Aims. The aim of this study was to evaluate the cost-effectiveness of arthroscopic partial meniscectomy versus physical therapy plus optional delayed arthroscopic partial meniscectomy in young patients aged under 45 years with traumatic meniscal tears. Methods. We conducted a multicentre, open-labelled, randomized controlled trial in patients aged 18 to 45 years, with a recent onset, traumatic, MRI-verified, isolated meniscal tear without knee osteoarthritis. Patients were randomized to arthroscopic partial meniscectomy or standardized physical therapy with an optional delayed arthroscopic partial meniscectomy after three months of follow-up. We performed a cost-utility analysis on the randomization groups to compare both treatments over a 24-month follow-up period. Cost utility was calculated as incremental costs per quality-adjusted life year (QALY) gained of arthroscopic partial meniscectomy compared to physical therapy. Calculations were performed from a healthcare system perspective and a societal perspective. Results. A total of 100 patients were included: 49 were randomized to arthroscopic partial meniscectomy and 51 to physical therapy. In the physical therapy group, 21 patients (41%) received delayed arthroscopic partial meniscectomy during follow-up. Over 24 months, patients in the arthroscopic partial meniscectomy group had a mean 0.005 QALYs lower quality of life (95% confidence interval -0.13 to 0.14). The cost-utility ratio was €-160,000/QALY from the healthcare perspective and €-223,372/QALY from the societal perspective, indicating that arthroscopic partial meniscectomy incurs additional costs without any added health benefit. Conclusion. Arthroscopic partial meniscectomy is arthroscopic partial meniscectomy is unlikely to be cost-effective in treating young patients with isolated traumatic meniscal tears compared to physical therapy as a primary health intervention. Arthroscopic partial meniscectomy leads to a similar quality of life, but higher costs, compared to physical therapy plus optional delayed arthroscopic partial meniscectomy. Cite this article: Bone Joint J 2023;105-B(11):1177–1183

Partial meniscectomy patients have a greater likelihood for the development of early osteoarthritis (OA). To prevent the onset of early OA, patient-specific treatment algorithms need to be created that predict patient risk to early OA after meniscectomy. The aim of this work was to identify patient-specific risk factors in partial meniscectomy patients that could potentially lead to early OA. Partial meniscectomy patients operated between 01/2017 and 12/2019 were evaluated in the study (n=317). Exclusion criteria were other pathologies or surgeries for the evaluated knee and meniscus (n = 114). Following informed consent, an online questionnaire containing demographics and the “Knee Injury and Osteoarthritis Outcome Score” (KOOS) questionnaire was sent to the patient. Based on the KOOS pain score, patients were classified into “low” (> 75) and “high” (< 75) risk patients, indicating risk to symptomatic OA. The “high risk” patients also underwent a follow-up including an MRI scan to understand whether they have developed early OA. From 203 participants, 96 patients responded to the questionnaire (116 did not respond) with 61 patients considered “low-risk” and 35 “high-risk” patients. Groups that showed a significant increased risk for OA were patients aged > 40 years, females, overweight (BMI >25 kg/m2 ≤ 30 kg/m2), and smokers (*p < 0.05). The “high-risk”-follow-up revealed a progression of early osteoarthritic cartilage changes in seven patients, with the remaining nineteen patients showing no changes in cartilage status or pain since time of operation. Additionally, eighteen patients in the high-risk group showed a varus or valgus axis deviation. Patient-specific factors for worse postoperative outcomes after partial meniscectomy and indicators for an “early OA” development were identified, providing the basis for a patient-specific treatment approach. Further analysis in a multicentre study and computational analysis of MRI scans is ongoing to develop a patient-specific treatment algorithm for meniscectomy patients

