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Orthopaedic Proceedings
Vol. 105-B, Issue SUPP_12 | Pages 47 - 47
23 Jun 2023
Garbuz DS
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The purpose of this study was to determine long-term survival free from all-cause revision and stem-related failure, as well as radiographic and functional outcomes of the ZMR stem in revision THA.

We retrospectively identified all patients in our institutional database who underwent revision THA using the ZMR Revision Hip system from the year 2000 to 2007 (minimum two-year follow-up). Of the 112 ZMR hips (110 patients) identified, a total of 106 hips (104 patients) met inclusion criteria. The mean study follow-up 13.9 years (range 2–22). Indications for index ZMR revision included aseptic loosening (72.1%), periprosthetic joint infection (17.3%), periprosthetic fracture (9.6%), and stem fracture (1.0%). Kaplan-Meier analysis was used to determine the all-cause and stem-related failure revision-free survival. Validated patient reported outcomes were collected and available radiographs were reviewed to determine implant stability.

A total of 17 hips (16.0%) underwent a re-revision of any component. The indications for re-revision were stem failure (35.3%), infection (29.4%), instability (29.4%), and aseptic loosening of the acetabular component (5.9%). The five- and 15-year all-cause survivorship was 89.5% (95% CI 86.5–92.5) and 83.0% (95% CI 79.2–86.8), respectively. There were six re-revisions for stem failure (5.7%); five for stem fracture and one for aseptic loosening. The average time to stem failure was 4.6 years (range 1.3–8.2). The five- and 15-year survivorship free from stem-related failure was 97.2% (95% CI 95.6–98.8) and 93.9% (95% CI 91.5–96.3), respectively. At final follow-up the mean Oxford hip score was 36.9 and all surviving ZMR stems were well fixed on radiographs.

Femoral revision with the ZMR stem offers satisfactory long-term survivorship and promising clinical outcomes. Although uncommon, stem fracture was the most common reason for stem-related failure.


Bone & Joint Open
Vol. 4, Issue 3 | Pages 182 - 187
14 Mar 2023
Sheridan GA Hanlon M Welch-Phillips A Spratt K Hagan R O'Byrne JM Kenny PJ Kurmis AP Masri BA Garbuz DS Hurson CJ

Aims

Hip resurfacing remains a potentially valuable surgical procedure for appropriately-selected patients with optimised implant choices. However, concern regarding high early failure rates continues to undermine confidence in use. A large contributor to failure is adverse local tissue reactions around metal-on-metal (MoM) bearing surfaces. Such phenomena have been well-explored around MoM total hip arthroplasties, but comparable data in equivalent hip resurfacing procedures is lacking. In order to define genetic predisposition, we performed a case-control study investigating the role of human leucocyte antigen (HLA) genotype in the development of pseudotumours around MoM hip resurfacings.

Methods

A matched case-control study was performed using the prospectively-collected database at the host institution. In all, 16 MoM hip resurfacing 'cases' were identified as having symptomatic periprosthetic pseudotumours on preoperative metal artefact reduction sequence (MARS) MRI, and were subsequently histologically confirmed as high-grade aseptic lymphocyte-dominated vasculitis-associated lesions (ALVALs) at revision surgery. ‘Controls’ were matched by implant type in the absence of evidence of pseudotumour. Blood samples from all cases and controls were collected prospectively for high resolution genetic a nalysis targeting 11 separate HLA loci. Statistical significance was set at 0.10 a priori to determine the association between HLA genotype and pseudotumour formation, given the small sample size.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_10 | Pages 19 - 19
1 Oct 2020
Roedel GG Sveom DS Garvin KL
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Introduction

THA for patient's 50 years and younger is a procedure at high risk for complications and failure because of the high level of activity of this population. Highly cross linked polyethylene (HXLPE) has greatly improved the durability of the implant because of the improved wear characteristics. Few studies have followed this population into the second decade and therefore the purpose of this investigation was to evaluate the clinical outcome for the patients 5o years of age and younger at a minimum of 15 years. The second purpose was to evaluate the radiographic findings secondary to wear or mechanical failure of the implant.

Methods

Between October 1999 and December 2005, 105 THAs were performed in 95 patients (53 female, 42 male) age 50 years and younger (mean 42 years; range 20–50). Ten patients (10 hips) were lost to follow-up or deceased. The remaining 95 hips and 85 patients were followed for a minimum of 15 years (mean of 16.8, range 15–20.5) for analysis. HXLPE (Longevity, Zimmer Biomet) was the acetabular bearing for all hips. Radiographs were evaluated for radiolucent lines and osteolysis.


Orthopaedic Proceedings
Vol. 102-B, Issue SUPP_10 | Pages 12 - 12
1 Oct 2020
Lamontagne M Catelli DS Cotter B Mazuchi FAS Grammatopoulos G
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Introduction

Spinopelvic mobility has been associated with THA outcome. To-date spine assessments have been made quasi-statically, using radiographs, in standing and seated positions but dynamic spinopelvic mobility has not been well explored. This study aims to determine the association between dynamic (motion analysis) and quasi-static (radiographic) sagittal assessments and examine the association between axial and sagittal spinal kinematics in hip OA patients and controls.

