A novel After ACL reconstruction, recruited cells from surrounding tissues play crucial roles in ligamentization to obtain adequate structural properties. To allow athletes to return sports activity sooner, these remodeling processes should be elucidated and be accelerated. However, in conventional animal models, it has been difficult to differentiate donor and recipient cells. Here we introduce the transgenic Kusabira-Orange pigs, in which cells produce fluorescence systemically, as Summary
Introduction
Signal intensity changes of the spinal cord on MRI in chronic cervical myelopathy are thought to be indicative of the prognosis. However, the prognostic significance of signal intensity change remains controversial. The purpose of this study was to investigate the characteristics of MR findings in cervical compression myelopathy that reflect the clinical symptoms and the prognosis and to determine the radiographical and clinical factors that correlate to the prognosis. The subjects were 73 patients who underwent cervical expansive laminoplasty. Their mean age was 64 years, and the mean postoperative follow-up was 3.4 years. The pathological conditions were cervical spondylotic myelopathy in 42 and ossification of the posterior longitudinal ligament in 31.MRI (spin-echo sequence) was performed in all patients. Three patterns of spinal cord signal intensity changes on T1-weighted sequences/T2-weighted sequences were detected as follows: normal/ normal. (N/N); normal/ high signal intensity changes (N/Hi); and low signal intensity changes/high signal intensity changes (Lo/Hi). Surgical outcomes were compared among these three groups. The most useful combination of parameters for predicting prognosis was determined. There were 2 patients with N/N, 67 with N/Hi and 4 with Lo/Hi signal change patterns before surgery. Regarding postoperative recovery, the preoperative Lo/Hi group was significantly inferior to the preoperative N/Hi group. The best combination of predictors for surgical outcomes included age, preoperative signal pattern and duration of symptoms. The low signal intensity changes on T1-weighted sequences indicated a poor prognosis. We speculate that high signal intensity changes on T2-weighted images include a broad spectrum of compressive myelomalacid pathologies and reflect a broad spectrum of recuperative potentials of the spinal cord. Predictors for surgical outcomes are preoperative signal intensity change pattern of the spinal cord on radiological evaluations, age at the time of surgery and chronicity of the disease.