Introduction. Partial meniscectomy, a surgical treatment for meniscal lesions, allows athletes to return to sporting activities within two weeks. However, this increases knee joint shear stress, which is reported to cause osteoarthritis. The volumes and locations of partial meniscectomy that would result in a substantial increase in knee joint stress is not known. This information could inform surgeons when a meniscus reconstruction is required. Aim. Our aim was to use a previously validated knee finite element (FE) model to predict the effects of different volumes and locations of partial meniscectomy on cartilage shear stress. The functional point of interest was at the end of weight acceptance in walking and running, when the knee is subjected to maximum loading. Method. An FE model of the knee joint was used to simulate walking and running, two of the most common functional activities. Forces and moments, obtained from the gait cycle of a 76.4 kg male subject, were applied at the tibia. Different sizes (0%, 10%, 30%, 60%) and locations (anterior, medial and posterior) of partial meniscectomies were simulated (Figure 1). Maximum cartilage shear stress was determined for the different meniscectomies. Graphs were plotted of the cumulative tibial cartilage volume subjected to stress values above specific thresholds. Results and analysis. Maximum shear stress values for the intact knee during walking were 2.00 MPa medially and 1.71 MPa laterally. During running these magnitudes rose to 3.48 MPa medially and 4.70 MPa laterally. For a 30% anterior, central and posterior meniscectomy during walking shear stress increased by 25.9%, 44.9% and 32.5% medially, and 12.4%, 25.7% and 17.8% laterally. During running shear stress increased by 9.6%, 8.3% and 7.1%, medially and 31.6%, 37.5% and 43.6% laterally. For a 60% meniscectomy, during walking shear stress increased by 47.2% medially and 31.8%, laterally. During running shear stress increased by 10.0%, medially and 51.8%, laterally. The percentage of cartilage volume exposed to shear stress levels above a specified threshold is illustrated in Figure 2 for different volumes and locations of partial meniscectomy. Discussion and conclusions. This is first study that has estimated the volume of cartilage exposed to specific stress thresholds in walking and running as a function of the amount and location of meniscectomy. Maximum shear stress was 100% higher at the end of weight acceptance in running compared to walking. Stress was higher in the lateral compartment during running while higher in the medial compartment during walking. This is because a valgus moment acts at the knee at the end of weight acceptance in running while a varus moment acts at the joint in walking. Clinical significance. The model developed from this research has potential for applications in planning meniscal surgeries and developing rehabilitation strategies for athletes. It could inform surgeons about the safe volume and location of partial meniscectomy that can be performed before meniscus reconstruction becomes necessary. Results of this study also highlight the importance of considering the effect of post-surgical outcomes following different common functional activities

Objectives: Partial meniscectomy is the current standard of care for torn menisci not suitable for repair. Arthroscopic partial meniscectomy is the most commonly performed orthopaedic surgical procedure. The purpose of this study was to determine what specific factors influence longevity of improvements in function and activity levels following arthroscopic partial meniscectomy. Methods: Six hundred forty (640) knees which had undergone isolated partial meniscectomy were identified from a clinical database. One hundred ninety-three (193) knees had partial lateral meniscectomy, 342 had partial medial meniscectomy, and 105 had partial medial and lateral meniscectomy. Average age was 52 years (range, 15 to 79) with 207 females and 433 males. Patients were excluded if they had concurrent ACL reconstructions or microfracture for chondral defects. Lysholm function and Tegner activity scores were collected for a minimum of 8 years after the index partial meniscectomy. Results: For all knees, Lysholm scores improved significantly from preoperative (54) to 1 year postoperative (76) (p< 0.001). Lysholm scores did not change from year 1 to year 5. At year 6, average Lysholm score decreased to 69, and by year 8, the score decreased further to 63. When comparing degenerative knees to non-degenerative knees, the non-degenerative group had greater improvement and maintained it longer. Medial meniscus patients maintained their improvement at 6 and 7 years while the lateral meniscus group showed less improvement and decreased at years 6 and 7. Anatomic location of meniscus tear (anterior, middle or posterior thirds) was not associated with changes in improvement of Lysholm or Tegner scores. Tegner activity levels improved significantly from preoperative (3.6) to 1 year postoperative (4.7) (p< 0.001). This improvement was maintained at years 2, 3, and 4. There was no significant difference between preoperative Tegner and year-5 Tegner scores (4.0) (p> 0.05). This same finding was also seen at years 6, 7, and 8. In degenerative knees, there was less improvement, and levels declined at years 6, 7, and 8. Conclusions: Patients who undergo partial meniscectomy can expect 4 to 5 years of improved function and activity levels. Knee function continues to improve up to 5 years, but it decreases as activity levels decrease. Patients who delay treatment or have degenerative changes experience a decrease in function and activity levels sooner. Meniscectomy provides a short term improvement in function and activity levels, but long term improvement seems unlikely. Our findings confirm that specific factors such as which meniscus (medial or lateral) undergoes meniscectomy, chronicity of the tear, and preexisting degenerative changes might be expected to influence longevity of improvements after partial meniscectomy

