Introduction and Aims: We undertook this study to detemine the results of acetabular fixation using the Duraloc 300 uncemented acetabular component in patients with inflammatory joint disease and poor bone stock. Method: Fifty consecutive total hip replacements using a Duraloc 300 cup in patients with imflammatory joint disease were reviewed at an average of 8.2 years. Postoperative x-rays were analysed for cup placement and interface gaps. Follow-up films were analysed for lucent lines, osteolysis, wear and migration. Kaplan-Meier survivorship analysis was performed. Results: All components were found to be stable with no evidence of loosening or migration. One patient developed sepsis seven years post-surgery. There was no evidence of excessive wear or osteolysis. Conclusion: The Duraloc 300 cementless acetabular component has excellent fixation with no cases of loosening at an average of 8.2 years in patients with inflammatory joint disease. The low rate of wear and pelvic osteolysis may be indicative of the decreased demands placed on the prosthesis in this cohort of patients. The poor bone stock has not however adversely effected acetabular fixation

Objective: To study the incidence of joint replacement procedure, arthrodesis, and synovectomy among patients with chronic inflammatory joint disease during the period 1994 to 2004. Methods: Data from the Norwegian Arthroplasty Register was used to find the number of joint replacement procedures performed in Norway 1994 – 2004. The incidences of arthrodeses and synovectomies were obtained from the Norwegian Patient Register. Incidence rates were calculated based on age, year, and gender specific population rates for the Norwegian population, obtained from Statistics Norway. Results: There were 8268 primary joint replacements, 3554 arthrodeses, and 5012 synovectomies performed in patients with inflammatory arthritis (IA) during the study period. A reduction in joint replacement procedures and synovectomies took place during the period 1994 to 2004, in patients with IA. For the oldest patients (80 years and older), no such trend was found. During the same time period, the incidence of joint replacements due to osteoarthritis increased. A significant reduction in the incidence of arthrodesis procedures was also found for the total study group, but not for the different subgroups. Conclusion: The incidence of joint replacements and synovectomies among patients with chronic inflammatory joint disease decreased from 1994 to 2004. This may be the result of improved medical treatment of these patients

Purpose: Arthodesis is the conventional treatment for the rheumatoid wrist. In the event of severe bilateral disease, bilateral arthrodesis can be discussed as an alternative to unilateral arthrodesis an contralateral prosthesis. We wanted to know the functional outcomes after bilateral arthrodesis. Material and methods: This retrospective analysis involved seven patients (one man and six women), mean age 46 years (28–69) who underwent total bilateral arthrodesis of the wrist for inflammatory joint disease (six rheumatoid, one chronic juvenile arthritis). Mean follow-up was five years. The patients were reviewed clinically and radiographically. We noted goniometric measurements of the upper limbs, the Jebsen hand function test (for activities of daily life), force (wrist and grip), and the Buck-Gramcko-Lohmann evaluation. Results: On average, the position achieved after arthrodesis was 2° flexion (−5° to +10°) with 6° ulnar inclination (−5° to +20°). Radiological fusion was achieved in all cases. At last follow-up, we noted that three patients had resumed their occupational activities, one had been reclassified as handicapped, and one as disabled. One patient was a housewife and one other woman was retired. The Jebsen hand test showed that our patients could perform 32 of the 49 daily activities (65%). Daily activity was noted excellent in three patients, good in two and fair in two. The Buck-Gramcko-Lohmann score was fair 6.8/10 (2–10) corresponding to good outcome. All patients were satisfied with the outcome. Discussion: Daily life activities could be performed readily after bilateral arthrodesis of the wrist. Perineal hygiene was possible for five of our patients. The only problems concerned activities requiring force and fine movements, because of the apprehension and the lack of fine dexterity. Poor results could be attributed to metacarpophalangeal deformations and decreased grip force. We observed an 80% reduction in force compared with a representative population of non-operated patients with rheumatoid disease. Bilateral arthrodesis is a valid alternative to bilateral arthroplasty or combined arthrodesis prosthesis implantation. It does not expose the patients to the risk of mechanical arthroplasty

Aims

Metabolic profiling is a top-down method of analysis looking at metabolites, which are the intermediate or end products of various cellular pathways. Our primary objective was to perform a systematic review of the published literature to identify metabolites in human synovial fluid (HSF), which have been categorized by metabolic profiling techniques. A secondary objective was to identify any metabolites that may represent potential biomarkers of orthopaedic disease processes.

