Cryocompression therapy is a non-invasive and non-pharmacological modality used in managing acute post-operative inflammation and pain. A prospective, randomised controlled trial (RCT) was undertaken to evaluate the effectiveness of a post-operative cryocompression protocol using the Game Ready™ (GR) device versus usual care on recovery following total knee arthroplasty (TKA). A single centre RCT was conducted with 70 TKAs (68 patients) randomised to a 2-week intervention period consisting of treatment with GR cryocompression (n=33, 33.3% males) or a usual care protocol of ice with static compression using tubigrip (n=35, 54.3% males). Knee range of movement (ROM) (flexion and extension), a visual analogue pain score (VAS) and limb circumference were documented at day 1, 2 and 14, as well as 6 and 12 weeks post-surgery. ROM was also recorded at day 90, while medication use and length of hospital stay were documented. Patient reported outcome measures (PROMs) including the KOOS and patient satisfaction questionnaire were employed. The GR group demonstrated 2.3° more (p=0.05) knee extension ROM overall, as well as 2. 8° more at day 1 (p=0.048), 3.8° at day 14 (p=0.007) and 5.4° at 3 months (p=0.017). There were no group differences (p>0.05) observed in pain (VAS), flexion ROM, limb circumference, opioid use or other PROMs. Across the full cohort, higher pain levels resulted in increased opioid intake (p=0.002), older patients used significantly less opioids (p<0.001) and males reported significantly less pain (VAS) than females (p=0.048). Using GR following TKA is a safe, non-invasive tool that can be used to aid in the post-operative recovery period. Patients using the GR cryocompression device gained significantly more extension ROM compared to the conventional ice with compression group, despite no other group differences

Aims. There are comparatively few randomized studies evaluating knee arthroplasty prostheses, and fewer still that report longer-term functional outcomes. The aim of this study was to evaluate mid-term outcomes of an existing implant trial cohort to document changing patient function over time following total knee arthroplasty using longitudinal analytical techniques and to determine whether implant design chosen at time of surgery influenced these outcomes. Methods. A mid-term follow-up of the remaining 125 patients from a randomized cohort of total knee arthroplasty patients (initially comprising 212 recruited patients), comparing modern (Triathlon) and traditional (Kinemax) prostheses was undertaken. Functional outcomes were assessed with the Oxford Knee Score (OKS), knee range of movement, pain numerical rating scales, lower limb power output, timed functional assessment battery, and satisfaction survey. Data were linked to earlier assessment timepoints, and analyzed by repeated measures analysis of variance (ANOVA) mixed models, incorporating longitudinal change over all assessment timepoints. Results. The mean follow-up of the 125 patients was 8.12 years (7.3 to 9.4). There was a reduction in all assessment parameters relative to earlier assessments. Longitudinal models highlight changes over time in all parameters and demonstrate large effect sizes. Significant between-group differences were seen in measures of knee flexion (medium-effect size), lower limb power output (large-effect size), and report of worst daily pain experienced (large-effect size) favouring the Triathlon group. No longitudinal between-group differences were observed in mean OKS, average daily pain report, or timed performance test. Satisfaction with outcome in surviving patients at eight years was 90.5% (57/63) in the Triathlon group and 82.8% (48/58) in the Kinemax group, with no statistical difference between groups (p = 0.321). Conclusion. At a mean 8.12 years, this mid-term follow-up of a randomized controlled trial cohort highlights a general reduction in measures of patient function with patient age and follow-up duration, and a comparative preservation of function based on implant received at time of surgery. Cite this article: Bone Joint J 2020;102-B(4):434–441

