Infection is still a major problem in implant surgery. Most infections are caused by bacteria that enter the wound at the time of the operation. Although prophylactic antibiotics given intravenously have been shown to be effective if given during the correct time frame, the concentration of local antibiotics in the knee in response to intravenous antibiotics is about 1/3 that achieved in the serum, and the level is transient. The concentration of antibiotics in the joint fluid achieved with antibiotics applied locally during surgery is 1000 times higher, and can be maintained throughout the procedure. High concentration persists in drainage fluid for 24 hours after surgery.

Studies done with use of local antibiotics in spinal implant surgery indicate a major reduction in the rate of infection, and costs analysis shows a remarkable monetary benefit to this effect.

Local antibiotic irrigation during implant surgery is inexpensive, easy, and effective.

Loss of the abductor portions of the gluteus medius and gluteus minimus muscles due to total hip arthroplasty (THA) causes severe limp and often instability. To minimise the risk of limp and instability the anterior half of the gluteus maximus was transferred to the greater trochanter and sutured under the vastus lateralis. A separate posterior flap was transferred under the primary flap to substitute for the gluteus minimus and capsule. To ensure tight repair, the flaps were attached and tensioned in abduction.

The technique was performed in 11 patients (11 hips) with complete loss of abductor attachment; the procedure was performed in 9 patients during THA and in 2 later as a secondary procedure. Pre-operatively, all patients had abductor lurch, positive Trendelenburg sign, and no abduction of the hip against gravity. The follow up ranged from 16 to 42 months.

Post-operatively, 9 patients had strong abduction of the hip against gravity, no abductor lurch, and negative Trendelenburg sign. One patient had weak abduction against gravity, negative Trendelenburg sign, and slight abductor lurch. One patient failed to achieve strong abduction, had severe limp after 6 months of protection and physical therapy, and was lost to follow up.

Gluteus maximus transfer can restore abductor function in THA, but it is technically demanding and requires careful, prolonged rehabilitation.

Total knee arthroplasty causes unresolved pain and swelling in about 10% of patients despite good alignment, ligament balance, and fixation. Metal sensitivity becomes more common in total knee patients as time passes, wear continues to be a clinically relevant issue, loosening increases in frequency with time, and infection continues to plague implant surgery. Ceramic bearing surfaces address all of these issues. New technologies make possible stronger, more flexible ceramic materials, and one ceramic in particular (magnesia-stabilised zirconia) is especially interesting because of its ability to accept a commercially pure titanium porous coating. These materials do not release metal debris or ions, wear is reduced by a factor of three, and biofilm formation is reduced by a factor of three or more when compared with cobalt-chromium.

After clearing regulatory requirements, this new ceramic technology is likely to advance our solutions to many of the most important clinical problems in knee arthroplasty.

Infection is one of the most devastating complications following total joint arthroplasty. Treatment is difficult, often requiring multiple surgical procedures, prolonged hospitalisation, and long-term intravenous (IV) antibiotic therapy. Failure rates are high for resistant organisms and mixed-flora infections, and antibiotic-loaded cement spacers deliver antibiotics for only a few days and can harbor resistant bacteria on the surface. We have adopted a direct-exchange method with antibiotics infused directly into the joint using Hickman catheters to achieve extremely high levels of intraarticular (IA) antibiotics for six weeks. Hickman catheters have a fibrous cuff that allows soft-tissue ingrowth and seals the surface of the tube to prevent contamination of the joint by tracking along the catheter. Two catheters are inserted to ensure that at least one will be functional for six weeks.

The safety and efficacy of this protocol was evaluated in patients undergoing primary or revision TKA by measuring joint and serum levels of vancomycin following IV administration (as a prophylactic) and IA administration (as a treatment for infected TKA), and comparing the levels with each method. Therapeutic levels of vancomycin were present in the knee following IV or IA administration, but much higher levels were possible with IA administration (avg. of 6.8 and 9,242 µg/mL). Vancomycin achieved therapeutic levels in the synovial fluid of the knee with IV administration, but clearance from the knee was rapid, suggesting that the synovial fluid concentration may be sub-therapeutic for hours before the next IV dose is given. In contrast, IA delivery of vancomycin resulted in peak levels that were many orders of magnitude higher, and trough levels remained therapeutic for 24 hours in both the joint space and in the serum (minimum trough levels of 8.4 and 4.2 µg/mL, respectively). The elimination constant (half-life) of IA-administered vancomycin was 3.1 hours.

