Introduction: Unicompartmental knee arthroplasty (UKA) is a proven for treatment of knee osteoarthritis (OA). Survival rates have been found comparable with total knee arthroplasty (TKA) in specialty hospitals series, but registry based studies show worse results of survival of UKA. High BMI, age of the patient, patellofemoral arthritis or learning curve have been found to have only mild consequences to the survival rates. Original indications for Oxford UKA in OA are severe pain and full thickness cartilage loss with bone-on-bone contact in the medial side. After widespread use of UKA surgeons are broadening their indications. Purpose of this study was to evaluate the influence of preoperative degree of OA on survival rate of UKA. Material and Methods: 113 knees in 103 patients were operated with Oxford phase 3 UKA. We evaluated all the patient data retrospectively and patient age, body mass index (BMI), sex, earlier arthroscopies, operation time, follow-up time, preoperative medial
Introduction. Chronic uneven distribution of forces over the articular cartilage, which are present in OA, has been shown to be a risk factor for the development of OA. Certain regions of the articular cartilage will be exposed to increased chronic peak loads, whereas other regions encounter a corresponding relative reduction of transmitted forces. This has a well known influence on cartilage viability and is a precursor of degenerative progression. Congruence of joints has an important impact on force distribution across articular surfaces. Therefore, tibiofemoral incongruence could lead to alterations of load distribution and ultimately to progressive degenerative changes. In clinical practice the routine method for evaluation of progressive OA is analysis of
Objectives. An important measure for the diagnosis and monitoring of knee osteoarthritis is the minimum
Background/Objective: Since estrogen receptors (ERα/ERβ) were identified in human chondrocytes, animal-and experimental studies have demonstrated the importance of continued estrogen production for the integrity of articular cartilage. However, human epidemiological support of the hypothesis has been inconclusive. The present study investigated the relationship between reduced bone mineral densities (BMD), as a surrogate parameter of endogenous estrogen status – assessed by digital x-ray radiogrammetry (DXR), and reduced minimum hip
Objectives. The purpose of this study was to compare the
Varus malalignment increases the susceptibility of cartilage to mechanical overloading, which stimulates catabolic metabolism to break down the extracellular matrix and lead to osteoarthritis (OA). The altered mechanical axis from the hip, knee to ankle leads to knee joint pain and ensuing cartilage wear and deterioration, which impact millions of the aged population. Stabilization of the remaining damaged cartilage, and prevention of further deterioration, could provide immense clinical utility and prolong joint function. Our previous work showed that high tibial osteotomy (HTO) could shift the mechanical stress from an imbalanced status to a neutral alignment. However, the underlying mechanisms of endogenous cartilage stabilization after HTO remain unclear. We hypothesize that cartilage-resident mesenchymal stem cells (MSCs) dampen damaged cartilage injury and promote endogenous repair in a varus malaligned knee. The goal of this study is to further examine whether HTO-mediated off-loading would affect human cartilage-resident MSCs' anabolic and catabolic metabolism. This study was approved by IACUC at Xi'an Jiaotong University. Patients with medial compartment OA (52.75±6.85 yrs, left knee 18, right knee 20) underwent open-wedge HTO by the same surgeons at one single academic sports medicine center. Clinical data was documented by the Epic HIS between the dates of April 2019 and April 2022 and radiographic images were collected with a minimum of 12 months of follow-up. Medial compartment OA with/without medial meniscus injury patients with unilateral Kellgren /Lawrence grade 3–4 was confirmed by X-ray. All incisions of the lower extremity healed well after the HTO operation without incision infection.
