC/ HA scaffolds were synthesized by in situmethod at room temperature (RT) and 60°C and are labelled as CHRT and CH60 respectively, keeping the molar ratio of Ca/P as constant ∼1.6. The nucleation of hydroxyapatite (HA) from calcium chloride (CaCl₂) and sodium dihydrogen phosphate (NaH₂PO₄) was initiated inside carboxymethyl cellulose (CMC). CaCl₂solution was introduced gently in aqueous solution of CMC, thereafter; NaH₂PO₄solution was added dropwise and the mixture was stirred vigorously, kept overnight for aging at RT to obtain milky white slurry. The slurry was washed with distilled water to neutralize, cast into moulds and dried in hot air oven for 72 h to obtain scaffolds. Scanning electron microscopy (SEM) was performed to determine the surface topography of the scaffolds. Mechanical properties were tested with Universal Testing Machine (UTM) and cytotoxicity was performed by MTT assay using fibroblast cells (NIH 3T3).

SEM images shows that HA aggregates like beads and knitted orderly over CMC backbone. There is an increase in HA agglomerates and decrease in bead size with increase in synthesis temperature from RT to 60°C. Scaffolds synthesized at 60°C show enhanced mechanical properties. Compressive strength of CHRT and CH60 are 0.68 MPa and 0.9 MPa respectively and compressive moduli of CHRT and CH60 are 33 MPa and 69 MPa respectively. MTT assay confirmed proliferation of fibroblast cells, hence; proved the non-toxic nature of the scaffolds. MTT assay reveals the cell viability (cell exoskeleton) on the scaffolds after 24 h incubation.

In this study, CMC/ HA scaffolds were synthesised by in situmethod at RT and 60°C. Enhanced mechanical properties and cytocompatibility reveal the potentiality of the scaffolds for bone tissue engineering purposes.

Aim

To evaluate the level of health resource utilisation by patients after lumbar total disc replacement (TDR) for mechanical low back pain.

Purpose

Prospectively evaluate the timescale of leg pain resolution after lumbar discectomy and decompression, in the immediate post-operative period and identify possible risk factors for failure/delay in leg pain resolution.

Aim

NICE guidance on lumbar total disc replacement (TDR) recommends ongoing audit should be an integral part of disc replacement surgery. We present our ongoing audit data and the extent of problem of patients lost to follow up.

Objective: Syrinx formation is estimated to occur in 20–25% patients after spinal cord injury. Aim of this study was to analyse the factors affecting the formation of post-traumatic syrinx.

Design: Retrospective study of 295 patients with spinal cord injury treated in a spinal injury centre with a minimum follow-up of two years since injury. Patient notes, x-rays and scans were reviewed.

Subjects: Two hundred and fifty-two men and 43 women were included in the study. The spinal injury was treated non-operatively in 172 (M 144, F28) patients and surgically in 123 (M 108, F 15) patients. Average age at the time of injury was 28.2 years. Mean follow-up was 6.4 years (2–34). There were 98 cervical, 134 thoracic and 73 lumbar and thoracolumbar injuries.

Outcome Measures: The incidence of post-traumatic syrinx in both groups and its relationship with level and type of skeletal injury, severity of spinal cord injury, sagittal angle at the injury level were assessed.

Results: In total 59 (20%) patients were identified with post-traumatic syrinx. Of the 123 patients managed operatively 15 (12.2%) had syrinx as did 44 (25.6%) of the 172 patients treated conservatively (p=0.001). Twenty-one (21.4%) cervical injuries, 29 (21.6%) thoracic injuries and nine (12.3%) lumbar injuries were found to have syrinx (p=0.023). Twenty-seven (46%) patients with syrinx had complete cord injury as did 130 (55%) patients who did not have syrinx (p=0.112). Fracture-dislocation was the injury most commonly associated with post-traumatic syrinx. Of the 40 `patients who had fracture dislocation as original injury, syrinx developed in 16 (40%). Eleven of the 18 patients with conservatively managed fracture dislocation, developed syrinx, compared to five of the 32 operatively treated fracture dislocations (p=0.0001). The mean sagittal angle at the level of injury was 25.2° in those syrinx formation, 20.4° in the conservatively treated patients without syrinx (p=0.1191) and 15.32° in the surgically treated patients without syrinx (p=0.016).

Conclusions: In a series of 295 patients, post-traumatic syrinx formation was found in 20% cases. It was significantly more common in patients treated conservatively, especially if the original injury was fracture dislocation. Syrinx formation was also significantly more common in cervical and thoracic cord injuries, but had no association with the completeness of cord injury. In the sagittal plane there was significantly more kyphotic deformity in those with syrinx formation.