Objective: Various tear types and patterns of meniscus injuries have been described. We record meniscus tear type and pattern in a standard manner for every knee arthroscopy in our database of more than 17,000 knee surgeries. We determined if meniscus tear type and pattern correlate with function and activity levels at least two years after partial meniscectomy. Methods: Two hundred six (206) patients underwent partial medial meniscectomy and 117 underwent partial lateral meniscectomy by a single surgeon (average age=49 years; range, 18 to 80). At index surgery, the type and pattern of meniscus tear was recorded. Tears were designated as bucket handle/vertical longitudinal (BV), flap/radial (FR), or complex (CH) which includes horizontal cleavage tears. Patients not in neutral or near-neutral alignment and those undergoing concurrent procedures for microfracture or ACL reconstruction were excluded. Patients were followed for a minimum of two years (average=4.6 yrs) after partial meniscectomy. Patients completed questionnaires including Lysholm and Tegner scores to assess function and activity. Results: For the medial meniscus, there was significant correlation between tear type and patient age. The BV lesion group (n=35) was significantly younger (41 years) than the FR (n=65) (50 years) and CH (n=193) (53 years) groups (p=0.01). The BV group had significantly higher Lysholm (89) scores versus FR (80) and CH (77) (p=0.04). The BV group also had higher Tegner activity levels (5.8) than FR (4.6) and CH (4.5) (p=0.04). For lateral meniscus, the BV (n=15) (40 years) and FR (n=37) (48 years) groups were significantly younger than the CH group (n=45) (56 years); p=0.03. FR patients had higher Lysholm and Tegner scores, but not significantly different. Twenty-five percent (25%) of BV medial meniscus tears required further surgery while less than 15% of other types of medial or lateral tears required further surgery. Average time to second surgery for all patients was 2.4 years, with medial being 2.6 years and lateral being 1.5 years. Conclusions: In this series, BV medial meniscus tears had better function and activity levels at least two years post-meniscectomy, perhaps due to younger age. This group also required more reoperations during the first two years after index meniscectomy than any other group, perhaps as a result of higher activity levels. Overall, partial lateral meniscectomy patients required reoperation sooner than medial meniscectomies. Tear type did not significantly influence outcomes after lateral meniscectomy. Therefore, meniscus tear type and pattern correlated with function and activity levels for medial but not lateral > 2 years after partial meniscectomy

Objective: Lysholm and Tegner scores have been validated to assess outcomes of meniscus surgery. We prospectively determined Lysholm scores for function and calculated Tegner index to determine percentage of pre-injury activity level regained by patients six years after partial meniscectomy alone versus placement of collagen meniscus implants (CMI, MenaflexTM). We hypothesized that in this prospective randomized multicenter clinical trial, patients who received collagen meniscus implant would have better function and would have regained more of their lost activity than patients with meniscectomy alone. Methods: Patients 18 to 60 years old who had undergone 1 to 3 prior partial medial meniscectomies (thus deemed “chronic”) and remained symptomatic randomly received either a CMI (n=76) or another partial medial meniscectomy (control) (n=69). Lysholm and Tegner data were collected prospectively. Tegner index was calculated by subtracting preoperative Tegner scores from the longest follow-up scores and then dividing that difference by the difference of pre-injury less preoperative scores. The quotient multiplied by 100 yields a percentage that represents amount of lost activity regained as a result of therapeutic intervention. The findings were then compared to earlier analyses of the same patients. Results: Average follow-up for both groups was 72 months (range for CMI, 24 to 88; for controls, 24 to 92). For both groups, Lysholm scores improved significantly (p=0.0001) from preoperative to 6 years postoperative, but there was no difference between treatments. Average Tegner index for CMI patients was 0.47; thus, 6 years after receiving CMI they had regained 47% of activity lost due to the inciting injury. Average Tegner index for controls was 0.22; thus, they regained 22% of lost activity. This difference was clinically and statistically significant (p=0.028). The Lysholm scores for both groups were unchanged from 2-year findings; however, Tegner index for CMI patients improved from 0.42 to 0.47, but Tegner index decreased for controls from 0.29 earlier to 0.22 at 6 years. Conclusion: CMI (Menaflex) and partial meniscectomy both allowed chronic patients to regain function equally 6 years after index surgery. However, patients treated with CMI had significantly higher Tegner index at 6 years compared to controls, thus chronic CMI patients regained more of the activity they had lost as a result of their inciting injury. Noteworthy, CMI patients continued to gain activity from 2 to 6 years while meniscectomy only controls lost activity. These findings suggest that control patients reduced their activity levels in an attempt to maintain their function

Aim: To determine the influence of concomitant partial meniscal resection on the medium-term clinical results after anterior cruciate ligament (ACL) reconstruction.

Method: Four hundred and sixty patients fulfilled the criteria for inclusion in this multi-center study. Four hundred and twelve of the 460 (90%) patients were re-examined by independent observers after a median 41 months (range: 24 months to 60 months). At the initial operation resection of a minimum of one third of the medial or lateral menisci was performed in 137 patients. The remaining 275 patients had stable, intact menisci. Patients who had undergone previous or subsequent meniscal surgery, a re-rupture of the ACL graft, or had an abnormal contralateral limb were excluded from the study.

Results: The patients who underwent concomitant meniscal resection at the ACL reconstruction had significantly more pain (p=0.012), a greater incidence of loss of motion (p=0.0006), increased laxity (p=0.001) and lower IKDC (p< 0.0001) and Lysholm (p< 0.0001) evaluation scores than patients who had intact menisci.

