Introduction: There is little epidemiological data on childhood injury in Ireland, despite large numbers of referrals to fracture clinics particularly in the summer months. Information is difficult to obtain retrospectively, and our aim was to quantify paediatric injury referrals to our clinics and analyse trends in injury patterns.

Methods: A prospective injury surveillance system was initiated in our department. Parents were asked to record demographic information and a brief description of the injury at fracture clinics or admission to the ward. Diagnosis and treatment was completed by the attending doctor. Details were transferred to a customised database for analysis.

Results: Overall compliance was excellent. Of 397 recorded referrals, 66% had confirmed fractures, and 20% of these were admitted for operative management. There was an equal sex distribution, and mean age at presentation was 9.1 years. The peak hour of injury was 7 – 8 pm, with fairly even distribution throughout the week. 62% of injuries were due to falls. 39% of injuries occured in or about the home, including 61% of all falls greater than 1 metre, most often from walls and slides. Other common locations for injury were school (16%) and sportsfields (14%). Gaelic football and soccer were the predominant sports causing injury. Fractures occuring during unsupervised sport were more likely to need surgery. Road traffic accidents were an uncommon cause of injury. Home ‘bouncy castles’ and trampolines were a notable cause of injury, causing 6% of all fractures, particularly of the upper limb. Predictably, 41% of all fractures involved the radius. Fractures of the distal humerus, diaphyses of radius, ulna and tibia were most likely to need operative management.

Discussion Analysis yielded a timely insight into the local epidemiology of childhood injuries. In comparison with other studies, sports related injuries were frequent and road accidents were unusually few in our group. Many injuries occurring late in the evening needed early reduction, with almost two thirds of surgical procedures performed out of hours with significant implications on theatre and radiology staffing. A large proportion of higher energy trauma occured in or about the home, representing a potential area for injury prevention stratgies.

There is little data regarding the epidemiology of childhood injury in Ireland. This is difficult to obtain retrospectively. The aim of this study was to prospectively evaluate paediatric trauma referrals to our department, describe their epidemiology, and identify potentially preventable injuries in children. Our unit at the National Childrens Hospital is located in a growing suburban area in South Dublin. Injury surveillance was conducted on orthopaedic referrals by distributing a form to parents of children attending fracture clinics or admitted acutely for surgery. Parents were asked for demographic information, and a brief description of the injury in terms of location, mechanism and circumstance of injury. Diagnosis was completed by the attending doctor and data was transferred to a computerised database. We analyzed data from the 397 referrals in the first month of this study. The mean age of injury was 9.1 years and the male: female ratio was 1.3:1. The peak hour of injury was 7 – 8 pm. Only 33% of injuries occured during the weekend. 62% of injuries were due to falls, usually form the standing position. The most common location for injury was in or about the home (39%), and other notable locations were school (16%) and sportsfield (14%). 61% of falls greater than 1 metre occurred at home, mostly from walls and childrens slides. 20% of injuries occurred while participating in organized sport, including Gaelic football, soccer and hurling. Injuries occuring during unsupervised sport were more likely to need surgery. Domestic ‘bouncing castles’ and trampolines, increasingly popular in our area, were a notable cause of significant trauma to the upper limb. 7% of injuries occurred by falling from a bicycle, but vehicular road traffic accident was an uncommon cause of injury. 263 children had confirmed fractures, other injuries consisting largely of sprains to the ankle, elbow and wrist. Predictably, the bones most commonly fractured were the radius (41%), phalanges (15%) and humerus (11%). 20% of fractures needed operative management, mostly forearm manipulation under anaesthesia. 63% of operative cases were performed outside of normal working hours. Several countries utilise injury surveillance as a means of development and evaluation of injury prevention strategies. In our initial study, basic surveillance has outlined local characteristics of chilhood trauma, and some trends were noted. In particular, we suggest home injuries need further attention in out catchment area.

Currently, data on the complication rates of primary total hip arthroplasty (THA) in Ireland is not available. We surveyed all consultant members of the Irish Orthopaedic Association (IOA) to determine the self reported complication rates of primary THA and analysed national audit data from the Economic and Social Research Institute (ESRI) for 2002. We received an 83% response rate to our survey. 58 surgeons reported data on 5,424 primary THAs for the year 2003. The mean dislocation rate was 1.02% and those using a posterior approach reported a significantly higher dislocation rate (p< 0.05). Deep infection rates were 0.44% and 29% of these were MRSA infections. There was no significant benefit reported from the use of body exhaust operative attire. The mean rate of venous thrombo-embolism (VTE) was 3.5%. There was no statistical difference reported in VTE rates when prophylaxis was commenced pre or post operatively, neither was there any significant benefit reported from using VTE prophylaxis for an extended period beyond the length of inpatient stay, nor from patients wearing graduated compression elastic stockings. ESRI national audit rates for dislocation were 25.7%, and rates of deep infection and VTE were 0.87% and < 0.1% respectively in 2002. Deficiencies in available ESRI data and questionable reliability of self reported rates, underline the necessity for a national Hip Register database in Ireland. The accurate recording of objective data on primary THA could provide an evidence base to improve surgical THA practices and patient outcomes and provide significant healthcare savings.

Introduction: Bone sialoprotein (BSP) is an RGD (Arginine-Glycine-Aspartate) containing non-collagenous extracellular matrix (ECM) protein that is extensively post-translationally modified, predominantly with glycosylated and phosphorylated residues. BSP plays a major role in bone mineralisation and this is thought to exert RGD and non-RGD effects on bone cells. In vivo studies have shown that BSP induces new bone formation in rat critical calvarial defects and that the state of phosphorylation of BSP and OPN changes during the healing of bone defects. We hypothesised that variable BSP phosphorylation was a determinant of bone turnover.

Methods: We adopted an ex vivo approach utilising neonatal mouse calvarial organ culture systems to test this hypothesis and utilised PTH (parathormone) treated mouse calvarial organ cultures to assess the effect of native BSP (phosphorylated) and dephosphorylated BSP on osteoclastogenesis. Seven day old outbred CD1 mice calvarial bone explants were incubated in culture media with 10nM PTH containing native or dephosphorylated BSP. Arsenazo III microplate calcium assays on the media and alkaline phosphatase and tartrate resistant acid phosphatase (TRAP) microplate assays were performed on calvarial lysates. At the end of culture, calvaria were fixed in 10% neutral buffered formalin and stained with H& E, von Kossa or Neutral Red.

Results: The cumulative release of calcium in response to PTH did not change significantly, in the presence of native BSP whereas in the presence of dephosphorylated BSP the calcium release was significantly (p< 0.001) inhibited, 3.1 μmol/ml +/− 0.2 and 1.5 μmol +/− 0.1. TRAP enzyme activity measurements on calvarial lysates were consistent with the above results. Histology showed readily apparent differences in osteoclastic activity on H& E, von Kossa and Neutral Red staining.

Discussion: BSP can inhibit osteoclast formation and activity, and this appears to be dependent on its state of phosphorylation. The dephosphorylation of ECM proteins by bone phosphatases is proposed as an auto-regulatory mechanism during bone turnover. Loss of organic phosphate with aging or disease may disturb auto-regulatory mechanisms of bone turnover leading to pathologic bone disease.