Aim. Reveal the rate of surgical site infection (SSI) after primary hip and knee arthroplasty in patients with inflammatory joint disease and analyse if the infection rate was correlated to the given anti-rheumatic treatment. The background is that since 2006 patients operated at the orthopaedic department at Skåne University hospital, Lund, Sweden, have continued treatment with TNF-alpha inhibitors during the perioperative period. Method. During 2006 to 2015 494 planned primary hip and knee arthroplasties were performed on 395 patients (236 hip arthroplasties and 239 knee arthroplasties). Data on age, sex, diagnosis, BMI, operation time, ASA-classification, treatment with cDMARDs (conventional disease modifying anti-rheumatic drugs) and bDMARDs (biological disease modifying antirheumatic drugs) and use of prednisolone was collected. The primary outcome variable was prosthetic joint infection (PJI) within 1 year from surgery with a secondary outcome variable being superficial SSI. Results. In 32% (n=159) of the cases the patient was treated with a TNF-alpha inhibitor. The rate of PJI was 1.4% (n=7). The overall rate of infection, including superficial infections, was 2.4% (n=12). All the PJIs occurred after a knee arthroplasty and only 1 patient was treated with a TNF-alpha inhibitor (etanercept). Conclusions. We could not find that continuing treatment with TNF-inhibitors perioperatively led to a higher incidence of PJI or SSI than generally would be expected in a group of patients with an inflammatory joint disease. Based on these results there is no need to discontinue treatment with TNF-inhibitors when performing arthroplasty surgery

Introduction. Synovectomy in children with juvenile rheumatoid arthritis (JRA) and psoriatic arthritis (PSA) is still subject of controversial discussion. Our results of arthroscopic synovectomy of the knee in children with chronic inflammatory joint disease are presented. Material. From 1989–1997 27 synovectomies were performed in 27 children with inflammatory arthritis (15 JRA, 12 PSA). Average age at surgery was 12. 5 y (2. 9–17. 8 y). Mean follow-up was 4. 9 years. Methods. Onset of disease and conservative therapy was documented. Each patient was physically and radiologically examined preoperatively and 24 children postoperatively (mean follow-up 4. 9 years). For arthroscopic shaver-assisted synovectomy of the knee we used minimum 4 portals and normally 6 portals (2 anterior, 2 suprapatellar and 2 posterior portals). In addition to the physical examination we used a special clinical score (Laurin 1974). We compared the pre- and postoperative limits of active and passive knee movement. We performed sonographs and radiographs of the infected joint. Radiography was classified following the Larsen-Scale. Patient and parents gave their opinion whether the operation was successful. Before surgery all children had intensive drug and physical therapy for 8–62 months (42 month). In the course of conservative treatment, knees had local joint treatment with triamcinolonhex-acetomid (THA), normally for three times before surgery. Preoperative X-rays showed Larsen stage I in 3 knee joints and Larsen stage 0 in the other knees. Results. In 85% of the children, we found good or excellent surgical outcome. 2 joints achieved fair and 2 joints poor outcome. Concerning subjective outcome 22 (82%) children had been very satisfied (56%) or satisfied (26%). 25 of the children’s parents would agree in the same surgical procedure again. In 6 knee joints we found recurrent synovitis. 2 of these knee joints were reoperated (30 and 22 month postoperatively with satisfying result), the other 4 joints were treated with THA i. a.. The 2 reoperations were regarded as poor result. We had no postoperative complications and the normal hospitalisation was 15 days. Prior to surgery, 12 knee joints had an average deficit of active knee extension of 10° (5–20°). Postoperatively, no extension deficit was found anymore in 25 of the knees. Compared to the contralateral knees, a flexion deficit of 10° (5–15°) was obtained postoperatively. At sonography, no joint effusion could be revealed. Postoperative X-rays showed no progression in Larsen stage. Outcome in children with oligoarthritis was better than in those with polyarthritic disease. Discussion. Early arthroscopic synovectomy of the knee in children with chronic inflammatory joint disease is, in case of failure of conservative treatment, a useful method of treatment. We propose early synovectomy of the knee joint as an essential part of the treatment scheme for children with inflammatory joint disease

