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Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_IV | Pages 511 - 512
1 Nov 2011
Haumont T Lemaire A Méliani AB Henry C Beyaert C Journeau P Lascombes P
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Purpose of the study: Intramuscular injection of the botulinum toxin into the psoas can be proposed for permanent hip flexion due to spastic disorders. Several approaches have been described: retrograde subinguinal, anterolateral suprailiac, and posterior. Ultrasound or computed tomography can be used to guide needle position. These approaches are however limited to access to the L4 region, i.e. far from the motor points and with the risk of injury to the ureter. The purpose of this work was to determine the innervations of the psoas muscle that would be best adapted to this type of injection and thus to describe the most effective and reliable approach. Material and methods: This anatomy study included 20 dissections to: describe vertebral insertions of the psoas major and the psoas minor and to measure their distance from the iliac crest; define the region where the ureter crosses in front of the psoas. Results: More than 80% of the psoas muscles presented a proximal insertion on the transverse process of T12 and the body of L1; the mean length of the psoas in the adult is 27 cm above the inguinal ligament; the nerve roots collateral to the lumbar plexus are: 33% L2, 25% L3, 19% L1, 9% L4, 3% L5 and 1% T12, the remainder arising directly from the femoral nerve; the L2-L3 region is situated 4.6 cm on average above the iliac crest. Discussion: The region facing the L2-L3 space enables access to more than 50% of the psoas nerve branches. Injection via a posterior approach situated in adults 4.6 cm above the iliac crest and identified fluoroscopically is the most reliable access. This will avoid injury to the ureter which lies lower. Conclusion: This anatomy study described a new more effective less dangerous approach for botulinum toxin injections into the psoas muscle


Orthopaedic Proceedings
Vol. 103-B, Issue SUPP_16 | Pages 46 - 46
1 Dec 2021
Yarwood W Kumar KHS Ng KCG Khanduja V
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Abstract. Purpose. The aim of this study was to assess how biomechanical gait parameters (kinematics, kinetics, and muscle force estimations) differ between patients with camtype FAI and healthy controls, through a systematic search. Methods. A systematic review of the literature from PubMed, Scopus, and Medline and EMBASE via OVID SP was undertaken from inception to April 2020 using PRISMA guidelines. Studies that described kinematics, kinetics, and/or estimated muscle forces in cam-type FAI were identified and reviewed. Results. The search strategy identified 404 articles for evaluation. Removal of duplicates and screening of titles and abstracts resulted in full-text review of 37 articles with 12 meeting inclusion criteria. The 12 studies reported biomechanical data on a total of 173 cam-FAI (151 cam specific, 22 mixed type) patients and 177 healthy age, sex and BMI matched controls. Cam FAI patients had reduced hip sagittal plane ROM (Mean difference −3.00 0 [−4.10, −1.90], p<0.001), reduced hip peak extension angles (Mean Difference −2.05 0[−3.58, −0.53], p=0.008), reduced abduction angles in the terminal phase of stance, and reduced iliacus and psoas muscle force production in the terminal phase of stance compared to the control groups. Cam FAI cohorts walked at a slower speed compared to controls. Conclusions. In conclusion, patients with cam-type FAI exhibit altered sagittal and frontal plane kinematics as well as altered muscle force production during level gait compared to controls. These findings will help guide future research into gait alterations in FAI and how such alterations may contribute to pathological progression and furthermore, how such alterations can be modified for therapeutic benefit


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 58 - 58
1 Jan 2011
Doku K Tayar R Klosok J
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Purpose: to alert readers to the possibility of a ruptured abdominal aortic aneurysm presenting with femoral neuropathy and back pain. Method: Our patient presented with a short history of left leg weakness, numbness and back pain but was otherwise in a stable condition. An MR of his lumbar spine was initially performed on a 1T GE scanner and this was followed by an abdominal ultrasound scan and a spiral CT on a Siemen’s Somatom with reconstructions. Results: The MR unexpectedly demonstrated a large abdominal aortic aneurysm and swelling of the left psoas muscle. These features were observed easily as the saturation band was placed anterior to the retroperitoneum. Ultrasound confirmed these findings and the subsequent CT demonstrated precisely the point of rupture with contrast entering the left psoas muscle. Conclusion: Rupture of an abdominal aortic aneurysm may present to the orthopaedic team with back pain and femoral neuropathy. This demands a high index of suspicion as timely intervention saves lives


