There is a significant positive association between hours of brace wear and rate of success in the treatment of Adolescent Idiopathic Scoliosis (AIS). The abandon rate reported in the literature averages 18%. In a recent randomized trial conducted at our center; the abandon rate was 4%. We aim to document the abandon rate towards brace treatment during the COVID-19 pandemic and its impact on AIS progression.

We reviewed a database of AIS patients recruited between March and September 2020. Inclusion criteria were patients with AIS under brace treatment according to SRS criteria. The patients were divided in 2 cohorts: those with a self-reported good adherence to treatment and those who voluntarily abandoned treatment during follow-up. Patients with irregular adherence were excluded. Data analysis included age, gender, Risser stage, type of brace, Cobb angles at first visit and last follow-up (mean 11 months) and % of progression. Unpaired student tests were used for comparison.

154 patients met inclusion criteria. 20 patients were excluded due to irregular adherence. 89 patients (age: 12.1 y.o. ±1.4) reported good adherence to treatment, while 45 patients (age: 12.6 y.o. ±1.5) abandoned treatment, an abandon rate of 29%. The cohort of compliant patients started treatment with a mean main thoracic (MT) curve of 26° and finished with 27°. The mean difference between measurements was +0.65°±7.5; mean progression rate was −4.6%. However, patients who abandoned treatment started with a mean MT curve of 28° and finished with 33°, with a mean increase of +5°±8 and a mean progression rate of −11%. The differences between the 2 cohorts were statistically significant (p=0.002). Five (5) patients from the abandon group were offered for surgery because of curve progression.

The abandon rate of brace treatment in AIS significantly increased during the first wave of COVID-19 pandemic. Patients who voluntarily discontinued treatment had significant increases in curve progression and surgical indication rates.

The increased incidence of type 2 Diabetes Mellitus is associated with an impaired skeletal structure and a higher prevalence of bone fractures. Sclerostin is a negative regulator of bone formation produced by osteocytes and there is recent evidence that its expression in serum is elevated in diabetic patients compared to control subjects. In this study, we test whether hyperglycemia affects serum and bone sclerostin levels in a rat model of type 2 Diabetes as well as sclerostin production by osteoblasts in culture.

We used Zucker diabetic fatty (ZDF) male rats (n=6) that spontaneously develop obesity and frank diabetes around 8–9 weeks of age and Zucker lean rats as controls (n=6) to examine sclerostin expression in serum at 9, 11 and 13 weeks using a specific ELISA. Sclerostin expression in bone tibiae was examined at 12 weeks using immunocytochemistry. Rat osteoblast-like cells UMR-106 were cultured in the presence of increasing concentrations of glucose (5, 11, 22 and 44 mM) during 48 hours and sclerostin mRNA expression and release in the supernatant determined by quantitative PCR and ELISA, respectively.

Our results show that serum sclerostin levels are higher in the diabetic rats compared to lean rats at 9 weeks (+ 140%, p<0.01). Our preliminary results using immunocytochemistry for sclerostin did not show any major difference in sclerostin expression in tibiae of diabetic rats compared to lean ones, although we observed many osteocytic empty lacunae in cortical bone from diabetic rats. Glucose dose-dependent stimulated sclerostin mRNA and protein production in mature UMR106 cells while it had no effect on osteocalcin expression.

Altogether, our data suggest that sclerostin production by mature osteoblasts is increased by hyperglycemia in vitro and enhanced in serum of diabetic rats. Furthers studies are required to determine whether sclerostin could contribute to the deleterious effect of Diabetes on bone.

Introduction: Prosthetic joint infections are a growing burden. Since we felt that we were far from the optimistic results recently published, we decided to find out the reality in our department. The goals were to determine:

The rate of infections in primary and revision surgery (hip and knee)

Materials and Methods: We retrospectively reviewed clinical records of all patients that underwent surgical treatment due to infected hip or knee prosthetic joint between 1st July 2001 and 31st December 2007.

Results: Since the majority of infections (67%) presented in the first two years after surgery, we determined the rate of infections taking in to consideration a minimum two years follow-up. We calculated a 1.8% (12/678) rate of infection for primary total hip and 3.3% (20/588) for primary total knee arthroplasty. There was no statistically significant difference between the two groups. Revision hip surgery had a 5.4% (15/243) infection rate and revision knee surgery revealed an even higher rate of 10.3% (4/42). The difference between primary and revision surgery was statistically significant both for hip and knee.

Considering an infection free arthroplasty as the goal, the overall success rate of treatment was under 48% (30/69). The success of treating infections with debridement and retention of components was even lower (29%). Further analysis revealed a higher success of this approach (45%) when considering more appropriate candidates (short term infections). An interesting statistically significant difference was found favoring this approach in the knee.

Two-stage revision strategy was successful in achieving revision arthroplasty in 43% (20/46) of the cases. Most patients were never considered candidates to the second stage procedure. Knee joint and resistant microorganisms were found to be predictors of bad prognosis.

There was a 90% (18/20) survival rate of revision arthroplasties after two years average follow-up. There were only 2 cases of relapsing infection both controlled without prosthetic removal.

Conclusion: Our results compare poorly with the latest published data from different centers. They led us to implement new prophylactic measures as well as review our diagnostic and treatment options.

