Aims: This biomechanical study was performed to evaluate the consequences of a total infrapatellar fat pad resection on knee kinematics and patellar contact pressure. Methods: Knee motion between 120∞ of flexion and full extension was performed in a knee kinemator on 10 fresh frozen knee specimens (6 male, 4 female, average age 44 years). The joint kinematics was evaluated by ultrasound sensors (Zebris-system), the patellar contact pressure was measured using a thin-film resistive ink pressure system (Tekscan). All data were taken before and after resection of the infrapatellar fat pad and statistically analyzed. Results: A total resection of the infrapatellar fat pad resulted in a significant (p< 0,05) decrease of the tibial external rotation in knee extension combined with a significant (p< 0,05) medial translation of the patella. The patellar contact pressure was significantly (p< 0,05) reduced, in knee flexion more than in knee extension. Conclusions: We conclude that a resection of the infrapatellar fat pad might reduce clinical symptoms in the anterior knee pain syndrome. A biomechanical function of the infrapatellar fat is suspected.