Conclusion: At the medium-term clinical follow-up the patients who underwent partial meniscal resection in conjunction with the ACL reconstruction revealed significantly worse subjective and objective measurements than the patients who had intact menisci. These findings demonstrated the effect of meniscectomy on the surgical outcome of ACL reconstruction and emphasised the importance of intact menisci for the function of the knee joint.

Discoid meniscus (DM) is a congenital variant of the knee joint that involves morphological and structural deformation, with potential meniscal instability. The prevalence of the Discoid Lateral Meniscus (DLM) is higher among the Asians than among other races, and both knees are often involved. Meniscal pathology is widely prevalent in the adult population, secondary to acute trauma and chronic degeneration. The true prevalence in children remains unknown, as pathologies such as discoid menisci often go undiagnosed, or are only found incidentally. A torn or unstable discoid meniscus can present with symptoms of knee pain, a snapping or clicking sensation and/or a decrease in functional activity, although it is not known if a specific presentation is indicative of a torn DM. While simple radiographs may provide indirect signs of DLM, magnetic resonance imaging (MRI) and arthroscopy is essential for diagnosis and treatment planning. Asymptomatic patients require close follow-up without surgical treatment, while patients with symptoms often require surgery. Partial meniscectomy is currently considered the treatment of choice for DLM. For children are more likely to achieve better results after partial meniscectomy

This study was proposed to evaluate the efficacy of fibrin clot augmentation in meniscal tear using inside-out meniscal repair. A total of 35 patients with meniscus tears were operated on with inside-out meniscus repair and fibrin clot augmentation. Patients were evaluated preoperatively and postoperatively with clinical criteria, Lysholm knee scoring system, and MRI. Out of the total 35 cases, 5 cases were lost to follow up. Clinical improvement was observed in 29 out of 30 patients (96.6%). The mean Lysholm score improved significantly from 67.63 ± 6.55 points preoperatively to 92.0 ± 2.9 points postoperatively (P < 0.05) in 2 years follow-up. Follow-up MRI in all patients revealed complete healing except in 1 case where the patient presented with recurrence of symptoms such as pain and locking which resolved with partial meniscectomy. Paraesthesia in the anterior part of the knee was observed in 2 cases. (6.6%). We conclude that fibrin clot augmentation is a good cost-effective modality of treatment for repairable meniscus tears to preserve the meniscus and decrease the point contact pressure on the condyles which may prevent the early occurrence of osteoarthritis

Abstract. Background. Meniscal tears affect 222 per 100,000 of the population and can be managed non-operatively or operatively with an arthroscopic partial meniscectomy (APM), meniscal repair or meniscal transplantation. The purpose of this review is to summarise the outcomes following treatment with a meniscal tear and explore correlations between outcomes. Methodology. A systematic review was performed of MEDLINE, EMBASE, AMED and the Cochrane Central Register of Controlled Trials to identify prospective studies describing the outcomes of patients with a meniscal tear. Comparisons were made of outcomes between APM and non-operative groups. Outcomes were graphically presented over time for all treatment interventions. Pearson's correlations were calculated between outcome timepoints. Results. 35 studies were included, 28 reported outcomes following APM; four following meniscal repair and three following meniscal transplant. Graphical plots demonstrated a sustained improvement for all treatment interventions. A moderate to very strong correlation was reported between baseline and three-month outcomes. In the medium term, there was small significant difference in outcome between APM and non-operative measures (SMD 0.17; 95 % CI 0.04, 0.29), however, this was not clinically significant. Conclusions. Patients with a meniscal tear demonstrated a sustained initial improvement in function scores, which was true of all treatments examined. APM may have little benefit in older people, however, previous trials did not include patients who meet the current indications for surgery as a result the findings should not be generalised to all patients with a meniscal tear. Further trials are required in patients who meet current operative indications

Meniscus tears have been treated using partial meniscectomy to relieve pain in patients, although this leads to the onset of early osteoarthritis (OA). Cell-based therapies can help preserve the meniscus, although the presence of inflammatory cytokines compromises clinical outcomes. Anti-inflammatory drugs (e.g. celecoxib), can help to reduce pain in patients and in vitro studies suggest a beneficial effect on cytokine inhibited matrix content. Previously, we have demonstrated that the inhibitory effects of IL-1β can be countered by culture under low oxygen tension or physioxia. The present study sought to understand whether physioxia, celecoxib or combined application can counter the inhibitory effects IL-1β inhibited meniscus cells. Human avascular and vascular meniscus cells (n =3) were isolated and expanded under 20% (hyperoxia) or 2% (physioxia) oxygen. Cells were seeded into collagen scaffolds (Geistlich, Wolhusen) and cultured for 28 days either in the presence of 0.1ng/mL IL-1β, 5µg/mL celecoxib or both under their expansion oxygen conditions. Histological (DMMB, collagen I and collagen II immunostaining), GAG content and gene expression analysis was evaluated for the scaffolds. Under hyperoxia, meniscus cells showed a significant reduction in GAG content in the presence of IL-1β (*p < 0.05). Celecoxib alone did not significantly increase GAG content in IL-1β treated cultures. In contrast, physioxic culture showed a donor dependent increase in GAG content in control, IL-1β and celecoxib treated cultures with corresponding histological staining correlating with these results. Additionally, gene expression showed an upregulation in COL1A1, COL2A1 and ACAN and a downregulation in MMP13 and ADAMTS5 under physioxia for all experimental groups. Physioxia alone had a stronger effect in countering the inhibitory effects of IL-1β treated meniscus cells than celecoxib under hyperoxia. Preconditioning meniscus cells under physioxia prior to implantation has the potential to improve clinical outcomes for cell-based therapies of the meniscus

