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Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_9 | Pages 70 - 70
1 Oct 2020
Staats K Sosa BR Kuyl E Niu Y Suhardi VJ Turajane K Windhager R Greenblatt MB Ivashkiv L Bostrom MP Yang X
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Introduction

Initial post-operative implant instability leads to impaired osseointegration, one of the most common reasons for aseptic loosening and revision surgery. In this study, we developed a novel murine model of implant instability and demonstrated the anabolic effect of immediate and delayed intermittent Parathyroid Hormone (iPTH) treatment in the setting of instability-induced osseointegration failure.

Methods

3D-printed titanium implants were inserted in an oversized drill-hole in the tibia of C57Bl/6 mice (n=54). After implantation, the mice were randomly divided in 3 treatment groups (control: PBS-vehicle; iPTH; delayed iPTH). Radiographic analysis was performed to confirm signs of implant loosening. Peri-implant tissue formation was assessed through histology. Osseointegration was assessed through µCT and biomechanical pullout testing.