Purpose of the study:
Aim. Persistent wound drainage has been recognized as one of the major risk factors of periprosthetic joint infection (PJI). Currently, there is no consensus on the management protocol for patients who develop wound drainage after total joint arthroplasty (TJA). The objective of our study was to describe a multimodal protocol for managing draining wounds after TJA and assess the outcomes. Methods. We conducted a retrospective study of 4,873 primary TJAs performed between 2008 and 2015. Using an institutional database, patients with persistent wound drainage (>48 hours) were identified. A review of the medical records was then performed to confirm persistent drainage. Draining wounds were first managed by instituting local wound care measures. In patients that drainage persisted over 7 days, a superficial irrigation and debridement (I&D) was performed if the fascia was intact, and if the fascia was not intact modular parts were exchanged. TJAs that underwent subsequent I&D, revision surgery, or developed PJI within one year were identified. Results. Draining wounds were identified in 6.2% (302/4,873) of all TJAs. Overall, 65% (196/302) of patients with draining wounds did not require any surgical procedures. Of the patients with persistent drainage, 9.8% underwent I&D, 25.0% underwent revision arthroplasty. Moreover, 15.9% of these patients developed PJI within one year. Compared to those without wound drainage, TJAs complicated by wound drainage demonstrated an odds ratio of 16.9 (95% CI: 9.1–31.6) for developing PJI, and 18.0 (95% CI: 11.3–28.7) for undergoing subsequent surgery. Conclusions. Wound drainage after TJA is a major risk factor for subsequent PJI and its proper management has paramount importance. Our results demonstrated that drainage ceased spontaneously in 65% of the patients with local wound care measures alone.
Carpal tunnel decompression is one of the most commonly performed orthopaedic operations. Last year 160 patients attended our department for surgery. There have been reports in the literature of good results and improved patient satisfaction for wound closure with Vicryl Rapide following Dupuytren's surgery. We looked at 200 consecutive patients who underwent carpal tunnel decompression.
Diabetic foot disease is a major public health problem with an annual NHS expenditure in excess of £1 billion. Infection increases risk of major amputation fivefold. Due to the polymicrobial nature of diabetic foot infections, it is often difficult to isolate the correct organism with conventional culture techniques, to deliver appropriate narrow spectrum antibiotics. Rapid DNA-based technology using multi-channel arrays presents a quicker alternative and has previously been used effectively in intensive care and respiratory medicine. We gained institutional and Local Ethics Committee approval for a prospective cohort study of patients with clinically infected diabetic foot wounds. They all had deep tissue samples taken in clinic processed with conventional culture and real-time PCR TaqMan array.Introduction
Methods
We present the first systematic review conducted by the UK Defence Medical Services in conjunction with the Cochrane Collaboration. Irrigation fluids are used to remove contamination during the surgical treatment of traumatic wounds in order to prevent infection. This review aims to determine whether there is evidence that one wound irrigation fluid is superior to another at reducing infection. A pre-published methodology was used and two reviewers independently assessed the search results. The search produced 917 studies, of which three met the inclusion criteria. All were studies in open fractures, incorporating a total of 2,903 patients. Each RCT involved a distinct comparison, precluding meta-analysis: i) sterile saline vs. distilled/boiled water; ii) antibiotic solution vs. soap solution; iii) saline vs. soap solution. The odds ratios of infection following irrigation with various fluids was as follows: i) saline vs. distilled or boiled water 0.25 (95%CI 0.08–0.73); ii) antibiotic solution vs. soap 1.42 (95%CI 0.82–2.46); iii) saline vs. soap solution 1.00 (95%CI 0.80–1.26). These results suggest that neither soap nor antibiotic solution is superior to saline and that saline is inferior to distilled or boiled water.
