This study addresses a crucial gap in the knowledge of normative spinal growth in children. The objective of this study is to provide detailed and accurate 3D reference values for global and segmental spinal dimensions in healthy children under the age of 11. Radiographic spine examinations of healthy children conducted to rule out scoliosis were reviewed in four scoliosis referral centers in North America. All consecutive children aged three to eleven years old with EOS biplanar good quality x-rays, but without diagnosed growth-affecting pathologies, were included. Postero-Anterior and Lateral calibrated x-rays were used for spine 3D reconstruction and computation of vertebral body height and spine length. Median and interquartile range were calculated from cross-sectional data. Smooth centiles growth curves for 3D True Spinal Length (3DTSL) between T1 and S1, as well as for mid-vertebral heights of T5, T12 and L3, where fit and calibrated from data using the Lambda-Mu-Sigma method (GAMLSS package for R). This method automatically selects the best performing distribution from a familly of choices. Tables of centiles were then predicted from the computed models for selected ages. A total of 638 full spine examinations from asymptomatic patients were reconstructed in 3D, 397 in girls and 241 in boys. Medians and interquartile ranges were calculated for 3DTSL (T1-S1): 285 (24) mm, 314 (26) mm and 349 (31) mm, and for selected vertebral heights T5: 10 (1) mm, 11 (1) mm and 12 (1) mm, T12: 13 (2) mm, 14 (1) mm and 16 (2) mm, and L3: 14 (1) mm, 16 (2) mm and 18 (2) mm, respectively for the 3–6, 6–8 and 8–11 age groups. Centile curves ready for clinical use of the 3DTSL (T1-S1) and of the vertebral heights of T5, T12 and L3 as a function of age were derived for the 5, 10, 25, 50, 75, 90 and 95th centiles. In general, boys presented linear relationships between spinal dimensions and age, and girls presented more diverging trends with increased variance for older ages. Accordingly curves for boys follow the Normal distribution whereas those for girls follow the original Box-Cox-Cole-Green distribution. Model diagnostic tests (normally distributed residuals, adequate wormplots and |Z statistics| < 2) confirmed adequacy of the models and the absence of significant misfit. Accurate reference values were derived for spinal dimensions in healthy children. Spinal dimension charts showed that the spinal lengths and vertebral heights changed relatively constantly across the age groups closely resembling WHO total body height charts. The reference values will help physicians better assess their patients' growth potential. It could also be used to predict expected spinal dimensions at maturity or changes in pathologic conditions as well as to assess the impact of growth friendly interventions in the correction of spinal deformities

Background. The knee joint morphology varies according to gender and morphotype of the patients. Objectives. To measure the dimensions of the proximal tibia and distal femur of osteoarthritic knees in a group of patients from the same ethnic group (Arabs) and to compare these measurements with the dimensions of six total knee implants. Patients and methods. Three-dimensional CT reconstructions were used to collect morphologic data from 124 osteoarthritic knees. Anteroposterior and mediolateral measurements were obtained from tibial and femoral bony resection surfaces planned for patient-specific instrumentation (Figures 1 and 2). These measurements were compared to the dimensions for six different types of knee implants. Results. The average tibial mediolateral (tML) and tibial anteroposterior (tAP) measurement for the study group were 74.36±6 mm and 48.94±4.57 mm, respectively; the medial tibial plateau was larger than lateral. The average femur mediolateral (fML) and femur anteroposterior (fAP) measurements for the same group were 72.04±6.6 and 68.1±7.75, respectively. For implant matching, the average tibial aspect ratio was 152.62±12.66 and the femoral average aspect ratio was 106.37±14.34. Differences were found between morphometric measurements of males and females with significantly higher parameters for males when compared to female when compared in AP and mediolateral dimensions. Also, 22.5% of the operated knees had mismatch within 2 size of the same implant. Conclusion. There is significant asymmetry of proximal tibial plateau and femur condyles. Our data suggest mismatch between osteoarthritic Arabian knees and implant designs. These ethnic differences should be considered when designing knee implants

Creating cement keyholes (i.e. drilling simple holes in cancellous bone to allow cement filling) is a practice used in multiple scenarios in orthopaedic surgery to ensure improved fixation between the bone-cement interface and as such between bone and prosthesis. It is most commonly used in hip arthroplasty to secure fixation of the cup to the acetabulum by drilling keyholes in acetabulum. However very little research has been conducted into what the dimensions of such cement keyholes should be. The following laboratory based research was performed to provide insight into the optimum dimensions of cement keyholes. The investigator designed a novel arrangement to enable testing of keyholes. Beechwood block models were then made to this design testing keyholes of varying diameters and depths. These were cemented with acrylic bone cement and then loaded to failure. A finite system analysis was also performed. Results show that stresses are concentrated at the base of the keyhole. As such increasing diameter of keyhole infers greater strength, but there is no relationship between depth and strength. This has been further confirmed with finite element analysis. We suggest the width of cement keyholes bears more importance than the depth and propose drilling wide but shallow keyholes