Osteoarthritis is a slowly progressive disease which includes the intervention of several cytokines and macrophage metalleinoproteinases reaction, leading to the degradation of the local cartilage but also having an impact on the serum acute phase proteins (APPs). Subsequently, biomarkers seem to be essential to estimate its progression and the need for any surgical intervention such as total arthroplasty, but also can be used as therapeutic agents. Recently, among APPs, fetuin-A drew attention regarding its possible anti-inflammatory role in animal models but also as a therapeutic agent in the inflammatory joint disease in clinical trials. The purpose of this study is to investigate the possible attenuating role of the intra-articular administration of Fetuin-A in post-traumatic induced secondary osteoarthritis in rats, and also its effect on the systematic levels of IL-2,4,7, BMPs 2,4,7, CRP and Fetuin-A. 30 male Sprague Dawley rats were separated in two groups where post-traumatic osteoarthritis was induced surgically by Anterior Cruciate Ligament Transection and the transection of the Medial Collateral Ligament of the right knee. In the Control Group, only surgical intervention took place. In Fetuin Group, along with the induction of osteoarthritis, a single dose of bovine fetuin was administrated intra-articularly intra-operatively in 5 and 8 weeks of the experimental protocol. Both groups were examined for 8 weeks. The levels of interleukins, bone morphogenetic proteins, Fetuin-A and C-Reactive Protein were evaluated by ELISA of peripheral blood in three time periods: preoperatively, 5 and 8 weeks post-operatively. Knee osteoarthritic lesions were classified according to Osteoarthritis Research Society International Grading System and Modified Mankin Score, by histologic examination. IL-2 levels were significantly decreased in the Fetuin Group. No statistical difference was signed on the levels of IL-7, BMP-2,4,7 and Fetuin-A between the two groups. CRP levels were significantly increased in the Fetuin Group in 5 weeks of the experiment. Fetuin Group signed better scores according to the OARSI classification system and Modified Mankin Score, without any statistical significance. Intra-articular administration of Fetuin-A restrictively affected the progression of post-traumatic arthritis in rats, as only the levels of IL-2 were decreased as well as limited osteoarthritic lesions were observed on the Fetuin Group

Osteoarthritis (OA) is a degenerative and inflammatory joint disease that affects the whole joint. Mesenchymal stem cells ability to secrete anti-inflammatory and immuno-modulatory factors represents an attractive tool in the treatment of OA. Considering the risk of cell leakage and the massive cell death upon intra-articular injection, we developed a micromolding protocol of encapsulation that allows to obtain particles that (i) could be injected with a 26G needle into a mouse joint and (ii) could provide a 3D microenvironment supporting cell biological activity. Polydimethylsiloxane (PDMS) chips containing circular micromolds were manufactured and a solution of alginate (2% w/v) containing human adipose stem cells (3 millions/mL) was deposited on the chips. Cell loading into the micromolds was performed either by sedimentation or by centrifugation. Following Ca2+ crosslinking, alginate particles (diameter 150±0.7μm) were obtained. The number of cells per particle was 5 times higher when the micromolds were loaded by centrifugation. Cell number and metabolic activity remained stable for 7 days after encapsulation and injection through a 26G needle had no impact on cell viability. When cells were stimulated with TNF-alpha and INF-gamma, prostaglandin E2 (PGE2) concentration in the supernatant was multiplied by 13 and 7 and indoleamine2,3-dioxygenase (IDO) activity was 2 and 4 times higher when cell loading was performed by sedimentation or centrifugation, respectively. We have demonstrated that encapsulated cells were able to sense and respond to an inflammatory stimulus and their therapeutic potential will be evaluated in a murine model of osteoarthritis

