Using flexible tethering techniques, porcine models of scoliosis have been previously described. These scoliotic curves showed vertebral wedging but very limited axial rotation. In some of these techniques, a persistent scoliotic deformity was found after tether release. The possibility to create severe progressive true scoliosis in a big animal model would be very useful for research purposes, including corrective therapies. The experimental ethics committee of the main institution provide the approval to conduct the study. Experimental study using a growing porcine model. Unilateral spinal bent rigid tether anchored to two ipsilateral pedicle screws was used to induce scoliosis on eight pigs. Five spinal segments were left between the instrumented pedicles. The spinal tether was removed after 8 weeks. Ten weeks later the animals were sacrificed. Conventional radiographs and 3D CT-scans of the specimens were taken to evaluate changes in the coronal and sagittal alignment of the thoracic spine. Fine-cut CT-scans were used to evaluate vertebral and disc wedging and axial rotation.Background
Methods
Gestational age was 1st trimester (3 cases), 2nd trimester (5 cases), 3rd trimester (5 cases). 10 women were treated surgically, 8 before finishing gestation. Gestation ended as and induced abortion (3 cases, 1 due to fetal death and 2 due to teratogenic risk), and birth (10 cases, all alive, 50% eutocic). Only 3 babies needed type II or type III neonatal reanimation.