Total knee replacement has proven to be a very successful procedure. However, problems have been encountered in fitting standard femoral implants to distal femurs using various popular total knee replacement systems. Authors observed that difficulties matching femoral components with distal femurs most frequently occurred in female patients. In practice, as far as femoral sizing is concerned, women are just treated as small men. Despite an extensive English literature search, only a limited number of studies addressing the gender differences in distal femurs proportions were identified. In view of our experiences, we hypothesize that 1) Anterior-posterior (AP) dimensions do not increase in the same proportion to medial-lateral (ML) dimensions in men and women. 2) The AP/ML ratio is different in males and females. 3) Femoral implants AP/ ML ratios are more inline with men ratios then with women. Materials and Methods: In order to test the hypothesis, 50 male and 50 female patients consecutive knee MRI scans of the knee were studied. The patients were referred to UMC MRI Center with a variety of diagnoses. The knees involved with conditions distorting bony anatomy were excluded. The age distribution of the patients ranged from 17 to 77 years for the males and 17 to 85 years for the females. Evaluation was focused on axial views of the distal femur. A cut with the maximum medial lateral dimensions of a studied femur was selected. The ML measurement was made along the epicondylar axis. The maximum AP dimension was obtained perpendicular to the epicondylar axis on the same cut. The ratios were then obtained. AP data for males and females was plotted against ML data. The data was found to approximate linear relation, permitting linear regression. Inside AP and ML dimensions of eight popular TKR systems produced by six manufactures were obtained. The AP vs. ML plots were made as well as ratios were calculated for each system. The implants data were compared with male and female data. A t-test was performed to demonstrate whether the AP/ML ratio was significantly different between males and females. In addition, ordinary least squares analyses were performed to establish whether the AP/ML ratios varied across different AP and ML sizes for both genders. Conclusions: Our study demonstrated a significant difference in distal femur proportions between males and females. The variation in dimensions did not appear to be well covered by femoral implant sizes from studied seven commonly used TKA systems. Dimensions propagation of femoral components for TKR fallowed significantly closer to males’ distal femur dimensions variation than to females’

Non-cemented components have traditionally employed several possible features, among them a stem and/or collar, to achieve proper alignment and initial implant stability within the proximal femoral cavity. The advent of MIS has stimulated an interest in reducing the dimensions of implants, specifically stem length, in order to facilitate introduction and implantation of the component. The consequence of this trend appears to be an increase in early aseptic failure, of some components, due to loosening and migration. Several important questions have arisen. What are the direction of the deforming forces about a hip during daily activities?. What design features should a short stem implant exhibit so as to provide optimum stability against these forces?. Is having a stem an absolute requirement of a femoral component?. What is the minimum “safe” length a stem must have?. How can proper short stem alignment be optimized? Is intra-operative x-ray exposure necessary?. This presentation will discuss the computer modeling, laboratory testing and clinical outcomes of various. component designs; and make suggestions concerning directions for future investigations

Comprehensive anthropometric information is essential to avoid patella-related complications after TKA. We compared the anthropometric patellar dimensions of Korean and Western patients. In particular, we determined whether the reestablishment of original patellar thickness, residual bony thickness, and pre- to postoperative deviations between the median ridge position and the component center position influence the clinical and radiographic outcomes of TKAs. We measured anthropometric patellar dimensions in 752 osteoarthritic knees treated with TKA in 466 Korean patients and compared them with those of Western patients reported in the literature. We investigated the effects of postoperative overall thickness deviations, residual bony thickness after bone resection, and postoperative deviations of component center positions from median ridge positions versus clinical and radiographic outcomes evaluated 1 year after surgery. Korean patients undergoing TKA had thinner and smaller patellae than Western patients. We found no associations between pre- to postoperative overall thickness differences and clinical and radiographic outcomes and no differences between knees with a residual bony thickness of 12 mm or more and knees with a residual thickness of less than 12 mm, with the exception of WOMAC pain scores. We found no associations between postoperative deviations of component center position and clinical or radiographic outcomes. Our findings indicate bone resection for patellar resurfacing can be flexible without jeopardizing clinical outcome

