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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_9 | Pages 54 - 54
17 Apr 2023
Virani S Asaad O Divekar O Southgate C Dhinsa B
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There has been a significant increase in waiting times for elective surgical procedures in orthopaedic surgery as a result of the coronavirus disease 2019 (COVID-19) pandemic. As per the hospital policy, patients awaiting elective surgery for more than 52 weeks were offered a consultant-led harm review.

The aim of this study was to objectively assess the impact of this service on the field of foot and ankle surgery.

The data from harm review clinics at a District General Hospital related to patients waiting to undergo elective foot and ankle procedures in the year 2021 (wait time of more than 52 weeks) were assessed. Clinical data points like change in diagnosis, need for further investigations, and patients being taken off the waiting list were reviewed. The effect of the waiting time on patients’ mental health and their perception of the service was assessed as well.

A total of 72 patients awaiting foot and ankle procedures for more than 52 weeks were assessed as a part of the harm review service. It was noted that 25% of patients found that their symptoms had worsened while 66.1% perceived them to be unchanged. Twelve patients (16.9%) were sent for updated investigations. Twenty-one patients (29.5%) were taken off the waiting lists for various reasons with the most common one being other pressing health concerns; 9% of patients affirmed that the wait for surgery had a significant negative impact on their mental health.

This study concludes that the harm review service is a useful programme as it helps guide changes in the diagnosis and clinical picture. The service is found to be valuable by most patients, and its impact on the service specialities and multiple centres could be further assessed to draw broad conclusions.


Orthopaedic Proceedings
Vol. 104-B, Issue SUPP_1 | Pages 22 - 22
1 Jan 2022
Naskar R Oliver L Velazquez-Ruta P Dhinsa B
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Abstract

Objectives

This study aims to evaluate the functional outcomes of early weight-bearing in a functional orthosis for conservatively managed, complete AT ruptures. Also we tried to evaluate the patient reported outcome with this form of treatment.

Design

In this prospective study, we have analysed data from 41 patients with ultrasound diagnosed compete AT ruptures, with a gap of less than 5 cm. Every patient was treated in a functional weight-bearing orthosis (VACOped®) for 8 weeks with early weight-bearing following a specific treatment protocol, followed by rehabilitation with a trained physiotherapist.


Orthopaedic Proceedings
Vol. 95-B, Issue SUPP_1 | Pages 31 - 31
1 Jan 2013
Dhinsa B Gallagher K Dawson-Bowling S Mohan A Miles J Carrington R Skinner J Briggs T
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Introduction

The aim of this study was to see if the evaluation of the initial postoperative radiograph following primary knee and hip arthroplasty correlated with clinical outcome at five years postoperatively.

Methodology

Using our institution database we identified forty-nine hip replacements and fifty-two knee replacements performed between 2000 and 2006. All the patients underwent postoperative radiographs one day after surgery and clinical evaluation up to at least five years postoperatively. A consultant radiologist evaluated the radiographs for alignment and component position. The hip arthroplasty patients were assessed clinically using the Harris hip score, Oxford hip score, and the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC). The knee arthroplasty patients were assessed using the Knee Society score, Oxford knee score, and the WOMAC score.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXIX | Pages 90 - 90
1 Sep 2012
Nawaz S Gallagher K Dhinsa B Carrington R Skinner J Briggs T Bentley G
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Chondral injuries of the knee are extremely common and present a unique therapeutic challenge due to the poor intrinsic healing of articular cartilage. These injuries can lead to significant functional impairment. There are several treatment modalities for articular osteochondral defects, one of which is autologous chondrocyte implantation. Our study evaluates the mid to long term functional outcomes in a cohort of 828 patients who have undergone an autologous chondrocyte implantation procedure (either ACI or MACI), identifying retrospectively factors that may influence their outcome.