Introduction. Expanded indications and patient demand have significantly increased the number of TKA performed in young and active patients under age 55. While improved materials have decreased the likelihood of early catastrophic wear, concerns remain with the performance and survivorship of TKA implants in this patient population. Therefore, the purpose this study is to evaluate the clinical outcomes, complications, and implant survivorship of TKAs performed in patients under age 55. Materials and Methods. We retrospectively reviewed 1194 primary TKA performed for the diagnosis of primary knee osteoarthritis performed at our institution between 2013–2016. There were 291 TKA performed in patients under age 55. Patients were excluded if they had 1) prior history of fracture, 2) renal disease, 3) inflammatory joint disease, and 4) required therapeutic anticoagulation. The primary outcome of interest was rate of revision at 30 days, 1, 2, and 5-year time points. Secondary outcomes included postoperative transfusion rate, calculated blood loss, length of stay(LOS), rate of DVT/PE, readmission and reoperation. Results. Patients under 55 were more likely to be obese and have a lower comorbidity burden. Overall, 31 patients required revision (2.6%; 97.4% survivorship at 5 years). Patients under 55 had significantly higher revision rate at 1(2.4%vs.0.9%; p=0.024), 2(3.8%vs.1.55%; p=0.02) and 5 years (5.5%vs.2.2%; p=0.004). The principal diagnosis for early revision in young patients were 1) instability, 2) infection, and 3) aseptic loosening. There was no difference in rate of transfusion, DVT/PE, LOS and readmissions between the 2 groups. Patients under 55 had a higher rate of all-cause reoperation at all time points. Multivariate regression showed patients under 55 were at significantly higher risk for revision at the latest time point (OR 2.51; p=0.012). Discussion. Despite improvements in the wear characteristics of TKA implants, young and active patients remained at higher risk of early revision compared to older patients even at 1, 2, and 5 years. The data should be used to counsel young prospective TKA patients about the early risk of reoperation and non-wear related complications

Introduction: The objective of this study was to investigate the clinical, radiographic and subjective outcome after salvage arthrodesis for failed total ankle arthroplasty (TAA), with a focus on salvage in inflammatory joint disease (IJD). Methods: Between 1994 and 2005, salvage arthrodesis for failed mobile-bearing TAA was performed in 18 ankles. Primary diagnosis was IJD 15 and osteoarthritis 3. Tibiotalar fusion was performed in 7 and tibiotalocalcaneal fusion in 11 ankles (in 9 out of these, the subtalar joint was already ankylosed). Serial radiographs were studied retrospectively by an independent observer for time to union. Clinical outcome at latest follow-up was measured by the AOFAS score, by the Foot function Index and by VAS scores for pain, function and satisfaction. Results: Blade plates were used in 7 ankles, all united. Nonunion developed in 7 IJD ankles stabilized by either a nail or screws or multiple K-wires. Revision arthrodesis was done for 4 nonunions, 3 were successful. Eleven patients (8 fused ankles, 3 nonunions) were available for clinical evaluation. At follow-up, their mean AOFAS score was 62.4; mean overall FFI was 70.1; VAS for pain was 20.1, for function 64.3, for satisfaction 73.8. Conclusions: Blade plate fixation is successful in salvage ankle arthrodesis. An high nonunion rate was found after salvage ankle arthrodesis in IJD with other methods of fixation. Several publications on primary arthrodesis also show an elevated nonunion rate in IJD. Clinical results were relatively good. The three non-unions in follow-up had subjective results similar to the fused ankles

Juvenile hip instability is associated with many conditions. Most of them belong to the group of neuromuscular diseases. Generally following categories can be enumerated: 1. Cerebral palsy, 2. Myelomeningocele, 3. Spinal cord injury, 4. Paraplegia following spine surgery, 5. Poliomyelitis, 6. Inflammatory hip disease, 7. Idiopathic instability, 8. Recurrent post-traumatic hip instability. In the groups 1–5 a chronic muscle imbalance is the reason of the displacement of the femoral head. Inflammatory joint disease produces displacement through cartilage and bone destruction and increased intra-articular pressure. Very rare idiopathic instability is usually associated with generalised hypermobility. For the early diagnosis a careful clinical examination is necessary involving range of motion, testing of the hip stability by the Palmén’s test in the same way like in new-borns. Routine x-ray screening at least once per year is mandatory. For the groups 1–5 a muscle imbalance has to be corrected first. Elimination of muscles contractures or muscles transfers respectively, showed a high efficiency if these surgical corrections were performed early. Femoral osteotomy alone does not provide reliable results. Any form of pelvic osteotomy is necessary to correct acetabular insufficiency. For the inflammatory hip disease early active surgical treatment is best prevention of displacement. Idiopathic hip instability has to be differentiated from common snapping hip. No treatment is necesary. Recurrent hip dislocation can be cured by a posterior capsulorrhaphy