The use of intramedullary column screws in the treatment of acetabular fractures is becoming more widely utilized. The development of percutaneous methods to insert these screws under image intensifier guidance is one of the main reasons for their increased use. Few groups are navigating insertion of these screws. The available screws are cannulated 6.5–8 mm screws. Most surgeons prefer using 3.2 mm guide wires to reduce deflection. With a shank diameter of 4.5 mm, 3.2 mm cannulation significantly weakens the screws. We postulated that both columns, specially the posterior column can accommodate larger screw diameters which will increase the stability of fixation allowing earlier full weight bearing. The currently used screws were designed for fixation of femoral neck fractures. As percutaneous fixation of acetabular fractures is a growing area of interest, this warrants designing suitable screws with larger diameters. Eight CT scans of the adult pelvis –performed for non fracture related indications-, were studied (7 females, 1 male). We found that the anatomical cross-section of the columns is irregular but approximately triangular. The method we used to determine the largest diameter of a screw to fit each column was fitting cylinders in the columns. Robin’s 3D software was used to segment acetabula and convert the CT data into polygon mesh (stereolithography STL format) bone surfaces at an appropriate Hounsfield value. The resulting STL files were imported in Robin’s Cloud software, where polygon mesh cylinders of 10 mm diameter were fitted in each column. These cylinders were then manipulated to achieve best fit and their diameters were gradually increased to the biggest diameter which still fitted in the column. The mean diameters of the fitted cylinders were 10.8 mm (range: 10–13mm) and 15.2 mm (range 14–16.5mm) for the anterior and posterior columns respectively. To our knowledge, this is the first investigation to study the cross sectional dimensions of the anterior and posterior columns of the acetabulum. Our small sample shows that both columns can safely accommodate larger screws than those currently used. We plan to investigate this further using cadavers

Aims: To investigate the optimal dimension interference screw for fixation of a tendon graft in a bone tunnel. Methods: A porcine model was developed to represent ACL reconstruction in the distal femur. A standard 8mm size pig flexor tendon graft was inserted into a standard 8mm bone tunnel. The screw dimensions were varied. The tendon was loaded with a constant force using a Universal Testing Machine. The construct was tested to failure at a rate of 50mm/minute. Load, deformation data and mechanism of construct failure were recorded. The screw diameters of 7, 8 and 9mm and lengths of 20, 25 and 30mm were tested in 80 individual reconstructions. Results: The mean pull out force was similar between the 7mm (191N) and 8mm screws (188N), but significantly different for the 9mm screw (109N) (p< 0.05) The 30mm screw (231N) was marginally better than the 20mm screw (215N) (p> 0.05). The mechanism of failure however, was significantly different between the groups. All grafts fixed with a 9mm screw failed at the tunnel opening (100%), whereas those fixed with a 7mm screw failed by slippage of the graft along the length of the tunnel (83%). The screw length did not affect the mechanism of graft failure. Conclusion: Our results suggest that a screw size equal to or 1mm less than the diameter of the tunnel gives the optimum initial interference screw fixation of tendon in a bone tunnel

Pelvic incidence is as a key factor for sagittal balance regulation that describes the anatomical configuration of the pelvis. The sagittal alignment of the pelvis is usually evaluated in two-dimensional (2D) sagittal radiographs in standing position by pelvic parameters of sacral slope, pelvic tilt and pelvic incidence (PI). However, the angle of PI remains constant for an arbitrary subject position and orientation, and can be therefore compared among subjects in standing, sitting or supine position. Such properties also enable the measurement of PI in three-dimensional (3D) images, commonly acquired in supine position. The purpose of this study is to analyse the sagittal alignment of the pelvis in terms of PI in 3D computed tomography (CT) images.

A computerised method based on image processing techniques was developed to determine the anatomical references, required to measure PI, i.e. the centre of the left femoral head, the centre of the right femoral, the centre of the sacral endplate, and the inclination of the sacral endplate. First, three initialisation points were manually selected in 3D at the approximate location of the left femoral head, right femoral head and L5 vertebral body. The computerised method then determined the exact centres of the femoral heads in 3D from the spheres that best fit to the 3D edges of the femoral heads. The exact centre of the sacral endplate in 3D was determined by locating the sacral endplate below the L5 vertebral body and finding the midpoint of the lines between the anterior and posterior edge, and between the left and right edge of the endplate. The exact inclination of the sacral endplate in 3D was determined from the plane that best fit to the endplate. Multiplanar 3D image reformation was applied to obtain the superposition of the femoral heads in the sagittal view, so that the hip axis was observed as a straight not inclined line and all anatomical structures were completely in line with the hip axis. Finally, PI was automatically measured as the angle between the line orthogonal to the inclination of the sacral endplate and the line connecting the centre of the sacral endplate with the hip axis.