The influence of factors including age, sex, presence of osteoarthritis and size and site of lesion have been assessed individually and with multivariate analysis. All patients were assessed using the Bentley Functional Score, Visual Analogue Score and the Cincinnati Functional Score. Assessment were performed pre-operatively and of their status in 2010.

The longest follow-up was 12 years (range 24 to 153 months) with a mean age of 34 years at time of procedure. The mean defect size was 409 mm2 (range 64 to 2075 mm2). The distribution of lesions was 51% Medial Femoral Condyle, 12.5% Lateral Femoral Condyle, 18% Patella (single facet), 5% Patella (Multifacet) and 6% Trochlea. 4% had cartilage transplant to multiple sites.

High failure rates were noted in those with previous cartilage regenerative procedures or evidence of early osteoarthritis and those with transplantation to multiple sites.

Autologous chondrocyte implantation is an effective method of decreasing pain and increasing function, however patient selection plays clear role in the success of such procedure.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 571 - 571
1 Sep 2012
Nawaz S Bentley G Briggs T Carrington R Skinner J Gallager K Dhinsa B
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Chondral injuries of the knee are extremely common and present a unique therapeutic challenge due to the poor intrinsic healing of articular cartilage. These injuries can lead to significant functional impairment. There are several treatment modalities for articular osteochondral defects, one of which is autologous chondrocyte implantation. Our study evaluates the mid to long term functional outcomes in a cohort of 828 patients who have undergone an autologous chondrocyte implantation procedure (either ACI or MACI), identifying retrospectively factors that may influence their outcome.

The influence of factors including age, sex, presence of osteoarthritis and size and site of lesion have been assessed individually and with multivariate analysis. All patients were assessed using the Bentley Functional Score, Visual Analogue Score and the Cincinnati Functional Score. Assessment were performed pre-operatively and of their status in 2010. The majority of patients had several interim scores performed at varying intervals.

The longest follow-up was 12 years (range 24 to 153 months) with a mean age of 34 years at time of procedure. The mean defect size was 486 mm2 (range 64 to 2075 mm2). The distribution of lesions was 51% Medial Femoral Condyle, 12.5% Lateral Femoral Condyle, 18% Patella (single facet), 5% Patella (Multifacet) and 6% Trochlea. 4% had cartilage transplant to multiple sites. 30% failed following this procedure at a mean time of 72 months. 52% patients stated a marked improvement in their functional outcomes within the first two years. 49% stated an excellent result following their procedure.

High failure rate was noted in those with previous cartilage regenerative procedures, transplants occurring on the patella, particularly if involving multifacets. Multiple site cartilage transplantation was also associated with a high failure rate.

Autologous chondrocyte implantation is an effective method of decreasing pain and increasing function, however patient selection plays clear role in the success of such procedure.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVI | Pages 5 - 5
1 Aug 2012
Dhinsa B Perera J Gallagher K Spiegelberg B Hanna S Tai S Pollock R Carrington R Cannon S Briggs T
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The aim of this study is to investigate whether MoM implants result in more chromosome aberrations and increased blood metal ions postoperatively whe compared to MoP implants.

MoM arthroplasties are being inserted in increasing numbers of younger patients due to the increased durability and reduced requirements for revision in these implants. Recent studies have raised many concerns over possible genotoxicity of MoM implants.

This is a prospective study of patients who have undergone elective total hip replacement, they were selected and then randomised into two groups. Group A received a MoP implant and group B received a MoM implant. Patients are reviewed pre-operatively (control group), at 3 months, 6 months, 1 year and 2 years post-operatively. On each occasion blood tests are taken to quantify metal ion levels (chromium, cobalt, titanium, nickel and vanadium) using HR-ICPMS method and chromosome aberrations in T lymphocytes using 24 colour fluorescent in situ hydridisation (FISH).