Despite long-standing dogma, a clear relationship between the timing of surgical irrigation and the development of subsequent deep infection has not been established in the literature. Traditionally, irrigation of an open fracture has been recommended within six-hours of injury based on animal studies from the 1970s, however the clinical basis for this remains unclear. Using data from a multi-centre randomized controlled trial of 2,447 open fracture patients, the primary objective of this secondary analysis is to determine if a relationship exists between timing of wound irrigation (within six hours of injury versus beyond six hours) and subsequent reoperation rate for infection or healing complications within one year for patients with open extremity fractures requiring surgical treatment. To adjust for the influence of patient and injury characteristics on the timing of irrigation, a propensity score was developed from the data set. Propensity-adjusted regression allowed for a matched cohort analysis within the study population to determine if early irrigation put patients independently at risk for reoperation, while controlling for confounding factors. Results were reported as odds ratios (ORs), 95% Confidence Intervals (CIs), and p-values. All analyses were conducted using STATA 14 (StataCorp LP, College Station, TX, USA). Two thousand, two hundred eighty-six of 2,447 patients randomized to the trial from 41 orthopaedic trauma centers across five countries had complete data regarding time to irrigation. Prior to matching, the patients managed with early irrigation had a higher proportion requiring reoperation for infection or healing complications (17% versus 12.8%, p=0.02), however this does not account for selection bias of more severe injuries preferentially being treated earlier. After the propensity score-matching algorithm was applied, there were 373 matched pairs of patients available for comparison. In the matched cohort, reoperation rates did not differ between early and late groups (16.1% vs 16.6%, p=0.84). When accounting for propensity matching in a logistic regression analysis, early irrigation was not associated with reoperation (OR 0.93, 95% CI 0.62 to 1.40, p=0.73). When accounting for other variables, late irrigation does not independently increase risk of reoperation.
We reviewed ninety-three civilian transpelvic gunshot wounds from 1998 to date. The patients were all recruited through our Trauma Unit. The first sixty were seen on a referral basis, yet for the subsequent patients we were informed on admission. Based on our earlier findings we promoted bullet tract washout, bullet removal when passed through hollow viscus, rectal stump washout and early removal of juxta-articular bullets. We review the nature of associated injuries and outcomes in relation to osteitis, osteoarthritis, nerve injuries and vascular injuries. Fifty-seven patients had an entry wound in the buttock. This is associated with a high incidence of sciatic nerve damage (14%), extra peritoneal rectal injury (21%), juxta-articular bullets (73%) and osteitis (12%). There were fifty patients with hollow viscus injuries in various combinations. Thirteen patients overall developed osteitis (14%), of these twelve had hollow viscus injuries. Of these extra-peritoneal rectal injuries carry the highest proportion of osteitis (33%) as a complication, followed by colonic injuries (25%) and bladder (21%). Small bowel injuries (29) were not associated with any osteitis. Peri and intra-articular injuries were grouped together totalling fifty-nine. Seven of these developed osteitis, leading to secondary osteoarthritis in all. The sciatic nerve was damaged in nine patients, and only three recovered fully. There were two femoral nerve injuries with no significant sequelae. In extra-peritoneal rectal injuries those who had early rectal stump wash-out (5/12) did not develop osteitis and yet of those not washed (5/12) three developed osteitis (60%). Tract washout has similar results. Of bullets that passed through a hollow viscus and were removed late 45% (8/18) were infected. Our preliminary results suggest that all missile tracts should be washed out and debrided, that all bullets traversing a hollow viscus should be removed, that all peri-articular bullets be removed, and that the rectal stump be washed out in extra-peritoneal rectal injuries.
Between June 1998 and April 2006, 93 patients with trans-pelvic gunshot injuries were admitted to our hospital. Initially the management was done by general surgeons, without any orthopaedic consultation. Later a good working relationship between general surgeons and orthopaedic surgeons developed, and good co-operation was achieved. We felt it was important to determine the direction of the bullet tract. A detailed history was taken to try and position the assailant, and the action taken by the victim. We tried to establish the number of shots that were fired, and whether any pervious gunshot injury had been sustained. We then drew an imaginary straight line between the entry and exit wound, in order to try and determine the anatomical structures that were likely to be injured by the bullet. When x-rays were not helpful in identifying the bony injury, then a CT scan with 3D reconstruction was performed. Contrast studies such as a sinogram, a cystogram and intravenous pyelogram, combined with contrast CT, was also helpful in determining the bullet tract. At laparotomy the entire bullet tract has to be debrided. All injured viscera are repaired, and the abdominal cavity thoroughly washed out. Any extra-peritoneal rectal injury requires a proximal colostomy, and rectal stump washout. All bullets lodged near or into a joint must be removed early, within 4 days of injury. We feel that using antibiotics alone for contaminated bullet tracts, without debriding the tract and removing the bullet from bone, does not prevent sepsis.