Computer navigation systems enable precise measurement and intra- operative knee range of movement analysis. We present a series of five knees that demonstrated unusual kinematics. Five of 80 computer navigated knee replacements that were part of a prospective randomised trial were found to have unusual joint lines. Range of motion assessment was performed with computer assisted navigation after exposure and registration of bony landmarks and before bony resection was commenced. This revealed valgus alignment in extension that drifted into varus with knee flexion. We referred to these unusual patterns as ‘oblique joint lines’. The data from the navigation log files of these five knees was analysed in detail. Average age of patients in this series was 68years and all were female. The average pre- operative angle between femoral axis and distal femoral articular surface was 101 degrees. All five knees had a tibial varus with average angle between the tibial axis and articular surface being 85 degrees. In two knees, more bone was resected from the medial posterior femoral condyle using 4 degrees external rotation. These two knees showed improved kinematics and horizontal joint line post- operatively. Computer assisted navigation provides a precise understanding of the pre- operative knee kinematics. Bony cuts can be tailored to suit the pre- operative deformity. Increased external rotation of the femur with adequate medial soft tissue release is an alternate approach for difficult knees with ‘oblique joint lines’

Objective. To determine differences in fracture stability and functional outcome between synthetic bone graft and allograft/autograft with internal fixation of tibia plateau metaphyseal defects. Patient & Methods. Between 2007- 2008, 84 consecutive cases of internal fixation of tibia plateaux were identified from our theater logbook. 29 patients required additional autologous, allogenic bone graft, or synthetic bone graft substitute to ensure fracture stability. 5 patients were excluded due to lost to follow up leaving a cohort of 24 patients. Hydroxyapatite calcium carbonate synthetic bone graft was utilised in 14 patients (6 male and 8 female). Allograft/autograft were utilised in the remaining 10 patients (6 male and 4 female). All 24 patients had closed fractures, classified using the AO and Schatzker classification. Roentograms at presentation, post-operatively and regular follow-up till 12 months were analysed for maintenance of reduction, early and late subsidence of the articular surface. Functional outcomes such as knee range of movement and WOMAC Knee scores were compared between groups. Results. There was no significant statistical difference between groups for post-operative joint reduction, long term subsidence, and WOMAC scores. The degree of subsidence was not related to age or fracture severity. Maintenance of knee flexion was found to be better in the allograft/autograft group (p=0.015) when compared between groups. Multivariate analysis compared graft type, fracture severity, postoperative reduction, subsidence rate, range of movement and WOMAC score. The only finding was a statistical significant (p=0.025) association with the graft type and range of movement. Conclusion. Allograft/autograft may allow better recovery of long-term flexion, possibly due to reduced inflammatory response compared with synthetic bone graft. However, all other parameters such as maintenance of joint reduction and subjective outcome measures were comparable with the use of hydroxyapatite calcium carbonate bone graft. This study shows that synthetic bone graft is a suitable option in fixation of unstable tibia plateau fractures, avoiding risk of viral disease transmission with allograft and donor site morbidity associated with autograft

Methods and materials: Between August 2000 and August 2002, 28 patients, average age of 78 years (range 62 to 94 years), with distal femoral fractures (33A1 – 17, 33A2 – 1, 33C1 – 6, 33C2 – 4) were treated with DFN. All the patients had sustained the injury following a simple fall. Periprosthetic fractures were excluded from this study. Two fractures required additional procedures in the form of circleage wires. Nailing was performed through a midline mini arthrotomy. Post operative protocol was to mobilise the patient weight bearing as tolerated. Results: All fractures healed without the need for secondary procedures. Average period of follow up was 8.5 months. Average hospital stay was 18 days (range 10 to 34). Post operative mobility returned to pre operative state in 15 patients. Three patients died within 3 months due to unrelated medical causes. There was no incidence of extension lag or malunion. Knee range of movement was on average 95°. Patients with pre existing knee arthritis had slight worsening of the pain. Hospital for Special Surgery knee scores were on average 78.3. 23 patients were rated as excellent, 4 good and 1 poor. In one patient the distal screws broke without significant functional impairment. Conclusion: We recommend the use of DFN in supracondylar femoral fractures in the elderly as it produced satisfactory results with low operative and post operative morbidity. It can be performed with minimal soft tissue damage with good purchase in the osteoporotic bone which allows early mobilisation