This protocol was used in 18 knees (18 patients) with methicillin-resistant Staphylococcus aureus treated between January 2001 and January 2007 with one-stage revision that included debridement, uncemented revision of total knee components, and IA infusion of 500 mg vancomycin via Hickman catheter once or twice daily for 6 weeks. No IV antibiotics were used after the first 24 hours. Serum vancomycin levels were monitored to maintain levels between 3 and 10 µg/mL. Mean serum vancomycin peak concentration was 6±2 µg/mL and the mean serum vancomycin trough concentration was 3±1 µg/mL at 2 weeks postoperative. Knee synovial fluid peak and trough vancomycin levels were measured in two knees. Synovial fluid peak concentrations were 10,233 µg/mL and 20,167 µg/mL and trough concentrations were 724 µg/mL and 543µg/mL, respectively. Minimum follow-up was 27 months (range, 27–75 months). Mean followup was 62 months, (range, 27–96 months). At 2-year follow-up, mean Knee Society score was 83±9. No radiographic evidence of implant migration has occurred. One knee reinfected with MRSA and was reoperated at 5 months. A necrotic bone segment was found, the knee was debrided and revised, and the antibiotic infusion protocol was readministered. The knee remained free of infection at 42 months postoperatively.

Directly infusing antibiotics into the infected area maintains a high local concentration level while minimising systemic toxicity. This method avoids the use of antibiotic-loaded cement and the potential for growth of antibiotic-resistant strains of bacteria. These findings support single-stage revision in cases treated with cementless revision and IA antibiotics.

Fixation of the femoral component in total hip arthroplasty is a surgical challenge in the best of circumstances. Achieving immediate fixation without breaking the femur is a challenge, even to highly skilled and experienced arthroplasty surgeons. Surgical procedures are available that offer cosmetic benefit or a slightly quicker recovery, but accepting this compromise for fixation should be avoided.

The mechanical environment of the femoral component is challenging. The implant is exposed to offset loading in two planes, which results in substantial bending stress and rotational loads in the frontal plane as well as bending stress and torsional loads in the sagittal plane. The proximal femur is built to transmit load through the surface fibers, not the central cavity, so efforts to change it to a centrally loaded structure are fraught with difficulty. The entire structure should be used. The least reliable material is the cancellous bone in the intertrochanteric metaphysis and the most effective is the cancellous bone of the femoral neck and cortical bone of the upper diaphysis. For best fixation of the femoral component, the cortical bone of the upper metaphysis should be contacted, and the diaphyseal cortical bone actually should be grooved by the femoral stem during insertion.

Approach to the hip is important in fixation of the femoral component. Approaches that require femoral neck resection and use of a short stem are especially treacherous. The posterior approach is attractive because it encourages preservation of the femoral neck, and it provides straight access to the medullary canal of the femur while protecting the abductor muscles.

Static axial load in the extended position is most readily resisted by the femoral component. Distal cortical contact is very important to prevent toggle. Torsional loads generated from offset loading of the femoral head in flexion and with front-to-back acceleration generated loads during rapid gait are the most challenging in securing fixation of the implant. Ideal conditions include preservation of the femoral neck, engagement of a rectangular stem in a rectangular cavity, and mechanical lock into grooves in the diaphyseal cortical bone. If all these conditions are met, femoral component fixation can be achieved every time without damaging the abductor muscle group, and with minimal danger of femoral fracture.

A posterior approach with femoral neck preservation and a rectangular shaped femoral component with diaphyseal engaging stem is safe surgery and good mechanics. The anterior approach with femoral neck sacrifice and round, short stems is unsafe surgery and bad mechanics.

The cornerstone to proper ligament balancing in TKR is correct varus and valgus alignment in flexion and extension. For alignment in the extended position, fixed anatomic landmarks such as the intramedullary canal of the femur and long axis of the tibia are accepted. When the joint surface is resected at an angle of 5 degrees to 7 degrees valgus to the medullary canal of the femur and perpendicular to the long axis of the tibia, the joint surfaces are perpendicular to the mechanical axis of the lower extremity, and roughly parallel to the epicondylar axis. In the flexed position, anatomic landmarks are equally important for varus-valgus alignment. Incorrect varus-valgus alignment in flexion not only malaligns the long axes of the femur and tibia, but also incorrectly positions the patellar groove both in flexion and extension.