Objective: To describe Sniff Nasal Inspiratory Pressure (SNIP) a new way of assessing the global respiratory function in scoliosis patients and explain it’s particular relevance in neuromuscular scoliosis. To correlate of SNIP with conventional lung function tests in scoliosis patients. To compare SNIP values between patients with neuromuscular and idiopathic scoliosis.

Design: A prospective observational study of 36 scoliosis patients. All patients underwent conventional lung function tests and SNIP during their pre-operative assessment. The SNIP values were correlated with FVC and FEV1 values obtained by spirometry. The SNIP values of those with neuromuscular scoliosis were compared to those with idiopathic scoliosis and also with the normative data of general population.

Subjects: Thirty-six patients (13M, 23F) with scoliosis. Of them, 17 (1M, 16F) had idiopathic scoliosis and 19 (12M, 7F) had neuromuscular scoliosis. The mean age was 16.5 years (7–54).

Outcome Measures: Comparison of the mean SNIP, FEV1, FVC and FEV1/FVC between the idiopathic and neuromuscular group. Assessing the degree of correlation between SNIP and spirometry data for all patients.

Results: Overall mean SNIP was 50.22 cm H₂O. Average SNIP in the neuromuscular group was 40.92±11.68 and 58.72±21.96 in the idiopathic group (p=0.0127). While the mean FEV1 (p=0.183), FVC (p=0.191) and FEV1/FVC (p=0.721) values were not significantly different between the two groups. The correlation coefficient for spirometry values and SNIP was −0.577 (mean x=−48.86, mean y=1.87) (p=0.0002), indicating very good correlation.

Conclusion: SNIP is the best measure of global inspiratory muscle strength and less subjective than spirometry. It is easier to administer to children. SNIP is better able to distinguish between idiopathic and neuromuscular scoliosis patients, than spirometry and shows good correlation with spirometry values. It can be a useful test in assessment and follow-up of breathing in neuromuscular scoliosis patients.

Introduction: Pelvic obliquity is a constant problem in neuromuscular scoliosis. Galveston and Luque L rod techniques are well described and achieve good correction of pelvic obliquity. We describe a sacral and iliac screw construct integrated with double-rod, pedicle screws and hook system, for correction of pelvic obliquity.

Method: 44 patients underwent posterior or combined anterior and posterior fusion to pelvis, for correction of neuromuscular scoliosis and pelvic obliquity. Average age at the time of surgery was 13.8 years. All patients were wheelchair-bound and nine of them were therapeutic walkers. Average follow-up was 44 months (range 24–69 months). Twenty-six patients had combined anterior and posterior surgery. All patients had posterior instrumentation to pelvis and 18 had anterior instrumentation as well. Eighteen patients had posterior instrumented fusion alone. Anterior instrumentation (when used) was Synergy and posterior instrumentation was Synergy or Colorado for all patients.

Result: Average time for surgery was 5 hours and 20 minutes and average blood loss 3600 ml. The average pre-operative Cobb angle was 69° and pelvic obliquity 23°. Post-operative average Cobb angle was 29° and pelvic obliquity 7.5°. At the latest follow-up the average Cobb angle was 36° and pelvic obliquity 10°. There were three deep wound infections. Two of the sacral screws have become prominent and two patients had de-linking of the iliac screw with the rod on one side. None showed significant loss of correction.

Conclusion: The sacraliliac screw construct with double rod segmental instrumentation achieved good correction of pelvic obliquity in patients with neuromuscular scoliosis. Implant related problems were infrequent

Background: The incidence of intra-spinal abnormality in congenital scoliosis is high. McMaster et al found an 18% incidence of myelographic abnormality in a series of 251 patients. Our objective was to report the MRI findings in a large series of patients with congenital scoliosis.

Method: The notes, X-rays and MRI of 126 congenital scoliosis patients were reviewed to note the vertebral abnormality, curve progression, MRI findings and the presence of non-spinal congenital abnormality. These findings were then correlated to detect any association between them.

Result: Forty-six patients (37%) had intra-spinal abnormalities detected on MRI. Sixty-six patients had failure of formation, 10 had failure of segmentation, 34 had mixed vertebral anomaly and 16 had congenital kyphosis or dislocation. MRI abnormality was significantly higher among patients with mixed anomaly (41%), congenital kyphosis (57%) and segmentation anomaly (40%) than those with failure of formation (29%). Presence of MRI abnormality did not correlate with curve progression or the presence of congenital abnormality affecting other organs.