When managing malignant bone tumours in the distal femur with limb salvage, resection and reconstruction with a distal femoral replacement (DFR) conventionally entails prosthetic replacement of the knee joint. In younger patients it is desirable to try to preserve the knee joint. We now use a new Joint-Sparing distal femoral prosthesis in those cases where it is possible to resect the tumour and preserve the femoral condyles. Purpose of study: To look at our early results with knee joint preserving DFR’s. Methods: Between June 2001 and March 2004 the prosthesis was implanted in 8 patients (5 males and 3 females) aged between 8 and 24 years at the time of surgery. The diagnosis was osteosarcoma in 6 cases and chondrosarcoma in 2 cases. All patients were followed regularly and knee range of movement was recorded as well as any complications that occurred. Patients were functionally evaluated using the MSTS Scoring System. Results: Six of the patients had a mean follow-up of 20 months (range 8–33) and in this group 4 had good knee flexion with a mean flexion of 122° (110–130), 1 patient had fair flexion of 60° and 1 patient had poor flexion of 20°. The mean fixed flexion deformity in the 3 patients who had such a deformity was 10° (5–15). There were no intraoperative complications but the patient with poor flexion required an arthrolysis and because of the poor result is under consideration for conversion to a conventional DFR. Two patients had follow-up periods of 3 months or less and are still in their early rehabilitation period. One patient in this group developed sepsis that resolved after an open washout. Conclusions: Our early results with this prosthesis, in the patients with adequate follow-up, have been good in the majority but the two cases of fair and poor knee flexion are disappointing. This particular problem may relate to design and technical factors, which will be discussed in detail

Unicompartmental knee replacement (UKR) is technically challenging, but has the advantage over total knee replacement (TKR) of conserving bone and ligaments, preserving knee range of movement and stability. Computer navigation allows for accurate placement of the components, important for preventing failures secondary to mal-alignment. Evidence suggests an increase in failure rates beyond 3 degrees of coronal mal-alignment. Our previous work has shown superior functional scores in those patients having undergone UKR, when compared with those having had TKR. However, to a certain extent, this is likely to be due to differences in the two cohorts. Those selected for UKRs are likely to be younger, with less advanced and less widespread degenerative disease. It is almost inevitable, therefore, that functional outcomes will be superior. We aimed to compare the functional and radiological outcomes of UKR vs TKR in a more matched population. Ninety-two patients having had one hundred consecutive computer navigated UKRs were reviewed both clinically and radiographically. The Smith & Nephew Accuris fixed-bearing modular prosthesis was used in all cases, with the ‘Brainlab’ navigation system. For our comparative group we identified patients who had actually undergone navigated TKR several years ago, but who, in retrospect, would have now been offered a UKR in line with our current practice. These patients were identified following review of pre-operative radiographs and operation notes, confirming degenerative disease confined mainly to one compartment of the knee, in the absence of any concern as to the integrity of the anterior cruciate ligament. This sub-group of patients were also assessed clinically and radiographically. Mean follow-up for the UKR group was 25 months, (range 8–45.) For our TKR sub-group, nineteen patients were identified. Average length of stay for the UKR group was 3.7 days, (range 2 to 7,) and for the TKR group this was 5.2 days, (range 3 to 10.). Functional scores (Oxford Knee Score) were good to excellent for the majority of patients in both groups, although they were significantly better in the UKR group. Mean Oxford Knee Score in the UKR group was 7.5, (0–48, with 0 being best.) Mean score in the TKR sub-group was 12.1. (p = 0.02). Reliably comparing TKR with UKR is difficult, due to the fundamental differences in the two groups. We have endeavoured to match these two cohorts as best possible, in order to compare the outcomes of both. Our use of computer navigation in both groups allows for accurate prosthesis placement. When measuring component position, there were no ‘outliers,’ outside of the widely accepted three degrees of deviation. We propose that, with the correct patient selection, UKR gives a better functional outcome than TKR. Longer-term follow-up of our UKR group is required to monitor the onset of progressive arthrosis in other joint compartments, although our early results are very encouraging. Furthermore, we advocate the use of computer navigation to firstly allow for more accurate component positioning, and secondly to make challenging UKR surgery less technically demanding

