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Orthopaedic Proceedings
Vol. 94-B, Issue SUPP_XXXVII | Pages 436 - 436
1 Sep 2012
A TISSUE ENGINEERING STRATEGY FOR THE TREATMENT OF OSTEONECROSIS: EVALUATION OF EFFICACY IN FOUR PATIENTS
Aarvold A Smith J Tayton E Jones A Briscoe A Lanham S Dunlop D Oreffo R
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Background

Skeletal stem cells (SSCs) have been used for the treatment of osteonecrosis of the femoral head to prevent subsequent collapse. In isolation SSCs do not provide structural support but an innovative case series in Southampton, UK, has used SSCs in combination with impaction bone grafting (IBG) to improve both the biological and mechanical environment and to regenerate new bone at the necrotic site.

Aims

Analysis of retrieved tissue-engineered bone as part of ongoing follow-up of this translational case series.