51 patients have been recruited to date, 23 of whom had MoP prosthesis and 28 a MoM. 47 of these had their 1 year follow-up with blood analysis and 38 have had 2 year follow up. There appeared to be a bedding period for both MoM and MoP groups, with an increase in metal ion release. The blood concentration of chromium, cobalt and titanium rise significantly in the MoM group at the 2 year stage. Chromosome aberrations occurred in both groups. Both the MoM and MoP groups showed increase frequency of aneuploidy aberrations and structural damage. The greatest increase in metal ion levels occurred at the 1 to 2 year interval corresponding to significant rise in chromosome aberrations.

Preliminary results of this study show that the levels of chromium, cobalt and titanium are significantly higher in the MoM group compared to the MoP group. This corresponds to increases in chromosome aberrations in the groups with increases in structural chromosome damage after two years.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVI | Pages 40 - 40
1 Aug 2012
Dhinsa B Nawaz S Gallagher K Carrington R Briggs T Skinner J Bentley G
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Introduction

Autologous chondrocyte implantation (ACI) is contra-indicated in a joint rendered unstable by a ruptured anterior cruciate ligament (ACL). We present our experience of ACI repair with ACL reconstruction

Methods

Patients underwent arthroscopic examination and cartilage harvesting of the knee. A second operation was undertaken approximately six weeks later to repair the ruptured ACL with hamstring graft or Bone patella-Bone (BPB) and to implant the chondrocytes via formal arthrotomy. Three groups were assessed: Group 1: Simultaneous ACL Reconstruction and ACI; Group 2: Previous ACL Reconstruction with subsequent ACI repair; Group 3: Previously proven partial or complete ACL rupture, deemed stable and not treated with reconstruction with ACI procedure subsequently. Patients then underwent a graduated rehabilitation program and were reviewed using three functional measurements: Bentley functional scale, the modified Cincinnati rating system, and pain measured on a visual analogue scale. All patients also underwent formal clinical examination at review.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 43 - 43
1 Jun 2012
Dhinsa B Jalgaonkar A Nawaz Z Briggs T Muirhead-Allwood S Carrington R Skinner J Bentley G Miles J
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Patients with osteochondrodysplasia frequently require Total Hip Arthroplasty at a younger age, as a result of early degenerative disease of the hip joint. The outcome of Modular Total Hip Arthroplasty in this group of patients has been reported previously. In this retrospective study we evaluated the outcome of custom made (CADCAM) Total Hip Arthroplasty in patients with osteochondrodysplasia.

Between 1974 and 2009, twenty one CADCAM Total Hip Arthroplasty procedures were performed in fourteen patients in our institution. There were eight female and six male patients, with the mean age at time of surgery of 40.95 years (20 to 78). The patients were followed up clinically and with the Harris hip score for a mean of 7.12 years (0.5 to 17 years).

Four of the twenty-one hips (23.8%) required revision surgery at a mean of 11.54 years (6.5 to 17 years); one required it for aseptic loosening of the femoral component; one required complete revision of the acetabular component; one required exchange of acetabular liner; and one was for symptomatic non-union of a lesser trochanter avulsion.

This study shows encouraging clinical outcomes of custom made (CADCAM) Total Hip Arthroplasty in patients with osteochondrodysplasia,


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 44 - 44
1 Jun 2012
Dhinsa B Nawaz Z Gallagher K Carrington R Skinner J Briggs T Bentley G
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Purpose

The rate of arthroplasty or osteotomy in patients who had undergone autologous chondrocyte implantation (ACI) for osteochondral defects in the knee was determined. Furthermore, we investigated whether any radiographic evidence of osteoarthritis (OA) prior to ACI was associated with poorer outcome following surgery.