Introduction: The emergence of Independent Sector Treatment Centres (ISTCs) in the UK for the provision of elective orthopaedic services began in 2002–3. Within our trust the bulk of elective orthopaedic surgery is performed in an ISTC however there is a small but significant cohort of patients who are deemed not suitable for treatment at the ISTC. Patients with a BMI (body mass index) ≥40 or an ASA (American society of anaesthesiologists) grade of 3 or more are automatically rejected. With increasing levels of obesity and an aging population the size of the reject cohort is going to rise. These patients are then returned to the NHS to be placed on a new (complex elective) waiting list for their surgery. The aim of this study was to assess the early outcomes and complications following primary knee arthroplasty on our high risk patients. Methods: A retrospective review of a consecutive series of 214 primary knee arthroplasties in patients rejected from the ISTC was performed. Data (demographics, ASA grade, BMI, length of stay, complications, range of knee movement and requirement for HDU/ICU) were collected from preoperative assessments, inpatient notes, anaesthetic charts, discharge summaries and follow up clinic letters. All patients were followed up for a minimum of 6 months. Results: 155 (72%) patients were female. 140 (65%) had ASA of 3 or more. 88 (41%) had a BMI of 40 or more. Median length of stay was 8 days (6 to 11 IQR) and did not vary with increasing BMI but increased to 10 days in the ASA 3 and 12 days in the ASA 4 group. There were a total 90 complications in 71 patients. The most common complications were 22 superficial wound infections (10.3%), 11 Pneumonias (5.1%), and 9 symptomatic DVTs (4.2%). There were 16 severe complications (2 Deep infections, 4 PEs, 2 CVAs, 4 acute renal failures and 4 dislocations) in 15 patients. Patients with a BMI < 40 had a total complication rate of 38% (7.9% severe) compared with 26% (5.7% severe) in BMI ≥40 group. Patients with an ASA < 3 had a complication rate of 31% (4.1% severe) vs. 34% (8.6% severe) in patients with an ASA ≥ 3. HDU/ICU beds were required postoperatively for 20 patients (9 planned and 11 unplanned). At six months 72% achieved a knee range of movement ≥ 0 to 90 degrees. Surgeons who performed high volumes of surgery in this difficult group had lower complications then lower volume surgeons. Conclusion: This is one of the largest consecutive groups of high risk patients undergoing primary total knee arthroplasty. Our results show that elevated BMI does not appear to adversely affect complication rates in knee arthroplasty in our series although ASA grades of 3 and 4 are associated with increased length of stay and complication rates. It is also clear that small groups of surgeons operating on these difficult patients may reduce complications

Introduction To assess five-year survivorship and clinical outcome following unicompartmental knee replacement (UKR) and total knee replacement (TKR) in pre-operatively matched patient groups. Methods From a prospective database of over 600 patients undergoing knee replacement for osteoarthritis, 70 primary Oxford UKRs (62 patients) were matched pre-operatively with 70 primary PFC TKRs (68 patients) for age, sex, body mass index, knee range of movement and Knee Society Score (KSS). The two groups were assessed at six, eighteen, thirty-six and sixty months following knee replacement and compared for survivorship of the prosthesis (with failure defined as revision for any reason or ‘worst-case’ assuming all patients lost to follow up are revised), post-operative ROM achieved and clinical outcome based on the KSS (reported as separate knee and function score). Results Three (5 percent) patients in the UKR group and two (3 percent) in the TKR group were unavailable for follow-up at five years. Five-year survivorship based on revision for any reason was 90 percent (95 percent Confidence Interval (CI): 82 to 98) for UKR and 100 percent (95 percent CI: 100 to 100) for TKR (log rank test: p=0.009). The ‘worst-case’ five-year survivorship (assuming all patients lost to follow up are revised) was 85 percent (95 percent CI: 76 to 94) for UKR and 97 percent (95 percent CI: 93 to 100) for TKR (log rank test: p=0.02). The mean post-operative ROM achieved was 105.3 degrees following UKR and 98.3 degrees following TKR (difference 7.0 (95 percent CI 3.3 to 10.6), p< 0.001). There was no difference in the KSS between the two groups for the knee score (difference 0.1 (95 percent CI: −4.3 to 4.5), p=0.9) and function score (difference 2.6 (95 percent CI: −1.7 to 6.9), p=0.2). Conclusion In comparable patients with osteoarthritis of the knee, survivorship remains superior for TKR at five years. The ROM achieved is greater for UKR but there is no difference in the overall clinical outcome following UKR or TKR. We believe that UKR should only be performed in carefully selected cases because mid-term clinical outcome is similar following UKR or TKR and the complication rate may be higher for UKR