Many studies report the incidence and prevalence of surgical site infections (SSIs) following open fractures; however, there is limited information on the treatment and subsequent outcomes of superficial SSIs in open fracture patients. There is also a lack of clinical studies describing the prognostic factors that are associated with failure of antibiotic treatment (non-operative) for superficial SSI. To address this gap, we used data from the FLOW (Fluid Lavage in Open Fracture Wounds) trial to determine how successful antibiotic treatment was for superficial SSIs and to identify prognostic factors that could be predictive of antibiotic treatment failure. This is a secondary analysis of the FLOW trial dataset. The FLOW trial included 2,445 operatively managed open fracture patients. FLOW participants who had a non-operatively managed superficial SSI diagnosed in the 12 months post-fracture were included in this analysis. Participants were grouped into two categories: 1) participants whose superficial SSI resolved with antibiotics alone and 2) participants whose SSI did not resolve with antibiotics alone (defined as requiring surgical management or SSI being unresolved at final follow-up (12-months post-fracture for the FLOW trial)). Antibiotic treatment success and the date when this occurred was defined by the treating surgeon. A logistic binary regression analysis was conducted to identify factors associated with superficial SSI antibiotic success. Based on biologic rationale and previous literature, a priori we identified 13 (corresponding to 14 levels) potential factors to be included in the regression model. Superficial SSIs were diagnosed in168 participants within 12 months of their fracture. Of these, 139 (82.7%) had their superficial SSI treated with antibiotics alone. The antibiotic treatment was successful in resolving the superficial SSI in 97 participants (69.8%) and unsuccessful in resolving the SSI in 42 participants (30.2%). We found that superficial SSIs that were diagnosed later in follow-up were associated with failure of treatment with antibiotic alone (Odds ratio 1.05 for every week in diagnosis delay, 95% Confidence Interval 1.004–1.099; p=0.03). Age, sex, fracture severity, fracture pattern, wound size, time from injury to initial surgical irrigation and debridement were not associated with antibiotic treatment failure. Our secondary analysis of prospectively collected FLOW data found antibiotics alone resolved superficial SSIs in 69.8% of patients diagnosed with superficial SSIs. We also found that superficial SSIs that were diagnosed earlier in follow-up were associated with successful treatment with antibiotics alone. This suggests that if superficial SSIs are diagnosed and treated promptly, there is a higher probability that they will resolve with antibiotic treatment.
Nine patients required a medial gastrocnemius flap. Three patients received fasciocutaneous flaps (one bipedicle); one patient was managed with a tissue expander pre-operatively; one with a split skin graft, and one patient required perforating skin incisions in order to close the wound. 60% of patients developed local wound complications and 27% required further soft tissue procedures. The overall limb salvage rate was 73.3% (four patients required an above knee amputation for persistent infection). Five patients had successful re-implantation surgery. Four patients had arthrodesis surgery with successful eradication of infection. Two patients developed chronic infection.
Our study is to evaluate a new scheme designed to treat at home patients with Prolonged Leakage from wounds after lower limb arthroplasty A prospective study of a 258 patients with leaking wounds after lower limb arthroplasty was conducted between August 2002 and February 2005. Each patient assessed, if meet the criteria entered the discharge scheme. A trained nurse visited each patient daily to provide wound care. The scheme could accommodate a maximum of 5 patients at any time. If the wound showed signs of infection the treating team was contacted and patient reviewed and treated if appropriate. For each patient Clinical data was collected including personal details, referral details, medical history and their progress. A satisfaction questionnaire was given at the completion of treatment. Of the 324 patients referred to the scheme, 258 were accepted. 66 refused because the service was full (17), the wound was dry on assessment (6), failed the criteria (16), and patients declined the scheme (27). The average age was 67 years (16–93), 19 (8%)of patient readmitted to hospital, 14(6%) related to wound problems non required further surgery. The average number of home visits were 6, 5% of the patients called for advice. The number of bed days saved assessed as from the day of discharge from hospital to the date wound dry was 232 days. The response rate to questioners was 98%; all patients describe the service as excellent or good. We concluded that the majority of leaking wounds after lower limb arthroplasty are self-limiting problems. The service provided an excellent way of treating patients at home and resulted in a major increase of available beds for little cost.
The authors call attention to the fact that puncture wounds of the foot are often considered simple, but can have potentially serious complications and sequelae. In the majority of the cases, osteomyelitis in children is a haematogenous infection and the microorganism involved is a gram-positive coccus. The role of the puncture wound in osteomyelitis has been overlooked in the past. We present our experience with six cases of osteomyelitis following deep puncture wounds of the foot. We reviewed six cases (1990–1999) of pseudomonas osteomyelitis in children. At the time of the injuries, five cases were boys younger than the age of seven and one was 12 years old. The sites affected were: metatarsal (2), phalanx (2) and calcaneous (2). The cause of injury was tree splinter (2), fork (1), needle (2) and nail (1). At the time of injury, all of the wounds contained foreign matter that was not initially completely removed and osteomyelitis developed as a result. The time interval until definitive diagnosis ranged from 5 to 730 days. There is a similar history in all of the cases. For two or three days following the injury, the symptoms showed improvement and the injured site became swollen, tender, and painful afterwards. Treatment in all cases was hospitalisation, debridement and parenteral antibiotics for 18 to 22 days. After hospitalisation, an oral antibiotic (ciprofloxacin) was taken in two cases for three months and in four cases for four months. After treatment, mean follow-up was 60 months (range 8 to 98 months). We have had no sequelae, recurrences or early growth arrest, and we consider the results to be good in all of the cases. Puncture wounds of the foot should not be considered as “simple” injuries. Proper initial treatment is critical for the prevention of subsequent and potentially serious complications.
