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Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 326 - 326
1 May 2009
Laporte D Marker D Ulrich S Johansson H Siddiqui J Mont M
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Introduction: Osteonecrosis is a devastating disease which can affect multiple joints including the distal radius. Although there are a number of studies that have reported the clinical outcomes of patients treated for osteonecrosis of the hip, knee, shoulder, and other locations, there are no known studies that have evaluated the outcome of patients who have this disease in the distal radius. The purpose of this study was to assess the characteristics of atraumatic, symptomatic osteonecrosis of the distal radius. In addition, based on reports that have shown the safe and effective use of core decompressions to treat early stages of osteonecrosis in other joints, we assessed whether this treatment modality also would provide pain relief and delay progression of the disease in the distal radius.

Methods: A review of 434 osteonecrosis patient records from the past 7 years in our prospectively collected database identified 4 patients (6 wrists) who had the disease in the distal radius. Two of these patients also had the disease in the ulna. All 4 patients were women, and their mean age was 46 years (range, 37 to 52 years). Clinical and radiographic outcomes were assessed at a mean of 39 months (range, 12 to 84) following treatment with core decompression. The clinical evaluations were conducted using the Michigan Hand Outcomes Questionnaire (MHQ). The reported pre-operative MHQ component scores for function, completion of everyday activities, pain, completion of work activities, overall appearance of the hands, and patient satisfaction were compared to the results of the MHQ at final follow-up. Radiographic success of the core decompressions was based on whether there was any progression in the stage of the disease.

Results: The most common risk factor for this cohort of patients was corticosteroids with 3 of the 4 patients having reported prior use. Other risk factors included alcohol consumption on a regular basis (n = 2), tobacco abuse (n = 2), blood dyscrasia (n = 2), and systemic lupus erythematosus (n = 1). Additionally, all 4 patients had multifocal osteonecrosis (affecting at least four separate anatomic sites. Overall, the patients reported a mean improvement in MHQ score (from 65% to 84%). Stratified by category, satisfaction improved from 64% to 88%, overall hand function increased from 64% to 81%, and pain was reduced from 60% to 25%, for pre- and post-operative values, respectively. One patient (2 wrists) required additional core decompressions in each wrist at one year following surgery but reported sustained improvement in her MHQ for both wrists at two years following her second core decompressions. There were no complications associated with the core decompressions, and there was no radiographic progression in the stage of the disease in any of the cases.

Discussion: Osteonecrosis of the distal radius is rarely found in patients with this disease (< 1%). It can be found in patients with osteonecrosis of other joints who have a symptomatic wrist and may have more than one risk factor. It can be readily diagnosed with x-rays and/or MRI. The results of the present study suggest that core decompression is a safe and effective treatment modality for symptomatic osteonecrosis of the wrist at the distal radius and/or ulna. Although the level of improvement in MHQ varied for each case, all patients reported reduced pain and improved function at final follow-up without any apparent complications. Based on these results, we recommend the use of core decompressions to alleviate the symptoms and to possibly delay the progression of distal radius osteonecrosis.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 335 - 335
1 May 2009
Marker D Seyler T Shilt J LaPorte D Mont M Frassica F
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Introduction: Osteonecrosis or avascular necrosis is a debilitating disease that can affect various joints such as the shoulder and knee, but it is most common in the hip. These cases may be challenging, and it is important that orthopaedic residents receive adequate training concerning the associated risk factors, diagnosis, and treatment modalities commonly used in treating this disease. Current scientific publications are often recommended as one of the main sources of information for surgeons in training. The purpose of the present study was to characterize the osteonecrosis information provided in the peer-reviewed literature, and to analyze the osteonecrosis related knowledge frequently tested on the Orthopaedic In-Training Examination (OITE). In addition, we assessed the relevance of recent literature as a tool for young physicians who are learning more about osteonecrosis as they prepare for their board examinations.

Methods: A systematic review was conducted using the Medline bibliographic databases of all literature from 5 years (2001–2005) in 4 high-impact orthopaedic journals (a total of 6750 articles): The Journal of Bone and Joint Surgery American (JBJS), Clinical Orthopaedics and Related Research (CORR), Journal of Arthroplasty (JOA), and Journal of Orthopaedic Research (JOR). For each year, the total number of articles and the number of articles related to “osteonecrosis” or “avascular necrosis” were determined. All articles were screened by two reviewers and grouped as having either a primary or secondary focus on osteonecrosis. The primary focus articles were stratified according to four subject areas including: etiology/associated risk factors, pathology/pathophysiology, diagnosis/classification, and treatment. Articles related to the treatment of osteonecrosis were further stratified according to non-invasive (such as pharmacological treatment and shock wave), core decompressions and nonvascularized graftings, revascularization techniques, osteotomies, and replacement surgeries (such as total hip arthroplasty and hemi- and total hip resurfacing). Next, the OITE was reviewed for each of the five years that followed the published literature (2002–2006). The questions were stratified in a similar manner as the literature. The overall proportions and the percentages in each category were compared between the OITE questions and the literature.

Results: Overall, 136 (2.0%) articles had an osteonecrosis primary focus, and 115 (1.7%) had a secondary focus. There were 30 primary focus articles every year except for 2002 when there were 16. Out of the four journals reviewed, CORR had the highest percentage of etiology and risk factor related articles (25%), whereas JOR was the most concentrated in pathology (33%) and diagnosis/classification (33%). JOA articles were mostly focused on treatment (83%). The percentage of OITE questions (0.6%) that had a primary osteonecrosis focus was statistically lower than the overall percentage of osteonecrosis articles (p < 0.001). The percentage of articles in each category was also different. Grouped by treatment, etiology/risk factors, pathology, and diagnosis/classification, there were 55%, 22%, 12%, and 11% for the articles and 25%, 25%, 0%, and 50% for the OITE questions. Additionally, the treatment questions in the OITE only focused on THA, but more than half of the articles discussing treatment reported other modalities such as vascularized bone grafting and the use of pharmacological agents.

Conclusions: Knowledge of the content and type of articles in literature can guide residents as they continue their education and learn more about osteonecrosis. All of the journals reviewed in this study provide an overall greater percentage of articles that are focused on osteonecrosis than the proportion of OITE questions. The results of this study suggest that students preparing for the OITE would benefit most by studying those articles that are related to the diagnosis/classification of osteonecrosis. Conversely, the OITE could more accurately reflect the literature by providing future questions concerning the pathology and the different treatment modalities frequently used depending on the stage and progression of this disease.