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_7 | Pages 30 - 30
1 Jul 2020
Faizan A Zhang J Scholl L
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Iliopsoas tendonitis after total hip arthroplasty (THA) can be a considerable cause of pain and patient dissatisfaction. The optimal cup position to avoid iliopsoas tendonitis has not been clearly established. Implant designs have also been developed with an anterior recess to avoid iliopsoas impingement. The purpose of this cadaveric study was to determine the effect of cup position and implant design on iliopsoas impingement. Bilateral THA was performed on three fresh frozen cadavers using oversized (jumbo) offset head center revision acetabular cups with an anterior recess (60, 62 and 66 mm diameter) and tapered wedge primary stems through a posterior approach. A 2mm diameter flexible stainless steel cable was inserted into the psoas tendon sheath between the muscle and the surrounding membrane to identify the location of the psoas muscle radiographically. CT scans of each cadaver were imported in an imaging software. The acetabular shells, cables as well as pelvis were segmented to create separate solid models of each. The offset head center shell was virtually replaced with an equivalent diameter hemispherical shell by overlaying the outer shell surfaces of both designs and keeping the faces of shells parallel. The shortest distance between each shell and cable was measured. To determine the influence of cup inclination and anteversion on psoas impingement, we virtually varied the inclination (30°/40°/50°) and anteversion (10°/20°/30°) angles for both shell designs. The CT analysis revealed that the original orientation (inclination/anteversion) of the shells implanted in 3 cadavers were as follows: Left1: 44.7°/23.3°, Right1: 41.7°/33.8°, Left2: 40/17, Right2: 31.7/23.5, Left3: 33/2908, Right3: 46.7/6.3. For the offset center shells, the shell to cable distance in all the above cases were positive indicating that there was clearance between the shells and psoas. For the hemispherical shells, in 3 out of 6 cases, the distance was negative indicating impingement of psoas. With the virtual implantation of both shell designs at orientations 40°/10°, 40°/20°, 40°/30° we found that greater anteversion helped decrease psoas impingement in both shell designs. When we analyzed the influence of inclination angle on psoas impingement by comparing wire distances for three orientations (30°/20°, 40°/20°, 50°/20°), we found that the effect was less pronounced. Further analysis comparing the offset head center shell to the conventional hemispherical shell revealed that the offset design was favored (greater clearance between the shell and the wire) in 17 out of 18 cases when the effect of anteversion was considered and in 15 out of 18 cases when the effect of inclinations was considered. Our results indicate that psoas impingement is related to both cup position and implant geometry. For an oversized jumbo cup, psoas impingement is reduced by greater anteversion while cup inclination has little effect. An offset head center cup with an anterior recess was effective in reducing psoas impingement in comparison to a conventional hemispherical geometry. In conclusion, adequate anteversion is important to avoid psoas impingement with jumbo acetabular shells and an implant with an anterior recess may further mitigate the risk of psoas impingement


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_4 | Pages 130 - 130
1 Apr 2019
Tamura K Takao M Hamada H Sakai T Sugano N
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Introduction. Most of patients with unilateral hip disease shows muscle volume atrophy of pelvis and thigh in the affected side because of pain and disuse, resulting in reduced muscle weakness and limping. However, it is unclear how the muscle atrophy correlated with muscle strength in the patient with hip disorders. A previous study have demonstrated that the volume of the gluteus medius correlated with the muscle strength by volumetric measurement using 3 dimensional computed tomography (3D-CT) data, however, muscles influence each other during motions and there is no reports focusing on the relationship between some major muscles of pelvis and thigh including gluteus maximus, gluteus medius, iliopsoas and quadriceps and muscle strength in several hip and knee motions. Therefore, the purpose of the present study is to evaluate the relationship between muscle volumetric atrophy of major muscles of pelvis and thigh and muscle strength in flexion, extension and abduction of hip joints and extension of knee joint before surgery in patients with unilateral hip disease. Material and Methods. The subjects were 38 patients with unilateral hip osteoarthritis, who underwent hip joint surgery. They all underwent preoperative computed tomography (CT) for preoperative planning. There were 6 males and 32 females with average age 59.5 years old. Before surgery, isometric muscle strength in hip flexion, hip extension, hip abduction and knee extension were measured using a hand held dynamometer (µTas F-1, ANIMA Japan). Major muscles including gluteus maximus, gluteus medius, iliopsoas and quadriceps were automatically extracted from the preoperative CT using convolutional neural networks (CNN) and were corrected manually by the experienced surgeon. The muscle volumetric atrophy ratio was defined as the ratio of muscle volume of the affected side to that of the unaffected side. The muscle weakness ratio was defined as the ratio of muscle strength of the affected side to that of the unaffected side. The correlation coefficient between the muscle atrophy ratio and the muscle weakness ratio of each muscle were calculated. Results. The average muscle atrophy ratio was 84.5% (63.5%–108.2%) in gluteus maximus, 86.6% (65.5%–112.1%) in gluteus medius, 81.0% (22.1%–130.8%) in psoas major, and 91.0% (63.8%–127.0%) in quadriceps. The average muscle strength ratio was 71.5% (0%–137.5%) in hip flexion, 88.1% (18.8%–169.6%) in hip abduction, 78.6% (21.9%–130.1%) in hip extension and 84.3% (13.1%–122.8%) in knee extension. The correlation coefficient between the muscle atrophy and the ratio of each muscle strength between the affected and unaffected side were shown in Table 1. Conclusion. In conclusion, the muscle atrophy of gluteus medius muscle, psoas major muscle and quadriceps muscle significantly correlated with the muscle weakness in hip flexion. The muscle atrophy of psoas major muscle and quadriceps muscle also significantly correlated with the muscle weakness in knee extension. There were no significant correlation between the muscle atrophy and the muscle weakness in hip extension and abduction