Abstract. Objective. Meta-analysis of clinical trials highlights that non-operative management of degenerative knee meniscal tears is as effective as surgical management. Surgical guidelines though support arthroscopic partial meniscectomy which remains common in NHS practice. Physiotherapists are playing an increasing role in triage of such patients though it is unclear how this influences clinical management and patient outcomes. Methods. A 1-year cohort (July 2019–June 2020) of patients presenting with MRI confirmed degenerative meniscal tears to a regional orthopaedic referral centre (3× ESP physiotherapists) was identified. Initial clinical management was obtained from medical records alongside subsequent secondary care management and routinely collected outcome scores in the following 2-years. Management options included referral for surgery, conservative (steroid injection and rehabilitation), and no active treatment. Outcome scores collected at 1- and 2-years included the Forgotten Joint Score-12 (FJS-12) questionnaire and 0–10 numerical rating scales for worst and average pain. Treatment allocation is presented as absolute and proportional figures. Change in outcomes across the cohort was evaluated with repeated measures ANOVA, with Bonferroni correction for multiple testing, and post-hoc Tukey pair-wise comparisons. As treatment decision is discrete, no direct contrast is made between outcomes of differing interventions but additional explorative outcome change over time evaluated by group. Significance was accepted at p=0.05 and effect size as per Cohen's values. Results. 81 patients, 50 (61.7%) male, mean age 46.5 years (SD13.13) presented in the study timeframe. 32 (40.3%) received conservative management and 49 (59.7%) were listed for surgery. Six (18.8%) of the 32 underwent subsequent surgery and nine of the 49 (18.4%) patients switched from planned surgery to receiving non-operative care. Two post-operative complications were noted, one cerebrovascular accident and one deep vein thrombosis. The cohort improved over the course of 2-years in all outcome measures with improved mean FJS-12 (34.36 points), mean worst pain (3.74 points) average pain (2.42 points) scores. Overall change (all patients) was statistically significant for all outcomes (p<0.001), with sequential year-on-year change also significant (p<0.001). Effect size of these changes were large with all Cohen-d values over 1. Controlling for age and BMI, males reported superior change in FJS-12 (p=0.04) but worse pain outcomes (p<0.03). Further explorative analysis highlighted positive outcomes across all surgical, conservative and no active treatment groups (p<0.05). The 15 (18%) patients that switched between surgical and non-surgical management also reported positive outcome scores (p<0.05). Conclusion(s). In a regional specialist physiotherapy-led soft tissue knee clinic around 60% of degenerative meniscal tears assessed were referred for surgery. Over 2-years, surgical, non-operative and no treatment management approaches in this cohort all resulted in clinical improvement suggesting that no single strategy is effective in directly treating the meniscal pathology, and that perhaps none do. Clinical intervention rather is directed at individual symptom management based on clinical preferences. Declaration of Interest. (b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project