The method was applied to axially reconstructed CT scans of 426 subjects (age 0–89 years, pixel size 0.4–1.0 mm, slice thickness 3.0–4.0 mm). Thirteen subjects were excluded due to lumbar spine trauma and presence of the sixth lumbar segment. For the remaining subjects, the computerised measurements were visually assessed for errors, which occurred due to low CT image quality, low image intensity of bone structures, or other factors affecting the determination of the anatomical references. The erroneous or ambiguous results were detected for 43 subjects, which were excluded from further analysis. For the final cohort of 370 subjects, statistical analysis was performed for the obtained PI. The resulting mean PI ± standard deviation was equal to 46.6 ± 9.2 degrees for males (N = 189, age 39.7 ± 20.3 years), 47.6 ± 10.7 degrees for females (N = 181, age 43.4 ± 19.9 years), and 47.1 ± 10.0 degrees for both genders (N = 370, age 41.5 ± 20.1 years). Correlation analysis yielded relatively low but statistically significant correlation between PI and age, with the correlation coefficient r = 0.20 (p < 0.005) for males, r = 0.32 (p < 0.0001) for females, and r = 0.27 (p < 0.0001) for both genders. No statistically significant differences (p = 0.357) were found between PI for male and female subjects.

This is the first study that evaluates the sagittal alignment of the pelvis in terms of PI completely in 3D. Studies that measured PI manually from 2D sagittal radiographs reported normative PI in adult population of 52 ± 10 degrees, 53 ± 8 degrees and 51 ± 9 degrees for 25 normal subjects aged 21–40, 41–60, and over 60 years, respectively [3], and 52 ± 5 degrees for a cohort of 160 normal subjects [4]. The PI of 47 ± 10 degrees obtained in our study is lower than the reported normative values, which indicates that radiographic measurements may overestimate the actual PI. Radiographic measurements are biased by the projective nature of X-ray image acquisition, as it is usually impossible to obtain the superposition of the two femoral heads. The midpoint of the line connecting the centres of femoral heads in 2D is therefore considered to be the reference point on the hip axis, moreover, the inclination of the sacral endplate in the sagittal plane is biased by its architecture and inclination in the coronal plane. On the other hand, the measurements in the present study were obtained by applying a computerized method to CT images that determined the exact anatomical references in 3D. Perfect sagittal views were generated by multiplanar reformation, which aligned the centres of the femoral heads in 3D. The measurement of PI was therefore not biased by acquisition projection or structure orientation, as all anatomical structures were completely in line with the hip axis. Moreover, the range of the PI obtained in every study (standard deviation of around 10 degrees) indicates that the span of PI is relatively large. It can be therefore concluded that an increased or decreased PI may not necessary relate to a spino-pelvic pathology.

The proximity of neural structures to the coracoclavicular ligaments limits the amount of coracoid process that can be harvested. The purpose of this study of 100 dry human scapulae was to define the anatomic limitations.

We found the mean measurement of the horizontal arm of the coracoid process anterior to the conoid tubercle was 21.5 mm (SD 0.9 mm). In 10% of the scapulae, it was larger than 30 mm. In 66%, the posterior aspect of the conoid fused with the vertical ramus and the lateral lip of the suprascapular notch.

This amount of coracoid appears to be large enough to expand the glenoid vault, and to hold two AO small fragment screws. It can be safely harvested if the conoid ligament is respected. Partial sacrifice of the trapezoid ligament is unavoidable, but does not compromise coracoclavicular stability. If the coracoid osteotomy is extended medial to the conoid tubercle it encroaches on the vertical ramus of the coracoid and can damage the suprascapular nerve. Posterior advancement of the osteotomy can extend onto the anterosuperior glenoid.

Introduction: While conventional acetate x-rays came at a fixed size and magnification, digital x-rays are freely scalable on the screen and thus must be individually calibrated for surgical measurements (templating). The standard technique is calibration by a reference object (ruler, ball, coin) to be placed into the x-ray. In clinical practice, x-rays are often taken without a calibration object, the object may be malpositioned or the bucky system’s objectfilm distance is unknown to scale with a fixed magnification. Thus calibration based on an anatomic dimension would be a useful alternative in clinical practice.

In this study x-ray calibration using the femoral head diameter as derived by an anatomic formula is compared to the standard technique of using a calibration ball and acetate type fixed magnification.

