INTRODUCTION. Musicians' hand problems are as old as music itself. These problems involve functional motor disorders which have been underestimated by musicians, who do not want to accept the possibility of reducing their professional activity and doctors who are either not knowledgeable about musicians' characteristics or underestimate this artistic activity. The aim of this study is to determine the causes of the pathologies instrumentalist musicians have, and their distribution according to age group, instrument and type of music, and thus infer the main risk factors in the occurrence of medical problems related to musicians' activity. MATERIALS AND METHODS. We consider musicians those who devote themselves to the study, teaching and playing of a musical instrument. In Argentina there are about 50.000 instrumental musicians. Since over 14 years the members of “Las Manos del Músico” have treated 574 musicians. The 84% of the medical problems related to the playing of the instrument. Ages are between 13 and 78 years. The musicians treated belong to different conservatories, symphonic and popular orchestras. Each musician was studied with the same protocol, filled in by the same professional. Variables such as type of music, age, sex, instrument, dominance andrelated variables were taken into account. RESULTS. The 47% of those treated are devoted to popular music and the 53% to classical music. The prevailing age group is 31–40 years, there being a variation between popular and classical performers (43% in the case of classical performers and 39% in that of popular performers). Traumatic pathology is of the 16%, and a clear predominance of chronic pathology (78%) was observed with 43% of musculotendinous injuries, 16% of nervous pathology andb18.% of joint pathology. Focal dystonia affected to 15% of the musicians treated. Within the musculotendinous pathology a 50% was due to overuse syndromes. CONCLUSIONS. In 86% of the cases the causes of injuries in musicians' upper extremity are related to the playing of the instrument. There is a clear predominance of chronic injuries, overuse syndromes, in a young age group (20 to 40 years). The diagnosis of this injuries must be based on an exhaustive physical examination, knowledge of the different instruments and of the most frequent injuries caused by each instrument. In order to get satisfactory results in the treatment and prevention of these injuries, it is necessary to create a space for communication, exchange and interdisciplinary reflection between hand and orthopedic surgeons, physical and occupational therapists and psychologists, as well as musician teachers. The challenge is to combine two parallel experiences, that of specialized medicine with that of the workers of the music culture, generating a link between science and art in order to improve the ways of preventing and treating the injuries of this professional group