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The Bone & Joint Journal
Vol. 106-B, Issue 5 | Pages 425 - 429
1 May 2024
Jeys LM Thorkildsen J Kurisunkal V Puri A Ruggieri P Houdek MT Boyle RA Ebeid W Botello E Morris GV Laitinen MK

Chondrosarcoma is the second most common surgically treated primary bone sarcoma. Despite a large number of scientific papers in the literature, there is still significant controversy about diagnostics, treatment of the primary tumour, subtypes, and complications. Therefore, consensus on its day-to-day treatment decisions is needed. In January 2024, the Birmingham Orthopaedic Oncology Meeting (BOOM) attempted to gain global consensus from 300 delegates from over 50 countries. The meeting focused on these critical areas and aimed to generate consensus statements based on evidence amalgamation and expert opinion from diverse geographical regions. In parallel, periprosthetic joint infection (PJI) in oncological reconstructions poses unique challenges due to factors such as adjuvant treatments, large exposures, and the complexity of surgery. The meeting debated two-stage revisions, antibiotic prophylaxis, managing acute PJI in patients undergoing chemotherapy, and defining the best strategies for wound management and allograft reconstruction. The objectives of the meeting extended beyond resolving immediate controversies. It sought to foster global collaboration among specialists attending the meeting, and to encourage future research projects to address unsolved dilemmas. By highlighting areas of disagreement and promoting collaborative research endeavours, this initiative aims to enhance treatment standards and potentially improve outcomes for patients globally. This paper sets out some of the controversies and questions that were debated in the meeting.

Cite this article: Bone Joint J 2024;106-B(5):425–429.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XIV | Pages 30 - 30
1 Apr 2012
Gulia A Puri A Agarwal M Laskar S Reddy K
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Introduction

We analyzed the results of extracorporeal radiated (ECRT) autogenous tumour bone for reconstruction of diaphyseal defects after tumour resection at our institute.

Methods

Sixteen diaphyseal bone tumours operated between March 2006 to March 2008 were reconstructed with ECRT bone after appropriate oncologic resection. These included 10 cases of Ewing's sarcoma, 5 of Osteosarcoma and 1 Adamantinoma. Nine involved femur, 5 tibia and 2 humerus. Suitable internal stabilisation (14 cases plate fixation, 2 intramedullary nails) was used after re-implanting ECRT bone. Average resection length was 18.9 cm (range, 11 to 30 cm).


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XIV | Pages 12 - 12
1 Apr 2012
Gulia S Arora B Puri A Gulia A laskar S Rangarajan V Shah S Basu S Medhi S Vora T Kurkure P Banavali S
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Background

Bone lesions in Ewing's sarcoma (ES/PNET) have been traditionally diagnosed with bone Scan. PET-scan is emerging as a promising investigative modality for detection of metastatic lesions. In this prospective study, we compare the utility of both to detect the metastatic sites.

Methods

One hundred and seventy five histologically proven cases of ESPNET from 2004-2009 were prospectively staged with bone scan and PET-scan with Breath- hold CT scan- thorax. The diagnostic value of PET-scan to pick up metastatic lesions was compared with bone scan.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 78 - 78
1 Jan 2011
Puri A Agarwal MG Gulia A
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Objective: To assess whether hemicortical excision and biological reconstruction instead of the conventional wide resection for selected cases of malignant surface tumors, may give adequate oncologic clearance with less morbidity and better function.

Methods: From January 2000 to June 2007 a total of 29 malignant surface tumors were managed at our institute. Fifteen of these were treated with hemicortical excision and reconstruction. They consisted of 10 parosteal osteosarcomas, 1 periosteal osteosarcoma, 1 high grade surface osteosarcoma, 1 adamantinoma and 2 surface chondrosarcomas. Nine were in the distal femur, 3 in tibia, 2 in the humerus and 1 in the radius. Four of these were residual/recurrent lesions following earlier intervention. After hemicortical excision with adequate margins the bone defect was reconstructed with allograft/autograft and suitable internal fixation where indicated.

Results: Margins were reported free in all cases. There were no infections. Three of five patients who did not have fixation with a plate at index surgery sustained a subsequent fracture which was then reduced and fixed. Follow up duration was from 24 to 90 months. Two patients had isolated soft tissue recurrences. Both underwent re excision and are currently disease free at 36 and 38 months respectively after recurrence. Eleven patients had a maximum possible score of 30 (MSTS functional scoring); other four had a score of 29. None of the cases have developed distant metastasis.