Introduction. Wear of polyethylene inserts plays an important role in failure
of total knee replacement and can be monitored in vivo by
measuring the minimum
The primary treatment goal for patients with femoroacetabular impingement syndrome, a common hip condition in athletes, is to improve pain and function. In selected patients, in the short term following intervention, arthroscopic hip surgery is superior to a pragmatic NHS- type physiotherapy programme. Here, we report the three-year follow-up results from the FemoroAcetabular Impingement Trial (FAIT), comparing arthroscopic hip surgery with physiotherapy in the management of patients with femoroacetabular impingement (FAI) syndrome. Two-group parallel, assessor-blinded, pragmatic randomised controlled study across seven NHS England sites. 222 participants aged 18 to 60 years with FAI syndrome confirmed clinically and radiologically were randomised (1:1) to receive arthroscopic hip surgery (n = 112) or physiotherapy and activity modification (n = 110). We previously reported on the hip outcome score at eight months. The primary outcome measure of this study was minimum
Aims. To assess the incidence of radiological lateral osteoarthritis (OA) at 15 years after medial unicompartmental knee arthroplasty (UKA) and assess the relationship of lateral OA with symptoms and patient characteristics. Methods. Cemented Phase 3 medial Oxford UKA implanted by two surgeons since 1998 for the recommended indications were prospectively followed. A 15-year cumulative revision rate for lateral OA of 5% for this series was previously reported. A total of 163 unrevised knees with 15-year (SD 1) anterior-posterior knee radiographs were studied. Lateral
Aims. To explore the clinical relevance of
Knee joint distraction (KJD) has been associated with clinical and structural improvement and synovial fluid (SF) marker changes. However, structural changes have not yet been shown satisfactorily in regular care, since radiographic acquisition was not fully standardized. AI-based modules have shown great potential to reduce reading time, increase inter-reader agreement and therefore function as a tool for treatment outcome assessment. The objective was to analyse structural changes after KJD in patients using this AI-based measurement method, and relate these changes to clinical outcome and SF markers. 20 knee OA patients (<65 years old) were included in this study. KJD treatment was performed using an external fixation device, providing 5 mm distraction for 6 weeks. SF was aspirated before, during and immediately after treatment. Weight-bearing antero-posterior knee radiographs and WOMAC questionnaires were collected before and ~one year after treatment. Radiographs were analysed with the Knee Osteoarthritis Labelling Assistant (KOALA, IB Lab GmbH, Vienna, Austria), and 10 pre-defined biomarker levels in SF were measured by immunoassay. Radiographic one-year changes were analysed and linear regression was used to calculate associations between changes in standardized
It is unclear whether patients with early radiographic osteoarthritis (OA) but severe hip symptoms benefit from total hip replacement (THR). We aimed to assess which factors were associated with successful THR in this patient group. From a consecutive series of 1,935 patients undergoing THR we identified 70 (3.6%) patients with early OA (Kellgren and Lawrence (KL) grades 0-2). These were compared with 200 patients with advanced OA (KL grades 3–4). Outcomes were Oxford Hip Scores (OHS), EQ5D and EQ-VAS scores; compared pre-operatively with one year post-operatively. We investigated which clinical and radiographic (plain x-ray, CT, MRI) features predicted successful THR in the early OA group. Success was defined as reaching a postoperative OHS≥42. The early OA group were significantly younger (61 vs 66 years; P=0.0035). There were no significant differences in body mass index, ASA grade or gender. After adjusting for confounders, the advanced OA group had a significantly greater percentage of possible change (PoPC) in OHS (75.8% versus 50.4%; P<0.0001) and improvement in EQ5D (0.151 versus 0.002; P<0.0001). There were no significant differences in complication, revision or readmission rates. In the early OA group, we identified 16/70 (22.9%) patients who had a ‘successful’ THR. Of those with early OA, 38 patients had pre-operative CT or MRI scans. Patients who had a ‘successful’ THR were significantly more likely to have subchondral cysts on CT/MRI (91.7% versus 57.7%; P=0.0362). The presence of cysts on CT/MRI was associated with a significantly greater PoPC in OHS (61.6% versus 38.2%; P=0.0353). The combination of cysts and
Aim: The aim of the study was to assess the correlation of CE angle to the ratios of medial hip
Introduction and Objective. To estimate the prevalence of acetabular ossifications in the adult population with asymptomatic, morphologically normal hips at CT and to determine whether the presence of labral ossifications is associated with patient-related (sex, age, BMI), or hip-related parameters (joint space width, and cam- and pincer-type femoroacetabular impingement morphotype). Materials and Methods. We prospectively included all patients undergoing thoracoabdominal CT over a 3-month period. After exclusion of patients with a clinical history of hip pathology and/or with signs of osteoarthritis on CT, we included a total of 150 hips from 75 patients. We analyzed the presence and the size of labral ossifications around the acetabular rim. The relationships between the size of labral ossifications and patient- and hip-related parameters were tested using multiple regression analysis. Results. The prevalence of labral ossifications in this population of asymptomatic, non-OA hips was 96% (95%CI=[80.1; 100.0]). The presence of labral ossifications and their size were correlated between right and left hips (Spearman coefficient=0.64 (95%CI=[0.46; 0.79]), p<0.05)). The size of labral ossifications was significantly associated with age (p<0.0001) but not with BMI (p=0.35), gender (p=0.05),