Methods

We retrospectively reviewed the medical notes and radiographs of 236 patients (mean age 34.9) who underwent ACI from 1998 to 2005 at our institution. Knee function was assessed according to the Modified Cincinnati Score (MCS) pre-operatively and at a mean of 64.3 months postoperatively (range 12 – 130). Radiographic changes were graded according to the Stanmore grading system.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXV | Pages 45 - 45
1 Jun 2012
Dhinsa B Gallagher K Nawaz Z Spiegelberg B Hanna S Tai S Pollock R Carrington R Cannon S Briggs T
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The aim of this study is to investigate whether Metal-on-Metal (MoM) implants result in more chromosome aberrations and increased blood metal ions post-operatively when compared to Metal-on-Polyethylene (MoP) implants. Metal-on-metal arthroplasties are being inserted in increasing numbers of younger patients due to the increased durability and reduced requirement for revision in these implants. Recent studies have raised many concerns over possible genotoxicity of MoM implants. This is a prospective study of patients who have undergone elective total hip replacement, they were selected and then randomised into two groups. Group A received a MoP implant and group B received a MoM implant. Patients are reviewed pre-operatively (control group), at 3 months, 6 months, 1 year and 2 years post-operatively. On each occasion blood tests are taken to quantify metal ion levels (chromium, cobalt, titanium, nickel and vanadium) using HR-ICPMS method and chromosome aberrations in T lymphocytes using 24 colour fluorescent in situ hybridisation (FISH). 53 patients have been recruited to date. 24 of whom had MoP prosthesis and 29 a MoM. 37 of these have had their one year follow-up with blood analysis and 14 have had 2 year follow up. Cobalt and chromium concentration increased during the first 6 months in both MoM and MoP groups, in the MoM group the chromium levels were twice that of MoP group and 12x that of the preoperative samples. Chromosome aberrations occurred in both groups. At 6 months both the MoM and MoP groups showed increase frequency of aneuploidy aberrations with further increases after one year. Structural damage in the form of translocations occurred in the MoM group after one year, but not in the MoP group, by two years there was a profound increase in translocations Preliminary results of this study show that the levels of chromium and cobalt are significantly higher in the MoM group compared to the MoP group. This corresponds to increases in chromosome aberrations in the groups with increases in structural chromosome damage after two years.


Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_IV | Pages 120 - 120
1 Mar 2012
Jain S Mohanlal P Dhinsa B
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To analyse the intra-operative variation in mechanical axes of the lower limb at various stages during navigated total knee replacement.

A prospective study was performed to analyse the intra-operative variation in the mechanical axes of the lower limb during navigated total knee replacement. All consecutive patients who underwent navigated total knee replacement were included and patients with inadequate data were excluded from the study. The intra-operative initial, trial and the final mechanical hip-knee-ankle axes were recorded from the navigation system. The differences between these axes were calculated and analysed. There were forty patients, of which 24 were females and 16 males with the age ranging from 37-89 (average 68.4) years. The right knee was replaced in 27 and the left knee in 13 patients. The average initial mechanical axes alignment was 0.03° valgus (3° varus to 3° valgus), trial alignment 0.64° varus (3° varus to 1.5° valgus) and final alignment 0.25° varus (4° varus to 4° valgus). Average deviation from initial to trial axes was 0.97°, trial to final axes was 0.74° and initial to final axes was 1.08°. The correlation co-efficient between the initial and the trial axes was 0.25, trial and final axes was 0.43 & initial and final axes was 0.09.

This study highlights a significant variation in mechanical axes between the different stages of navigated total knee replacement. The potential sources of intra-operative errors causing these changes could be soft tissue imbalance, variations in implant placement and possible tracker micro motion. Execution of bony cuts in near normal neutral alignment does not guarantee achievement of near normal final alignment. We advocate surgeons to be vigilant to avoid potential malalignment during navigated total knee replacement.