Infection is disastrous in arthroplasty surgery and requires multidisciplinary treatment and debilitating revision surgery. Between 80-90% of bacterial wound contaminants originate from colony forming units (CFUs) present in operating room air, originating from bacteria shed by personnel present in the operating environment. Steps to reduce bacterial shedding should reduce wound contamination. These steps include the use of unidirectional laminar airflow systems and the introduction of theatre attire modelled on this principle (e.g. total body exhaust suits). Our unit introduced the use of the Stryker Sterishield Personal Protection System helmet used with laminar flow theatre systems. This study compares an enclosed helmet system used with standard gowns, with standard hood and mask attire. 12 simulated hip arthroplasties were performed, six using disposable sterile impermeable gown, hood and mask and a further 6 using a Sterishield helmet and hood. Each 20 minute operation consisted of arm and head movements simulating movements during surgery. Air was sampled at wound level on a sterile draped operating table using a Casella slit sampler, sampling at 700l/minute. Samples were incubated on Blood agar for 48 hours at 37°c and the CFUs grown were counted.Introduction
Method
To determine if immediate closure of open wounds is safe, we examined our results over a five year period. Of the two hundred and ninety-seven open fractures, two hundred and fifty-five (86 %) were closed immediately. Grade III open fractures accounted for 24.2% of cases. The superficial infection rate was 10.9%. The combined deep infection and osteomyelitis rate was 4.7%. Neither region of injury, Gustilo grade, velocity of trauma, nor time to primary closure had a significant influence on the incidence of infection. Primary closure may be a safe practice and could be accepted as a viable treatment plan in the care of most open fractures. The purpose of this study was to determine if immediate primary closure of open fracture wounds is a safe practice without increased deep infections and delayed/ nonunions? There was neither an increase in deep infection nor delayed union/non-union. Benefits include a decreased requirement for repeat debridements and soft tissue procedures, minimized surgical morbidity, hospital stay, and cost of treatment. Primary closure may be a safe practice in the care of most open fractures. The standard of care has been to leave traumatic wounds open after initial emergent surgical debridement. Due to orthopedic advancements and current resource limitations, treatment at our institution has evolved to immediate closure of all open wounds after adequate irrigation and debridement. Of the two hundred and ninety-seven open fractures, two hundred and fifty-five (86 %) were closed immediately after irrigation and debridement. Grades 3a, 3b and 3c open fractures accounted for 24.2% of cases. The superficial infection rate of primary closure was 10.9 %. All cases resolved with oral antibiotics. The combined deep infection and osteomyelitis rate was 4.7%. Neither region of injury, Gustilo grade, velocity of trauma, nor time to primary closure had a significant influence on the incidence of infection. The study reviewed all open fractures presenting to a Level One Trauma center over a five-year study period. Patients were followed until fracture union or complication resolution. Multiple variables were examined including patient demographics, injury mechanism, fracture location, Gustilo classification, time to antibiotic administration, surgical debridement and wound closure, and method of wound closure. Outcome measurement included infection or union problems.
Cluster bombs are an inhuman weaponary, intended, among other things, for mass kiling of humans. The use of modern weaponary can cause very serious damage of all structures in injured extremity. During the war on teritory of Yugoslavia in 1999. at our clinic for orthopaedic and tramatology Ð Clinical Center Nis, we have treated 120 injured patients. The youngest injured patient was 17 the oldest 77. In evaluated group the patients of third and forth decade of life have been dominated. Multiple injuries were the most often (caused by cluste bombs). All victims got hard wounds of lesia type due to injuring by a great number of sharpnelñs. The hospital treatment complexity of these wounds is pointed out. Such treatment is caused by a number of simultaneous wounds of many sistems in organisam. We have treated war wounds with fractures of extremity with the Ç Mitkovic È external þxator (using convergent method of pin applications), living the wounds open and performing necessary debridments.AT and antibiotic therapy was administrated. Surgical treatment of war wounds, external þxation, living the wounds open and performing necessary debridments, adequate drug therapy, are essential in achieving good results in this patients. To take care of casualties is a complex task requesting the teamwork of orthopaedists, common surgeries and plastic surgery specialists.