Finding suitable landmarks for varus-valgus alignment has led to efforts to use the posterior femoral condyles, epicondylar axis, and anteroposterior (AP) axis of the femur. The posterior femoral condyles provide excellent rotational alignment landmarks if the femoral joint surface has not been worn or otherwise distorted by developmental abnormalities or the arthritic process. However, as with the distal surfaces, the posterior femoral condylar surfaces sometimes are damaged or hypoplastic (more commonly in the valgus than in the varus knee) and cannot serve as reliable anatomic guides for alignment. The epicondylar axis is anatomically inconsistent and in all cases other than revision total knee arthroplasty with severe bone loss, is unreliable for varus-valgus alignment in flexion just as it is in extension. The AP axis, defined by the lateral border of the posterior cruciate ligament posteriorly and the deepest part of the patellar groove anteriorly, is highly consistent, and always lies within the median sagittal plane that bisects the lower extremity, passing through the hip, knee, and ankle. When the articular surfaces are resected perpendicular to the AP axis, they are perpendicular to the AP plane, and the extremity can function normally in this plane throughout the arc of flexion.

The cornerstone to correct ligament balancing is correct varus and valgus alignment in flexion and extension. For alignment in the extended position, fixed anatomic landmarks such as the intramedullary canal of the femur and long axis of the tibia are accepted. When the joint surface is resected at an angle of 5° to 7° valgus to the medullary canal of the femur and perpendicular to the long axis of the tibia, the joint surfaces are perpendicular to the mechanical axis of the lower extremity, and roughly parallel to the epicondylar axis. In the flexed position, anatomic landmarks are equally important for varus-valgus alignment. Incorrect varus-valgus alignment in flexion not only malaligns the long axes of the femur and tibia, but also incorrectly positions the patellar groove both in flexion and extension.

Finding suitable landmarks for varus-valgus alignment has led to efforts to use the posterior femoral condyles, epicondylar axis, and anteroposterior (AP) axis of the femur. The posterior femoral condyles often are not reliable rotational alignment landmarks because the femoral joint surface has been worn or otherwise distorted by developmental abnormalities or the arthritic process. As with the distal surfaces, the posterior femoral condylar surfaces sometimes are damaged or hypoplastic (more commonly in the valgus than in the varus knee) and cannot serve as reliable anatomic guides for alignment. The epicondylar axis is anatomically inconsistent and in all cases other than revision total knee arthroplasty with severe bone loss, is unreliable for varus-valgus alignment in flexion just as it is in extension. The AP axis, defined by the centre of the intercondylar notch posteriorly and the deepest part of the patellar groove anteriorly, is highly consistent, and always lies within the median sagittal plane that bisects the lower extremity, passing through the hip, knee, and ankle. When the articular surfaces are resected perpendicular to the AP axis, they are perpendicular to the AP plane, and the extremity can function normally in this plane throughout the arc of flexion. Once the knee is set up in correct alignment, ligament balancing can be done with simple procedures based on basic anatomy. Anterior structures tighten in flexion, and posterior structures tighten in extension. Release of tight structures in a controlled fashion completes the aligned and balanced knee.

Infection is one of the most devastating complications following total joint arthroplasty. Treatment is difficult, often requiring multiple surgical procedures, prolonged hospitalisation, and long-term intravenous (IV) antibiotic therapy. Failure rates are high for resistant organisms and mixed-flora infections, and antibiotic-loaded cement spacers deliver antibiotics for only a few days and can harbor resistant bacteria on the surface. We have adopted a direct-exchange method with antibiotics infused directly into the joint using Hickman catheters to achieve extremely high levels of intra-articular (IA) antibiotics for six weeks. Hickman catheters have a fibrous cuff that allows soft-tissue ingrowth and seals the surface of the tube to prevent contamination of the joint by tracking along the catheter. Two catheters are inserted to ensure that at least one will be functional for six weeks.

The safety and efficacy of this protocol was evaluated in patients undergoing primary or revision TKA by measuring joint and serum levels of vancomycin following IV administration (as a prophylactic) and IA administration (as a treatment for infected TKA), and comparing the levels with each method. Therapeutic levels of vancomycin were present in the knee following IV or IA administration, but much higher levels were possible with IA administration. Vancomycin achieved therapeutic levels in the synovial fluid of the knee with IV administration, but clearance from the knee was rapid, suggesting that the synovial fluid concentration may be sub-therapeutic for hours before the next IV dose is given. In contrast, IA delivery of vancomycin resulted in peak levels that were many orders of magnitude higher, and trough levels remained therapeutic for 24 hours in both the joint space and in the serum (trough levels of 8.4 and 4.2 μg/mL, respectively). The elimination constant (half-life) of IA-administered vancomycin was determined to be 3.06 hours.