Methods

This is a prospective, IRB approved, cohort study of 12 patients with hip OA pre-THA (6F/6M, 67±10 years) and six healthy controls (3F/3M, 46±18 years). All underwent lateral spinopelvic radiographs in standing and seated bend-and-reach (SBR) positions. Pelvic tilt (PT), pelvic-femoral-angle (PFA) and lumbar lordosis (LL) angles were measured in both positions and the differences (Δ) in angles between SBR and standing were computed. All participants performed two dynamic tasks at the motion laboratory: seated maximal trunk rotation (STR) and seated bend and reach (SBR). Three-dimensional joint motion data were collected and processed by a 10-camera infrared motion analysis system (Vicon, Nexus 2.10, UK). Total axial and sagittal spine (mid-thoracic to lumbar) range of motion (ROM) were calculated for STR and SBR, respectively.


Bone & Joint Open
Vol. 1, Issue 8 | Pages 500 - 507
18 Aug 2020
Cheruvu MS Bhachu DS Mulrain J Resool S Cool P Ford DJ Singh RA

Aims

Our rural orthopaedic service has undergone service restructure during the COVID-19 pandemic in order to sustain hip fracture care. All adult trauma care has been centralised to the Royal Shrewsbury Hospital for assessment and medical input, before transferring those requiring operative intervention to the Robert Jones and Agnes Hunt Orthopaedic Hospital. We aim to review the impact of COVID-19 on hip fracture workload and service changes upon management of hip fractures.

Methods

We reviewed our prospectively maintained trust database and National Hip Fracture Database records for the months of March and April between the years 2016 and 2020. Our assessment included fracture pattern (intrascapular vs extracapsular hip fracture), treatment intervention, length of stay and mortality.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_12 | Pages 54 - 54
1 Oct 2019
Lamontagne M Catelli DS Beaulé PE
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Osteochondroplasty procedure for cam deformity provides excellent outcomes on alleviating pain, improving quality of life and clinical function in femoroacetabular impingement syndrome (FAIS) patients. Although medium-term outcomes on gait biomechanics have been reported, it is unclear how it would translate to better hip muscle forces and joint loading in high range of motion tasks. The purpose of this study was to compare the muscle forces and hip joint contact forces (HCF) during a squat task in individuals before and after cam-FAIS surgical correction. Ten cam-FAIS patients prior and 2-years after osteochondroplasty, and 10 BMI- age- and sex-matched healthy control participants (CTRL) underwent 3D motion and ground reaction forces capture while performing a deep squatting task. Muscle and HCF were estimated using musculoskeletal modeling and comparisons were done using statistical parametric mapping (SPM).

Postoperatives squatted down with a higher anterior pelvic tilt and higher hip flexion compared with the preoperatives. Preoperative semimembranosus generated lower forces than the two other groups on the squat ascending, with no differences detected between post-ops and CTRLs. Preoperatives also showed reduced forces for the distal, ischial and medial portions of the adductor magnus relative to the CTRLs, which although reduced, still presented differences postoperatively. Preoperative anterior and medial contact forces were significantly lower than the CTRL group during both phases of the squat. Postoperative vertical and medial forces were also lower compared to the CTRLs. However, with higher vertical forces during the ascent phase of the squat compared to the preoperative, the postoperative group, significantly increased its HCF magnitude. A higher anterior pelvic tilt was associated with an innate restoration of the pelvis position, once the cam deformity no longer existed. The increased force of the semimembranosus muscle while ascending the squat generated higher vertical HCF, which also influenced the increased HCF total magnitude.

For any tables or figures, please contact the authors directly.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_12 | Pages 20 - 20
1 Oct 2019
Masri BA Waly F Duncan CP Greidanus NV Garbuz DS
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Introduction

The practice of overlapping surgery has been increasing in the delivery of orthopaedic care, aiming to provide efficient, high-quality care. However, there have been concerns about the safety of this practice. The purpose of this study is to examine safety and efficacy of a model of partially overlapping surgery that we termed “the swing room” in practice in primary hip and knee arthroplasty.

Methods

A retrospective review of prospectively collected data using an administrative database was carried out on patients who underwent primary unilateral total hip and total knee arthroplasty from 2006 to 2017 at two sites of one academic center staffed by four arthroplasty surgeons. All revisions and bilateral primary procedures were excluded. Cases were stratified as overlapping or non-overlapping. Overlapping was defined when a surgeon had access to two operating rooms with two teams, and non-overlapping was defined as when a surgeon only had access to a single operating room on a particular day. Patient demographic characteristics, operating room time, procedure time, length of stay, Postoperative complications within 30 days of the procedure, unplanned hospital readmissions, unplanned reoperations, and emergency department visits were collected. The Fisher's exact Wilcoxon rank-sum test and logistic regression analysis were used for statistical analysis.