Purpose: The aetiology of primary omarthrosis is still unclear. Typical radiological changes are joint space narrowing and the development of caudal osteophytes. The objective of the study is the analysis of the joint space of the shoulder in four different age groups. Materials and Methods: Retrospective analysis of n=342 standardized X-rays (2002–2009) (true ap, axillary). Inclusion criteria: normal adulthood group I (n=60), instability group II (n=53), calcifying tendonitis of the supraspinatus tendon group III (n=109), advanced primary omarthrosis group IV (n=120). Measurement of joint space at three levels (ap: superior, central, inferior; axillary: anterior, central, posterior). Two independent measurements. Statistical analysis SPSS 17.0: U-Test acc. Mann and Whitney. Bivariate correlation analysis (Spearman), partial correlation analysis, intraclass correlation coefficient. Results: Mean age group I 17.84±1.54, group II 31.6±11.8, group III 48.2±8.0, group IV 66.43 ±9.74 (p=0.001). Measurement joint space: interobserver reliability excellent in the ap-projection (r=0.887–0.910) and in the axillary projection (r=0.879–0.886). Joint space group I: 4.79mm±0.84 superior ap, 4.28mm±0.75 central ap, 4.57mm±0.80 inferior ap, 6.59mm±1.44 anterior axillary, 6.12mm±1.09 central axillary and 7.03mm±1.17 posterior axillary; group II: 3.78mm±0.99 superior ap, 3.12mm±0.73 central ap, 3.38mm±0.80 inferior ap, 3.92mm±1.08 anterior axillary, 3.92mm±0.77 central axillary and 4.79mm±1.18 posterior axillary; group III: 3.43mm±1.06 superior ap, 2.87mm±0.80 central ap, 3.25mm±0.79 inferior ap, 3.95mm±0.83 anterior axillary, 3.34mm±0.84 central axillary and 4.05mm±0.84 posterior axillary; group IV: 2.00mm±1.40 superior ap, 1.47mm±1.07 central ap, 1.48mm±1.93 inferior ap, 3.01mm±2.22 anterior axillary, 1.08mm±1.12 central axillary and 1.17mm±1.04 posterior axillary. The differences between the four groups for the
Summary. In this study we validate that weight-bearing images are needed for accurate polyethylene liner wear measurement in total knee prostheses by measuring the difference in minimum
Background. A consecutive series of 76 patients (101 hips) underwent primary open reduction, capsulorrhaphy and innominate osteotomy for late presenting developmental hip dislocation. They were aged 1.5 to 5 years at the time of surgery between 1958 and 1965. This study was designed to review their outcome into middle age. Methods. We located and reviewed 60 patients (80 hips) using a public records search. This represents a 79% rate of follow-up at 40-48 years post-operatively. 19 patients (24 hips) had undergone total hip replacement and 3 had died. The remaining 38 patients (53 surviving hips) were assessed by the WOMAC. ¯. and Oxford hip outcome questionnaires, physical examination and standing pelvic radiograph. The radiographs were analysed for minimum
Background. To conduct a systematic review and network meta-analysis of RCTs with the aims of comparing relevant clinical outcomes (i.e. VAS, WOMAC total and sub-score score, Lequesne Algofunctional index,
Introduction. As orthopaedics shifts towards value-based models of care, methods of evaluating the value of procedures such as a total hip arthroplasty (THA) will become crucial. Patient reported outcome measures (PROMs) can offer a meaningful way for patient-centered input to factor into the determination of value. Despite their benefits, PROMs can be difficult to interpret as statistically significant, but not clinically relevant, differences between groups can be found. One method of correcting this issue is by using a minimal clinically important improvement (MCII), defined as the smallest improvement in a PROM determined to be important to patients. This study aims to find demographic and surgical factors that are independently predictive of failing to achieve a MCII in pain and physical function at 1-year following THA. Methods. A total of 976 patients were enrolled into a prospective international, multicenter study evaluating the long-term clinical performance of two acetabular shells and two polyethylene liners from a single manufacturer. All patients consented to be followed with plain radiographs and a set of PROMs preoperatively and at 1-year after surgery. The outcomes considered in this study were achieving literature-defined MCIIs in pain and physical function at one year after THA. The MCII in pain was defined as achieving a 2-point decrease on the Numerical Rating Scale (NRS)-Pain or reporting a 1-year NRS-Pain value of 0, indicating no pain. The MCII in physical function was defined as achieving an 8.29-point increase on the SF-36 Physical Function subscore. Univariate analyses were conducted to determine if there were statistically significant differences between patients who did achieve and did not achieve a MCII. Variables tested included: demographic and surgical factors, general and mental health state, and preoperative radiographic findings such as deformity and
Introduction: The degenerative changes in the patello-femoral joint after an autologous bone-tendon-bone anterior cruciate ligament reconstruction were studied using plain radiology more than 24 years after the surgical procedure. Material and Methods: One hundred patients out of a total of 148 patients could be reviewed at 24.5 years follow-up. Radiological analysis included