Total knee arthroplasty (TKA) is an established and successful procedure. However, the design of prostheses continues to be modified in an attempt to optimise the functional outcome of the patient. . The aim of this study was to determine if patient outcome after TKA was influenced by the design of the prosthesis used. A total of 212 patients (mean age 69; 43 to 92; 131 female (62%), 81 male (32%)) were enrolled in a single centre double-blind trial and randomised to receive either a Kinemax (group 1) or a Triathlon (group 2) TKA. . Patients were assessed pre-operatively, at six weeks, six months, one year and three years after surgery. The outcome assessments used were the Oxford Knee Score; range of movement; pain numerical rating scales; lower limb power output; timed functional assessment battery and a satisfaction survey. Data were assessed incorporating change over all assessment time points, using repeated measures analysis of variance longitudinal mixed models. Implant group 2 showed a significantly greater range of movement (p = 0.009), greater lower limb power output (p = 0.026) and reduced report of ‘worst daily pain’ (p = 0.003) over the three years of follow-up. Differences in Oxford Knee Score (p = 0.09), report of ‘average daily pain’ (p = 0.57) and timed functional performance tasks (p = 0.23) did not reach statistical significance. Satisfaction with outcome was significantly better in group 2 (p = 0.001). These results suggest that patient outcome after TKA can be influenced by the prosthesis used. Cite this article: Bone Joint J 2015;97-B:64–70

Viscosupplementation with hyaluronic acid (HA) is an established intervention for pain control in patients with mild to moderate osteoarthritis (OA) of the hip and knee. It is highly concentrated at the surface of the articular cartilage and the superficial layers of the synovial membrane. In the synovial fluid, HA acts as both a lubricant and a shock absorber. Due to the meshwork it forms with aqueous solutions, it acts as a semi-permeable barrier regulating metabolic exchanges between cartilage and the synovial fluid, and a viscoelastic shield around synoviocytes and adjacent nerve endings. Through its molecular size HA hinders the free movement of lytic enzymes and inflammatory mediators, and enhances chondrocyte metabolism. Osteoarthritis is associated with a decrease in concentration and average molecular weight of native HA in synovial fluid. The mechanism of action of administered intra-articular HA is not completely understood, but as its clinical benefit exceeds its intra-articular presence, it is thought to perhaps induce native biosynthesis of HA and other extracellular matrix components and in particular suppress the inflammatory response and inhibit substance P, in addition to contributing to shock absorption by means of its viscoelastic properties. Problems include inconvenience, expense and the logistical problems associated with multiple injections, injection technique and level of skill required by the administering physician, variable clinical response and adverse reactions. In this independent, prospective, randomized trial, we compare efficacy and complications associated with treatment 100 athletes (112 knees) using durolaneTM and synvisc oneTM using the Visual Analogue Score, SF-36 V2 questionaire, and Oxford knee scores. Range of movement and absence from sporting activity is recorded at each visit. These assessments are repeated at 3, 6, 9 and 12 months. Significant improvement is seen in the VAS, SF 36 V2 and Oxford Knee Scores (p=0.01) and reduction in the use of analgesics and anti-inflammatories is seen with both products at 3 months post injection, with a significant advantage to the duro-lane group (p=0.001). At 6 months, this difference is extended even further. A small but statistical difference is noted in the time taken for the athlete to return to sporting activity following a rest period due to pain. Adverse reactions occur significantly less with the more effective product. We conclude that intra-articular HA a useful intervention in patients with mild to moderate OA of the knee, can produce sustained pain relief at 6 months, and can reduce the requirement for analgesia and anti-inflammatory medication during this time

