Introduction: Throughout known medical literature the proximal humeral fracture is mentioned with an approximately 5% contribution to all fractures. The optimal operative strategy regarding proximal humeral fractures is still being discussed controversely. This study was conducted to show implant associated problems and their clinical relevance.

Materials and methods: Of a total 198 patients with proximal humeral fractures 166 patients, 98 females and 68 males at a mean age of 74,7 years were treated operatively from 2000 to 2004 in our clinic with an angle-stabile plate osteosynthesis and underwent a clinical and radiological follow-up. Retrospectively we characterised the fractures by using the most common classification of NEER and assessed the functional results with the CONSTANT score.

Results: The 166 evaluated patients with 8 cases of a type I fracture, 13 patients with type II fracture, 34 patients with type III fracture, 47 cases with type IV fracture, 42 patients with type V fracture and 22 cases with type VI were all operatively treated with an angle-stabile plate osteosynthesis. 142 patients underwent early assisted physical therapy. Of all assessed patients the average CONSTANT score was 79,7 points. Among the 8 patients with type I fracture the average CONSTANT score was 84,4 points, among the 13 patients with type II fracture it reached an average 87,4 points. The average score of the 34 patients with type III fracture was 78,8 points. The more complex fractures, according to NEER’s classification, reached average scores of 71,2 points among the 47 cases with type IV fractures, 69,8 points (42 patients, type V) and 61,6 points (22 patients, type VI). The presence of avascular necrosis of the humeral head in 18 cases resulted in a significantly worse functional outcome and therefore a lower average score of 48,1 points. For 36 patients the follow-up revealed intraarticular dislocation of the proximal locking screws which required operative revision in 15 cases.

Conclusion: Even in the complex proximal humeral fracture one can achieve good clinical results for the patients by using an angle-stabile plate osteosynthesis and therefore establishing a secure and rigid situation for an optimized consecutive physical therapy, especially in the elderly. To prevent from intraarticular screw placement the proximal locking screws should be chosen shorter, if possible, then initially measured.

Introduction: Since the establishment of osteosynthesis as the treatment of choice for bone fractures, the issues relating to complications and their prophylaxis have become a major topic of scientific discussion and research in the field of traumatology. Infection of the bone and soft tissue represents one major complication that arises after the implantation of osteosynthetic material at the fracture site. The treatment of these infections is often time-consuming and involves repeated, extensive surgical interventions. The aim of this study was to acquire information about the effect of an antibacterial and biodegradable poly-L-lactide (PLLA) coated titanium plate osteosynthesis on local infection resistance.

Material and Methods: We compared infection rates in white New Zealand rabbits after titanium plate osteosynthesis of the tibia with or without antibacterial coating after local percutaneous bacterial inoculations at different concentrations (2x10⁵–2xlO⁸):

group I (n=12):uncoated titanium plate,

group II (n=12): PLLA coated titanium plate,

group III (n=12): titanium plate coated with PLLA + 3% Rifampicin and 7% Fusidic acid, group IV (n= 12): titanium plate coated with PLLA + 2% Octenidin und 8% Irgasan.

The plate, the contaminated soft tissues and the underlying bone were removed under sterile conditions after 28 days and quantitatively evaluated for bacterial growth. A stepwise experimental design with an “up-and-down” dosage technique was used to adjust the bacterial challenge in the area of the ID50 (50% infection dose). Statistical evaluation of the differences between the infection rates of both groups was performed using the two-sided Fisher exact test (p< 0.05).

Results: The overall infection rate was 50%. For group I and II the infection rate was both 83% (10 of 12 animals). In group III and IV with antibacterial coating the infection rate was both 17% (2 of 12 animals). The ID50 in the antibacterial coated groups III and IV was recorded as lxl10⁸ CFU, whereas the ID50 values in the groups I and II without antibacterial coating were a hundred times lower at lxl10⁶ CFU, respectively. The difference between the groups with and without antibacterial coating was statistically significant (p=0.033).

Conclusions: Using an antibacterial biodegradable PLLA coating on titanium plates, a significant reduction of infection rate in a canine infection model could be demonstrated. For the first time we were able to show, under standardized and reproducable conditions, that an antiseptic coating leads to the same reduction in infection rate as an antibiotic coating. Taking the problem of antibiotic-induced bacterial resistance into consideration, we thus regard the antiseptic coating, which shows the same level of effectiveness, as advantageous.

Introduction: Knee arthrodesis is a well-recognized salvage procedure in patients with septic destruction of the knee joint. If fusion can be achieved, it offers the opportunity for a stable lower limb and eradication of infection, but at the expense of knee motion. However, knee arthrodesis in this setting may be difficult to achieve because of poor bone stock, persistent infection and soft tissue compromise. In this study we present clinical and radiological results after knee fusion as well as an algorithm according to different surgical techniques (hybrid external fixator (HEF), antegrad compression nail (ACN) and modular cement less titanium rod (MCR)) and types of soft tissue damages and bone loss caused by infection

Patients and Methods: Between 10/2000 and 10/2002 in 37 patients knee arthrodesis was indicated after septic joint destruction. In 23 Pat. (67.0 y, 19.4–88,8 y) septic failure of total knee arthroplasty (TKA)caused severe bone loss and soft tissue damage. Because solid bony fusion was not to be expected weight bearing capability was restored by the use of MCR in a second stage procedure, using a PMMA Gentamycin spacer for eradication. In 14 Pat. (54.3 y, 23.l–87.7 y) remaining bone stock indicated direct fusion. In 10 of these cases HEF was used (6x primary joint infection, 3x septic failure of TKA, lx infected osteosynthesis). 2 pat. denied written consent for HEF, another 2 pat. had infected ipsilaterale midshaft femor-and/or tibia non unions. Because of these we used the ACN.

Results: In 5 pat. (21.7%) treated with MCR 1,4 revision procedures were indicated to eradicate infection before the implantation of MCR. Recurrence of infection after implantation occurred in 13% (n=3): 2 pat. were treated non surgically, lx amputation had to be done. No radiological signs for implant loosening were seen. HEF was removed after 15 weeks (12–18w) on average. 5 revision procedures were necessary in HEF cases (lx Pin-, lx ring exchange, lx sequestrectomy after pintractinfection,)- hi 2 cases the procedure was changed to MCR because of a non-union. Using the ACN we saw a 100% fusion rate, in one case the sinus tract persisted. The check up examinations were done 8,7 month (2,4–22,4mo) after arthrodesis procedure. 82,6% of pat. after MCR, 100% after HEF- and ACN-had full weight bearing capability. Eradication of infection was achieved in 86,9% (n=20) after MCR, in 70% (n=7) after HEF and in 75% (n=3) after ACN. In all 3 groups soft tissue reconstruction by flap surgery was indicated in 20%.

Conclusion: HEF is indicated when bone loss allows bony fusion. Failure occurred when bone defects were underestimated ort he fixator was removed before the 14th week. MCR can be used when eradication of infection is success and because of bone defects direct fusion is not possible. When eradication is not possible and bone stock makes the fusion reliable the ACN can be used under ongoing infection. ACN is also used when HEF is not recommended by the patient or because of mechanical reasons (floating knee).