Orthopaedic Proceedings
Vol. 101-B, Issue SUPP_12 | Pages 21 - 21
1 Oct 2019
Huddleston JI Chen AF Browne JA Jaffri H Weitzman DS Bozic KJ
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Introduction

Meaningful clinical improvement as demonstrated through patient-reported outcome measures (PROMs) are increasingly used to evaluate success of total hip arthroplasty (THA) procedures. This patient perspective can provide a full picture when used with clinical data to best evaluate surgical outcomes.

Methods

All primary THA procedures reported to the American Joint Replacement Registry from 2012–2018 with linked pre-operative and 1-year post-operative functional or anatomical PROMs were included. The achievement of minimal clinically-important difference (MCID) was calculated using the distribution method. Logistic regression models with covariate adjustment for patient demographics, American Society of Anesthesiologists (ASA) score, and body mass index (BMI) were constructed to identify associations with PROMs. Results were analyzed based on hospital size (small, medium and large) and teaching type (non-teaching, minor and major) based on the American Hospital Association Survey (2015).


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 72 - 72
1 Oct 2018
El-Husseiny M Masri BA Duncan CP Garbuz DS
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Background

Fully constrained liners are used to treat recurrent dislocations or patients at high risk after total hip replacements. However, they can cause significant morbidities including recurrent dislocations, infections, aseptic loosening and fractures. We examine long term results of 111 patients with tripolar constrained components to assess their redislocation and failure rate.

Questions/purposes

The purpose of this study was to assess survivorship, complications and functional outcomes at a minimum 10 years after the constrained tripolar liners used in our institute.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 73 - 73
1 Oct 2018
El-Husseiny M Masri BA Duncan CP Garbuz DS
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Background

High complication rates and poor outcomes have been widely reported in patients undergoing revision of large head metal-on-metal arthroplasty. A previous study from our center showed high rates of dislocation, nerve injury, early cup loosening and pseudotumor recurrence. After noting these issues, we implemented the following changes in surgical protocol in all large head MOM revisions: 1. Use of highly porous shells in all cases 2. Use of largest femoral head possible 3. Low threshold for use of dual mobility and constrained liners when abductors affected or absent posterior capsule 4. Use of ceramic head with titanium sleeve in all cases 5. Partial resection of pseudotumor adjacent to sciatic and femoral nerves.

Questions/purposes

The purpose of the present study is to compare the new surgical protocol above to our previously reported early complications in this group of patients

We specifically looked at (1) complications including reoperations; (2) radiologic outcomes; and (3) functional outcomes. Complication rates after (Group 1), and before (Group 2) modified surgical protocol were compared using Chi-square test, assuming statistical significance p<0.05.


Orthopaedic Proceedings
Vol. 100-B, Issue SUPP_13 | Pages 17 - 17
1 Oct 2018
Garvin KL Otten MR Sveom DS
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Introduction

Patients under the age of 50 who undergo a total hip arthroplasty (THA) are at high risk for wear-related complications due to their higher activity level. Previous studies have shown that highly crosslinked polyethylene (HXLPE) is more durable with no evidence of loosening compared to conventional polyethylene due to its improved wear characteristics. Unfortunately, there are few studies with long term follow-up of HXLPE in this patient population. The purpose of this study was to evaluate two questions related to this population of patients undergoing THA. First, what were the clinical outcomes for HXLPE in patients 50 years or younger at an average follow-up of 15 years? Second, was osteolysis observed in any of these hips?

Methods

Between November 1999 and April 2005, 105 THAs were performed for 90 patients 50 years of age or younger (mean, 42 years; range, 20–50 years). The mean body mass index (BMI) was 30 kg/m2 (range, 17–51 kg/m2). The mean follow-up was 15.25 years (range, 12–19 years). Eight patients (two bilateral) were lost to follow-up, which left 82 patients with 95 hips for analysis. HXLPE was the acetabular bearing for all hips. Harris Hip Scores were collected from all patients. Radiographs were obtained on all patients to evaluate for wear and osteolysis.


Bone & Joint Research
Vol. 5, Issue 2 | Pages 66 - 72
1 Feb 2016
Gebhart JJ Weinberg DS Bohl MS Liu RW

Objectives

Sagittal alignment of the lumbosacral spine, and specifically pelvic incidence (PI), has been implicated in the development of spine pathology, but generally ignored with regards to diseases of the hip. We aimed to determine if increased PI is correlated with higher rates of hip osteoarthritis (HOA). The effect of PI on the development of knee osteoarthritis (KOA) was used as a negative control.

Methods

We studied 400 well-preserved cadaveric skeletons ranging from 50 to 79 years of age at death. Each specimen’s OA of the hip and knee were graded using a previously described method. PI was measured from standardised lateral photographs of reconstructed pelvises. Multiple regression analysis was performed to determine the relationship between age and PI with HOA and KOA.