Methods: In a prospective study three calibration Methods: were applied to post-op AP digital x-rays of 42 patients (m/f=12/30, height: 151–185cm) following primary total hip arthroplasty (ABG-II, 28mm heads) using a common templating software (Endomap): M1) 30mm metal ball lateral to the affected side at the height of the trochanter, M2) a fixed magnification of 121% (average of bucky system as derived from a pilot study) and M3) anatomic calibration by assigning to the natural femoral head of the contralateral side its diameter derived by an anatomic formula. The gender specific linear relationship between height (h [cm]) and the bony femoral head diameter (d [mm]) was obtained from a CT study (n=120): Males: d=0.156h+23.941, Females: d=0.154h+20.040). For each method applied by two independent observers, the implant’s metal head was measured and the relative error [%] calculated.

Results: The standard technique, calibration by a reference object produced a relative error (mean +/−SD) of 2.01+/−1.82% (max=7.9%). Fixed magnification had sign. less error at 1.41+/−1.3% (max=6.5%, p< 0.05). Anatomic calibration produced sign. higher errors at 2.77+/−1.96% (max=8.4%, p< 0.05). Inter-rater reliability was highest for the fixed magnification (r=0.93) and less for ball calibration (r=0.67) and anatomic calibration (r=0.52).

Discussion: It was shown once more that in THR fixed magnification of digital x-rays is on average more accurate and reliable than using a calibration object such as a ball. The theoretical benefit of individual calibration is lost by the variability in landmark palpation, object placement and patient movement though last can be limited by taping the object (e.g. coin) to the skin. Anatomic calibration based on the current formula cannot replace the use of calibration objects. However its error is within clinically tolerable ranges and it can be used when no calibration object is available or the system’s magnification is unknown. The error may be reduced by more accurate height measurements.

Aim: A study was done to investigate the range in size and morphological features of a series of human clavicles.

Method: A Phillips CT scanner was used to examine morphometric properties of 42 right and 36 left adult cadaveric clavicles. The resulting data was analysed with Voxar 3D software. The length of the s-shaped clavicle was measured and the planar cross-sectional geometry of the intramedullary canal and cortical thickness assessed at 10% increments along the length of the bone. MPR (multi-plane reformat) imaging allowed ‘fly-through’ reconstruction of cross-sectional morphology as one travels along the length of the bone.

Results: The sample studied followed a normal distribution with mean size= 136.2mm (range: 112.6– 172.0 mm). In general the sternal portion of the clavicle is circular or prismatic in cross-section where as the acromial portion is flatter on its superior and inferior surfaces. A spacious, variably shaped canal is observed at the sternal and acromial thirds in contrast to the denser, smaller, more circular shaped canal in the central third of the bone. Unlike most long bones, the clavicle was observed to have an extensive network of trabeculae along the entire length of the intramedullary canal. The central third of the clavicle has the thickest cortex. The mean cortical thickness (3.37mm; range: 1.8– 7.9mm) was greatest at a point 60% from the sternal end with the mean thinnest cortex (1.37 & 1.15mm) found at the extreme sternal and acromial ends of the bone respectively.

Conclusion: The clavicle is highly variable in shape and exhibits dramatic variations in both curvature and cross-sectional geometry along its length. Contrary to previous teaching, MPR reconstruction accurately demonstrates clear visualization of a distinct intra-medullary canal.

Aims. To identify the responsiveness, minimal clinically important difference (MCID), minimal clinical important change (MIC), and patient-acceptable symptom state (PASS) thresholds in the 36-item Short Form Health Survey questionnaire (SF-36) (v2) for each of the eight dimensions and the total score following total knee arthroplasty (TKA). Methods. There were 3,321 patients undergoing primary TKA with preoperative and one-year postoperative SF-36 scores. At one-year patients were asked how satisfied they were and “How much did the knee arthroplasty surgery improve the quality of your life?”, which was graded as: great, moderate, little (n = 277), none (n = 98), or worse. Results. Physical function, role limitations due to physical problems (‘role physical’), bodily pain, and the total score SF-36 scores demonstrated the greatest effect sizes (> 0.9). The MCID for each of SF-36 dimensions ranged from 1.7 for role emotional to 6.4 for bodily pain. The MICs for a cohort of patients ranged from -1.0 for general health to 11.1 for bodily pain. The MICs for an individual patient were marginally greater (one to two points) compared to those for a cohort, and ranging from 0.0 for general and mental health to 13.5 for physical function. The lowest PASS score threshold was associated with physical function (> 34 points) whereas the greatest threshold (> 69 points) was associated with mental health. Conclusion. The SF-36 is a responsive tool, and the estimates for MCID, MIC, and PASS thresholds that can be used to power studies, assess whether there has been a meaningful change in patients’ health-related quality of life, and can be used as a marker of achieving patient satisfaction following TKA. Cite this article: Bone Joint Res 2022;11(7):477–483