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown aetiology. In RA, inflammation and pain are initial symptoms followed by bone and cartilage destruction. Proinflammatory cytokines play a significant role in the initiation and progress of inflammation and tissue destruction. Sensory neuropeptide substance P (SP) participates not only in nociception but also in pro-inflammatory processes by enhancing vasodilatation and recruitment of inflammatory cells. Ubiquitin proteasome system (UPS) activates a transcription factor, NF-κB which regulates the synthesis of proinflammatory mediators like cytokines; however its role in regulating pro inflammatory sensory neuropeptides is unknown. A number of proteasome inhibitors have been shown to down regulate the activity of NF-κB and hence reduce inflammation. In the present study, the effect of proteasome inhibitor (MG 132) on the severity of arthritis and pain was observed along with the expression of SP-positive nerve fibres in the ankle joint in a chronic inflammatory model of rat adjuvant arthritis. Histology and mechanical pain tests showed a significant reduction in inflammation and pain in ankle joint by daily administration of proteasome inhibitor MG132 at the dose of 1mg/kg body weight compared to untreated groups. Radiographic analysis of ankle joints indicated a reduction in soft tissue swelling and joint destruction in the treatment group. A marked reduction in the NF-κB activity was observed by EMSA. Furthermore, proteasome inhibition resulted in the normalization of up regulated neuronal response occurred during inflammation by significantly reducing the expression of SP-positive fibres in the ankle joint as demonstrated by immunohistochemistry. Our data provide the evidence that proteasome inhibitor MG132 can reduce severity of arthritis and reverse inflammatory pain behaviour by influencing the peripheral sensory nervous system. The drugs targeting UPS can be developed for treatment of chronic inflammatory joint disorders

Aims: To investigate the effect of age and occupation on the outcome of carpal tunnel decompression. Patients and Methods: A total of 271 patients undergoing primary carpal tunnel decompression by a single surgeon were studied. Patients with inflammatory joint disease, thyroid disease and diabetes mellitus were excluded. Outcome was assessed using the Levine-Katz carpal tunnel questionnaire at two weeks preoperatively and six months postoperatively. Cases were divided into six age groups (less than 40 years of age, 40 to 49, 50 to 59, 60 to 69, 70 to 79, and over 80 years of age) and 12 occupational groups according to the International Standard Classification of Occupations (ISCO-88). Statistical analysis was performed using one-way analysis of variance (ANOVA) and post ad-hoc analyses. Results: Overall there was an improvement in total Levine scores in 269 (99.3%) patients (mean change 33.1, 95%CI: 31.5 to 34.7). This change was greatest in those over 80 years of age (mean 35.8, 95%CI: 29.0 to 42.6) and in those who were service or sales workers (mean 39.6, 95%CI: 34.9 to 44.2), and least in the 70–79 age group (mean 30.7, 95%CI 25.7 to 35.8) and craft and trade workers (mean 29.8, 95%CI: 21.8 to 37.9). Patients reported a greater improvement in symptoms (mean score change 21.4, 95%CI: 20.2 to 22.2), than function (mean 12, 95%CI: 11.1 to 12.7). We found no significant difference in the total, functional or symptomatic Levine score changes between the six age groups (p=0.05) and the 12 occupation groups (p=0.05) following carpal tunnel decompression. Conclusion: Almost all patients improved after carpal tunnel decompression. However, we found no influence of age and occupation on the outcome of carpal tunnel decompression in our series of patients