Introduction: Mönckeberg sclerosis or medial artery calcification (MAC) is a well known phenomenon associated with the diabetic and other altered blood parameters. However its consequence within the foot and specifically the 1st dorsal metatarsal artery has not previously been studied.

Materials and Methods: Nearly 1000 foot x-rays were studied over a nine month period in a busy District General Hospital to identify the prevalence of first dorsal metatarsal artery calcification. The electronic medical notes for all the patients were reviewed to confirm which patients were known to be diabetic. The patients with positive findings were then identified and their HbA1c, creatinine, and previous foot interventions recorded.

Results: 1.4% of the population studied had medial artery calcification of the 1st dorsal metatarsal artery. 93% were known diabetics and 100% had impaired glucose tolerance (a glucose plasma concentration of > 7.8mmol/l two hours post glucose loading). 79% have required previous podiatric care for foot ulceration and 64% had required surgical intervention for their diabetic feet. MAC has a high positive predictive value (92.9% (95% CI 69.2–98.7)) for diabetes, with a good specificity (99.9% (95%CI 99.4–100)) and low false positive rate (0.1% (05%CI 0.0–0.6)).

Discussion: Medial artery calcification in the first dorsal metatarsal artery is characteristic of impaired glucose metabolism, and if seen on routine x-ray should be an indication for screening of the patient. It should also be considered as a foot at risk sign in the established diabetic due to the high incidence of foot ulceration and need for surgical intervention in this group.

Conclusion: The prevalence of MAC seen on routine foot x-rays has been demonstrated in a large cohort of patients. The specificity and positive predictive value for diabetes has been calculated and the prevalence of these patients requiring surgical or specialist podiatric care recorded.

Purpose: Functional, radiological and instrumental comparison between ACL reconstruction with Single Bundle plus lateral augmentation (SB) versus Double Bundle technique (DB).

Materials and methods: Random choice of 70 patients operated by the same equipe for ACL reconstruction with autologous hamstrings, 35 with SB+lateral augmentation and 35 with DB technique.

Investigation based on: Sport activity recover; IKDC; KT2000; isokinetical tests; muscular throphysm recover; Tegner and Lyshom score; Activity Rating Scale (ARS); Psychovitality Questionnaire; radio graphical evaluation in AP, LL and Rosemberg.

Results: IKDC results superior for DB group, with no bad results and superposable ROM for both groups. Sport activity recover in 100% patients of DB group, with reduced time respect to SB group. Excellent and superposable results for both groups at KT2000. Better muscular throphysm and isocinetic tests results for DB group. Ahlback score same to pre-op in both groups. ARS and Psychovitality questionnaire results better for DB group.

Discussion: Both surgical techniques guarantee excellent results.

DB technique allows a faster sport activity and muscular throphysm recover and better results in the isoci-netical tests.

Introduction: Concave ribs are in a position to act as a butttress preventing the reduction of the spine towards the midline. Segmental concave ribs osteotomy decrease the buttress effect increases the flexibility of the curve and allow the spine to approach a more mideline position.

Purpose: To analyze radiographic and perioperative data in patients undergoing posterior thoracic instrumented fusion and concave ribs osteotomies.

Methods: 34 patients with rigid thoracic curves treated with hybrid constructs (hooks, wires and pedicle screw) and concave rib osteomies( averaged 5) between 2000 and 2003 are included. All patients obtained pre-operative upright and bending films and postoperative upright films. Cobb angle was collected and three parameters were assessed: percent flexibility, percent scoliosis correction and the percent bend corecction. Main age was 14 years with 20 females and minimun follow up 1 year.

Results: There were 13 A.I.S., 8 neuromuscular cases and the rest associate to different pathologies (syringomyelia, cardiopathy ect.). Preoperative thoracic curve averaged 78(60–112); percent bend correction veraged 25% and postoperative correction averaged 58%. There were no neurological complications, 4 patients developed pulmonary complications ( pleural effusion) who required suction drenage.

Conclusions. Rigid curves undergoing concave rib osteotomies achieved a postoperative curve that was 58% of the preoperative bend curve. Concave rib osteomomies increase flexibility of severe rigid curves avoiding anterior realese in the great majority of large curves with minimmal pulmorary complication. Overlapping the osteotomized ribs on the concave rod the chest asymmetry improves and the cosmetical result of the operation is improved.

Introduction Foot surgery has an increased risk of postoperative infection when compared with surgery of other anatomical regions. A pre-surgical foot bath in a bactericidal solution is thought to reduce the incidence of postoperative wound infection. We compared the incidence of post-operative wound infection in two groups, one undergoing a pre-surgical footbath and one group that did not.

Method We prospectively assessed 83 patients undergoing forefoot surgery under the care of two surgical teams. Forty-one patients underwent a pre-surgical foot bath in povidone iodine solution. Forty-two patients did not have a pre-surgical foot bath. All patients had microbiological swabs taken on admission and following surgical preparation and draping. These were cultured for bacterial growth. All patients were reviewed at 2 and 6 weeks after surgery and were monitored for signs of infection. The results for each group were analysed and compared.

Results There were seven post-operative infections in the pre-surgical foot bath group. This compared with only two infections for the group who did not undergo pre-surgical bathing. Correlation of infection with complexity of surgery, medical co-morbidities, operative time, method of closure and use of metalwork was examined.

Conclusions These results suggest that pre-surgical bathing in a bactericidal solution is not effective in preventing post-operative infection.