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_6 | Pages 12 - 12
1 Apr 2018
Lazennec J Kim Y Pour AE
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Introduction. Few studies are published about total hip arthroplasties (THA) in Parkinson's disease as it is often considered as a contraindication for hip replacement. THA for fracture is reported as a high complication rate surgery. Regarding bone quality these cases are assimilated to elderly patients and cemented implants are generally preferred. However, due to the improved length and quality of life, we face more potential indications for joint replacement. The aim of this study is to report our experience of cementless dual mobility implants for primary THAs for osteoarthrosis and THA revisions focusing on the risks and benefits of surgery. Material and methods. 65 THA were performed in 59 patients (34 men, 25 women, mean age 73 years, 55–79). Mean latest follow-up was 8,3 years (4–14). Indications were 42 primary THA (osteoarthrosis) and 21 revisions (11 recurrent dislocation, 6 acetabular PE wear, 4 femoral loosening). Surgical approach was always antero-lateral. All patients were implanted with the same dual mobility cementless cup. The same cementless corail-type stem was used for primary THA cases. All the cemenless implants were hydroxyapatite coated. The disability caused by the disease was classified according to Hoehn and Yahr. (19 stage 1, 21 stage 2,16 stage 3). Results. 2 patients were lost for follow-up before 2 years. general complications were 3 pulmonary infection, 7 urinary tract infection, 12 cognitive impairment and 2 sacral pressure ulcer. A post-op. wound infection (E Coli) required an early revision in 2 cases without secondary consequencies (7 and 9 years follow-up). We did not observe early or late THA dislocation except in one case at 9 years follow-up (intraprosthetic dislocation due to an increase of ilio psoas muscle retraction requiring a revision of the dual mobility mechanism). We did not observe loosening cases of the cementless cup. 4 patients fell and fractured the femur. The cementless cup was not affected. 10 patients died. Good to excellent pain relief was achieved in 53/57cases at 2 years and in 40/47 cases at latest follow-up. The progression of neurological disability was observed in most of cases. At the latest follow-up for the 47 remaining patients, we had 5 stage 1, 12 stage 2, 21 stage 3,9 stage 4. Discussion. According to literature infection and dislocation are the main concerns for THA in Parkinson patients. This study does not report any trauma cases; this may explain the rather good results on a mean follow-up to more than 8 years. Nevertheless progression of Parkinson's disease is the rule, with significant disability or even death (10 /57 cases). Cementless fixation is possible even on the acetabular side. The poor bone quality of these patients was not an argument against hydroxyapatite coated implants. Conclusion. THA in Parkinson's disease is a challenging surgery due to associated comorbidity. For all patients the functional status improved in the early follow-up and declined with the disease progression. Cementless dual mobility cups and femoral stems can be used with a very low rate of mechanical complication