Discussion: Early results indicate that in selected cases, hemicortical excision is an oncologically sound procedure. The ability to do a biological reconstruction with bone helps avoid some of the serious complications of a megaprosthetic reconstruction while permitting full active loading of the extremity and near normal function. Internal fixation at index surgery permits early mobilization and minimises the incidence of subsequent fractures.


Orthopaedic Proceedings
Vol. 93-B, Issue SUPP_I | Pages 77 - 77
1 Jan 2011
Puri A Gulia A Agarwal MG Srinivas CH
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Objectives: To analyse functional outcome of giant cell tumor (GCT) distal radius treated with en bloc excision and reconstruction with ulnar translocation and wrist arthrodesis.

Methods: Between June 2005 and March 2008 fourteen patients of Campanacci grade 3 GCT distal radius treated with en bloc excision were reconstructed with ulnar translocation (radial transposition of ulna) and wrist arthrodesis. Seven (50%) patients had recurrent disease. Average resection length was 7.9 cm (range 5.5cm–15 cm). Twelve cases were fixed with a plate and in 2 an intramedullary nail was used. Union at both junctions was evaluated and functional assessment done using MSTS score.

Results: All 14 patients had followed up till bony union. Eleven patients were available at time of final review with an average follow up of 24.5 months (range 13–48 months). Average time for union at ulnocarpal junction was 4 months and ulnoradial junction was 5 months. No case required any additional procedure to augment union. Three cases had a soft tissue recurrence and one had pulmonary metastasis. Average range of prono supination was 80 degrees, one patient with synostosis had complete restriction of prono supination. Average MSTS Score at last follow up was 26 (86.6%).

Conclusions: Ulnar translocation provides a local vascularised bone graft to bridge the defect after excision of distal end radius tumors without the need for microvascular procedures. Unlike centralization of the ulna it retains prono supination while maintaining good hand function.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 222 - 222
1 Mar 2010
Krause B Puri A Matthews A
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Thromboembolic complications following lower limb arthroplasty are reported to be high. The aim of this of this study is to ascertain the incidence of symptomatic venous thromboembolic disease following lower limb arthroplasty without Pharmacological thrombo prophylaxis.

Retrospective review was undertaken of 752 patients following total hip or total knee replacement between January 1st 2002 and June 30th 2005.

Fifty one patients were considered high risk and received thrombopharmacologal prophylaxis with Clexane and Warfarin. Information on all patients was obtained from medical records, computerised information system, general practitioners and patients themselves to produce a complete picture of the three months immediately following the index arthroplasty. All patients who presented with calf symptoms suggestive of venous thrombosis, respiratory distress or died in that three months were investigated.

Two patients were lost to follow up. All others had full documentation. Twenty-nine patients presented with calf related symptoms and after ultrasound investigation nine (five THR, four TKR) were confirmed to have venous thrombosis and were treated. One of these patients developed tense haemarthrosis while on treatment. Twelve other patients presented with respiratory symptoms. Eight (six THR two TKR) were confirmed to have pulmonary embolism on either VQ scan or spiral CT. Four of these on VQ scan were low probability. All patients were treated for thromboembolic disease and while on treatment one patient developed persistent wound discharge and infection. Of the 51 patients treated with pharmacological prophylaxis one developed a DVT and five developed wound problems, one of which was major. Two patients died during the three month period, but neither was related to thromboembolic disease.

From the 699 patients the symptomatic DVT rate was 1.1%. Symptomatic pulmonary embolism rate was 1.5% including the low probability of VQ scans. There was no mortality from thromboembolism in this study. These results compare favourably with the recent literature. Our department has a policy to select patients for thromboembolic prophylaxis based on high risk factors. All other patients are fully informed of this risk and are treated with elevation, avoidance of swelling, early supervised and regular mobilisation. Our result from this study substantiate our policy for selection of patients for thromboembolic prophylaxis.


Orthopaedic Proceedings
Vol. 92-B, Issue SUPP_I | Pages 218 - 218
1 Mar 2010
Puri A Hadlow S
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The volume of spinal procedures have increased over the last two decades (220% in lumbar region). A simultaneous increase in re-operation rates (up to 20%) has been reported. Our aim was to compare with literature the reoperation rates and complications for various spinal procedures from a peripheral unit and to provide this information to the patients

This was a retrospective study of all patients who underwent spinal surgery during the period 1995 to 2005 by one surgeon. Using ICDM-9 codes and private notes patients were identified and medical records were used to gather relevant data. The following information was extracted-demographics, diagnosis, ASA criteria, primary procedure, any complication/s, secondary procedures, duration of follow up and to secondary procedure. The index procedures were grouped into regional and according to indication. Both complications and reoperations were grouped into early (within three months) or delayed (after three months) from the index operation. Reoperation rates and complications were calculated and compared with literature.