The purpose of this study was to determine the incidence of graft-tunnel mismatch (GTM) when performing anatomic anterior cruciate ligament reconstruction (ACLR) using bone-patella tendon-bone (BPTB) grafts and anteromedial portal drilling. Beginning in November 2018, 100 consecutive patients who underwent ACLR by two sports fellowship-trained, orthopedic surgeons using BPTB autograft and anteromedial portal drilling were prospectively identified. The BPTB graft dimensions and the femoral tunnel distance, tibial tunnel distance, intra-articular distance, and total distance were measured. Surgeons determined the depth and angle of tunnels based on the patella tendon graft length dimensions in each case. After passage of the graft, the distance from the distal graft tip to the tibial cortex aperture was measured. GTM was defined as the need for additional measures to obtain satisfactory tibial graft fixation (< 1 5e20 mm of bone fixation). The incidence of mismatch was 6/100 (6%). Five cases involved the graft being too long, with the tibial bone plug protruding excessively from the tibial tunneld4/5 had a patella tendon length ? 50 mm. Three cases were managed with femoral tunnel recession, and two were treated with a free bone plug technique. One patient with a patella tendon length of 35 mm had a graft that was too short, with the tibial bone plug recessed in the tibial tunnel. Of patients whose tibial tunnel distance was within 5 mm of the patella tendon length, only 1/46 (2%) patients had mismatch, whereas 5/54 (9%) of patients who had >5 mm difference had mismatch. The incidence of grafttunnel mismatch after anatomic ACLR using BTPB and anteromedial portal drilling in this study is 6%. To limit the occurrence of GTM where the graft is too long, surgeons should drill tibial tunnel distances within 5 mm of the patella tendon length

Aims. Fracture-related infections (FRIs) are a devastating complication of fracture management. However, the impact of FRIs on mental health remains understudied. The aim of this study was a longitudinal evaluation of patients’ psychological state, and expectations for recovery comparing patients with recurrent FRI to those with primary FRI. Methods. A prospective longitudinal study was conducted at a level 1 trauma centre from January 2020 to December 2022. In total, 56 patients treated for FRI were enrolled. The ICD-10 symptom rating (ISR) and an expectation questionnaire were assessed at five timepoints: preoperatively, one month postoperatively, and at three, six, and 12 months. Results. Recurrent FRI cases consistently exceeded the symptom burden threshold (0.60) in ISR scores at all assessment points. The difference between preoperative-assessed total ISR scores and the 12-month follow-up was not significant in either group, with 0.04 for primary FRI (p = 0.807) and 0.01 for recurrent FRI (p = 0.768). While primary FRI patients showed decreased depression scores post surgery, recurrent FRI cases experienced an increase, reaching a peak at 12 months (1.92 vs 0.94; p < 0.001). Anxiety scores rose for both groups after surgery, notably higher in recurrent FRI cases (1.39 vs 1.02; p < 0.001). Moreover, patients with primary FRI reported lower expectations of returning to normal health at three (1.99 vs 1.11; p < 0.001) and 12 months (2.01 vs 1.33; p = 0.006). Conclusion. The findings demonstrate the significant psychological burden experienced by individuals undergoing treatment for FRI, which is more severe in recurrent FRI. Understanding the psychological dimensions of recurrent FRIs is crucial for comprehensive patient care, and underscores the importance of integrating psychological support into the treatment paradigm for such cases. Cite this article: Bone Jt Open 2024;5(7):621–627