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 40 - 40
1 Oct 2018
Faizan A Scholl L Zhang J Ries MD
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Introduction. Iliopsoas tendonitis after total hip arthroplasty (THA) can be a considerable cause of pain and patient dissatisfaction. The optimal cup position to avoid iliopsoas tendonitis has not been clearly established. Implant designs have also been developed with an anterior recess to avoid iliopsoas impingement. The purpose of this cadaveric study was to determine the effect of cup position and implant design on iliopsoas impingement. Materials. Bilateral THA was performed on three fresh frozen cadavers using oversized (jumbo) offset head center revision acetabular cups with an anterior recess (60, 62 and 66 mm diameter) and tapered wedge primary stems through a posterior approach. The relatively large shell sizes were chosen to simulate THA revision cases. At least one fixation screw was used with each shell. A 2mm diameter flexible stainless steel cable was inserted into the psoas tendon sheath between the muscle and the surrounding membrane to identify the location of the psoas muscle radiographically. Following the procedure, CT scans were performed on each cadaver. The CT images were imported in an imaging software for further analysis. The acetabular shells, cables as well as pelvis were segmented to create separate solid models of each. To compare the offset head center shell to a conventional hemispherical shell in the same orientation, the offset head center shell was virtually replaced with an equivalent diameter hemispherical shell by overlaying the outer shell surfaces of both designs and keeping the faces of shells parallel. enabled us to assess the relationship between the conventional shells and the cable. The shortest distance between each shell and cable was measured. To determine the influence of cup inclination and anteversion on psoas impingement, we virtually varied the inclination (30°/40°/50°) and anteversion (10°/20°/30°) angles for both shell designs. Results. The CT analysis revealed that the original orientation (inclination/anteversion) of the shells implanted in 3 cadavers were as follows: Left1: 44.7°/23.3°; Right1: 41.7°/33.8°; Left2: 40.0/17; Right2: 31.7/23.5; Left3: 33.0/2908; Right3: 46.7/6.3. For the offset center shells, the shell to cable distance in all the above cases were positive indicating that there was clearance between the shells and psoas. For the hemispherical shells, in 3 out of 6 cases, the distance was negative indicating impingement of psoas. With the virtual implantation of both shell designs at orientations 40°/10°, 40°/20°, 40°/30° we found that greater anteversion helped decrease psoas impingement in both shell designs. When we analyzed the influence of inclination angle on psoas impingement by comparing wire distances for three orientations (30°/20°, 40°/20°, 50°/20°), we found that the effect was less pronounced. Further analysis comparing the offset head center shell to the conventional hemispherical shell revealed that the offset design was favored (greater clearance between the shell and the wire) in 17 out of 18 cases when the effect of anteversion was considered and in 15 out of 18 cases when the effect of inclinations was considered. Discussion. Our results indicate that psoas impingement is related to both cup position and implant geometry. For an oversized jumbo cup, psoas impingement is reduced by greater anteversion while cup inclination has little effect. An offset head center cup with an anterior recess was effective in reducing psoas impingement in comparison to a conventional hemispherical geometry. In conclusion, adequate anteversion is important to avoid psoas impingement with jumbo acetabular shells and an implant with an anterior recess may further mitigate the risk of psoas impingement


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 478 - 478
1 Aug 2008
Roberts D Shanbhag V Coakley M Jones A Davies P Howes J Ahuja S
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Paravertebral anaesthesia is a particularly effective, safe and reliable option in scoliosis patients undergoing anterior release in whom percutaneous epidural placement may be difficult to perform. A recent systematic review and meta-analysis of randomized trials has demonstrated that whilst paravertebral block and thoracic epidural insertion provide comparable pain relief after thoracic surgery, paravertebral block placement is associated with a better side effect profile, including a reduction in pulmonary complications, hypotension, nausea and vomiting and urinary retention. We describe a case of a 16 year old female patient who underwent staged correction of her thoracolumbar scoliosis. A paravertebral catheter was inserted under direct vision for continuous infusion post operative analgesia following the anterior release. 48 hours after surgery a swelling was noted in the groin, which was confirmed with ultrasonography as a fluid collection. The swelling resolved upon removing the paravertebral catheter. This suggests that it was caused by the local anaesthetic fluid tracking along the psoas muscle. Retroperitoneal infections, venous thrombosis, femoral hernia, femoral artery aneurysm and inguinal lymphadenopathy are other differentials. Ultrasonography was a fast and sensitive investigation to rule out these differentials and determined that fluid communicating with the abdominal cavity was the cause for this swelling. The infused local anaesthetic had tracked down into the femoral triangle and the swelling resolved upon cessation of the infusion


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 336 - 336
1 Nov 2002
Bertagnoli R Ray CD Vazquez RJ
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Objective: To determine the success of the Anterior Lateral transPsoatic Approach (ALPA) for implanting the PDN disc nucleus prosthesis. Design: Eight patients were implanted with the PDN device via the ALPA technique. After making a 4cm incision in the lateral-abdominal area, the peritoneum was accessed and followed medially towards the lumbar spine, where a blunt-dissection technique through the psoas muscle was used to reach the disc. The anulus was then incised, and the nucleus material was removed before inserting the PDN device into the vacated disc cavity. Subjects: Five female and three male patients, all with moderate degenerative disc disease, were implanted. Average age was 44.5 years (+/− 8.3). Seven patients were implanted at L4–L5 and one at L2–L3. These eight subjects were followed for twelve months. Outcome measures: Improvements in Oswestry scores and disc-height measurements were considered indicative of implant success. Results: Oswestry scores improved from a preoperative mean of 33.8 (+/− 15.1) to a postoperative mean of 10.0 (+/− 11.1), and disc height increased from a preoperative mean of 8.6mm (+/−2.4) to 9.4mm (+/− 2.3) postoperatively. Conclusion: The ALPA technique facilitates implantation of the PDN device, with excellent clinical results