This protocol was used in 18 knees (18 patients) with methicillin-resistant Staphylococcus aureus treated between January 2001 and January 2007 with one-stage revision that included debridement, uncemented revision of total knee components, and IA infusion of 500 mg vancomycin via Hickman catheter once or twice daily for 6 weeks. No IV antibiotics were used after the first 24 hours. Serum vancomycin levels were monitored to maintain levels between 3 and 10 μg/mL. Mean serum vancomycin peak concentration was 6±2 μg/mL and the mean serum vancomycin trough concentration was 3±1 μg/mL at 2 weeks post-operative. Knee synovial fluid peak and trough vancomycin levels were measured in two knees. Synovial fluid peak concentrations were 10,233 μg/mL and 20,167 μg/mL and trough concentrations were 724 μg/mL and 543μg/mL, respectively. Minimum follow-up was 27 months (range, 27–75 months). Mean follow-up was 62 months, (range, 27–96 months). At 2-year follow-up, mean Knee Society score was 83±9. No radiographic evidence of implant migration has occurred. One knee reinfected with MRSA and was reoperated at 5 months. A necrotic bone segment was found, the knee was debrided and revised, and the antibiotic infusion protocol was readministered. The knee remained free of infection at 42 months post-operatively.

Directly infusing antibiotics into the infected area maintains a high local concentration level while minimising systemic toxicity. This method avoids the use of antibiotic-loaded cement and the potential for growth of antibiotic-resistant strains of bacteria. These findings support single-stage revision in cases treated with cementless revision and IA antibiotics.

Loss of the quadriceps tendon, patella, and patellar tendon leaves a major anterior defect that is difficult to close and compromises knee extension strength. Gastrocnemius muscle transfer does not sufficiently cover such major defects. A new surgical procedure is described that transfers the vastus medialis or the vastus lateralis and their tibial attachments, or both muscles and their distal expansions to cover major deficiencies in the anterior knee.

Nine cadaver knee specimens were dissected to ensure that the blood and nerve supply of the muscles would remain intact in the flap transfer. Eight clinical cases were done between 2005 and 2009. Four knees had vastus medialis transfer, two knees required vastus medialis and vastus lateralis transfer, two knees required transfer of the vastus medialis and medial gastrocnemius muscles, and two knees required transfer of both the medial gastrocnemius and medial half of the soleus muscle to close the knee and to secure distal attachment of the vastus transfer.

All patients achieved closure of the knee joint without synovial leaks by 10 days post-operatively. Mean flexion contracture at last follow-up was 3° (range, 0–7°). Mean extension lag was 22° (range, 5–65°). Extension lag was less in those cases that included gastrocnemius or soleus muscle transfer. None of the flaps developed necrosis.

The vastus medialis and vastus lateralis muscles are effective as muscle transfers about the knee.

Introduction

Resistant organisms are difficult to eradicate in infected total knee arthroplasty, and treatment of methicillin-resistant Staphylococcus aureus (MRSA) is especially challenging. Whereas most surgeons use antibiotic-impregnated cement during revision to treat infection, the delivery of the drug in adequate doses is limited in penetration and duration. This study presents the 2- to 8-year prospective results of one-stage revision and intraarticular antibiotic infusion protocol used to treat MRSA.

Introduction

Recent clinical studies found no apparent reduction in wear using yttria-stabilized zirconia (Y-TZP) instead of cobalt chromium alloy femoral heads bearing against cross-linked UHMWPE. The purpose of this study was to compare the surface topography of retrieved Y-TZP and magnesia-stabilized zirconia (Mg-PSZ) femoral heads and evaluate the influence of time in vivo. The increase in average roughness (Ra, Sa) of Y-TZP due to phase transformation in vivo is well documented, while Mg-PSZ does not roughen or undergo phase transformation in vivo. However, the effects of phase transformation on the polarity (skewness, Ssk) of the surface of retrieved ZrO₂ heads has not been reported. We hypothesized that phase transformation associated with the increased roughness of Y-TZP would influence skewness and thus the wear potential of the heads.