The causes of a stiff elbow are numerous including: post-traumatic elbow, burns, head injury, osteoarthritis, inflammatory joint disease and congenital. Types of stiffness include: loss of elbow flexion, loss of elbow extension and loss of forearm rotation. All three have different prognoses in terms of the timing of surgery and the likelihood of restoration of function. Contractures can be classified into extrinsic and intrinsic (all intrinsic develop some extrinsic component). Functional impairment can be assessed medicolegally; however, in clinical practice the patient puts an individual value on the arc of motion. Objectively most functions can be undertaken with an arc of 30 to 130 degrees. The commonest cause of a Post-traumatic Stiff elbow is a radial head fracture or a complex fracture dislocation. Risk factors for stiffness include length of immobilisation, associated fracture with dislocation, intra-articular derangement, delayed surgical treatment, associated head injury, heterotopic ossification. Early restoration of bony columns and joint stability to allow early mobilisation reduces incidence of joint stiffness. Heterotopic ossification (HO) is common in fracture dislocation of the elbow. Neural Axis trauma alone causes HO in elbows in 5%. However, combined neural trauma and elbow trauma the incidence is 89%. Stiffness due to thermal injury is usually related to the degree rather than the site. The majority of patients have greater than 20% total body area involved. Extrinsic contractures are usually managed with a sequential release of soft tissues commencing with a capsular excision (retaining LCL/MCL), posterior bundle of the MCL +/− ulna nerve decompression (if there is loss of flexion to 100 degrees). This reliably achieved via a posterior incision, a lateral column exposure +/− ulna nerve mobilisation. A medial column exposure is a viable alternative. Arthroscopic capsular release although associated with a quicker easier rehabilitation is associated with increased neural injury. Timing of release is specific to the type of contracture, i.e. flexion contractures after approx. six months, extension contractures ASAP but after four months, loss of forearm rotation less 6 to 24 months. The use of Hinged Elbow Fixators is increasing. The indications include reconstructions that require protection whilst allowing early movement, persistent instability or recurrent/late instability or interposition arthroplasty. Post-operative rehabilitation requires good analgesia, joint stability and early movement. The role of CPM is often helpful but still being evaluated

Purpose: Indications for tibiotalar arthrodesis persist in patients with septic or inflammatory joint disease. Arthroscopic arthrodesis can be used to limit immediate postoperative morbidity. This technique has been used in our unit since 1994. The purpose of this work was to assess long-term outcome and specific complications. Material and methods: All patients who underwent arthroscopic tibiotalar arthrodesis since 1994 (16 patients) were reviewed by an independent observer. There were nine women and seven men, mean age 56 years (37–81). The cause of the tibiotalar disease was post-traumatic degeneration in 12 cases, primary osteoarthritis in two and rheumatoid polyarthritis in two. The ankle was centred preoperatively in all cases. Osteosynthesis was achieved with screw fixation in 14 cases and with an external fixator in two. Mean follow-up was 43.4 months (6–80 months). Outcome was assessed on the basis of delay to fusion, presence of residual pain, and complications induced by the technique. Results: Mean hospital stay was five days (3–11 days). There was no infectious or cutaneous complication. Three patients had a sensorial deficit in the territory of the superficial fibular nerve. Fusion was obtained in all patients. Mean delay to fusion was 3.4 months (range 2–7.5 months). All patients except one who had a painful fibulotalar non-union could walk without pain after fusion had been achieved. Discussion: Arthroscopic tibiotalar arthrodesisis a reliable procedure for the treatment of destroyed joints after centring the ankle. We were satisfied with the results of percutaneous screw fixation. Delay to fusion was comparable with delays observed after open procedures and complication rate was lower. Conclusion: Since the postoperative morbidity is low and long-term results are equivalent, we propose arthroscopic arthrodesis for the treatment of tibiotalar destruction