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 287 - 287
1 Nov 2002
Coldham G Gruber H Hanley E
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Introduction: Eighty percent of individuals experience low back pain in their lifetime. This is often due to disc injury or degeneration. Conservative treatment of discogenic pain is often unsuccessful whilst surgery with the use of spacers or fusion is non-physiological. Aim: To develop an animal model to assess the viability of autologous disc cell therapy. Methods: The fat sand rat (Psammomys obesus obesus) was chosen because of its predisposition to the early development of spondylosis. Using microsurgical techniques fragments of annulus and nucleus were harvested from a single disc in 50 sand rats. Vascular clips were placed on the adjacent psoas muscle to mark the harvested level. Disc material was initially cultured in a monolayer then transferred into a three-dimensional culture medium of agarose. This technique yields greater cellular proliferation and the development of cell growth in colonies. Cells were labelled with bromodeoxyuridine for later immunohistochemical identification. Twenty thousand cells in a carrier medium were then reimplanted at a second operation at an adjacent disc level in the same animal. The rat was subsequently sacrificed and the histology of the disc space was reviewed. Results: To date, 50 primary disc harvests and 30 reimplantations have been performed. Two rats died prior to reimplantation. All histological specimens confirmed the presence of viable transplanted disc cells. Conclusions: Autologous disc cell transplantation can be performed in the rat. Further modification of these techniques may lead to the development of autologous disc cell therapy comparable to that currently successfully used in hyaline cartilage defects of synovial joints in humans


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_III | Pages 255 - 255
1 Mar 2003
Gonzalez-Moran G Garcia-Duran C Albiñana J
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Pyomyositis in a temperate climate is a rare condition in children according the number of reports. Most authors postulate trauma with simultaneous bacteriemia is the most likely mechanism. We reviewed 8 cases, 4 boys and 4 girls. Their mean age was 9,2 y. ( 5 to 16 y.). Pain, tenderness, limp and fever were the most common signs. Duration of symptoms before initial evaluation was 8,1 d. (5 to 15 d.). 6 patients had fever (> 38,5°C), all had leukocytosis and a shift to the left in the WBC, and a elevated ESR 69,3 mm/h(32 to110), as well as an increased C-protein reactive (mean=10). All cases had radiographs, US in 6, CT scan in 6 and MRI in 5. These studies demonstrated involvement of psoas muscle in 4, obturator internus and externus in 3, and gluteal and quadratus femoris in 1. We found simultaneous involvement of ischiopubic ramus in 3, one iliac osteomyelitis, one piogenic sacro-ileitis, one supurative lymphadenitis and one resection for Crohn’s disease. Incision and drainage of muscular abcess (5 cases)plus IV antibiotics(8 cases) provided uneventfully resolution. 4 cultures were positive to Staf Aureus, 1 to E. Coli and 3 negatives. In this series we found 87% of pelvic pyomyositis with simultaneous septic factors. We consider them more causative factors than predisponing, and pyomyositis as a secondary entity. Previous reports propose pyomyo-sitis as a primary condition after a speculative bacter-aemia with a muscle strain, as the likeliest cause. MRI could be helpful to determine bone involvement or other regional problems in pelvic pyomyositis


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_II | Pages 313 - 313
1 Jul 2008
Komarasamy B Vadivelu R Kershaw C
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Background: Internal snapping often resolves with conservative treatment but persistent significant symptoms may require surgical treatment. Different approaches and treatments have been suggested in the literature with weakness of hip flexion, recurrence of symptoms and nerve injury following surgery. We describe a modified surgical approach for internal snapping of hip in adults with good results. Methods: Patients who failed conservative treatment for internal snapping between September 02 to February 04 were included. All patients had x-rays of relevant hips; ultrasound and MRI were done when required to exclude other causes. Patients were operated in supine position. A skin crease incision was made just lateral to the ASIS. The psoas tendon was reached sub-periosteally along the internal iliac surface hooked into the wound and divided releasing its musculo-tendonous junction. The patients were allowed to mobilise as able in the postoperative period. Results: There were 8 snapping hips (3 right, 3 left, 1 bilateral) in 7 patients (6 females, 1 male) with average age of 30 years (17–51 yrs). The mean follow was 11 months. The average duration of symptoms before operation was 4.5 years (range 2–10 years). Clicking was relieved in all patients. Two patients felt slight weakness of hip flexion. One patient had temporary neuropraxia of lateral cutaneous nerve of thigh. Discussion: The diagnosis is made by ultrasound or examination for a palpable click. Surgical correction of snapping is considered after failure of conservative treatment. Different extra pelvic (medial and iliofemoral) and intrapelvic extraperitoneal approaches have been described with varying results. With our slightly modified intrapelvic and sub-periosteal approach through oblique inguinal incision in adults, psoas muscle release at musculo-tendonous junction seems safe and effective (all clicking resolved) method. This method could be used as an alternative surgical approach for treatment of internal snapping of hip in adults