Orthopaedic Proceedings
Vol. 91-B, Issue SUPP_II | Pages 293 - 293
1 May 2009
Mohanlal P Dhinsa B Jain S
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To analyse the intra-operative variation in mechanical axes of the lower limb at various stages during navigated total knee replacement. A prospective study was performed to analyse the intra-operative variation in the mechanical axes of the lower limb during navigated total knee replacement. All consecutive patients who underwent navigated total knee replacement were included and patients with inadequate data were excluded from the study. The intra-operative initial, trial and the final mechanical hip-knee-ankle axes were recorded from the navigation system. The differences between these axes were calculated and analysed. There were forty patients, of which 24 were females and 16 males with the age ranging from 37–89 (average 68.4) years. The right knee was replaced in 27 and the left knee in 13 patients. The average initial mechanical axes alignment was 0.03° valgus (3° varus to 3° valgus), trial alignment 0.64° varus (3° varus to 1.5° valgus) and final alignment 0.25° varus (4° varus to 4° valgus). Average deviation from initial to trial axes was 0.97°, trial to final axes was 0.74° and initial to final axes was 1.08°. The cor-relation co-efficient between the initial and the trial axes was 0.25, trial and final axes was 0.43 & initial and final axes was 0.09.

This study highlights a significant variation in mechanical axes between the different stages of navigated total knee replacement. The potential sources of intra-operative errors causing these changes could be soft tissue imbalance, variations in implant placement and possible tracker micro motion. Execution of bony cuts in near normal neutral alignment does not guarantee achievement of near normal final alignment. We advocate surgeons to be vigilant to avoid potential malalignment during navigated total knee replacement.


Orthopaedic Proceedings
Vol. 90-B, Issue SUPP_III | Pages 568 - 568
1 Aug 2008
Jain S Mohanlal P Dhinsa B
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Significant concerns remain in computer navigated surgery regarding potential errors due to inadequate tracker or array fixation, cutting guide block movements, saw blade deviation, variable component seating and standardisation and validity of radiographic measurements of alignment for outcome assessment. There are no studies in the literature comparing computer generated axes at different steps of operation as well as radiographic axes using scanograms to our knowledge. Long leg films involve significant radiation, which can be minimised by the use of scanograms.

A prospective study was performed to compare the per-operative and post-operative alignment of the lower limbs after navigated total knee replacements. All consecutive patients who underwent navigated total knee replacement between May 2006 and November 2006 were included in the study. Patients with inadequate data, patients who refused to participate in the study or lost contact, obvious measurement errors and patients having had recent operations were excluded. The intra-operative initial, trial and the final axes were recorded from the navigation system. Post-operatively a CT (Computer Tomogram) scanogram of the lower limbs was performed as per the scanogram protocol. Measurement of the mechanical hip-knee-ankle axis of the lower limb was performed on the computer. Results were analysed using appropriate statistical methods and comparison made between initial, trial, final and scanogram axes with assessment of their correlation coefficients.

Twenty-five patients were initially recruited in the study, of which, 15 were available with completed data. There were four males and 11 females with the age ranging from 57–80 (average 70) years. The right knee was replaced in 12 and the left knee in three patients. The average initial alignment was 0.09° valgus (0.5° varus to 1° valgus), trial alignment 0.59° varus (2° varus to 1° valgus), final alignment 0.56° varus (4° varus to 1.5° valgus) and average radiographic alignment was 0.52° varus (3.1° varus to 1.8° valgus) in maximum possible extension. Average deviation from initial to trial alignment was 0.69° varus, trial to final was 0.03° varus and final to radiographic alignment was 0.12° valgus.

Correlation co-efficient of 0.62 between the initial and final axes with average difference of 0.72° varus (p= 0.11, unequal variance 2 tailed) demonstrates reasonable reproducibility of the alignment with computer-guided surgery, also confirming the fact that there is some variation between the initial cut angles and final mechanical axes. Correlation co-efficient of 0.92 between final axes and radiographic axes suggests that scanogram is an imaging modality with reasonable accuracy for measuring mechanical limb alignment despite significantly low radiation and relatively low resolution. Potential errors in radiographic measurements due to rotational malposition combined with flexion deformity is highlighted.