Aims. This study aimed, through bioinformatics analysis and in vitro experiment validation, to identify the key extracellular proteins of
Aims. Interleukin (IL)-1β is one of the major pathogenic regulators during the pathological development of
Aims. In this investigation, we administered oxidative stress to nucleus pulposus cells (NPCs), recognized DNA-damage-inducible transcript 4 (DDIT4) as a component in
Objectives. Interleukin 18 (IL-18) is a regulatory cytokine that degrades the disc matrix. Bone morphogenetic protein-2 (BMP-2) stimulates synthesis of the disc extracellular matrix. However, the combined effects of BMP-2 and IL-18 on human
Using deep learning and image processing technology, a standardized automatic quantitative analysis systerm of lumbar disc degeneration based on T2MRI is proposed to help doctors evaluate the prognosis of
Purpose of study and background. Clinical researchers use Pfirrmann classification for grading
Current therapies for
Biomechanical overloading initiates
Introduction: Osteoporotic fractures affect certain bones more than others, suggesting that systemic bone loss is not the only underlying cause. We have shown that age-related
Low back pain affects 80% of the population with half of cases attributed to
Background. The association between lumbar
Purpose of study and background. Mechanical overloading initiates
Back pain is a leading cause of disability worldwide and it is primarily considered to be triggered by
Introduction.
Mesenchymal stem cells (MSCs) are exciting candidates for cellular repopulation and repair in