Introduction. A good anatomic fit of a Total Knee Arthroplasty is crucial to a good clinical outcome. The big variability of anatomies in the Asian and Caucasian populations makes it very challenging to define a design that optimally fits both populations. Statistical Shape Models (SSMs) are a valuable tool to represent the morphology of a population. The question is how to use this tool in practice to evaluate the morphologic fit of modern knee designs. The goal of our study was to define a set of bone geometries based on SSMs that well represent both the Caucasian and the Asian populations. Methods. A Statistical Shape Model (SSM) was built and validated for each population: the Caucasian Model is based on 120 CT scans from Russian, French, German and Australian patients. The Asian Model is based on 80 CT scans from Japanese and Chinese patients. We defined 7 Caucasian and 5 Asian bone models by using mode 1 of the SSM. We measured the antero-posterior (AP) and medio-lateral (ML) dimensions of the distal femur on all anatomies (input models and generated models) to check that those bone models well represent the studied population. In order to cover the whole population, 10 additional bone models were generated by using an optimization algorithm. First, a combined Asian-Caucasian SSM was generated of 92 patients, equally balanced between male and female, Caucasian and Asian. 10 AP/ML dimensions were defined to obtain a good coverage of the population. For a given AP/ML dimension, Markov chain Monte Carlo sampler was used to find the most average shape with AP/ML dimensions as close as possible to the target dimensions. The difference of the AP/ML dimensions of the generated models to the target dimensions was computed. A chi-squared distribution was used to assess how average the resulting shapes were compared to typical patient shapes. Results. The AP-ML dimensions of the 7 Caucasian bones and the 5 Asian bones well cover the range of the respective populations. For the Caucasian Femur, the AP/ML dimensions range from (53,6/64,9mm) for size 1 to (67,7/80,7mm) for size 7. For the Asian Femur, the AP/ML dimension range from (53,0/62,4mm) for size 1 to (60,5/72,4mm) for size 5. The dimensions of the 10 additionally generated bones differed in average (± 1 standard deviation) by 0,2±0,4mm in AP and 0,5±0,5mm in ML to the target dimensions. The maximal deviation was 0,9mm in AP and 1,0mm in ML. All 10 bones had a P-value of P < 10. -27. according to the chi-squared distribution. Conclusion. The proposed models of 7 Caucasian and 5 Asian bones well represent both populations. The 10 additional geometries enable to get a complete coverage of the population. Since they are very close to average, all these bone models provide more generalized reference shapes compared to individual patients. By performing a virtual implantation on those anatomies, the anatomical fit of implants to these populations can be evaluated. For any figures or tables, please contact authors directly

Abstract. The lateral ligaments of the ankle composed of the anterior talofibular (ATFL), calcaneofibular (CFL) and posterior talofibular ligaments (PTFL), are amongst the most commonly injured ligaments of the human body. Although treatment methods have been explored exhaustively, healing outcomes remain poor with high rates of re-injury, chronic ankle instability and pain persisting. The introduction and application of tissue engineering methods may target poor healing outcomes and eliminate long-term complications, improving the overall quality of life of affected individuals. For any surgical procedure or tissue-engineered replacement to be successful, a comprehensive understanding of the complete anatomy of the native structure is essential. Knowledge of the dimensions of ligament footprints is vitally important for surgeons as it guides the placement of bone tunnels during repair. It is also imperative in tissue-engineered design as the creation of a successful replacement relies on a thorough understanding of the native anatomy and microanatomical structure. Several studies explore techniques to describe ligament footprints around the body, with limited studies describing in-depth footprint dimensions of the ATFL, CFL and PTFL. Techniques currently used to measure ligament footprints are complex and require resources which may not be readily available, therefore a new methodology may prove beneficial. Objectives. This study explores the application of a novel technique to assess the footprint of ankle ligaments through a straightforward inking method. This method aims to enhance surgical technique and contribute to the development of a tissue-engineered analogue based on real anatomical morphometric data. Methods. Cadaveric dissection of the ATFL, CFL and PTFL was performed on 12 unpaired fresh frozen ankles adhering to regulations of the Human Tissue (Scotland) Act. The ankle complex with attaching ligaments was immersed in methylene blue. Dissection of the proximal and distal entheses of each ligament was carried out to reveal the unstained ligament footprint. Images of each ligament footprint were taken, and the area, length and width of each footprint were assessed digitally. Results. The collective area of the proximal entheses of the ATFL, CFL and PTFL measures 142.11 ± 12.41mm2. The mean areas of the superior (SB) and inferior band (IB) of the distal enthesis of the ATFL measured 41.72 ± 5.01mm2 and 26.66 ± 3.12mm2 respectively. The footprint of the distal enthesis of the CFL measured 146.07 ± 14.05mm2, while the footprint of the distal PTFL measured 126.26 ± 8.88mm2. The proximal footprint of the ATFL, CFL and PTFL measured 11.06 ± 0.69mm, 7.87 ± 0.43mm and 10.52 ± 0.63mm in length and 8.66 ± 0.50mm, 9.10 ± 0.92mm and 14.41 ± 1.30mm in width on average. The distal footprint of the ATFL (SB), ATFL (IB), CFL and PTFL measured 10.92 ± 0.81 mm, 8.46 ± 0.46mm, 13.98 ± 0.93mm and 11.25 ± 0.95mm in length and 7.76 ± 0.59mm, 7.51 ± 0.64mm, 18.98 ± 1.15mm and 24.80 ± 1.25mm in width on average. Conclusions. This methodology provides an effective approach in the identification of the footprint of the lateral ligaments of the ankle to enhance surgical precision and accuracy in tissue-engineered design. Declaration of Interest. (b) declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported:I declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project