Orthopaedic Proceedings
Vol. 86-B, Issue SUPP_III | Pages 211 - 211
1 Mar 2004
Hirvensalo E Lindahl J
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Since 1989 we have treated most rotationally or vertically unstable pelvic fractures operatively. An anterior extra peritoneal approach has been used to achieve access to all parts of the anterior ring. This can be combined with the lateral approach on the iliac wing or with posterior approach for the SI and sacral lesions. The extra peritoneal midline approach is created through a 10–15 cm long midline incision beginning from the symphysis. The rectus muscles are not detached. Blunt preparation along the superior ramus gives more space laterally and reveals the obturator foramen. The corona mortis vessels are ligated. The iliac vessels, femoral nerve and the psoas muscle can be gentle elevated with a long hook. The eminential area, linea terminalis as well as the quadrilateral space are then visualised. All essential fragments can be reduced and fixed with plates and screws. Our study of 101 patients with an unstable pelvic ring (68 rotationally and vertically unstable injuries, 21 lateral compression injuries and 12 open book injuries) showed excellent or good reduction in 88, fair in 11 and poor in 2 cases. The overall functional results were excellent or good in 83, fair in 13 and poor in 5 patients. The correlation between anatomical reduction and good functional result was clear. Our experience and new data strongly support the use of ORIF in Type C pelvic ring injuries, in Type B- open book injuries, and in markedly displaced Type-B lateral compression injuries. Good reduction and a reliable stability can be achieved. Moreover, short postoperative morbidity and hospital stay as well as full weight bearing after 4 to 8 weeks resulted after adopting ORIF in pelvic fractures. External fixation is still used by us as a temporary bleeding control device before the final operative treatment when the bleeding is considered significant


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 348 - 348
1 Nov 2002
Coldham G Gruber H Hanley E
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Purpose/introduction: 80% of individuals experience low back pain in their lifetime. This is often due to disc injury or degeneration. Conservative treatment of discogenic pain is often unsuccessful whilst surgery with the use of spacers of fusion is non-physiological. The aim of this study was to develop an animal model to assess the viability of autologous disc cell therapy. Method: The Fat Sand Rat (Psammomys obesus obesus) was chosen due to its predisposition to the early development of spondylosis. Using microsurgical techniques fragments of annulus and nucleus were harvested from a single disc in 52 sand rats. Vascular clips were placed on the adjacent psoas muscle to mark the harvested level. Disc material was initially cultured in monolayer then transferred into a three dimensional culture media of agarose. This technique yields greater cellular proliferation and the development of cell growth in colonies. Cells were labelled with Bromodeoxyuridine for later immunohistochemical identification. 20 000 cells in a carrier media were then re-implanted at a second operation at an adjacent disc level in the same animal. The rat was subsequently euthanised and the histology of the disc space reviewed. Results: To date 52 primary disc harvests and 20 reimplantations have been performed. 15 rats have been euthanised and sectioned. Average age at primary surgery was 6.8 months reimplantation eight months and euthanisation 11.2 months. Cell colony viability was inversely related to rat age at harvest. Immunohistochemical analysis of colony extracellular matrix revealed production of type 1 and 2 collagen, chondroitin and keratin sulphate Two rats died prior to reimplantation. All histological specimens confirm the presence of viable transplanted disc cells. Transplanted cells did not alter the progression of degenerative changes on x-ray. Conclusion: Autologous disc cell transplantation can be performed in the rat. Further modification of these techniques may lead to the development of autologous disc cell therapy comparable to that currently successfully used in hyaline cartilage defects of synovial joints in humans


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_I | Pages - 18
1 Mar 2002
Pfeiffer M Wilke A Goetz W Chaparro F Coetzee E Griss P
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Anatomisches Institut der Georg-August-Universität Göttingen, Germany. Biomedical Research Centre, Dept. of Orthopaedic Surgery, Academic Hospital, Pretoria, South Africa. To date, no animal model for disc degeneration has gained much acceptance, mostly due to the fact that most animals are quadrupeds and thus lack basic biomechanical characteristics of human spines. An adequate model would be of invaluable interest for degeneration related research. In a standardized series of animal experiments in 18 adult Minipigs and 20 adult Cercopithecus aethiops monkeys all animals obtained nucleotomy in one lumbar FSU from a ret-roperitoneal approach and were sacrificed at last 24 weeks afterwards. The Minipigs were x-rayed at time of sacrifice, the monkeys prior to operation and at termination of the experiment. Vice versa, the Minipigs obtained intradiscal pressure recordings at these occasions. The Minipig spines were formol fixed whereas the monkey spines were harvested after perfusion with PBS, fresh frozen, and obtained CT and MRI scans prior to thawing, fixation and comprehensive histological evaluation. The lumbar FSU of Minipig and Cercopithecus mainly consists of the same elements as in man. There are certain differences concerning the porcine endplates which ossify as an epiphyseal-like formation with ossification starting in its center, different from the so-called “Randleiste”. Whereas the operative procedure in the Minipigs came in handy, in the Cercopithecus monkey it proved to be demanding, though feasible, due to relatively wide transverse processes and thick psoas muscle structures. The psoas could not be easily detached and needed to be split instead, thus directly exposing the segment nerves. The histological, standard radiological, CT, MRI, and mechanical observations were very similar to those which can be made during the natural aging process of the disc in man. Both animal models are recommendable for further research: Cercopithecus FSUs are more difficult to expose. Logistic reasons may favour Minipigs in Europe. In case of fusion related experiments the use of primates yet seems inevitable