Malalignment of knee arthroplasty components can lead to abnormal wear, premature loosening and patellofemoral problems. Computer assisted surgery has been developed to improve surgeons ability to achieve correct alignment and thereby improve outcomes. This project compares the accuracy of computer assisted total knee arthroplasty with a conventional jig-assisted technique. A total of 150 patients were recruited. Selection criteria included patients presenting with degenerative or inflammatory joint disease who were candidates for total knee arthroplasty. Patients having revision procedures were excluded as were patients who previously had a corrective osteotomy. Ethics approval was obtained and patients consented for the study. Patients were randomly allocated to either the computer navigated or jig alignment groups via the sealed envelope system. Demographic patient data and intraoperative data were collected. Quality of life and function assessments made using the WOMAC and Knee Society Scores. The component position was assessed using the Perth CT protocol. One hundred and fifty patients were recruited from Dec 2005 to July 2007. Five patients were excluded due to machine malfunction and two others were excluded due to insufficient data collected leaving 143 patients for the study. There was no difference in blood loss, post operative hemoglobin or patient length of hospital stay. There was no difference in the Knee Society knee or function scores at 12 weeks or the knee flexion range either at discharge or at 3 months follow up. There was a significant correlation in duration of surgery (p< 0.05) with the navigated cases taking an average 23 minutes longer. Both the conventional jig alignment and computer navigated techniques produced accurate results in all CT measurements except for the tibial slope where the navigated group (4.8+/−1.6) was closer to the elected posterior slope of 3.5+/− 1.5 than the jig system (6.4+/−2). Statistically significant differences in favour of the navigated group were also found for both femoral component rotation and tibial coronal alignment but the outliers beyond the accepted ideal alignment of 0+/−3 degrees for each parameter were minimal and equivalent for the two groups. Computer navigation in knee replacement surgery is gaining popularity to improve component alignment and consequently the outcome of total knee arthroplasty. This study has shown only marginal benefits in alignment of the navigated group but this needs to be considered against the increased surgical time despite familiarity with the hardware

Aims: This study reports the mid-term results of a prospective series of 200 ankle replacements using the Scandinavian Total Ankle Replacement (STAR). 105 patients were more than five years since surgery. Method: 200 patients; 85 male, 115 female; mean age 60 years (18–83) underwent primary replacement. The mean follow-up was 54 months (4–110). The diagnosis was inflammatory joint disease (IJD) for 119 patients and osteoarthritis (OA) for 81. Results: 144 patients had a good outcome and uncomplicated recovery. A further 18 patients had a complication, which resolved with non-operative treatment (three prolonged wound healing, 15 malleolar fractures, either at surgery or at a later date). A further eight patients were clinically satisfactory but the x-rays showed adverse features (five aseptic loosening and three recurrent deformity). Five patients have a poor outcome due to persistent pain and stiffness but have not required further surgery. A further nine patients had a complication necessitating surgery (three calcaneal osteotomy and lateral ligament reconstruction, one tibial osteotomy to improve alignment, one autogenous bone graft for osteolysis, one for late medial malleolar fracture, one split skin graft for delayed healing, two for removal of heterotopic bone). At two years the AOFAS score for pain improved from 0 to 35 (maximum 40) and the functional score from 28 to 35 (maximum 60). There were 16 total failures that required fusion (11) or revision (five). The causes were nine aseptic loosening, three recurrent deformity, two fracture malleolus, one deep infection, one persistent pain. The cumulative five-year survival rate was 89% (95% CI 81% to 96%), with time to decision to revision or fusion as the endpoint. Conclusions: There was no difference in survival between ankle replacement for OA or IJD. Ten out of the 16 failures occurred early (< two years), which we attribute to technical error or attempting replacement of ankles with severe deformity. The failure rate after two years is approximately 1% per annum