Introduction and Objective. The meniscus is composed of two distinct regions, a vascular outer zone and an avascular inner zone. Due to vascularization, tears within the vascular zone can be treated by suturing. However, tears in the avascular zone have a poor healing capacity and partial meniscectomy is used to prevent further pain, although this leads to early osteoarthritis. Previous studies have demonstrated that the vascular zone contains a progenitor population with multilineage differentiation potential. Isolation and propagation of these progenitors can be used to develop cell-based therapies for treating meniscal defects. In vivo, the meniscus resides under a low oxygen environment, also known as physioxia (2–7% oxygen) and previous work suggests that it promotes the meniscal phenotype. The objective of the study was to isolate progenitor populations from both meniscus regions and to examine their clonogenecity and differentiation potential under both hyperoxia (20% oxygen) and physioxia (2% oxygen). We hypothesize that physioxia will have a beneficial effect on colony formation and trilineage differentiation of meniscal cells. Materials and Methods. Human meniscus (n =4; mean age: 64 + 6) tissue was split into vascular and avascular regions, finely cut into small pieces and then sequentially digested in pronase (70U/mL) and collagenase (200U/mL) at 37. 0. C. Avascular and vascular meniscus cells were counted and split equally for expansion under hyperoxia and physioxia at a seeding density of 5 × 10. 3. cells/cm. 2. At passage 1, cells were seeded at 2, 5 and 20 cells/cm. 2. in 10cm dishes for observing colony formation using crystal violet assay. At passage 3, vascular and avascular meniscus cells were differentiated towards the chondrogenic, osteogenic and adipogenic lineage. Chondrogenesis was evaluated using DMMB staining for GAG deposition, osteogenesis was assessed using Alizarin Red staining for calcium deposition, whilst adipogenesis was observed using Oil-Red-O staining for fat droplets. Results. Expansion of vascular and avascular meniscus cells showed no difference in doubling time between hyperoxic or physioxic culture. However, physioxia significantly increased the number of colonies compared to hyperoxia for both meniscus cell types (p < 0.05). Both vascular and avascular meniscus cells differentiated towards the chondrogenic, osteogenic and adipogenic lineage under both oxygen tensions. Interestingly, we observed greater DMMB, alizarin red and oil-red-o staining for vascular meniscal cells under physioxia compared to corresponding hyperoxic cultures and avascular meniscal cells. Conclusions. Physioxia enhances the clonogenecity of vascular and avascular meniscus cells. Trilineage differentiation potential was observed from both regions with increased capacity detected under physioxia for vascular meniscal cells. Physioxic isolation of meniscal cells for the propagation of these progenitors can used be for the treatment of meniscal tears/defects

Purpose of the study: For symptomatic discoid meniscus, the treatment of choice in children is arthroscopic meniscoplasty. The treatment of associated meniscal lesions remains a subject of debate. The purpose of our work was to evaluate our results with arthroscopic meniscoplasty associated with meniscal repair as needed and the findings of the systematic postoperative MRI. Material and methods: This was a retrospective series of patients treated by one operator. There were 23 discoid menisci (21 patients) treated from 2004 to 2007 with arthroscopic meniscoplasty followed by a complementary procedure depending on the residual meniscus: abstention if there was no associated lesion, suture or reinsertion for reparable lesions, partial meniscectomy for non-reparable lesions. The Lysholm and Tegner scores, plain x-rays, and MRI were obtained systematically. Results: Mean age at surgery was 9.8 years. The Watanabe classification was I:9, II:9, III:5. Arthroscopy revealed 15 lesions, including 11 longitudinal tears. Meniscoplasty was performed in 9 cases alone, associated with partial meniscectomy in 6 and with repair in 8 (5 cases of disinsertion and 3 tears). Mean follow-up was 37.1 months. The mean postoperative Lysholm was 87.9, the Tegner 5.9. Outcome was considered satisfactory or very satisfactory by 90% of patients. MRI failed to reveal any signs of chondral degeneration or meniscal tear. There were however four cases of high intensity intra-meniscal signals and one meniscal cyst. Mean measurements of the residual meniscus were: anterior segment 8.6 mm thickness and 2.6 mm height; middle segment 5.5 and 2.3 mm; posterior segment 5.8 and 3.0 mm. One case of osteochondritis of the lateral condyle was noted postoperatively. Discussion: To our knowledge, there is no other study evaluating the outcome of discoid meniscus surgery with postoperative MRI. There have been few reports concerning meniscoplasty then repair. This approach spares meniscal tissue, essential for children. We obtained good clinical results and patient satisfaction. At the MRI, the residual meniscus had a morphology close to normal. There were no signs of tears. The high intensity signals occurred in patients with good outcome. Conclusion: Arthroscopic meniscoplasty associated with repair or partial meniscectomy as needed appears to be a good therapeutic solution for discoid meniscus in children

Aim: To assess and establish the reason for repeating knee arthroscopies. A retrospective study at Torbay General Hospital. Methods and results: The sample period was from January-2004 to July 2007 during which 695 knee arthroscopies were done, of which 71 patients (10 %) were coded as having same knee scoped again. A total of 58 out of 71 patients notes were available for review of which 12 were excluded due to coding-error and septic-arthritis. Among the 45 patients included, 67% were males and mean age was 44 years (range 17 to 70 years). The average time from listing the patient to actual scope was 20 weeks (range 0 to 54). At their first scope 24 patients required partial meniscectomies, of which 11 (45%) and 6 (25%) patients had posterior-horn and body of medial meniscal tears respectively, and 7 (29%) had tears in posterior-horn of lateral meniscus. Among the 23 who had chondral defects, 73% had changes on medial femoral condyle, 70% on patella, 52% on medial tibial condyle, 47% over lateral femoral condyle, 43% on trochlear grove, and 39% on lateral tibial condyle. Thirty-three-percent patients had anterior cruciate ligament (ACL) tears and 6% require loose bodies removal. Average time between re-scopes was 16 months (range 0 to 3.5 years). The numbers of patients requiring repeat knee arthroscopy for similar clinical problems were 16 out of 695 patients (2.3%). During repeat arthroscopies, 10/16 (62%) required procedures on meniscus, 4/16 (25%) for osteochondral lesions 2 patients had same diagnosis as ACL tears. 90% of partial meniscectomies were repeated on the posterior horn of both medial and lateral meniscus, and 20% required trimming of body of the meniscus. Conclusion: Contrary to general opinion being too many patients knees are been re-scoped, only 16/695 patients (2.3%) had their knees re-scoped for similar problem as found at first arthroscopy. 62% of these patients required partial meniscectomy mainly on the posterior-horns and 25% had chondral defects. We concluded that MR-arthrogram should be considered due to its specificity and sensitivity as detailed in literature, before performing repeated knee arthroscopy