Conclusion: Intra-spinal abnormality in congenital scoliosis occurred in 37% cases. The incidence of such abnormality is higher in patients with congenital kyphosis, failure of segmentation and mixed vertebral anomalies.

Background: Surgical treatments described for congenital spinal deformity are i) convex growth arrest, ii) posterior or combined anterior and posterior fusion and iii) hemivertebrectomy. Posterior instrumentation is used as an adjunct to fusion, whenever possible.

Anterior instrumentation for correction of congenital scoliosis has not been described. A preliminary report of the use of anterior instrumentation following hemi-vertebrectomy for correction of congenital spinal deformity is reported.

Method: 15 patients with congenital scoliosis and 5 patients with congenital kyphosis underwent hemiverte-brectomy and anterior instrumentation with fusion for single-stage correction of deformity . The average age of the patients at the time of surgery was 31 months and at last follow-up 59 months. All patients had pre-operative MRI. Twelve patients had normal and 8 had abnormal MRI. The average operating time was 135 minutes and average blood loss was 462 ml. Implants used were downsize Synergy, Orion Colorado and AO Cervifix.

Average sagittal Cobb angle for the scoliosis patients was 45.5° pre-operatively and 16.8° post-operatively. Average coronal Cobb angle in patients with congenital kyphosis was 61° pre-operatively and 21° postoperatively. At an average follow-up of 17 months, the correction is well maintained in all except one. This patient developed pseudarthrosis at 19 months post-operatively. This was treated with posterior instrumented fusion. There were no cases of neurologic compromise or deep wound infection.

Conclusion: Because of the young age at which hemiver-tebrectomy is performed in congenital scoliosis patients, instrumentation is difficult. Posterior instrumentation has been well described in literature. Our early experience with anterior instrumentation after hemivertebrectomy shows promising results with very good correction of the deformity and no increase in complication rate.

Objective: To assess the result of surgical stabilisation of spine in Spinal cord injured patients.

Design: Retrospective review of patients managed and followed at a spinal injury centre.

Subjects: Sixty-six patients with spinal cord injury, treated with surgical stabilisation of their spinal fracture and followed for a minimum of two years.

Outcome Measures: Delay in starting ambulation from injury/surgery, sagittal balance, metalwork failure and surgical complications.

Results: The mean age was 29.5 years (17–67), and five patients were female. The median follow up was 7.9 years (2–24). There were 19 cervical, 21 thoracic and 28 thoracolumbar and lumbar fractures. A total of 36 patients had over six weeks delay in starting ambulation. Of these 11 were due to inadequate fixation. Ten patients (50%) with cervical fracture and seven patients (25%) with lumbar fractures had normal lordosis. Significantly more patients with anterior cervical fixation had normal lordosis compared to those with posterior fixation. Nineteen with thoracic fracture had thoracic kyphosis within 40°. Nine patients had failure of metalwork. Surgical complications occurred in 21 (33%) patients.

Conclusion: Early ambulation was not achieved in the majority. The maintenance of lordosis was successful in cervical but not in lumbar spine. Posterior fixation of thoracic spine was successful in maintaining normal sagittal balance.

The aim of this study was to test the effectiveness of a nurse practitioner-led clinic for managing the pre and postoperative care of patients undergoing lumbar spine surgery, against traditional clinic treatment.

Ninety patients were randomised- 46 (Group 1) attended a nurse practitioner run pre-operative class and post-operative follow-up clinic and 44 (Group 2) were seen by the surgeon before and after the operation. All patients completed the Low Back Outcome Score, MSPQ and Zung score, pre-operatively and at six months post-op.

There were 46 male and 44 female patients, and mean age was 45.4 years (range 20–77). The two groups were demographically similar (p = 0.418). The mean pre-op outcome score was 23.49 in group 1 and 17.41 in group 2 (p = 0.038) and the mean post-op scores were 44.67 and 35.38 for group 1 and 2 respectively (p = 0.021). Intra-group comparison showed an improvement in post-op outcome score for all patients (p = 0.001), but those in group 1 were significantly more satisfied (p = 0.008). Four theatre slots were lost in group 2 but none in group 1.

A nurse practitioner-led pre-op counselling and post-op follow-up is more effective than the traditional clinic attendance for patients undergoing lumbar spine surgery and prevented waste of theatre time.