Four hundred and thirty-nine patients formed the study population. Five patients had inadequate data and were excluded. 23 patients have since died. Demographics showed 22% were smokers and 9% were either unemployed or sickness beneficiary. The commonest diagnosis in the lumbar spine was disc herniation (194). Stenosis and disc degeneration were the next most common surgical indications. In the cervical spine 27 patients had disc herniation and 15 patients were operated for trauma. Lumbar discectomy was the commonest procedure-191 patients with one third having microdiscectomy. Instrumented fusion was performed in 97 while 37 patients underwent decompression only. The majority of cervical spine patients (46) had discectomy and fusion.

Stabilisation for trauma formed a reasonable workload in both cervical and lumbar regions. Early complications included dural tears (seven), neurological symptoms (eight), wound infections (12) and pulmonary embolism (one) and repeat disc herniation. Delayed problems included repeat disc herniation, pseudoarthrosis and implant related symptoms. Overall re-operation rate was 14.52% with 5.02% early and 9.4%delayed repeat surgery. Repeat discectomy (eight) and decompression and exploration (seven) were the common early reoperation whereas fusion post discectomy (19) and recurrent disc herniation (12) were indications for delayed intervention. Removal of metalware (8) was another large late re-operation group.

Our re-operation rates fall within the quoted figures in literature. However our early re-operation rates are somewhat higher. These figures help us to inform patients better at the time of consent for the primary procedure especially lumbar disc surgery as most of the re-operation were required after discectomy.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 319 - 319
1 May 2006
Puri A Kusel R Krause B
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The aim was to determine the knowledge patients have about Total Hip Joint Replacement, their expectations from it and to evaluate the degree of disability from their hip and co-morbidities.

A total of eighty questionnaires were posted to two groups of patients. The survey consisted of open ended questions. They were also requested to complete Hospital for Special Surgery Hip Replacement Expectation Survey. Patients awaiting a Total Hip Joint replacement were assessed using Harris Hip Score and Index for Coexistent Disease.

Response rate was 81%. Average Harris hip score of 44.96 for the group on the waiting list for THJR.16 of 29 patients fell between mild to severe ICED. Questions to ascertain patient’s knowledge of THJR its risks and complications were open ended. 32–67% either expressed being unaware or answered incorrectly to these questions. Analysis of the Expectation survey revealed that over 75%of patients in both groups rated 15 of the 18 items as being an important expectation. The three items rated low/not applicable in expectation were related to employment, sexual activity and use of support for mobilizing.

This survey reveals a population waiting for a THJR possessing inadequate and unacceptable levels of knowledge about it while having high expectations of improvement in their quality of life. Unmet expectations can form grounds for complaints and even recourse to medico legal action. The expectations of the patients waiting for a THJR should be discussed and realistic goals set.


Orthopaedic Proceedings
Vol. 88-B, Issue SUPP_II | Pages 315 - 315
1 May 2006
Puri A Calder J
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Rotator cuff tears are an increasingly recognizable and common problem amongst the elderly. We undertook this review to assess outcome from open surgical rotator cuff repair and acromioplasty in patients over the age of 70 years.

A retrospective review of 61 patients with 64 full thickness rotator cuff tears treated with open repair and decompression acromioplasty between 1/1/92 and 30/6/04.To evaluate the current functional state and satisfaction (mean time from surgery 46.3 months) 50 patients were contacted and invited to attend for clinical evaluation using Constant and Murley’s functional score and/or answer a modified subjective 12 point Simple Shoulder Test. Eleven patients were not contactable despite attempts through post and phone.

All grades of tears were reparable with 48 being good tendon to bone. All the patients underwent a six week supervised physiotherapy programme. Complications included 6 frozen shoulder and seven cases of re- rupture .One patient each developed pulmonary embolism and reflex sympathetic dystrophy. Based on the definitive scoring of Constant and Murley’s 31 were rated as excellent (80–100 points) 9 good (65–79), 2 fair (50–64) and 2 poor (less than 50). Out of the total 43 patients (44 shoulders) examined and scored 90% showed excellent and good results.

Symptomatic rotator cuff tears in the elderly, active and healthy patients treated by a surgical repair results in good and early functional return, lasting pain relief and excellent patient satisfaction and should be actively considered as a definitive mode of treatment in this age group.