For the treatment of irreparable meniscal injuries, we developed a novel multilayer meniscal scaffold, consisting of collagen, strontium and cellulose derived from Luffa Cylindirica; and we evaluated its effects on meniscal regeneration and arthritic changes in a rabbit partial meniscectomy model. The meniscus has a key role in shock absorbtion, load distribution, chondroprotection and stability of the knee joint. Meniscal injuries are one of the most common orthopedic injuries and may lead to degenerative cartilage changes and eventually osteoarthritis. Repair of the meniscal tissue is the treatment of choice for patients with a meniscus lesion, however, this is not always possible, especially for degenerative tears or injuries located on the inner avascular zone. To overcome the devastating outcomes of meniscectomy for such injuries, several materials have been developed and tried to replace the resected meniscal tissue. These scaffolds were designed primarily to relieve pain after meniscectomy, and later on were aimed to prevent osteoarthritis and cartilage damage that may develop in the future. In the quest for optimum scaffold material small intestine, tendons and other isolated tissues, collagen and polyurethane have been researched. Nevertheless, none of these materials have absolutely proven satisfying identical replacement of resected meniscal tissue. Therefore, we developed and investigated a novel multilayer meniscal scaffold, consisting of collagen, strontium and cellulose derived from Luffa Cylindirica (a cucumber shaped and sized plant, known as sponge gourd). The aim of the study was to evaluate the meniscal regeneration and arthritic changes after partial meniscectomy and application of novel multilayer meniscal scaffold in a rabbit model and to compare the results with clinically used polyurethane scaffold (Actifit, Orteq Ltd, London, UK). Sixteen male, mature, NewZealand rabbits weighing between 2600–3500 g were randomly divided into three groups. All groups underwent knee surgery via a medial parapatellar approach and a reproducible 1.5-mm cylindrical defect was created in the avascular zone of the anterior horn of the medial meniscus bilaterally. Defects were filled with the polyurethane scaffold in Group 1 and novel multilayer scaffold was applied to fill the defects in Group 2(n:6). Four rabbits in Group 3 did not receive any treatment and defects were left empty. Animals were sacrified after 8 weeks and bilateral knee joints were taken for macroscopic, biomechanical, and histological analysis. No signs of inflammation or infection were observed in all animals. Macroscopic evaluation of tibial plateaus after excision of menisci was performed with digital images of inked condylar surfaces. No significant degenerative changes were detected between groups. Digital photographs of excised menisci were also obtained and surface areas were measured by a computer software (Image J version 1.46, National Institute of Health, Bethesda, MD). There was a slightly larger meniscus area in the first two groups than the no treatment group, however, this was not found significant. Indentation testing of the tibial condyle and compression tests for the relevant meniscal areas with a diameter of 3mm was also performed in all groups. Histological analysis was made and all specimens were stained with safranin O and scored according to a scoring system. In this study, the initial evaluation of novel multilayer meniscal scaffold demonstrated promising biomechanical and histological results; besides no adverse events related to scaffold material was observed

INTRODUCTION:. To avoid the early onset of osteoarthritis after partial meniscectomy an effective replacement of injured meniscal tissue would be desirable. The present study investigates the behaviour of a new silk derived scaffold supplied by Orthox Ltd. (Abingdon, UK) in an in vivo sheep model. METHODS:. The scaffolds where derived from silk fibres by processing into an open porous matrix. Nine sheep (4 ± 1 years) underwent partial meniscectomy at the anterior horn of the medial meniscus followed by implantation of a scaffold. The unoperated contralateral stifle joint served as control. After six months the animals were sacrificed and the joints inspected for inflammation. The Young's modulus of the tibial cartilage, meniscus and scaffold was determined by indentation or confined compression tests. All tissues were fixed in formaldehyde for histology. The data were analysed by a Wilcoxon and Mann-Whitney-U-test. RESULTS:. The sheep were free of lameness 4 days p.o. The macroscopic analysis of the genual region and of the synovial membrane showed no signs of inflammation. This was confirmed by histological sections of synovial membrane, meniscus and scaffold. In histology, amorphous material, some fibroblast-like cell clusters and connective tissue formation was visible inside the pores of the scaffold. There were no statistically significant differences between the Young's moduli of the three measuring points in the operated and unoperated stifle joints. The meniscal tissue showed a higher modulus than the scaffolds. The scaffold's modulus significantly increased after three months implantation. DISCUSSION & CONCLUSIONS:. The presented silk scaffold withstood the loads occurring during the six months implantation period. It showed promising properties concerning biocompatibility and cartilage protection and its mechanical properties started to approach those of meniscal tissue