Purpose. To report clinical results and demonstrate any posterior femoral translation (PFT) in medial rotation total knee arthroplasty (TKA) of posterior cruciate ligament (PCL) retaining type. Materials and Methods. A prospective study was performed upon thirty consecutive subjects who were operated on with medial rotation TKA of PCL retaining type (Advance® Medial Pivot prosthesis with ‘Double High’ insert; Wright Medical Technology, Arlington, TN, USA) (Fig. 1). between March 2009 and March 2010 and had been followed up for a least 2 years. Inclusion criteria were age between 60 and 75 years and primary degenerative joint disease of knee graded as Kellgren Lawrence grade III or higher. Exclusion criteria were age under 60 years, any inflammatory joint disease including rheumatoid arthritis, early stage of primary degenerative joint disease of knee or any history of previous osteotomy around knee. Clinically, the knee society knee score and function score were used to evaluate pain and function. At last follow-up, all subjects performed full extension, thirty degree flexion and full active flexion sequentially under fluoroscopic surveillance. In each of these lateral radiographs, anteroposterior(AP) condylar position was pinpointed and the magnitude of PFT was determined by degree of transition of AP condylar position from full extension to full active flexion radiograph (Fig. 2 A–B). Statistical methods used were paired t-test, Pearson correlation, Steadman rank correlation and regression analysis. Component migration and radiolucent line were also observed. Results. At last follow-up, the mean knee society knee score and the mean function score improved significantly compared to preoperative scores (from 61.5 to 90.4 and from 57.8 to 84.7 respectively). The mean maximum flexion of knee increased postoperatively compared to preoperative one without any significant difference (105.5Ëš±11.2Ëšvs 109.3Ëš±9.8Ëš, p=0.051, β=0.387). Neverthless, regression analysis showed a good linear association (r = 0.53, p=0.0027) between the pre- and post-operative maximum flexions of knee. The AP condylar positions were consistently posterior to midline throughout the entire range of flexion. The mean maximum PFT was 10.5 mm (± 4.3 mm) and the magnitude of maximum PFT was greater in higher flexion cases (r = 0.57, p = 0.0009) (Fig. 3). There were no cases having either component migration or radiolucent line except for one case showing instability related to trauma. Conclusions. In medial rotation total knee arthroplasty of PCL retaining type, clinical outcomes were satisfactory and the maximum obtainable flexions tended to be in narrower ranges than those of preoperative ones and smaller than those of other TKA prostheses. Nonetheless, reliable posterior femoral translations were observed during progressive flexions of knees, which was considered to be one of important kinematic factors in increasing the level of knee flexion of medial-rotation TKA in longer follow-ups by providing greater posterior clearance and reduced femoro-tibial impingement

Aim: The healing capacity of human articular cartilage is very limited in the adult. Therefore tissue engineering techniques were developed to treat cartilage lesions. To it, autologous chondrocytes are harvested from the affected joint and expanded in vitro. During expansion chondrocytes may dedifferentiate, characterized by an increase in type I collagen and a decrease in type II collagen expression. Since high expression of type II collagen is of central importance for the properties of cartilage after transplantation, we investigated if the human platelet supernatants (hPS) containing PDGF and TGF-b or recombinant human bone morphogenetic protein-2 (BMP-2) may modulate the chondrogenic phenotype in monolayer cell cultures (2D) and in three-dimensional culture (3D) systems. Methods: Chondrocytes from articular knee cartilage of 14 individuals (mean age 36.5 6.5 years) with no history of inflammatory joint disease were isolated and expanded under GMP conditions suitable for clinical purposes. The hPS was prepared from blood of 3 donors and pooled. Cells were seeded either in 2D cultures or embedded in alginate beads (3D) in presence or absence of hPS or recombinant human BMP-2 (generous gift of Dr. Hortschansky, Jena, FRG). After two weeks in culture, cells were harvested and analysis of the chondrogenic phenotype was performed using quantitative RT-PCR, immunocytochemistry and ELISA methods. Results: Expansion of chondrocytes in primary culture (P0) did not yield populations of dedifferentiated or hypertrophic cells. Expanding cells in first subculture (P1) resulted in spontaneous reduction of type II collagen expression and increase in type I collagen mRNA amounts. Seeding P1 chondrocytes in 3D culture significantly reduced type I collagen, BMP-4 and IL-18 and maintained high type II collagen and BMP-2 encoding mRNA (p < 0.05). Reduction of IL-1b and elevation of IL-10 mRNA were noted but were statistically not significant. Addition of BMP-2 to 2D chondrocytes had no effect on type II collagen or IL-1b mRNA amounts (p < 0.05). In alginate cultures BMP-2 induced type II collagen and reduced IL-1b mRNA amounts. In contrast, addition of hPS containing PDGF and TGF-b, promoted mitotic activity in 2D and alginate cultures. The hPS reduced in 2D cultures type II and induced type I collagen expression. Even in alginate beads induction of type I collagen was detected. Conclusions: We conclude that the chondrogenic phenotype is stabilized by BMP-2 more effectively in alginate beads but not in monolayer cultures. The hPS promotes proliferation of chondrocytes in vitro but induces elevated type I expression, an indicator of chondrocyte dedifferentiation

Aims

This study evaluated the definitions developed by the European Bone and Joint Infection Society (EBJIS) 2021, the International Consensus Meeting (ICM) 2018, and the Infectious Diseases Society of America (IDSA) 2013, for the diagnosis of periprosthetic joint infection (PJI).