Aims. Periprosthetic proximal femoral fractures (PFFs) are a major complication after total hip arthroplasty (THA). Health status after PFF is not specifically investigated. The aim of this study is to evaluate the health status pattern over two years after sustaining a PFF. Methods. A cohort of patients with PFF after THA was derived from the Brabant Injury Outcomes Surveillance (BIOS) study. The BIOS study, a prospective, observational, multicentre follow-up cohort study, was conducted to obtain data by questionnaires pre-injury and at one week, and one, three, six, 12, and 24 months after trauma. Primary outcome measures were the EuroQol five-dimension three-level questionnaire (EQ-5D-3L), the Health Utility Index 2 (HUI2), and the Health Utility Index 3 (HUI3). Secondary outcome measures were general measurements such as duration of hospital stay and mortality. Results. A total of 70 patients with a PFF were included. EQ-5D utility scores were significantly lower on all timepoints except at six months’ follow-up compared to pre-injury. EuroQol visual analogue scale (EQ-VAS) scores at one month's follow-up were significantly lower compared to pre-injury. The percentage of reported problems at two years was higher for all dimensions except anxiety/depression when compared to pre-injury. The mean EQ-5D utility score was 0.26 higher in males compared to females (95% confidence interval (CI) 0.01 to 0.42; p = 0.003). The mean EQ-VAS score for males was 8.9 points higher when compared to females over all timepoints (95% CI 1.2 to 16.7; p = 0.027). Mortality was 10% after two years’ follow-up. Conclusion. PFF patients are a frail population with substantial functional impairment at baseline. Post-injury, they have a significant and clinically relevant lower health status two years after trauma when compared to pre-injury. Health status improves the most between one and three months after injury. Two years after PFF, more patients experience problems in mobility, self-care, usual activities, and pain/discomfort than pre-injury. Cite this article: Bone Joint J 2024;106-B(5):442–449

Recently, technologies to culture one or more cell types in three dimensions have attracted a great deal of attention in tissue engineering. Particularly, the improved viability, self-renewal capacity, and differentiation potential have been reported for stem cell spheroids. However, it is crucial to modulate spheroid functions with instructive signals to use multi-cellular spheroids in tissue engineering. We have been developing ECM-mimicking fibrous materials decorated with cell-instructive cues, which were incorporated within 3D stem cell spheroids to fine-tune their functions as modular building blocks for bottom-up tissue-engineering applications. In particular, we created composite spheroids of human adipose-derived stem cells (hADSCs) incorporating nanofibers coated with instructive signal of either transforming growth factor-β3 or bone morphogenetic growth factor-2 for chondrogenesis or osteogenesis of stem cells, respectively. The bilayer structure of osteochondral tissue was subsequently mimicked by cultivating each type of spheroid inside 3D-printed construct. The in vitro chondrogenic or osteogenic differentiation of hADSCs within the biphasic construct under general media was locally regulated by each inductive component. More importantly, hADSCs from each spheroid proliferated and sprouted to form the integrated tissue with interface of bone and cartilage tissue. This approach may be applied to engineer complex tissue with hierarchically organized structure

Olecranon plates used for the internal fixation of complex olecranon fractures are applied directly over the triceps tendon on the posterior aspect of the olecranon. The aim of the study is to describe the relationship of the plates and screws to the triceps tendon at the level of the olecranon. Eight cadaveric elbows were used. Dimensions of the triceps tendon at the insertion and 1cm proximal were measured. A long or a short olecranon plate was then applied over the olecranon and the most proximal screw applied. The length of the plate impinging on the tendon and the level of the screw tract on the tendon and bone were measured. The mean olecranon height was 24.3cm (22.4-26.9cm) with a tip-to-tendon distance of 14.5cm (11.9-16.2cm). The triceps tendon footprint averaged 13.3cm (11.7-14.9cm) and 8.8cm (7.6-10.2cm) in width and length, respectively. The mean width of the central tendon 1 cm proximal to the footprint was 6.8 cm. The long olecranon plate overlay over more movable tendon length than did the short plate and consequently the superior screw pierced the triceps tendon more proximally with the long plate. Using the Mann-Whitney U test, the differences were significant. The long olecranon plates encroach on more triceps tendon than short plates. This may be an important consideration for olecranon fractures with regards implant loosening or triceps tendon injury