Orthopaedic Proceedings
Vol. 85-B, Issue SUPP_I | Pages 31 - 31
1 Jan 2003
Takemitsu M Takemitsu Y Matsuno T Atsuta Y Kobayashi T Iwahara T Kamo Y
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Lumbar Degenerative Kyphosis (LDK) is a clinical entity showing kyphosis in the lumbar spine in elderly with multilevel disc narrowing and a varied degree of osteoporosis. LDK patient complains of stooped gait with persistent low back pain and weakness. Purpose of this paper is to study the lumbar muscle in LDK patients with histopathologic and biophysical evaluations to investigate the pathogenesis. Materials and Methods: 1. Intramuscular pressure (IMP) (a) of the lumbar extensor compartment and hemoglobin content (Hb)□@(b) of 25 young volunteers were also investigated comparing in standing upright and flexion positions using (a)□@pressure monitoring kits and an non-invasive oxygenation monitor. 2.Muscle biopsy specimens obtained from the lumbar extensors of 9 LDK patients were histopathologically examined with HE, cytochrome c oxidase and other methods. These data were compared with muscles taken from age-match controls. Mitochondria function was also examined on biochemistry. 1. IMP of the extensors markedly increased in the flexion position (130.0□}45.4 in males and 86.3 mmHg in fem.) comparing to straight upright□@(22.8□}14.4, 17.0□}6.0). Oxy-Hb concentration decreased from 100% to 92.9, 95.5 % respectively in flexion, which was a sign of ischemia. 2. Both multifidus and sacrospinalis m. showed moderate to marked interstitial fibrosis, decreased number of muscle fibers and decreased stain intensity of cytochrome c oxidase. These finding were similar to those seen in repeatedly compressed muscles of an animal model of the chronic compartment syndrome. In comparison the rectus abd. and psoas muscles in the patients showed almost normal except for some aging changes. Conclusion: There appeared to be definite atrophy of the lumbar extensor muscles with histochemical and biochemical methods in LDK patients, whereas the flexors showed no change. This extensor atrophy is limited in the lumbar region in LDK. These localized atrophy of the lumbar extensors would suggest a result of high IMP during working in deep bending position of the spine for many years and may play important role in etiology of this disease condition


Orthopaedic Proceedings
Vol. 87-B, Issue SUPP_III | Pages 405 - 405
1 Sep 2005
Brau S
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Introduction Based on 27 years of peripheral vascular surgery practice and 21 years of experience in performing anterior lumbar spine approaches the author will make recommendations for management of the more common complications of the approach to the lumbar spine. Methods A database of 2020 cases performed since August of 1997 has been evaluated to determine the best way to manage the complications of the approach encountered in that time period. Results 6 patients had left iliac artery thrombosis (0.29%) and 24 had major vein lacerations (1.1%). Two patients developed compartment syndrome and two other patients required arterial reconstruction. One of the patients had ureteral injury. None of the patients had retrograde ejaculation, lymphoedema, bowel injury or neurological injury. Left iliac artery thrombosis is best managed by immediate thrombectomy using balloon catheters, either via the main incision of via a left femoral incision. The diagnosis is clinical and the patient should not be taken to the radiology department for diagnostic angiography. Avoidance of delay is important in preventing compartment syndrome. If ischemia is present for 4 hours or more a prophylactic fasciotomy may be indicated. For patients with intimal disruption or atherosclerosis, in whom thrombectomy fails, arterial reconstruction or stenting may be necessary and is best left to a vascular surgeon. Venous lacerations can be repaired using 5-0 monofilament sutures. Lacerations of 5mm or less that are not easily accessible can be treated with hemostatic agents and pressure. For major disruptions of the iliac veins or inferior vena cava ligation of these vessels is an acceptable option. Proximal and distal control of vessels during exposure is not necessary and may actually lead to a higher incidence of arterial thrombosis. Control of bleeding can usually be obtained by pressure with sponge sticks or balloon catheters. The sympathetic fibres run with the peritoneum and retrograde ejaculation can be avoided by carefully elevating the peritoneum away from the promontory with blunt dissection while exposing L5-S1. The ureter similarly runs with the peritoneum and should be lifted away with it to prevent devascularization. Lymphedema is due to the disruption of the lymphatics while mobilising the iliac vessels. It is very rare and unavoidable. Injury to the genito-femoral nerve is avoided by identifying it over the psoas muscle and preserving it from injury. Bowel injury is prevented by staying retroperitoneal. Discussion Anterior exposure to the lumbar spine carries with it a low complication rate, but these complications can have significant negative results. Prompt recognition and management of these complications will result in lower overall morbidity