Purpose: The purpose of this study was to review the clinical results of a series of 108 children treated artroscopically for symptomatic discoid lateral menisci. Methods: The medical records of more than 100 consecutive patients who underwent arthroscopic treatment for symptomatic discoid meniscus between 1990 and 2005 were reviewed. Results: The mean patient age was 8.7 years (range, 2,5 to 14 years), with 55% female and 45% male patients. The mean duration of symptoms before surgery was 20 months (range, 2 to 48 months), with 95% having pain and 38% having mechanical impingment. All patients were treated arthroscopically. Partial or subtotal arthroscopic meniscectomy was performed. Operative classification of the menisci revealed 64 complete, 18 Wrisberg type and 26 incomplete discoid menisci, with meniscal tears being present in 48 knees (45%). At final follow-up, all patients exhibited full knee flexion beyond 135 degrees. Three patients reported residual knee pain, and four reported intermittent mechanical symptoms. At final follow-up, 3 years minimum, according to Ikeuchi clinical score more than 50 % of the patients were considered very good and 25 % good. Only 8 patients felt that their activity level remained partially limited. Conclusions: Our results show the middle-term efficacy of arthroscopic partial or subtotal meniscectomy in cases of symptomatic lateral discoid menisci. Arthroscopic partial meniscectomy is preferrable only when the posterior attachment of the discoid meniscus is stable. A total meniscectomy is indicated for the Wrisberg-ligament type of discoid meniscus and when the meniscus is completely degenerated. This to our knowledge is the largest series of discoid lateral menisci arthroscopically treated. Level of evidence: Level IV, therapeutic case series

Purpose: Lateral meniscectomy is thought to confer a less optimal prognosis compared to medial meniscectomy however little information exists on the effect on elite sportsmen in the context of career performance and sporting ability. Study type: Retrospective case study. Methods: 61 international or premiership level sportsmen (36 Football, 22 Rugby, 3 Cricket) who had no previous significant knee surgery, received either medial or lateral partial meniscectomy by a single surgeon. Their subsequent career performance was analysed over a 1 to 5 year follow-up period to highlight differences in their recovery and maintenance of an elite sporting career. Results: From our cohort 96% of sportsmen from the medial meniscectomy group were able to return to professional sports, compared to 88% in the lateral meniscectomy group. The average time to return to sports was 3.5 weeks in the medial meniscectomy group compared to 8 weeks in the lateral meniscectomy group. A statistically significant decrease in performance was noted in the lateral group, whereby 14 of the 36 sportsmen subsequently played in lower level leagues, or suffered premature retirement compared to only 1 sportsmen out of the 25 sportsmen who received a medial meniscectomy. Conclusions: The majority of elite sportsmen who undergo partial meniscectomy are able to return to high level sporting activities and maintain their career. Unfortunately, sportsmen who undergo Lateral meniscectomy are at higher risk of not returning to their previous performance. If they do return to sport they are more likely to have diminished performance compared to those who have a medial meniscectomy. Lateral meniscectomy is associated with a relatively unpredictable recovery time-frame and higher risk of premature retirement. Athletes should be warned of these findings when treatment decisions are made

Aim of this study is the investigation of lower limbs biomechanics before and after meniscectomy. Materials and methods: Ten volunteers candidate to partial medial meniscectomy underwent motion analysis before surgery, six months and one year after. Ten healthy volunteers acted as a control group. Data were acquired by means of Vicon motion analysis system. Results: In gait patterns investigation, joint kinematics does not show significant modifications before and 6 months after surgery, 12 months after surgery hip and knee show a greater flexion. The dynamic analysis stresses alterations in knee sagittal moment. Before surgery the knee flexion moment is reduced. After partial meniscectomy the knee flexion moment increases in both the limbs. In squatting investigation, main focus was on repeatability. Before surgery high inter subjects variability affects knee joint angle; while after surgery high variability affects also hip and ankle. Conclusions: After meniscectomy, gait and squatting patterns are still altered. Before surgery, the joint mechanical structure is not highly altered and modifications are mainly due to pain avoidance schemas; after partial meniscectomy, pain disappears and the new joint behaviours are probably caused by the new mechanical asset and/or proprioceptive mechanisms