Aims: To assess the results of Anterior Cruciate Ligament (ACL) reconstruction at a minimum of two years follow-up, using the Rolimeter [AIRCAST, Europe] as an adjunct to routine knee examination and subjective scoring systems. Methods: The Warrington Knee Injury database was initiated in June 2001 and data from all knee ligament injuries has been collected prospectively, from preoperative status through to all follow up assessments. Inclusion criteria for our study were, all ACL reconstructions performed by the senior author with minimum 24 months follow up; other ligaments being intact and presence of a normal contralateral knee. 50 patients satisfied the inclusion criteria. There were 41 males and 9 females in ages ranging from 17 to 51 (mean 30.6 years), with no significant difference in age between sexes. Hamstring grafts were used in 29 knees and Bone-Patellar tendon – Bone (BPTB) grafts in 21. Knee laxity was measured using the Rolimeter with IKDC knee examination and functional assessments using the Lysholm, IKDC and KOOS scoring systems. Results: 20/21 of patients with BPTB grafts (95.2%) and 26/29 of patients with Hamstring grafts (89.7%) achieved normal or near normal knee laxity compared to their opposite knee. The Range of movement in 48 of 50 knees (96%) fell within normal or near normal limits according to IKDC description (Lack of extension < 3 degrees and lack of flexion < 10 degrees). Two patients with abnormal range of movement had a similar lack of movement preoperatively. Though none of the knees were abnormally tight (AP laxity difference < -3), there was a relationship between knee tightness and lack of extension, but this was not statistically significant. There was no association between age or sex of patient and lack of movement. The mean IKDC, Lysholm and KOOS symptom scores were 80.45, 87.3 and 81.3 respectively. Conclusions: We have achieved a normal or near normal AP laxity in 92% of our ACL reconstructions on assessment at 2 years postoperatively. We report no signifi-cant difference in outcome between use of Hamstring or BPTB grafts. The functional outcome has been optimal as revealed by subjective evaluation

Aims

The interest in unicompartmental knee arthroplasty (UKA) for medial osteoarthritis has increased rapidly but the long-term follow-up of the Oxford UKAs has yet to be analysed in non-designer centres. We have examined our ten- to 15-year clinical and radiological follow-up data for the Oxford Phase III UKAs.

The June 2015 Knee Roundup360 looks at: Cruciate substituting versus retaining knee replacement; What’s behind the psychology of anterior cruciate ligament (ACL) reconstruction?; Is there a difference in total knee arthroplasty risk of revision in highly crosslinked versus conventional polyethylene?; Unicompartmental knee arthroplasty: is age the missing variable?; Satisfaction rates following total knee arthroplasty; Is knee alignment dynamic?; Unicompartmental knee arthroplasty: cemented or cementless?; Can revision knee services pay?

Objectives

Effective analgesia after total knee arthroplasty (TKA) improves patient satisfaction, mobility and expedites discharge. This study assessed whether continuous femoral nerve infusion (CFNI) was superior to a single-shot femoral nerve block in primary TKA surgery completed under subarachnoid blockade including morphine.

The October 2014 Research Roundup³⁶⁰ looks at: unpicking syndesmotic injuries: CT scans evaluated; surgical scrub suits and sterility in theatre; continuous passive motion and knee injuries; whether pain at night is melatonin related;venous thromboembolic disease following spinal surgery; clots in lower limb plasters; immune-competent cells in Achilles tendinopathy; and infection in orthopaedics.