Orthopaedic Proceedings
Vol. 84-B, Issue SUPP_III | Pages 346 - 346
1 Nov 2002
Sears W
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Introduction: The management of patients with thoracolumbar burst fractures has evolved over the last 60 years from the days of conservative management through to the current era of anterior decompression combined with either anterior or posterior stabilisation. There is no doubt that surgical outcomes have improved markedly with the more modern techniques. Nevertheless, there are still technical and other difficulties, which the surgeon may encounter. Based upon his experience with posterior vertebrectomy and reconstruction for thoracolumbar tumours, the author has used this technique for the management of acute burst fractures in this region. This paper presents a review of 10 patients with severe thoracolumbar burst fracture or fracture dislocation managed since 1997, using a single stage posterior decompression, realignment and stabilisation/interbody fusion. Methods: Data were acquired prospectively on consecutive patients between June 1997 and October 2000. All patients underwent single stage posterior decompression via laminectomy and then a subtotal eggshell vertebrectomy with removal of any herniated bone fragment(s) or partial vertebrectomy/ pedicle subtraction osteotomy. Pedicle screw stabilisation was performed to include one or two vertebrae above and below the involved vertebra(e). The intervertebral discs adjacent to the fractured vertebra were removed prior to realigning the vertebral column and performing inter-body fusion using carbon fibre spacers and autograft (4 patients) or vertebral body reconstruction with Titanium mesh cages and autograft (6 patients). Results: The mean age was 37 years (21–52 years). There were six males and four females. Three patients had no neurological deficit. Seven had incomplete paraplegia, three of which were severe with no or only a flicker of leg movement. The principal fracture involved L1 in 6 patients, L2 in 2, L4 in 1 and L5 in 1. Seven had herniated bone fragments occupying 90+% of the spinal canal. Of the seven patients with incomplete paraplegia, all recovered the ability to walk. Two with conus lesions still self catheterize. There were no serious early complications. A serious late complication was the development at three months of a severe deep wound infection, which required debridement and subsequent anterior/ posterior revision surgery. One patient with severe polytrauma and an L4 burst fracture/dislocation has developed a chronic pain syndrome. Discussion: The decompression, realignment, interbody reconstruction and stabilisation of thoracolumbar burst fractures/dislocations using a single stage posterior technique is technically demanding but the neurological outcome and restoration of spinal balance in these 10 patients was gratifying. The procedure appears to have two advantages over an anterior decompression and reconstruction combined with anterior or posterior stabilisation: first, it appears to provide easier access and improved visualisation for lumbar burst fractures where the psoas muscle may be swollen and contused, and second, it allows for easier realignment of any coronal or sagittal deformity


The Bone & Joint Journal
Vol. 103-B, Issue 2 | Pages 234 - 244
1 Feb 2021
Gibb BP Hadjiargyrou M

Antibiotic resistance represents a threat to human health. It has been suggested that by 2050, antibiotic-resistant infections could cause ten million deaths each year. In orthopaedics, many patients undergoing surgery suffer from complications resulting from implant-associated infection. In these circumstances secondary surgery is usually required and chronic and/or relapsing disease may ensue. The development of effective treatments for antibiotic-resistant infections is needed. Recent evidence shows that bacteriophage (phages; viruses that infect bacteria) therapy may represent a viable and successful solution. In this review, a brief description of bone and joint infection and the nature of bacteriophages is presented, as well as a summary of our current knowledge on the use of bacteriophages in the treatment of bacterial infections. We present contemporary published in vitro and in vivo data as well as data from clinical trials, as they relate to bone and joint infections. We discuss the potential use of bacteriophage therapy in orthopaedic infections. This area of research is beginning to reveal successful results, but mostly in nonorthopaedic fields. We believe that bacteriophage therapy has potential therapeutic value for implant-associated infections in orthopaedics.

Cite this article: Bone Joint J 2021;103-B(2):234–244.